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조창래,백승엽,이은상 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-
Electrochemical micromachining which is not normally considered as a precision process is presented in this paper. The application of voltage pulses between a tool electrode and a workpiece in an electrochemical environment allows the three-dimensional machining of conducting materials with micrometer precision. In this paper tool-electrodes(5μm in diameter, l㎜ in length) are developed by electrochemical micromaching and micro holes are manufactured using this tool-electrodes we developed already. Micro holes are achieved the accuracy below 50μm in diameter using ultrashort voltage pulses(0.1-5μs).
Polymorphisms in cancer-related pathway genes and lung cancer
Lee, Shin Yup,Kang, Hyo-Gyoung,Choi, Jin Eun,Jung, Deuk Kju,Lee, Won Kee,Lee, Hyun Chul,Lee, So Yeon,Yoo, Seung Soo,Lee, Jaehee,Seok, Yangki,Lee, Eung Bae,Cha, Seung Ick,Cho, Sukki,Kim, Chang Ho,Lee, European Respiratory Society 2016 The European respiratory journal Vol.48 No.4
<P>We evaluated the associations between potentially functional variants in a comprehensive list of cancer-related genes and lung cancer in a Korean population.</P><P>A total of 1969 potentially functional single nucleotide polymorphisms (SNPs) of 1151 genes involved in carcinogenesis were evaluated using an Affymetrix custom-made GeneChip in 610 nonsmall cell lung cancer patients and 610 healthy controls. A replication study was conducted in an independent set of 490 cases and 486 controls. 68 SNPs were significantly associated with lung cancer in the discovery set and tested for replication.</P><P>Among the 68 SNPs, three SNPs (corepressor interacting with RBPJ 1 (<I>CIR1</I>) rs13009079T>C, ribonucleotide reductase M1 (<I>RRM1</I>) rs1465952T>C and solute carrier family 38, member 4 (<I>SLC38A4</I>) rs2429467C>T) consistantly showed significant associations with lung cancer in the replication study. In combined analysis, adjusted odds ratio for <I>CIR1</I> rs13009079T>C, <I>RRM1</I> rs1465952T>C and <I>SLC38A4</I> rs2429467C>T were 0.69, 0.71 and 0.73, respectively (p=4×10<SUP>−5</SUP>, 0.01 and 0.001, respectively) under the dominant model. The relative mRNA expression level of <I>CIR1</I> was significantly associated with rs13009079T>C genotypes in normal lung tissues (ptrend=0.03).</P><P>These results suggest that the three SNPs, particularly <I>CIR1</I> rs13009079T>C, may play a role in the pathogenesis of lung cancer.</P>
Polymorphisms in Apoptosis-Related Genes and <i>TP53</i> Mutations in Non-Small Cell Lung Cancer
Bae, Eun Young,Lee, Eun Jin,Kang, Hyo-Gyoung,Lee, Shin Yup,Jin, Gwang,Lee, Won Kee,Choi, Jin Eun,Jeon, Hyo-Sung,Lim, Jeong Ok,Lee, Eung Bae,Park, Jae Yong The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.11
<P>Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of <I>TP53</I> mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and <I>TP53</I> mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with <I>TP53</I> mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of <I>TP53</I> mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of <I>TP53</I> mutations in lung cancer.</P>
이재은(Jae-Eun Lee),이세은(Se-Eun Lee),김왕수(Wang-Soo Kim),이정엽(Chung-yup Lee),한상근(Sang-Keun Han),채주승(Joo-Seung Chae),이근득(Keun-Deuk Lee),구기갑(Kee-Kahb Koo) 한국추진공학회 2015 한국추진공학회 학술대회논문집 Vol.2015 No.11
고에너지 물질의 성능 향상뿐만 아니라 둔감도 향상은 고에너지 물질 연구에 있어 매우 중요한 항목으로, 최근에는 안정성의 문제로 성능보다는 외부의 비의도적 자극에 대한 둔감도 향상에 초점을 맞추어 많은 연구가 수행되고 있다. 고에너지 물질 결정 내부 결함은 외부 충격에 의한 폭발의 시발점으로 작용하기 때문에 그들의 크기와 수를 감소시키기 위해 결정의 입도를 제어하는 연구가 현재 각광받고 있다. 본 연구에서는 결정화를 이용하여 나노 수준의 고에너지 물질을 제조하였으며, 그들의 둔감도를 평가하였다. 결정 입도 제어에 있어 분사 거리, 용액의 농도, 용액/반용매 온도 등과 같은 변수들의 영향을 확인하였다. An improvement of a performance and an insensitivity of high energetic materials(HEMs) is very important evaluation index in a research of HEMs. Studies on the improvement of the insensitivity against a external unintended stimuli rather than the performance owing to stability have been done for decades. Current researches focus on to control of a size of crystal for reducing the number and the size of the internal defects because the internal defects are worked as the trigger of explosion by the external stimuli. In this work, nano-sized HEMs were producted by drowing-out or milling/crystallization and the improvement of insensitivity of them was confirmed. The effect of a spraying distance, a concentration of solution, a temperature of solution/antisolvent on the size of crystals were investigated.
Yoo Seung Soo,Lee Sunwoong,Choi Jin Eun,Hong Mi Jeong,Do Sook Kyung,Lee Jang Hyuck,Lee Won Kee,Park Ji Eun,Lee Yong Hoon,Choi Sun Ha,Seo Hyewon,Lee Jaehee,Lee Shin Yup,Cha Seung Ick,Kim Chang Ho,Kang 대한의학회 2023 Journal of Korean medical science Vol.38 No.45
Background: Neurogenic differentiation 1 (NeuroD1) is a representative small cell lung cancer (SCLC) transcription regulator involved in the carcinogenesis and behavior of SCLC. Histone modifications play an important role in transcription, and H3 lysine 4 trimethylation (H3K4me3) is primarily associated with promoter regions. Methods: We investigated the association between single nucleotide polymorphisms (SNPs) in NeuroD1 and H3K4me3 coincident regions, selected using ChIP sequencing (ChIP-seq), and the clinical outcomes of 261 patients with SCLC. Results: Among 230 SNPs, two were significantly associated with both the chemotherapy response and overall survival (OS) of patients with SCLC. RNF145 rs2043268A>G was associated with worse chemotherapy response and OS (under a recessive model, adjusted odds ratio [aOR], 0.50, 95% confidence interval [CI], 0.26–0.94, P = 0.031, and adjusted hazard ratio [aHR], 1.88, 95% CI, 1.38–2.57, P < 0.001). CINP rs762105A>G was also associated with worse chemotherapy response and OS (under a dominant model, aOR, 0.47, 95% CI, 0.23–0.99, P = 0.046, and aHR, 2.03, 95% CI, 1.47–2.82, P < 0.001). ChIP–quantitative polymerase chain reaction and luciferase assay confirmed that the two SNPs were located in the active promoter regions and influenced the promoter activity of each gene. Conclusion: To summarize, among SNPs selected using ChIP-seq in promoter regions with high peaks in both NeuroD1 and H3K4me3, RNF145 rs2043268A>G and CINP rs762105A>G were associated with clinical outcomes in patients with SCLC and also affected the promoter activity of each gene.
Lee, Jae Yeon,Yoo, Seung Soo,Kang, Hyo-Gyoung,Jin, Guang,Bae, Eun Young,Choi, Yi Young,Choi, Jin Eun,Jeon, Hyo-Sung,Lee, Jaehee,Lee, Shin Yup,Cha, Seung-Ick,Kim, Chang Ho,Park, Jae Yong The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.12
<P>A genome-wide association study has identified the 15q25 region as being associated with the risk of chronic obstructive pulmonary disease (COPD) in Caucasians. This study intended as a confirmatory assessment of this association in a Korean population. The rs6495309C > T polymorphism in the promoter of nicotinic acetylcholine receptor alpha subunit 3 (<I>CHRNA3</I>) gene was investigated in a case-control study that consisted of 406 patients with COPD and 394 healthy control subjects. The rs6495309 CT or TT genotype was associated with a significantly decreased risk of COPD when compared to the rs6495309 CC genotype (adjusted odds ratio = 0.69, 95% confidence interval = 0.50-0.95, <I>P</I> = 0.023). The effect of the rs6495309C > T on the risk of COPD was more evident in moderate to very severe COPD than in mild COPD under a dominant model for the variant T allele (<I>P</I> = 0.024 for homogeneity). The <I>CHRNA3</I> rs6495309C > T polymorphism on chromosome 15q25 is associated with the risk of COPD in a Korean population.</P>