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한국형 자궁경부 촬영진 ( New Cervicography ) , 세포검사 그리고 HPV-DNA 검사를 이용한 새로운 자궁경부암 검진 모델 ( Model ) 개발
김승조(SJ Kim),박찬규(CK Park),이효표(HP Lee),남궁성은(SE Namkoong),강순범(SB Kang),서호석(HS Saw),이재관(JK Lee),김수녕(SN Kim),김재원(JW Kim),배석년(SN Bae),김찬주(CJ Kim),이근호(KH Lee),이선영(SY Lee),김인호(IH Kim),이찬(C Lee),이정노(JN Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
Objective : The false negative rate of conventional cytology is reported to range from 18 to 45%. It is necessary to develop more effective screening strategies that would ideally be more accurate than conventional cytology. This study is designed to investigate the potential of conventional cytology, cervicography, HPV-DNA testing and their combinations as primary screening techniques for cervical neoplasia. The purpose of this project is to develop the models and guidelines for screening tools of cervical cancer of the uterus by evaluating sensitivity, specificity and cost-effectiveness of all the screening methods. Study design : We conducted a screening of random sample of women who visited the department of OB-Gyn. of five different major university hospitals such as Catholic University Hospital, Korea University Hospital, Seoul National University Hospital, Yeonsei University Hospital and Pochon CHA University Bundang CHA Hospital, from May 1, 1996 to April 30, 1999. In a cohort women with an age range of 20 to 70 who underwent routine cytologic screening at Catholic University, Hospital Bundang CHA General Hospital and local clinics from April 1, 1996 to Decomber 31, 2000. cervicography (n=417,125) and testing for HPV-DNA (n=1,347) by the hybrid capture assay were studied for the ability of the cervical cancer screeuing. A new cervicography system with Kim's classification which was developed by Prof. Kim Seung Jo as an adjunctive method for the cervical cancer screening was applied in this cohort study. And then, accuracy, effectivencess, cost-effectiveness of the single or combined screening method were analysed. Result : Sensitivity and specificity of Pap smear were ranged from 55.6% to 83.1% and 72.8% to 88.3% respectively. The combination of Pap smear and cervicography had sensitivity from 89.7% to 98.6%, specificity from 68.2% to 93.2%. With combination of Pap smear, HPV DNA test and cervicography, sensitivity became also highest accuracy among all screening methods from 92.8% to 98.8%. Considering medical charges for diagnosis and social cost occurred by false positive and false negative results, the most cost-effective diagnostic modality was thought to be the combination of Pap smear and cervicography(91,433 won). In patients who were diagnosed as LSIL, colposcopic examination confirmed progression to high grade intraepithelial lesion(HSIL) in 10.7% patients, persistence of LSIL in 55% patients during the 3 year follow-up period. Accuracy of the screening for cervical cancer and CIN can significantly be improved by cytology with new cervicography rather than cytology alone. We concluded that cervicography can be important adjunctive tests for cervical cytology, improving the effectiveness of cervical screening by allowing a more sensitive detection of cervical neoplasia.
표식한 HEMA 유사체를 이용한 상아질 부착계면의 STEM/EDS 분석
에?, 제이 디,한호진,김철위 서울대학교 치과대학 치과생체재료학교실 1997 치과생체재료학 논문집 Vol.5 No.1
상아질 부착제 계면의 모습과 상아질 표면과 관계하여 부착제의 습윤과 침투정도를 비교하기 위해 STEM과 EDS로 4종의 상아질 부착체계를 연구하였다. 많은 상아질 부착제 체계에 상용하는 단량체인 HEMA를 황화물 유사체인 HETMA로 변형하였다. HEMA 분자의 골격에서 산소원자를 EDS와 STEM으로 추적할 수 있는 황으로 대체하였다. 이 유사체는 용해도와 습윤성 및 기타 물성이 HEMA와 유사하며 각각 다른 프라이머나 식각제로 전처리한 4 세트의 치아표본에 이유사체를 적용하였다. 3종의 전처리제 (질산, 말레이산 및 구연산)로 상아질 표면에 약 1~3㎛의 탈회부위를 형성하였다. 셋중 뒤의 2종의 전처리제를 사용하였을 때 HET-MA는 이 부위로 자유로이 침투하였으나 질산으로 탈회한 상아질 층은 HETMA에 불투과성 이었다. 4째 전처리제로 인산에스터인 PENTA와 HEMA를 포함하는 알콜성 용액으로 도말층을 약간 변형하였으며 상아질을 탈회하지 않았다. PENTA와 HEMA로 전처리한 표본에 HETMA를 적용하였을 때 상아질과 긴밀한 접촉을 하여 도말층을 변형하였으나 이 부위로 침투하거나 확산하지 못하였다. 각각 다른 체계에서 명확히 일어나듯 상아세관으로 흘러들어갔다. 결론으로 산으로 상아질을 전처리하여 상아질 결합제의 습윤성에 큰 영향을 주었으며 상아질 결합체계의 결합강도에 영향을 주었다.
자궁내막암에서의 수술 전 혈중 종양표지물질 CA-125 농도와 예후인자와의 관계에 관한 연구
김병기,강순범,이효표,김낙연,안치석,송용상,김우호 대한부인종양 콜포스코피학회 1992 Journal of Gynecologic Oncology Vol.2 No.1
We evaluated 2l women with endometrial carcinoma to determine the relationship between the preoperative tumor marker CA-125 level and the postoperative histologic grade and depth of myometrial invasion, from February 1987 to Februaury 199l. In all patients, the clinical stage was Ⅰ or Ⅱ In histologic grade, serum CA-l25 level was elevated($gt;35 U/ml) in 25.0%(2/8) of patients with G l, 20.0%(2/10) of patients with G2, and 33. 3%(1/3) of patients with G3. There was not a significant relationship between elevated serum CA-l25 level and histologic grade, In depth of myometrial invasion, serum CA-125 level was elevated($gt;35 U/ml) in 6.7%(l/l5) of patients with less than half of the myometrium and 66.7% (4~g6) of patients with more than half of the myometrium. A statistically significant relationship was recorded when the tumor had penetrated more than half of the myometrium, Preoperative evaluation of serum CA-125 level could be successfully combined with other techniques in therapy planning of endometrial carcinoma.
자궁겨우암에 있어서 Nucleolar Organizer Regions과 예후인자로서의 효용성에 관한 연구
김병기,최영민,강순범,이효표,송용상,김우호,김종훈,박중신,전혜원 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.1
We evaluated 17 women with normal cervix and 67 women with invasive cervical carcinoma to determine the relationship between the clinical variables of the cervical cancer(age, clinical stage, tumor size, depth of invasion, lymph node meatstasis, 5-year disease free survival rate) and nucleolar organizer regions by silver colloid technique with formalin fixed paraffin embedded tissues from January 1985 to December 1986 We calculated the mean number of AgNQRs per cell among 100 cells using an oil immersion lens and classified two groups according to the me number of AgNOR, 1.5(group I$lt;.l.5, group II1.5). There was significantly higher number of AgNORs in the invasive cervical carcinoma than in the normal cervix(Mean±SEN: 1.20±0.15, 1.65±0.06), The number of AgNORs was not significantly associated with age, tumor size, depth of invasion and clinical stage. And there was no significant difference in the 5-year disease free survival rates between the two groups in invasive cervical carcinoma. So we concluded that the number of AgNOR may be useful for the differential diagnosis between the normal and the malignancy but may not be useful as the prognostic factor of cervical carcinoma.
김종혁,최영민,이효표,김필수,김승철,서진석 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.11
저자들은 1988년 9월 임신과 병합된 난소의 순수융모상피암을 발견하여 수술 및 화학요법을 시행하고 1년간 외래추적중 현재까지 병의 재발없이 지내는 환자를 경험하였으며, 이에 문헌고찰과 함께 보고하는 바이다. A rare case of pure ovarian choriocarcinoma coexistent with a normal pregnancy is presented. In this case, the patient was managed with surgery and combination chemotherapy along with termination of pregnancy by hysterecotomy. Here we report our experience with the review of literature.
배란유도시 발생한 중증 난소과자극증후군에 대한 임상적 고찰
김홍필(HP Kim),정정은(JE Chung),박성우(SW Park),김안택(AT Kim),오대출(DC Oh),문용호(YH Moon),박경도(KD Park),정기성(KS Chung) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10
Ovarian hyperstimulation syndrome(OHSS)is an iatrogenic complication of ovulation induction agents used for ovulatory dysfunction. This reports is to review the records of 10 patients who were hospitalized for the management of severe ovarian hyperstimulation syndrome from September, 1990 to June, 1994. retrospectively. Treatment was conservative with infusion of plasma volume expander and electrolyte solutions. In 3 cases, transvaginal paracentesis was performed for symptomatic relief. The result were as follows: 1. The regimens for controlled ovarian hyperstimulation were hMG/hCG in 9 cases, CC/hMG/hCG in one case. 2. In all cases, abdominal patin, ovarian enlargement, ascites and weight gain were presented. There was no case of thromboembolism. 3. The mean age of 10 patients was 27 years. The duration from hCG injection to hospital admission was 15 dyas and the mean hospital day was 12 days. The mean preovualtory serum E2 level has 9760.6 pg/ml. 4. In 3 cases, paracentesis was performed under the transvaginal ultrasonographic guidances. An average amount of paracentesis per one time was 1660 ml. 5. 9 patients(90%) including 2 twin gestations were associated with conception. As a conclusion, severe OHSS was recevered with conservative treatment, including fluid therapy and correction of electrolyte imbalance, and transvaginal ultrasonography guided paracentesis without any serious complication.
자궁경부암에서의 표피성장인자 수용체의 발현과 자궁경부암의 예후와의 관계에 관한 연구
이효표(HP Lee),송용상(YS Song),김종훈(JH Kim),최영민(YM Choi),강순범(SB Kang),김우호(WH Kim),박성희(SH Park) 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.3
The cervical carcinoma is the most common malignant tumor in Korean women. But the pathophysiology of the cervical carcinoma is not well known. So, several different classification systems have been proposed through the years, but the international classification adopted by FIGO is now widely used for the determination of therapeutic modalities and prognosis. And it is the most helpful prognostic factor in predicting survival. We cannot know the biological characteristics of cervical cancer precisely by the histopathological finding alone. So many investigators have been studying to find the other prognostic factors. During the last few years, epidermal growth factor (EGF) and its receptor (EGFR) have been intensively investigated in many other tumors such as lung cancer, breast cancer and brain tumor. In this study, author examined the tissue localization of EGFR by means of immunohistochemical staining in the formalin fixed paraffin embedded tissues of normal squamous epithelium (42 cases), dysplasia (5 cases), carcinoma in situ (4 cases), microinvasive carcinoma (7 cases), invasive carcinoma (48 cases) of the uterine cervix. And we tried to find out the relationship among the expression of EGFR and the survival and clinical characteristics of cervical carcinoma. The results wer as follows ; 1. Normal squamous epithelium was weakly postive for EGFR in 2.4%(1/42). But the lesions of cervical dysplasia and cervical carcinoma were positive for EGFR in 20% and 50.8% (P0.5). 3. There was no significant relationship between the primary tumor size and histological type(P>0.1). 4. There was no significant relationship between the metastasis to lymph node and cervical depth of invasion (P0.1).
DMBA-TPA에 의해 유도된 Mouse 생식기 암 발현의 Indomethacin투여에 의한 조절
김해석(HS Kim),김완영(WY Kim),강순범(SB Kang),이효표(HP Lee) 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.1
The Chemopreventive activity of indomethacin has been studied in many animal tumor models, and the mechanism of its chemopreventive activity was supposed in diverse aspects, but still at controversary. We have developed a mouse model of genital tract milignancies using DMBA as initiator and TPA as promoter. Using this model we studied the potency of chemoprevention of indomethacin which was given intraperitoneally. The results were as follows. 1. The incidence of uteirne cervical cancer in mice treated with indomethacin was significantly lower than the untreated(p<0.01). 2. The incidence of vulvar cancer in mice treated with indomethacin was significantly lower than the untreated(p<0.05). 3. The side effect of indomethacin administered intraperitoneally was negligible.