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Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth
Ga-Yeon Go,Sang-Jin Lee,Ayoung Jo,Jaecheol Lee,Dong-Wan Seo,Jong-Sun Kang,Si-Kwan Kim,Su-Nam Kim,Yong Kee Kim,Gyu-Un Bae 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4
Background: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth. Methods: C2C12 myoblasts, MyoD-transfected 10T1/2 embryonic fibroblasts, and HEK293T cells were treated with Rg1 and differentiated for 2 d, subjected to immunoblotting, immunocytochemistry, or immunoprecipitation. Results: Rg1 activated promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promote the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, Rg1 induced myotube growth and prevented dexamethasone-induced myotube atrophy. Furthermore, Rg1 increased MyoD-dependent myogenic conversion of fibroblast. Conclusion: Rg1 upregulates promyogenic kinases, especially Akt, resulting in improvement of myoblast differentiation and myotube growth.
Ga-Yeon Go,Ayoung Jo,Dong-Wan Seo,Woo-Young Kim,Yong Kee Kim,Eui-Young So,Qian Chen,Jong-Sun Kang,Gyu-Un Bae,Sang-Jin Lee 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.3
Background: As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 and Rb2 play a role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, and Rb1 reduces oxidative stress in aged skeletal muscles through activating the phosphatidylinositol 3-kinase/Akt/Nrf2 pathway. We examined the effects of Rb1 and Rb2 on differentiation of the muscle stem cells and myotube formation. Methods: C2C12 myoblasts treated with Rb1 and/or Rb2 were differentiated and induced to myotube formation, followed by immunoblotting for myogenic marker proteins, such as myosin heavy chain, MyoD, and myogenin, or immunostaining for myosin heavy chain or immunoprecipitation analysis for heterodimerization of MyoD/E-proteins. Results: Rb1 and Rb2 enhanced myoblast differentiation through accelerating MyoD/ E-protein heterodimerization and increased myotube hypertrophy, accompanied by activation of Akt/ mammalian target of rapamycin signaling. In addition, Rb1 and Rb2 induced the MyoD-mediated transdifferentiation of the rhabdomyosarcoma cells into myoblasts. Furthermore, co-treatment with Rb1 and Rb2 had synergistically enhanced myoblast differentiation through Akt activation. Conclusion: Rb1 and Rb2 upregulate myotube growth and myogenic differentiation through activating Akt/mammalian target of rapamycin signaling and inducing myogenic conversion of fibroblasts. Thus, our first finding indicates that Rb1 and Rb2 have strong potential as a helpful remedy to prevent and treat muscle atrophy, such as age-related muscular dystrophy.
Go, Ga-Yeon,Jo, Ayoung,Seo, Dong-Wan,Kim, Woo-Young,Kim, Yong Kee,So, Eui-Young,Chen, Qian,Kang, Jong-Sun,Bae, Gyu-Un,Lee, Sang-Jin The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.3
Background: As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 and Rb2 play a role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, and Rb1 reduces oxidative stress in aged skeletal muscles through activating the phosphatidylinositol 3-kinase/Akt/Nrf2 pathway. We examined the effects of Rb1 and Rb2 on differentiation of the muscle stem cells and myotube formation. Methods: C2C12 myoblasts treated with Rb1 and/or Rb2 were differentiated and induced to myotube formation, followed by immunoblotting for myogenic marker proteins, such as myosin heavy chain, MyoD, and myogenin, or immunostaining for myosin heavy chain or immunoprecipitation analysis for heterodimerization of MyoD/E-proteins. Results: Rb1 and Rb2 enhanced myoblast differentiation through accelerating MyoD/E-protein heterodimerization and increased myotube hypertrophy, accompanied by activation of Akt/mammalian target of rapamycin signaling. In addition, Rb1 and Rb2 induced the MyoD-mediated transdifferentiation of the rhabdomyosarcoma cells into myoblasts. Furthermore, co-treatment with Rb1 and Rb2 had synergistically enhanced myoblast differentiation through Akt activation. Conclusion: Rb1 and Rb2 upregulate myotube growth and myogenic differentiation through activating Akt/mammalian target of rapamycin signaling and inducing myogenic conversion of fibroblasts. Thus, our first finding indicates that Rb1 and Rb2 have strong potential as a helpful remedy to prevent and treat muscle atrophy, such as age-related muscular dystrophy.
Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth
Go, Ga-Yeon,Lee, Sang-Jin,Jo, Ayoung,Lee, Jaecheol,Seo, Dong-Wan,Kang, Jong-Sun,Kim, Si-Kwan,Kim, Su-Nam,Kim, Yong Kee,Bae, Gyu-Un The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.4
Background: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth. Methods: C2C12 myoblasts, MyoD-transfected 10T1/2 embryonic fibroblasts, and HEK293T cells were treated with Rg1 and differentiated for 2 d, subjected to immunoblotting, immunocytochemistry, or immunoprecipitation. Results: Rg1 activated promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promote the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, Rg1 induced myotube growth and prevented dexamethasone-induced myotube atrophy. Furthermore, Rg1 increased MyoD-dependent myogenic conversion of fibroblast. Conclusion: Rg1 upregulates promyogenic kinases, especially Akt, resulting in improvement of myoblast differentiation and myotube growth.
조가람 ( Ga-ram Jo ) , 김준식 ( Joon-sik Kim ) , 김연수 ( Yeon-soo Kim ) , 유형곤 ( Hyeong-gon Yu ) , 조인환 ( In-hwan Cho ) , 마대중 ( Dae-joong Ma ) , 김운형 ( Woon-hyung Ghim ) , 홍인환 ( In-hwan Hong ) 한국스포츠정책과학원(구 한국스포츠개발원) 2020 체육과학연구 Vol.31 No.1
[목적] 본 연구는 중도시각장애인의 신체활동 참여 소외와 극복과정과 이에 영향을 미치는 요인을 탐색하는 것이다. [방법] 연구목적을 달성하기 위해 성인 중도시각장애인 21명을 연구참여자로 선정하였으며, 반구조화된 면접방법으로 1:1 면담을 진행하여 자료를 수집하였다, 자료의 분석은 Strauss와 Corbin이 제시한 근거이론 분석방법에 따라 개방코딩, 축 코딩, 선택코딩의 순서를 따라 이루어졌다. [결과] 연구결과 총 203개의 개념이 도출되었고, 이를 21개의 하위범주로 구성하였으며 하위범주들의 공통되는 주제를 다시 9개의 주제로 상위범주화할 수 있었다. 구체적인 연구결과는 다음과 같다. 첫째, 중도시각장애인의 신체활동 소외현상에 직접적인 영향을 미치는 요인은 체육시설과 체육프로그램 관련 정보 그리고 전문 지도자의 부재 등과 같은 열악한 제반환경인 것으로 나타났다. 이러한 인과적 조건은 중도시각장애인의 ‘분주한 일상’과 ‘위축된 심리상태’라는 맥락 조건 속에서 ‘여가경험의 상실’이라는 중심현상으로 귀결되었다. 둘째, 건강관리 필요성의 인식 정도와 주변인의 긍정적인 관여 정도에 따라 중도시각장애인들은 운동 효과에 대한 기대를 품게 되었으며 운동 효과에 대한 기대가 크면 클수록 자신을 둘러싼 제약 속에서 제한적으로 신체활동에 다시 참여하게 되었다. 셋째, 이때 참여하게 되는 신체활동의 성격은 건강개선이라는 목적을 달성하기 위한 도구적 의미가 강했다. 이러한 신체활동의 유형은 단순히 심신의 회복을 목적으로만 진행되는 신체활동의 형태이다 보니 이들의 자율성과 흥미를 내재하고 있지 못했다. 그래서 이들은 지속적인 신체활동의 참여를 유지하는데 어려움을 겪었다. [결론] 중도시각장애인의 신체활동 보장을 위한 제반 환경에 대한 개선과 정비가 필요하며 시력과 시야를 상실해가는 초기단기에 있는 중도시각장애인에게 집중적인 신체활동 지원서비스가 제공되어야 할 것이다. 또한, 중도시각장애인 당사자와 보호자를 대상으로 운동의 효과와 가치에 대한 교육과 홍보가 수행되어야 하며 지속적인 신체활동 참여를 위해 운동프로그램을 다양화 및 개발하는 한편 장애 진단을 받기 전 참여했던 운동 종목에 지속적으로 참여할 수 있도록 돕는 방향으로 재정적·정책적 지원이 뒷받침되어야 할 것이다. [Purpose] The purpose of this study is to investigate the alienation and the overcoming process of the physical activity participation of people with Adventitious Visual Impairment(AVI) [Methods] 21 Adults with AVI were recruited and one on one semi-structured interview was conducted. Ground theory was used to analyze the data. Member check, peer debriefing was conducted to enhance the trustworthiness of this study. [Results] As a result, a total of 203 concepts were derived. This consisted of 21 subcategories and the common themes of the subcategories were categorized into nine categories. Specific results are as follows. First, the physical activity of people with AVI was directly affected by the sports facilities, physical activity programs, and professional instructor. This causal condition resulted in the loss of leisure experience in the context of the busy daily life and the depressed psychological state. Second, due to the perceived need of health care and the positive involvement of others, people with AVI came to expect the effect of exercise. Third, people with AVI participated in physical activity again as a tool to achieve the purpose of health improvement. This type of physical activity has a limitation that it can not guarantee the continuity of physical activity due to the limitation that it does not contain autonomy and interest of people with AVI. [Conclusion] Based on these results, the following suggestions were made. First, it is necessary to improve the environment for ensuring participation in physical activity of people with AVI. Moreover education and promotion of the effects and values of the exercise should be carried out for people with AVI and their guardians. Second, it is necessary to diversify physical activity types and reconstruct existing exercise programs.
모방범죄 방지를 위한 Scikit-learn 기반의 얼굴인식 도어락
정가영(Ga-Young Jung),이현정(Hyeon-Jung Lee),이창순(Chang-Soon Lee),조주연(Joo-Yeon Jo),황영준(Young-Jun Hwang),김남호(Nam-Ho Kim) 한국정보통신학회 2023 한국정보통신학회 종합학술대회 논문집 Vol.27 No.1
현대사회의 방범 시스템은 대부분 패스워드를 필요로 하는 전자 잠금 형태이다. 최근 비밀번호 키패드의 특성이 악용되는 모방 범죄가 지속적으로 발생되면서 도어락 관련 보안 문제가 사회적 문제로 대두되고 있다. 모방 범죄는 패스워드가 유출되거나 도어락의 남아있는 지문 등으로 암호를 유추하는 방식으로 발생한다. 이를 예방하기 위해 생체 기반의 바이오 인식과 일회성 인증 시스템을 활용하는 스마트 방범 시스템이 주목받고 있다. 따라서 본 논문에서는 라즈베리파이와 파이썬 머신러닝을 이용한 얼굴인식을 목표로 OpenCV를 통한 실시간 스트리밍 데이터베이스와 비교하여 흔적이 남지 않게 이용자 개인의 얼굴을 식별한다. 또한 아두이노 난수 코드를 활용해 임의로 생성되는 OTP(one time password)를 사용자에게 제공하여 일정 주기 동안만 유효한 일회성 패스워드로 보안성과 편의성을 확보한 도어락을 제안한다. Most of the home security systems in modern society are electronic locks that require passwords. Recently, as copycat crimes, which abuse the characteristics of a password keypad, continue to occur, security problems related to door locks have emerged as a social problem. Copycat crimes involve hacking or inferring passwords from fingerprints left on door locks. Smart crime prevention systems that utilize bio-based bio-recognition and one-time authentication systems are attracting attention as a means of preventing such crimes. Therefore, in this study, we develop a framework in which the face of the user is identified without leaving a trace by using a real-time streaming database via OpenCV with the goal of face recognition using Raspberry Pi and Python machine learning. In addition, we propose a door lock that ensures security and convenience by providing the users with a one time password that is generated randomly using Arduino random number code and is valid only for a limited time.