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( Hyun Sun Yun ),( Ju Hee Heo ),( Seok Jun Son ),( Mi Ri Park ),( Sang Nam Oh ),( Min Ho Song ),( Jong Nam Kim ),( Gwang Woong Go ),( Ho Seong Cho ),( Nag Jin Choi ),( Seung Wha Jo ),( Do Youn Jeong ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.8
We investigated whether Bacillus spp., newly isolated from Korean traditional food resources, influence the resistance of hosts to foodborne pathogens, by using Caenorhabditis elegans as a surrogate host model. Initially, we selected 20 Bacillus spp. that possess antimicrobial activity against various foodborne pathogens, including Staphylococcus aureus. Among the selected strains, six strains of Bacillus spp. used in preconditioning significantly prolonged the survival of nematodes exposed to S. aureus. Based on 16S rRNA gene sequencing, all six strains were identified as B. licheniformis. Our findings suggest that preconditioning with B. licheniformis may modulate the host defense response against S. aureus.
중쇄지방산 강화 디아실글리세롤(MCE-DAG)이 간세포 내 콜레스테롤 흡수 및 합성 기전에 미치는 영향
김현경(Hyun Kyung Kim),최종훈(Jong Hun Choi),김훈중(Hun Jung Kim),김우기(Wooki Kim),고광웅(Gwang-woong Go) 한국식품과학회 2019 한국식품과학회지 Vol.51 No.3
본 연구진은 선행연구에서 MCE-DAG를 섭취한 마우스에서 혈중 총 콜레스테롤과 LDL 콜레스테롤의 감소를 보고한 바 있어, 본 연구에서 in vitro를 통해 MCE-DAG와 간의 콜레스테롤 항상성 기전의 관련성을 구명하고자 하였다. LDLR과 같은 콜레스테롤 흡수 관련 인자의 발현이 MCE-DAG에 의해 증가한 반면, LDLR을 억제하는 PCSK9의 발현은 감소하였다. 또한, 콜레스테롤 합성 관련 인자인 HMGCR의 발현이 MCE-DAG에 의해 증가하였고, 전사조절인자인 SREBP2의 발현이 증가하였다. 이러한 결과들은 콜레스테롤의 합성과 흡수가 동시에 증가하였음을 뒷받침한다. 즉, 간 내 콜레스테롤 필요량이 증가함에 따라, 간의 콜레스테롤 합성 및 흡수를 활성화시켜 콜레스테롤 항상성을 유지하는 기전이 촉진되었음을 의미한다. 하지만 간 세포 내 총 콜레스테롤 양은 MCE-DAG에서 영향을 받지 않았다. 콜레스테롤 흡수 및 합성 기전이 촉진되었음에도 세포 내 콜레스테롤 농도가 증가하지 않은 현상은 담즙산 등 콜레스테롤 분비 촉진에 의한 것일 수 있다. 이러한 추론은 추후 콜레스테롤 분비 기전을 검증할 수 있는 실험을 설계하여 검증해볼 필요성이 있다. 결론적으로 MCE-DAG는 세포 내 콜레스테롤 흡수 작용을 촉진하는 효과가 있어 추후 기능성 유지로 활용 가능할 것으로 판단된다. The effects of medium-chain enriched diacylglycerol (MCE-DAG) oil on hepatic cholesterol homeostasis were investigated. HepG2 hepatocytes were treated with either 0.5, 1.0, or 1.5 μg/mL of MCE-DAG for 48 h. There was no evidence of cytotoxicity by MCE-DAG up to 1.5 μg/mL. The level of proteins for cholesterol uptake including CLATHRIN and LDL receptor increased by MCE-DAG in a dose-dependent manner (p<0.05). Furthermore, proprotein convertase subtilisin/kexin type 9, an inhibitor of LDLR, was dose-dependently diminished (p<0.05), indicating cholesterol clearance raised. MCE-DAG significantly increased 3-hydroxy-3-methylglutaryl-coenzyme A reductase and acetyl-CoA acetyltransferase2 (p<0.05), required for cholesterol synthesis, and their transcriptional regulator sterol regulatory element-binding protein2 (p<0.05). These findings suggest that given conditions of prolonged sterol fasting in the current study activated both hepatic cholesterol synthesis and clearance by MCE-DAG. However, total intracellular level of cholesterol was not altered by MCE-DAG. Taken together, MCE-DAG has the potential to prevent hypercholesterolemia by increasing hepatic cholesterol uptake without affecting intracellular cholesterol level.
저층 트롤에서 3차원 위치를 이용한 만곡형 전개판의 영각 추정
고광수 ( Gwang Su Go ),조봉곤 ( Bong Kon Chol ),배재현 ( Jae Hyun Bae ),조성옥 ( Seong Ok Cho ),원성재 ( Sung Jae Won ),윤홍근 ( Hong Keun Yoon ),박해훈 ( Hae Hoon Park ) 한국수산해양기술학회 2015 수산해양기술연구 Vol.51 No.1
The angle of attack of a cambered otter board in a bottom trawl was estimated using a three-dimensional semi-analytic treatment of a towing cable (warp) system that was applied to the field experiments of a bottom trawl obtained by the Scanmar system. The equilibrium condition of the horizontal component and vertical component of forces was used to the three forces acting on the otter board in the horizontal plane. Those forces were the force on the warp at the bracket, hydrodynamic lift and drag forces on the otter board and the force on the hand rope attached just behind the otter board. Also the equilibrium of moment about the front edge of the otter board was used to find out the angle of attack of the cambered otter board. When the warp length was 120m and 180m long and the towing speed was between 1.23 and 1.90 m/s, the estimated angle of attack of the cambered otter board was ranged between 26.1° and 29.6°, respectively, though the maximum lift force was at the angle of attack 22.6°. The angle of attack of the otter board was tended to increase weakly with the longer length of warp (180 m) at the same towing speed in the experiment.
Aronia melanocarpa reduced adiposity via enhanced lipolysis in high-fat diet-induced obese mice
Kim, Hyun Kyung,Jung, Jiyeon,Kang, Eun Young,Gang, Gyoungok,Kim, Wooki,Go, Gwang-woong Korean Society of Food Science and Technology 2020 한국식품과학회지 Vol.52 No.3
Obesity is a critical health issue in Korea, where half of all adults are overweight and a third obese. Aronia melanocarpa -rich in flavonoids and phenolics- with antioxidant and anti-inflammatory activities, could have anti-obesity activity and reduce body fat mass by upregulating lipolysis and β-oxidation in obese mice. Male C57BL/6J mice (n=12) were assigned into four groups: normal chow (18% kcal from fat); high-fat diet control (HFD, 45% kcal from fat); HFD+A. melanocarpa (200 mg/kg diet); HFD+Xenical (500 mg/kg diet, positive control). Antioxidant capacity of A. melanocarpa was established in vitro and in vivo. Weight loss was induced as decreased adiposity and lowered respiratory quotient at rest suggested oxidation of stored fat. Adiposity reduction, accompanied with elevated fat utilization, was owing to enhanced activity of hormone-sensitive lipase. Thus, A. melanocarpa lowered adiposity by enhancing lipolysis and utilization of fatty acids in visceral fat.
박정현 ( Jung Hyun Park ),이규 ( Gyu Lee ),고진우 ( Jin Woo Go ),박성남 ( Sung Nam Park ),이화정 ( Wha Jung Lee ),안광순 ( Gwang Sun Ahn ),이충원 ( Choong Won Lee ) 대한내과학회 2007 대한내과학회지 Vol.72 No.1
Background: Elderly-onset rheumatoid arthritis (EORA) is considered to be different from younger-onset rheumatoid arthritis (YORA) in clinical manifestations, laboratory indices, and in prognosis. However, the differences between these two diseases have not been clearly defined. The aim of this study was to more clearly define the clinical characteristics of EORA. Methods: We retrospectively reviewed 50 EORA and 58 YORA patients who met the classification criteria established by the American College of Rheumatology (ACR). The two groups (EORA and YORA) were compared by three criteria. First, we considered the patterns of the joints involved and the presence of rheumatoid nodules. Second, we compared the disease activity indices and the level of auto-antibodies. Finally, we compared the use of medications. Results: The mean age-of-onset and the women-to-men ratio in the EORA group was 66.2±5.5 years and 2.1:1, respectively. There was more large joint involvement seen in the EORA group. The titer of disease activity indices (ESR, CRP) and positive rate of auto-antibodies (rheumatoid factor, ANA, but not anti-CCP antibody) were also higher in the EORA group. We found no differences in the prescribed medications between the two groups. Conclusions: From these studies, we believe that EORA has higher disease activity indices at onset and greater joint involvement, along with higher titers of auto-antibodies as compared to YORA. (Korean J Med 72:62-67, 2007)