서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

밸리댄스 참가자의 참가동기 요인 분석

김장환,허은숙,엄대영 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

This study aims to confirm the existence of participating motives of those who participate in bellydance in terms of demographic characteristics to examine the role of bellydance as leisure sports and the diferences in the motives according to the degree of participation, and to study the effective aspects of bellydaqnce as a way of sound leisure activities of modern people. A total of 200 questionnaire were distributed to those who participate in the bellydance programs of the Social Education Centers and Life Long Education Centers in Seoul, Daegu and Busan and 190 of them were collected, 177 questionnaires(93.2%), except those questionnaires whose answers were not sincere and some parts of which were missing, were analyzed positively. The data of this study were processed by using SPSs/PC+11.0.Cronbach's Alpha Coefficient was calculated for Frequency Analysis and Reliability Test to confirm general characteristics. And Principal Component Factor Analysis was conducted by using Verimax Orthogonal Rotation Factor Analysis to confirm the structure of motive factors ofr participation in bellydance. In order to confirm the differences between group and in the group by each factor. One-Way (ANOVA) was conducted. The findings obtained from the study model based on these methods of the study and the analysis of the dats are as follow: First, it is confirmed that there are significant differences in the participating motives by demographic characteristics. Second, it is confirmed that there are significant differences in the participating motives by the degrees of participation.

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.

알콜중독자 부부집단 프로그램에 관한 연구 : For the development of a Couples Group Intervention Program for Recovery of Alcoholics(Ⅲ) 알콜중독자의 회복을 위한 부부집단 개입 프로그램 개발 연구(Ⅲ)

윤명숙,김미혜,엄예선,이은주 한국 정신보건 사회사업학회 1995 정신보건과 사회사업 Vol.2 No.-

Couple therapy has been recognized as an effective way to treat alcoholism. However, research by the authors indicate there are no couple therapy porgrams currently in the Korean psychiatric setting. The purpose of this study is to develop an effective program to aid in the recovery alcoholics and their spouses. This program is specifically designed for the couples of hospitalized alcoholics. The program consists of 10 sessions, the first four held with gender specific groups, the final five as co-joint couple sessions. The groups will meet 2 times weekly with five monthly after care follow ups. The program is divided into 3 phases ; The first phase deals with the symptoms of alcoholism and its impact on relationships with in 1st-2nd sessions. The second phase treats the issues of co-dependency and the recovery process with in 3th-4th sessions. In the final phase, conflict resolution, communication, anger control, and stress management skills are developed with in 5th-9th sessions. In the final session of the last phase, all 3 phases are integrated and summarized. At this point the group sessions are terminated, five follow up after care sessions are scheduled, to be conducted on a monthly bases. These sessions are designed to help the couple with unresolved issues, assist with implementation of their after care plan, and to monitor the couples progress with in a life of sobriety. The methods of implementing the program are centered on the cognitive behavioral approach, utilizing lectures, group discussion, role play and feedback sessions.

혈관 반응성에 대한 Cyclooxygenase 억제제 효과와 Cyclooxygenase 발현 변화

이기영,박진우,엄은아,강영진,이광윤,최형철 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

진통과 해열작용을 가진 NSAIDs는 소화기계에 대한 부작용 때문에 COX-2 선택성 억제제로 대체되고 있다. 그러나 COX-2 선택적 억제제는 심혈관계에 대한 부작용이 보고되고 있어 혈관 평활근에 대한 직접적인 연구가 필요하다. 이에 본 연구에서는 혈관 반응성에 미치는 celecoxib와 aspirin, indomethacin의 영향을 비교 분석하였다. 또한 COX-1, COX-2 단백질 발현에 대한 indomethacin과 NO 공여제의 영향을 조사하였다. Phenylephrine 유발 수축반응에서 전처치 된 celecoxib, indometacin, aspirin 순서로 혈관 반응성을 증가시켜, cyclooxygenase를 억제하면 혈관 수축성물질에 대한 반응성이 커질 수 있음을 나타낸다. 이중 cyclooxygenase에 대해 비가역적으로 강한 억제를 나타내는 aspirin이 제일 강한 효과를 나타내어 여기에 대한 연구는 더 필요할 것으로 생각된다. 혈관평활근 세포의 COX-2 단백질 발현은 indomethacin과 SNP, NOR-3 처치에 의해 증가되었으며, LPS를 이용하여 혈관염증을 유발시키는 경우 혈관평활근 세포의 COX-2 단백질 발현이 증가되었고, 이 상태에서 SNP 100μM 전처치로 COX-2 단백질 발현을 감소되었으며, NOR-3 100 μM은 COX-2 단백질 발현을 증가시켰다. LPS 유도 nitrite 생성에서 NOR-3는 SNP 보다 더 많은 nitrite를 생성시켰다. 이는 혈관의 수축반응에서 aspirin은 강한 상승작용을 유발하고, 혈관평활근 세포의 COX-2 발현은 NO 공여제, 혈관염증 유무에 따라 차이가 있는 것을 나타낸다. Background: There is controversy regarding whether COX-2 specific inhibitors are associated with elevation of blood pressure. We compared the effects of aspirin, indomethacin, and celecoxib for vascular reactivity induced by phenylephrine. We also tested the effects of indomethacin and NO donor on COX-1 and COX-2 protein expression, as well as nitrite production in culture medium of vascular smooth muscle cells. Materials and Methods: In this experiment, we used the isometric tension study for vascular reactivity. After 45 minutes of pretreatment with aspirin, indomethacin, celecoxib, and phenylephrine induced contractions were tested. COX-1 and COX-2 protein expressions were analyzed by Western blot and nitrite production by the Griess reaction. Results: Although celecoxib pretreatment caused enhanced arterial contraction, aspirin pretreatment induced more potent arterial contraction than celecoxib in the isometric tension study of rabbit femoral artery. COX-1 protein expression was unchanged by indomethacin, SNP and NOR-3; COX-2 protein expression was increased by the addition of indomethacin, SNP, and NOR-3. Especially, NOR-3, a NO donor, significantly increased COX-2 protein expression with unstimulated conditions as well as LPS stimulation. Induction of nitrite production was higher with NOR-3 treatment than SNP treatment with LPS stimulation. Conclusion: These results suggest that aspirin caused more potent vascular contraction than celecoxib and indomethacin. COX-2 expression in VSMC depended on the types of NO donor and LPS stimulation.

The effects of strengthening exercise, stretching and meditation on electromyography onset timing of the rectus femoris and gastrocnemius during vertical jump performance in healthy adults

Eum, Ji Young,Kim, Yeoung Kyun,Park, Eun Ji,Lee, Ju Hee,Lee, Ji Eun,Lim, Jin Ju,Choi, Man Ho,Kim, Hyun Hee korean Academy of Physical Therapy Rehabilitation 2015 Physical therapy rehabilitation science Vol.4 No.1

Objective: Jump training helps increase the muscle power by improving the muscle strength and reaction time of the muscle in operation. The purpose of this study was to identify the effects of strengthening, stretching exercise and meditation on electromyographic (EMG) onset timing of rectus femoris and gastrocnemius muscle during vertical jump performance. Design: Cross-sectional study. Methods: Ten healthy adults (5 male and 5 female) who were familiar with the vertical jumping task and had no lower extremity injuries or any bone or joint disorders, were recruited for this study. Muscle onset timing was measured by surface EMG. After EMG onset timing were measured during performing three baseline vertical jump trials, strengthening and stretching exercises of the rectus femoris and gastrocnemius, and meditation were performed in random order. EMG onset timing was measured during vertical jump after intervention, respectively. EMG value was averaged for the three trials and analyzed using one-way repeated ANOVA. Results: During vertical jump, EMG onset timing of gastrocnemius was a significant difference after intervention (p<0.05), and then there was significantly faster in strengthening exercise than meditation (p<0.05). Conclusions: These results indicate the potential positive effect of performing strengthening exercise of the gastrocnemius before a jumping event. Future research is required to identify the effects of intervention over a long period.

Optimization simulation anlaysis of local energy supply based on renewable energy

Eun Seok Eum(음은석),Yong Beum Yoon(윤용범) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.11

In response to global environmental issues, the IEA announced Net Zero 2050 and the Korean government announced the Carbon Neutrality Declaration 2050. For now, it is expected that our expectations for the future development of the renewable energy industry will increase. Not only isolated regions, but also regions connected to the entire power grid are faced with the need to utilize renewable power generation facilities as an important axis of the power generation system. In this paper, the possibility of utilizing a distributed power system of renewable energy optimized for local energy supply connected to the power grid through HOMER, a microgrid design program, is reviewed.

Anorectal and gastric peripheral T-cell Lymphoma in non-AIDS patient

( Eun A Eum ),( Hawk Kim ),( Young Joo Min ),( In Du Jeong ),( Young Min Kim ),( Hee Jeong Cha ),( Dan Hwa Choi ),( Jae Hoo Park ) 대한내과학회 2004 대한내과학회 추계학술발표논문집 Vol.2004 No.1

Skin-whitening and Anti-wrinkle Effects of Water Extract of Clove (Syzygium aromaticum)

Eun Min SHIN,Ju Yeon KIM,Si Eun PARK,Sung Eum OH,Min Sung KIM,Chang-Joon KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10

The cloves are herbs with a refreshing and sweet scent. They include high amount of antioxidants such as polyphenols and are often used as tea ingredients, spices, and herbal medicines. In this study, we aimed to investigate the possibility of using cloves as a functional cosmetic material. Extract was obtained from dried flower buds of clove by heating clove-distilled water mixture (200 g/L) at 60℃ for 2 hours and then removing suspended solids by filtration. The total phenolic and total flavonoid contents in the extract were measured. The antioxidant capacity of extract was measured by DPPH and ABTS assay. The whitening potency of extract was determined by measuring tyrosinase inhibitory activity. To evaluate the anti-wrinkle ability, the inhibitory activities of collagenase and elastase were measured. The DPPH and ABTS+ radical scavenging activities were 73.9% at 9.7 g/L of extract and 100% at 0.1 g/L of extract, respectively. Tyrosinase activity was inhibited by 56.3% at 19.4 g/L of extract. In the presence of extract, collagenase and elastase activities were decreased by 88.2% at 19.4 g/L and 80.0% at 4.9 g/L, respectively. The result clearly shows that extracts have high antioxidant activity at a relatively low concentration, moderate whitening activity, and marked anti-wrinkle activity. The result demonstrates that water extract of clove can be used as a potential material for functional cosmetics.

Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway

( Eun Ji Yeo ),( Won Sik Eum ),( Hyeon Ji Yeo ),( Yeon Joo Choi ),( Eun Jeong Sohn ),( Hyun Jung Kwon ),( Dae Won Kim ),( Duk-soo Kim ),( Sung-woo Cho ),( Jinseu Park ),( Kyu Hyung Han ),( Keun Wook L 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.3

Oxidative stress plays a crucial role in the development of neuronal disorders including brain ischemic injury. Thioredoxin 1 (Trx1), a 12 kDa oxidoreductase, has anti-oxidant and anti-apoptotic functions in various cells. It has been highly implicated in brain ischemic injury. However, the protective mechanism of Trx1 against hippocampal neuronal cell death is not identified yet. Using a cell permeable Tat-Trx1 protein, protective mechanism of Trx1 against hydrogen peroxide-induced cell death was examined using HT-22 cells and an ischemic animal model. Transduced Tat-Trx1 markedly inhibited intracellular ROS levels, DNA fragmentation, and cell death in H₂O₂-treatment HT-22 cells. Tat-Trx1 also significantly inhibited phosphorylation of ASK1 and MAPKs in signaling pathways of HT-22 cells. In addition, Tat-Trx1 regulated expression levels of Akt, NF-κB, and apoptosis related proteins. In an ischemia animal model, Tat-Trx1 markedly protected hippocampal neuronal cell death and reduced astrocytes and microglia activation. These findings indicate that transduced Tat-Trx1 might be a potential therapeutic agent for treating ischemic injury.