Extracts and Essential Oil of Ledum palustre L. Leaves and Their Antioxidant and Antimicrobial Activities

Dongmyong Kim,Bongwoo Nam 한국식품영양과학회 2006 Preventive Nutrition and Food Science Vol.11 No.2

The in vitro antimicrobial and antioxidant activities of the essential oil and methanol extracts of Ledum palustre L. were investigated. Using GC-MS analysis, we identified 37 compounds in the essential oil, constituting 87.58% of the total oil. There are several monoterpenes, of which sabinene is the major compound (16~17%). There are several oxygenated monoterpenes of which terpinen-4-ol (7.6%) and myrtenal (3.5%) are the main constituents. β-Selinene, a-selinene, y-elemene, a-caryophyllene are the main sesquiterpenes (2~6% range). The oil strongly reduced the diphenylpicrylhydrazyl radical (IC??=1.56 ㎍/mL) formation and exhibited a hydroxyl radical scavenging effect in the Fe³?-EDTA-H₂O₂ deoxyribose system (IC??=2.7 ㎍/mL), and also inhibited the nonenzymatic lipid peroxidation of rat liver homogenate (IC??=13.5 ㎍/mL). The polar phase of the extract showed antioxidant activity. The oil showed antimicrobial activity against Streptococcus pneumoniae, Clostridium perfringens, Candida albicans, Mycobacterium smegmatis, Acinetobacter lwoffii and Candida krusei while the water-insoluble parts of the methanolic extracts exhibited slight or no activity. This study confirms that the essential oil of Ledum palustre L. possesses antioxidant and low antimicrobial properties in vitro.

Azelaic Acid 함유 밀크 나노분말과 여드름 나노화장품을 위한 나노캡슐의 최적화 공정

김동명 ( Dongmyong Kim ),최지은 ( Jieun Choi ),김덕훈 ( Duckhoon Kim ),이준탁 ( Juntack Lee ) 대한화장품학회 2011 대한화장품학회지 Vol.37 No.1

여드름 나노화장품(nanocosmetics) 개발을 위하여 azelaic acid-milk nano powder의 nanoencapsulation을 fluid-bed processor로 중심합성계획에 따라 유입공기온도(60 ~ 80 ℃), 분무속도(0.5 ~ 0.9 mL/min) 및 분무압력(1.2 ~ 2.0 kg/cm²)을 달리하여 나노캡슐(nanoencapsule)을 제조하고, 나노캡슐의 품질특성을 조사하여 회귀분석을 실시하였다. 나노캡슐의 예측된 수율의 최대값은 70.97 %로 수율은 유입공기온도, 분무속도 및 분무압력 에 의해 크게 영향을 받고 있었다. 시료의 입자크기는 유입공기온도가 높고 분무속도가 빠르며, 분무압력이 낮을수록 커지는 것으로 나타났고, 생리식염수에서 나노캡슐의 용출율은 모두 유입공기온도 및 분무속도에 의해서 가장 많은 영향을 받고 있었다. 수분함량은 분무 속도가 증가하고 분무압력이 높아질수록 증가하였고, 수분활성도는 수분함량과 유사한 경향을 나타내었다. 기계적 색도인 L값과 b값은 유입공기온도가 높아질수록 증가하였다. 수율이 높고 입자크기가 작으며, 피부적합성 나노캡슐 제조의 최적조건은 유입공기온도 67 ~ 73 ℃, 분무속도 0.6 ~ 0.8 mL/min 및 분무압력 1.8 ~ 2.0 kg/cm² 범위로 예측되었다. 이상의 예측범위 내의 임의의 점에서 실제 실험한 실험치는 반응표면분석법에 의해 예측된 값과 유사한 경향을 보여 도출된 회귀식의 신뢰성을 검증할 수 있었다. The conditions in fluid-bed processor for nanoencapsulation of azelaic acid-milk nano powder for acne nanocosmetics were optimized by response surface methodology (RSM). The maximum value of yield was 70.97 %. The yield was appreciably influenced by inlet air temperature, atomizing pressure, and feeding speed. The particle size increased with an increase in the feeding speed and a decrease in the atomizing pressure. The elution rate in saline solutions was appreciably influenced by inlet air temperature and atomizing pressure. The moisture content increased with higher atomizing pressure, which was demonstrated to be similar to the nanoencapsulation characteristics related to water activity. The Hunter’s L and b values increased with an increase in the inlet air temperature. The optimum conditions estimated by RSM for the maximized values of yield, moisture content, particle size and elution rate in skin suitability were 67 ~ 73 ℃ of inlet air temperature, 0.6 ~ 0.8 mL/min feeding speed and 1.8 ~ 2.0 kg/cm² of atomizing pressure, respectively. These estimated values were in agreement with those measured by real experiments.

차체 라인 유연화를 위한 다차종 공용 대차 기술 개발

김동명(Dongmyong Kim),장인성(Insung Chang),최재호(Jaeho Choi) 한국자동차공학회 2012 한국자동차공학회 부문종합 학술대회 Vol.2012 No.5

자동차 산업은 과거 공급자 중심의 소품종 대량 생산 체제에서 현재 소비자 중심의 다품종 소량 생산 체제로 빠르게 변화하여 왔다. 이러한 급격한 변화에 맞추어 자동차 제조사들은 설계 및 제조 등 다방면에 걸쳐 기술 개발 노력을 경주하여 왔다. 설계 측면에서는 전 세계적으로 플랫폼 공용화를 개발하여 왔으며 제조 측면에서는 설비의 공용화 기술을 개발해 왔다. 본 논문에서는 자동차 생산 설비 중 차체 라인에서 많이 사용되는 이송 설비인 대차의 유연화기술 개발에 대한 내용을 기술 한다.

Engineered Self-Expander Hydrogel for Sustained Release of Drug Molecules

Ji-eun KIM,Dongmyong KIM,Hochang KANG,Jonghoon CHOI 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.4

Functional Self-Expander Hydrogel for Sustained Release of Growth factor

Ji-eun KIM,Dongmyong KIM,Hochang KANG,Jonghoon CHOI 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.10

Effect of Annealing Sequence on the a-IGZO FeTFT Ferroelectric Switching Characteristics

Hyojin Yang,Haesung Kim,Sanghyuk Yun,Seongwon Lee,DongMyong Kim,Dae Hwan Kim,Sung-jin Choi,Jong-Ho Bae 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6

암과 스트레스를 이기는 神草 씀바귀의 항산화 요법

정동명,김형민,김중만 한국정신과학학회 2002 韓國精神科學學會誌 Vol.6 No.1

Studies on the biological activities of Ixeris dentata(IXD) were carried out for develop to find Its bioactive compounds. Fresh juice and dried powder of IXD were partitioned with n-hexane followed by EtOAc, and n-BuOH to give n-hexane, EtOAc, n-BuOH and aqueous fractions, respectively The DPPH test, lipid peroxidation, and microcidal activities of each fractions were investigated. The EtOAc and n-BuOH soluble fractions of fresh Juice and dried powder showed the potent antioxidative, anticancer, antistress and inhibition activity against lipid peroxidation the fractions of dried powder showed more effects than those of fresh juice. In microcidal effects, the n-haxane 250 ㎍/ml In addition, Using mouse peritoneal macrophages, we have examined the mechanism by which green sap of Ixeris dentata regulates nitric oxide(NO) production. When IXD was used in combination with recombinant interferon-γ(rIFN-γ), there was a marked cooperative induction of NO production. From these results, it is suggested that IXD is to be useful in source material for neutraceutical and pharmaceutical applications.

암과 스트레스를 이기는 神草 씀바귀의 항산화 요법

정동명,김형민,김중만 한국정신과학학회 2002 한국정신과학회 학술대회 논문집 Vol.16 No.-

Studies on the biological activities of Ixeris dentata(IXD) were carried out for develop to find its bioactive compounds. Fresh juice and dried powder of IXD were partitioned with n-hexane followed by EtOAc, and n-BuOH to live n-hexane, EtOAc, n-BuOH and aqueous fractions, respectively. The DPPH test, lipid peroxidation, and microcidal activities of each fractions were investigated. The EtOAc and n-BuOH soluble fractions of fresh juice and dried powder showed the potent antioxidative, anticancer, antistress and inhibition activity against hpid peroxidation. the fractions of dried powder showed more effects than those of fresh juice. In microcidal effects, the n-haxare and EtOAc fractions exhibited microcidal effects against E. coli at the concentration of 250 ㎍/ml. In addition, Using mouse peritoneal macrophages, we have examined the mechanism by which green sap of Ixeris dentata regulates nitric oxide(NO) production. When IXD was used in combination with recombinant interferon- r(rIFN- r), there was a marked cooperative induction of NO production. From these results, it is suggested that IXD is to be useful in source material for neutraceutical and pharmaceutical applications.

세포의 정보통신과 개체의식의 전파에 관한 고찰

정동명,김재수 한국정신과학학회 2000 韓國精神科學學會誌 Vol.4 No.1

Nowadays, the mentality and the material are separated by dualism. In addition, the mental science which wants to prove scientifically about the mental and the energy of the body and the natural science are separated too. In spite of the consideration of the latest science, our thinking have been divided into the metaphysIcs and a concrete science, the rallonalism and the idealism, the mental and the material. In addition, we regarded unknown things in the same light with the non existent things. We rarely consider the things as a whole and its harmony. About this contradiction, in this paper trying to extract of relationship between the mechanism of the individual consciousness propagated to other indIviduals or cell, and the mformation communication system of the cell and the consciousness. The body that is to say the mental and the matenal which is associated with the human body through the hypothesIs and the logical evidence with venflcation.

조직의 지원환경이 일-가족갈등에 미치는 영향

김인선(lnseon Kim),이동명(Dongmyong Lee) 한국고용노사관계학회 2009 産業關係硏究 Vol.19 No.2

본 연구에서는 기존의 역할갈등이론을 넘어 자원보존이론 관점에서 구성원의 일-가족갈등에 영향을 미치는 선행요인을 실증하고자 하였다. 이를 위해 일-가족에 대한 조직의 지원환경을 일-가족지원제도, 일-가족 지원적 조직 분위기, 상사 지원 등 3 차원으로 나누고, 이들 지원환경이 일-가족갈등(일가족갈등, 가족일갈등) 감소에 미치는 영향을 실증하였다. 본 연구는 전 산업에 걸쳐 77개 사업체, 638명의 근로자를 표본 대상으로 하였다. 분석 결과는 다음과 같다. 첫째, 일-가족지원제도는 일가족갈등(wfc)과 가족일갈등(fwc) 감소에 영향을 미치지 못하였다. 둘째, 일-가족 지원적 조직 분위기는 구성원의 일가족갈등(wfc) 및 가족일갈등(fwc)에 강한 부(-)의 영향을 미치는 것으로 나타났다. 셋째, 상사 지원은 일가족갈등(wfc)을 유의하게 감소시켰으나, 가족일갈등(fwc) 감소에 미치는 효과는 실증되지 못했다. 이러한 연구 결과는 일-가족 균형관련 조직의 인적자원관리정책에 다음과 같은 시사점이 있다고 판단된다. 첫째, 일-가족 지원적 조직 분위기 형성을 통해 구성원의 일-가족갈등을 효과적으로 관리할 수 있다. 또 상사 지원을 통해 일가족갈등(wfc)을 완화시킬 수 있다. 따라서 조직은 지원적 분위기 및 상사 지원을 촉진하는 방안을 강구해야 한다. 둘째, 일-가족지원제도의 시행효과가 나타나지 않은 점은 우리나라 기업의 일-가족제도가 형식적으로 도입되고 있음을 시사한다. 이에 제도 시행의 실효성 제고와 함께 제도의 자유로운 이용이 가능하도록 다양한 지원방안을 강구할 필요가 있다. This study examines the effects of the organizational supportive environments on reducing work/family conflict based on the conservation of resource(COR) model, beyond the sources of work/family conflict according to the role conflict theory. Organizational supportive environments are composed of three facets, work-family programs, supportive organizational climate, and supervisor support. Data were gathered from 638 participants employed in 77 corporations in a variety of industries and occupations. This study reveals the following three findings; First, work-family programs had no significant influences in reducing both work to family conflict(wfc) and family to work conflict(fwc). Second, supportive organizational climate had a effect on reducing both work family conflict(wfc) and family work conflict(fwc) significantly. Third, supervisor support was related not to reduce family to work conflict(fwc) but to reduce work to family conflict(wfc). On the basis of main findings, the implications of HRM are as follows; First, overall supportive environments, especially work-family supportive climate and supervisor support, play important role in managing of work-family conflict. Second, it is very important to make a supportive climate for usage of work-family programs freely, in order for employees to get the benefits of work-family policies.