數種의 弗素製材에 의해 前處置 再植 齒牙의 祖織學的 反應에 關한 硏究

金鐘秀,金殷淑,金鐘好,金容琦 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.2

The effect of fluoride pretreatment upon root resorption after delayed replantation was studied in beagle dogs. Upper and lower incisors were extracted and bench dried for 45minutes. 1% Stannous Fluoride solution, 2% neutral sodium fluoride gel and 1.23% acidulated phosphate fluoride gel were used for the pre-treatment of replanted root surface in the experimental groups. Replantation was done with no treatment in control group. After of an experimental periods 3 weeks, animals were sacrificed by perfusion followed by sample preparation. A histomorphometric method was applied for evaluation of tissue reactions observed in each group under light microscope. Scanning electron microscopic observation was done to find out any different surface topography between groups. The results were as follows: 1. Fluoride-treated groups showed in general the better healing patterns than untreated control group. 2. Comparisons between three experimental groups revealed the superiority of APF-treated group over the other groups in terms of tissue healing reaction by showing the highest frequency in uncomplicated healing pattern and surface resorption and the lowest in inflammatory resorption, but with no statistical significance(p>.05) 3. Scanning elecron micrographs showed the irregular distribution of resorption cavitie s and the attached bone of variable size and shape in all groups. 4. It can be conclued that the types of fluoride did not have significant impact on the early tissue reactions after delayed replantation under the condition of the present experiment.

Original Article : Geographic difference of epidemiological features of HCV infection in Korea

( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4

Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.

생물반응기를 이용한 국화 기내 배양 시 환경조건이 식물체 증식 및 품질에 미치는 영향

김선자,한은주,백기엽 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

학교와 학원의 비교를 통해 본 청소년의 플로우 및 내적경험

김기옥,현은자,최인수,유현정 대한가정학회 2004 Human Ecology Research(HER) Vol.42 No.4

The purpose of this study was to compare the school life of Korean high school students between public and proprietary schools, especially focused on their internal experience and flow. Internal experiences were composed of three dimensions: emotion, cognitive efficiency, and satisfaction. Flow was classified into four conditions: apathy, boredom, anxiety, and flow. The study results are: 1. Korean high school students felt more flow when they were in public school than in proprietary school,. In public school, they felt relatively more bored, and on the other hand, they were relatively more anxious in proprietary school. 2. Korean high school students felt more positive emotions when they were in public school than in proprietary school. 3. Korean high school students were more involved into study when they were in public school than in proprietary school. 4. Korean high school students were more satisfied when they were in public school than in proprietary school.

요관 및 방광의 무형성이 동반된 신무발육증 1예

김동출,신은택,이동명,이윤경,기근홍 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2

Bilateral renal agenesis is an uniformly lethal malformation occurring in 1-2/10000 birth. This condition is associated with severe oligo-hydroamnios, intrauterine growth retardation, pulmonary hypoplasia and extrarenal anomalies. We experience a case of bilateral renal agenesis associated with agenesis of both ureters and bladder, and single umbilical artery. But the infant had normal pulmonary development. Specific IgM for herpes virus in maternal serum was detected.

정신분열병 환자 가족의 연성 신경학적 특성

김은남,장기용,강병조 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.1

연구목적 본 연구는 정선분열형 환자가족들의 연성 신경학적 징후를 살펴봄으로써 연성 신경학적 징후가 체질 표지(trait marker)로서의 의미가 있는지를 알아보기 위한 것이다. 연구방법 정신분열병 환자 가족군은 정신분열병 환자의 1차 인척 중 정신병에 이환되지 않은 자를 대상으로 하였다. 연성 신경학적 검사는 Buchanan과 Heinrich의 신경학적 평가척도의 한국어판을 이용하여, 가족군 20명과 정상대조군 20명에게 시행하였다. 연구결과 1) 연성 신경학적 평가척도의 총점은 정신분열병 환자 가족군이 13.55±6.12, 정상대조군은 3.55±2.46으로 두 군 간에 유의한 차이를 나타내었다(P<0.0001). 각 하위영역인 김각통합 영역, 운동조정 영역, 복합운동활동순서화 영역, 기타 영역에서 가족군이 정상대조군보다 유의하게 높은 점수를 나타내었다(P<0.05). 2) 정신분열병 환자 부모군과 형제군은 신경학적 평가척도의 총점에서 유의한 차이가 없었다. 하위영역에서는 감각통합 영역에서 두 군간에 유의한 차이를 나타내었다(P<0.05). Objective : This study was performed to assess Neurological soft sign(NSS) in schizophrenic's relatives and to know the relationship between NSS and trait marker. Method : The study sample of relatives consisted of 20 nonpsychotic subjects, each of whom was a biological parent or sibling of a proband meeting DSM-Ⅳ criteria for schizophrenia. The authors evaluated NSS using the structured tool for measuring neurological abnormalities, Neurological Evaluation Scale-Korean Version(NSE-K). A comparison of NSS score was made between 20 relatives and 20 normal controls. Results : 1) The schizophrenic's nonpsychotic relatives were significantly more impaired than normal controls on total scores(P<0.0001) and on scores of sensory integration, motor coordination, sequencing of complex motor acts and other areas(P<0.05). 2) There were statistically no difference in NSS total scores between schizophrenic's nonpsychotic parents and siblings. Schizophrenic's nonpsychotic parents were significantly more impaired than siblings on scores of sensory integration(P<0.05). Conculsions : These findings suggest that abnormal NSS may be one of possible trait markers in schizophrenia.

장기간 고농도 수유후 발행한 고장성 탈수증 2례

김국환,안영준,양은석,박상기,박영봉,문경래 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

Hypernatremia(serum sodium>150meq/L) is caused by conditions that produce an excessive gain of sodium or result in an excessive loss of body fluid that is greater than the loss of sodium. The prognosis for hypernatremic dehydration is poorer than isotonic or hypotonic dehydration, because severe hyperosmolarity may result in cerebral damage( seizures, cerebral hemorrhages, thromboses, and subdural effusions). This cerebral injury may result in a permanent neurologic deficit. We experienced two cases of hypernatremic dehydration. Theses cases may have resulted from faulty preparation of infant formulas, as with the use of condensed milk powder. The first case experienced seizures during treatment, but survived, yet the second case died in spite of intensive care.

염증성 근섬유모세포종의 증례보고

은상아,박혁,차인호,김현실,정호걸,김기덕,박창서 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.3

The inflammatory myofibroblastic tumor (inflammatory pseudotumor) is a rarely occurring soft tissue lesion of unknown etiology. It can be of any location, but commonly it is found in lungs. It has been considered as a nonneoplastic reactive inflammatory lesion, but nowadays, confusion and dispute about its character is increasing due to its high recurrence rate and metastasis. We present a patient who had been diagnosed with an inflammatory pseudotumor in the right maxilla area, 1 year before visiting our hospital. After that, her pain and swelling did not resolved and she visit our hospital. On radiographic examination, aggressively infiltrative growth of the lesion with destruction of adjacent bony structure was noted. We found unusual aggressiveness of the inflammatory myofibroblastic tumor of the head and neck region. Because the typical behavior of the inflammatory myofibroblastic tumor is not defined yet, we recommend the surgical excision of the lesion and close follow-up.

신생아 위자연천공 2례

김은영,정명숙,박상기,김정용 朝鮮大學校 附設 醫學硏究所 1995 The Medical Journal of Chosun University Vol.20 No.2

Gastric perforation is a rare abdominal catastrophe which associated with high mortality in newborn infant. Mostly the causes are not known but those are asphyxia, congenital muscle defect, sepsis, gastric tube insertion, trauma, ulcer and intestinal obstruction, etc. It usually occurs within the first week of life. Roentgenograms of the abdomen are most helpful in making a positive diagnosis and surgical repair is the treatment of choice. We had two cases of spontaneous gastric rupture in neonate. One had perforation on the greater curvature of the fundus and the other on the anterior wall of body. Failure to feed and abdominal distension with radiographic demonstration of pneumoperitoneum were seen in them. Two cases underwent surgical repairs. So one was survived, but the other died in the early postoperative period.