http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이동섭,김준모,우경인,장혜란,Dong Sub Lee,Joon Mo Kim,Kyung In Woo,Hae Ran Chang 대한안과학회 2006 대한안과학회지 Vol.47 No.9
Purpose: To determine postoperative astigmatic changes after surgery for congenital ptosis and the astigmatic changes depending on surgical method and to discern cases of postoperatively developed anisometropia or amblyopia. Methods: Fifty-one patients who underwent surgery due to congenital ptosis were reviewed. Refraction or cycloplegic refraction was conducted preoperatively and 3 to 6 months after surgery to measure astigmatic changes. Astigmatic changes in operated eyes were compared to control eyes. Astigmatic changes were compared depending on surgical method. Results: The mean astigmatism was 1.33±1.29D preoperatively and 1.48±1.13D postoperatively (P=0.10) and the mean astigmatic change in the ptotic and control eye was an increase in cylinder +0.56±0.55D and +0.68±0.72D (P=0.37). The mean astigmatic change of patients receiving frontalis sling was +0.57±0.67D which was similar to those who received levator resection (+0.56±0.50D). Newly developed anisometropia was found in three patients postoperatively due to an increase in astigmatism, but newly developed amblyopia was not found. Conclusions: The increase of astigmatism by ptosis surgery was not statistically significant and there was no statistically significant difference when accounting for surgical method. However, it is necessary to monitor refractive error carefully in younger patients to prevent amblyopia because postoperative increase of astigmatism can cause anisometropia.
노인인구에서 ApoE 유전자형에 따른 머리둘레와 인지기능간의 연관성
김경란,오병훈,이준영,김은아,정해관,이동우,홍창형 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3
Objectives : The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community. Methods : A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype. Results : On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE ε4 allele, current smoking and alcohol drinking status (β=0.15, P=0.04). Only in the lowest qu-artile group, presence of ApoE ε4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alco-hol drinking and smoking status (β= -1.39, P= 0.008) Conclusion : These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE ε4 allele may be a medicating factor.
( Hae Lim Lee ),( Sung Won Lee ),( Nam Ik Han ),( Hee Yeon Kim ),( Chang Wook Kim ),( Chan Ran You ),( Sang Wook Choi ),( Se Hyun Cho ),( Joon-yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: The advent of direct-acting antiviral agents (DAA) has enabled high sustained viral response (SVR) rates in hepatitis C virus (HCV) infected patients. We aimed to evaluate longitudinal changes in liver function parameters and fibrosis scores in patients who achieved SVR. Methods: A total of 963 patients who received interferon free DAA combination ± ribavirin for HCV infection between December 2015 and February 2017 at the liver unit of the Catholic University of Korea were consecutively recruited. Patients with hepatocellular carcinoma, other liver diseases, or those who received liver transplantation were excluded. Four hundred and thirteen patients who achieved sustained viral response 12 weeks post treatment (SVR12) were analyzed and the parameters of liver function, AST to Platelet Index (APRI) and Fibrosis-4 (FIB-4) scores before treatment was compared to that of SVR12. Results: Of the 413 patients, 308 (75%) patients had chronic hepatitis and 105 (25%) patients had liver cirrhosis. In the total patients, aspartate aminotransferase were decreased from 61 to 28 IU/L and alanine aminotransferase levels were decreased from 57 to 21 IU/L between baseline and 4 weeks post treatment (p<0.001, both). In the patients with chronic hepatitis, APRI and FIB-4 scores were all significantly improved; APRI score was 0.93±1.28 and 0.51±0.56, p<0.001, FIB-4 score was 3.25±3.79 and 2.67±2.21, p=0.022, (mean±SD), at baseline and SVR12, respectively. In the patients with liver cirrhosis, platelet (PLT), albumin, prothrombine time international normalized ratio (PT INR) levels, APRI and FIB-4 scores were all significantly improved; PLT level was 115±53 and 166±82, p<0.001, albumin level was 3.8±0.6 and 4.3±0.3, p<0.001, PT INR level was 1.15±0.13 and 1.05±0.09, p<0.001, APRI score was 2.13±1.59 and 0.55±0.42, p<0.001, FIB-4 score was 7.83±5.56 and 2.79±1.73, p<0.001, at baseline and SVR12, respectively (mean±SD). Conclusions: This study suggested that a significant improvement in liver function parameters and non-invasive fibrosis markers could be achieved in HCV infected patients who achieved SVR.
B 형 간염 바이러스에 의한 간질환에서 혈청 B 형 간염 바이러스 DNA 의 검출 양상
박영태(Young Tae Bak),이창홍(Chang Hong Lee),유혜경(Hae Kyoung Yoo),문해란(Hae Ran Moon),최규완(Kyoo Wan Choi),김경호(Kyong Ho Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.3
N/A Serum HBV-DNA was measured by spot hybridization technique in 189 cases with HBsAg positive acute and chronic liver diseases, HBV-DNA was detected in 62% (68/110) of HBeAg positive, in 16% (10f62) of anti-HBe positive, and in 18% (3/17) of both HBeAg and anti-HBe negative patients. Cases with higher levels of HBV-DNA among HBeAg positive patients were significantly more than those among the HBeAg negative patients, Among the HBeAg positive patients, HBV DNA was detected in 36% of AVH, 86% of healthy carriers, 63% of CPH, 62% of CAI-l-m, 58% of CAH-s, 65% of LC, and 71% of HCC. Among the HBeAg positive patients, those with histologically minimal or mild inflammatory change (healthy carrier, CPH, CAH-m) had higher levels of HBV-DNA, and those with histologically greater inflammatory or destructive change (CAH-s, LC, HCC, AVH) had lower levels of HBV-DNA. Above results suggest that detection of serum HBV- DNA in patients with HBV-related liver diseases may be useful to evaluate the degree of viral replication and infectivity and to predict the histological severity and relative prognosis.
Hypomorphic Mutations in <i>TONSL</i> Cause SPONASTRIME Dysplasia
Chang, Hae Ryung,Cho, Sung Yoon,Lee, Jae Hoon,Lee, Eunkyung,Seo, Jieun,Lee, Hye Ran,Cavalcanti, Denise P.,Mä,kitie, Outi,Valta, Helena,Girisha, Katta M.,Lee, Chung,Neethukrishna, Kausthubham,Bhava Elsevier 2019 American journal of human genetics Vol.104 No.3
<P>SPONASTRIME dysplasia is a rare, recessive skeletal dysplasia characterized by short stature, facial dysmorphism, and aberrant radiographic findings of the spine and long bone metaphysis. No causative genetic alterations for SPONASTRIME dysplasia have yet been determined. Using whole-exome sequencing (WES), we identified bi-allelic <I>TONSL</I> mutations in 10 of 13 individuals with SPONASTRIME dysplasia. TONSL is a multi-domain scaffold protein that interacts with DNA replication and repair factors and which plays critical roles in resistance to replication stress and the maintenance of genome integrity. We show here that cellular defects in dermal fibroblasts from affected individuals are complemented by the expression of wild-type <I>TONSL</I>. In addition, <I>in vitro</I> cell-based assays and <I>in silico</I> analyses of TONSL structure support the pathogenicity of those <I>TONSL</I> variants. Intriguingly, a knock-in (KI) <I>Tonsl</I> mouse model leads to embryonic lethality, implying the physiological importance of TONSL. Overall, these findings indicate that genetic variants resulting in reduced function of TONSL cause SPONASTRIME dysplasia and highlight the importance of TONSL in embryonic development and postnatal growth.</P>