혈관모세포종의 임상 분석

김은성,강삼석,이정길,김태선,정신,김재휴,김수한,이제혁 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.1

혈관모세포종의 임상 분석

김은성,강삼석,이정길,김태선,정신,김재휴,김수한,이제혁 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.5

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

보행훈련방법이 편마비 환자의 보행요소와 족저압에 미치는 영향

김은정,황보각,권혁철 대구대학교 특수교육재활과학연구소 2009 再活科學硏究 Vol.27 No.2

이 연구는 뇌졸중으로 인한 편마비 환자에게 보행훈련방법을 달리하였을 때, 일반적인 지면과 트레드밀, 불안정면을 이용한 보행훈련이 보행요소와 족저압에 미치는 영향을 알아보기 위하여 편마비 환자 30명을 지면과 트레드밀, 불안정면 보행훈련군으로 무작위 배정하고 각 치료군들은 주 5회, 8주 간의 보행훈련을 실시하였다. 실험 전과 후, 보행요소를 알아보기 위하여 보행속도, 보장, 보각과 족저압을 측정하여 수집된 자료를 분석하여 다음과 같은 결과를 얻었다. 이 연구의 결과를 종합해 보면 보행훈련방법에 따라 지면 보행훈련은 보행속도와 족저압 전족부, 트레드밀 보행훈련군은 보행속도와 보각, 족저압 중족부, 불안정면 보행훈련군은 보행속도와 보장, 보각에서 유의한 증가를 보였다. 이러한 결과는 뇌졸중으로 인한 편마비 환자에게 보행훈련방법을 달리함에 따라 많은 영향을 끼치어, 환경의 변화와 다양한 과제에 대한 적절한 반응을 만들어 낼 수 있음을 의미하며, 기능 회복의 임상적 접근에서 치료 중재의 시점과 기간, 제공되는 환경, 과제의 선택에 대한 광범위한 연구가 필요할 것으로 생각되어진다. Purpose : This study was performed for effects of gait component and plantar foot pressure on gait training way needed in gait with hemiplegic patients caused by cerebrovascular accident. Methods : Three groups of adult hemiplegia(n=30) were allocated randomly in this study : group I(TGT : treadmill gait training), group II(USGT : unstable surface gait training) and group III(SGT : surface gait training). The gait training was provided to experimental groups for 8 weeks(5 times a week). Measurements of pre and post experiment were gait velocity, step length, toe out angle, foot plantar pressure which demonstrate temporal-spatial parameter of gait component. Results : The results of this study showed that in comparison of pre and post changes of gait training, SGT group has statistically significant differences in gait velocity, metatarsal area of foot plantar pressure, TGT group has statistically significant differences in gait velocity, toe out angle, midfoot of foot plantar pressure. USGT group has statistically significant differences in gait velocity, step length, toe out angle. Conclusion : These results mean gait training resulted by gait training way provides effective gait, with stroke, and therefore proper response about environmental changes and various tasks could be made.

사람 백혈병 암세포의 증식에 미치는 Berberine의 저해효과

김은영,김광혁 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : The isoquinoline alkaloid berberine is widely distributed in a variety of plants, especially in the genera Berberis and Coptis. The berberine, an alkaloid initially isolated from Chinese herbal medicine, has antibiotic activities against a variety of organisms including bacteria, viruses, fungi, protozoans, and chlamydia. Furthermore, berberine has shown a number of beneficial effects, including anti-tumor, anti-inflammation, and vasodilatory effects. Materials and Methods : In this work we have investigated the effects of berberine on cytotoxic activity against cancer cells. The direct cytotoxicity of berberine or berberine-combined chemotherapeutic agents for human leukemia cells K-562 was observed. Results: The effect of growth inhibition for cancer cells, K-562 was shown in the cytotoxicity test of berberine or berberine-combinated chemotherapeutic agents. Conclusion: These findings suggest that berberine shows tumor cell growth inhibition. These results show the probability of its usefulness for cancer therapy if more research results were accumulated.

여성 미용사의 만성 유기용제 폭로에 의한 정신신경학적 증상에 영향을 미치는 요인분석

김상아,김은주,박웅섭,정상혁 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 이 연구는 여성 미용사의 만성 유기용제 폭로에 의한 정신신경학적 증상에 영향을 미치는 요인들을 알아보기 위하여 수행되었다. 방 법 : 1999년 강릉시 전화번호부에 기재된 372개의 미용실 중 100개를 확률 추출의 방법으로 조사대상을 선정하고 총 75개의 미용실에서 143명의 미용사를 면접설문한 결과를 분석하여 수행하였다. 만성 유기용제 폭로에 의한 정신신경학적 증상에 영향을 미치는 독립변수로서 미용사들이 인구사회학적특성, 직업관련특성, 미용행위 수행시간 등을 문헌고찰을 통해 선정하였고, 종속변수로는 조수헌 등(1993)의 유기용제 자각증상 설문을 이용하여 측정하였다. 결 과 : 각 요인에 대한 다중회귀분석 결과를 포함하여 이 연구 결과를 종합하면, 미용사들이 사용하는 염색약품의 주요 성분은 방향족 아민류로서 주로 피부를 통해 흡수된다는 것을 문헌고찰을 통해 확인하였고, 장갑착용정도와 정신신경학적 증상 점수가 유의한 음의 상관관계를 나타내었다. 또한 다른 변수들의 영향을 통제한 상태에서는 파마수행시간보다 염색수행시간이 정신신경학적 증상 점수와 유의한 양의 상관관계에 있었으며, 미용경력이 증가할수록 작업관련 증상군들의 자각증상 점수가 유의하게 증가하였다. 결 론 : 만성 유기용제 폭로에 의한 정신신경학적 증상을 예방하기 위하여서는 일반적으로 생각되는 환풍기 또는 공기정화기 등의 시설보다 미용행위수행 시 보호장갑을 착용하는 것이 중요하다는 것과 파마수행 시 보다 염색수행 시 더욱 주의 있게 약품을 취급해야 할 것으로 판단된다. Objectives : This study was designed to examine the influencing factors on female hairdresser's neuropsychiatric symptoms due to chronic organic solvent exposure. Methods : We collected data from 143 female hairdressers employed in 75 hair salons selected by random sampling from the telephone directory of Gangnung City. Using multiple regression analysis we analyzed the influencing factors(i.e. ventilating fans, air-cleaners, work duration, total time of exposure to solvents during hair-dyeing and permanent, etc.) on neuropsychiatric symptoms. Results : The neuropsychiatric aymptom scores were significantly positively correlated with the total time of hair-dyeing work and work duration, and significantly negatively correlated with the glove wearing proportion. However, the total time of permanent work, ventilating fans and air-cleaners were not significantly correlated. Conclusions : The results of this study suggest that for the prevention of neuropsychiatric symptoms due to chronic organic solvent exposure, more attention is required regarding hair-dyeing work than permanent work and to skin absorption rather than respiractory inhalation.

응급의학과로 내원한 환자중 내원시 예상치 못했던 사망에 대한 고찰

김승렬,김상은,양혁준,정호성,박철완,이 근 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Patients die in the emergency department frequently ; however, there has been little about the incidence and cause of Emergency Department death in the emergency medicine literature. This study was conducted retrospectively to gain insight into the patients who die suddenly and unexpectedly in the Emergency Department(ED). A total of 360 patients were pronounced dead in the ED from 1991 through 1994 in Chung Ang Gil Hospital. Of the 360 patients, 309 (86%) were brought to the ED with cardiopulmonary resuscitation in progress or as do not resuscitation(DNR) patients, leaving 51(14%) patients who met the unexpected death criteria. Of the unexpected deaths, 32(62.7%) patients presented to the ED with either abnormal vital sign (24 of 32) or some alteration in consciousness (18 of 32), or both of them (10 of 56). Medical and surgical causes of death represented 47.1% (24 patients) and 15.6% (8 patients) of the unexpected deaths respectively. Trauma represented 19 (37.3%) of the unexpected deaths, with 14 of these being the result of motor vehicle collision. The yearly incidence of unexpected ED death is presented in numbers of deaths per 10,000 ED visits. In 1991, the incidence was 3.4, and in 1992, 1993 and 1994 those were 2.7, 2.2 and 2.1 respectively.

만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예

김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-

페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.

Alendronate가 흰쥐 뼈끝 연골판 성장에 미치는 영향

김현진,이은주,이계혁,김민석,김선헌 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.2

Bisphosphonates inhibit bone resorption by affecting osteoclastic function and formation of osteoclasts from their precursor cells. Chondroclasts have the same origin and differentiation as osteoclasts. Thus, it is hypothesized that bisphosphonate can affect on cartilage metabolism. This study was aimed to elucidate effects of alendronate, a nitrogen containing bisphosphonate, on cartilage development in the tibial proximal and femoral distal epiphyseal plates in rats. Alendronate (1 mg/kg) was subcutaneously administered in growing rat pups for 10 days. Several parameters such as the number and size of chondroclasts, involved in cartilage resorption, size of secondary ossification center and thickness of cartilage cell layers were measured and analysed by histomorphometry. The size of the secondary ossification centers in the tibial proximal and femoral distal epiphysis was smaller in the alendronate treated group (p<0.01). The number of osteoclasts in the both the ossification centers and chondroclasts beneath the epiphyseal plates was significantly decreased byalendronate treatment (p<0.01). The size of chondroclasts was not significantly changed (p>0.05). The thickness of proliferating cartilage layer was not changed, but by contrast, hypertrophied cartilage layer was increased in thickness by alendronate treatment. These findings suggest that bisphosphonates can affect cartilage cell metabolism in a chondroprotective way.

APF Gel이 심미 수복재료의 표면에 미치는 영향

최원혁,김은정,김현정,김영진,남순현 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

현재 소아치과 영역에서 소아의 치아 우식증을 예방하기 위해 다양한 불소 도포법이 시행되고 있다. 이들은 법랑질 내 불소함량을 증가시키고 보다 안정된 결정 구조를 형성하게 하여 치아 우식증을 예방한다는데 근거하고 있다. 하지만 최근에 불소 도포제재가 심미 수복재료의 표면에 부작용을 일으킬 수 있다는 문제가 제기되고 있다. 이에 본 연구는 수종의 심미 수복재료의 표면에 APF gel이 미칠 수 있는 영향을 주사 전자 현미경을 통해 관찰하고 표면 조도를 측정한 후 비교 분석하여 다음과 같은 결과를 얻었다. 1. glass ionomer cement와 compomer를 이용한 실험에서 APF gel 4분 침적군과 pH 순환군은 인공타액 침적군에 비해 표면 조도가 증가하였다(p<0.01). 2. composite resin 인 Charisma와 Z250을 이용한 실험에서는 모든 군간의 표면 조도의 차이는 없었다(p>0.05). 3. 주사 전자 현미경으로 관찰한 결과 glass ionomer cement, compomer, composite resin의 순으로 filler의 소실이 많았으며 군별로는 pH 순환군, APF gel 4분 침적군, 인공타액 침적군의 순으로 filler의 소실이 많았다. Topical fluoride application for children is a widely performed procedure in the field of Pediatric Dentistry for its dental caries prevention effects. However, it is recently recognized as having some unwanted effects on several esthetic restorative materials, the author immersed glass ionomer cement, compomer and composite resin specimens in APF gel and measured the surface roughness and also, examined the specimens under the scanning eletron microscope. The followings are the results: 1. In the specimens of glass ionomer cement and compomer, APF gel 4 minute immersion group and pH cycling group show statistically significant increased surface roughness than artificial saliva immersion group(p<0.01). 2. There was no statistically significant surface roughness for composite resin in all group(p>0.05). 3. When the specimens were examined under scanning electron microscope, the surface change were in the order of glass ionomer cement, compomer, composite resin and also in the order of pH cycling group, APF gel 4 minutes immersion group, artificial saliva immersion group.