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Yun, Young Jin,Kim, Han-Jun,Lee, Deok-Won,Um, Sewook,Chun, Heung Jae Elsevier 2018 Journal of industrial and engineering chemistry Vol.67 No.-
<P><B>Abstract</B></P> <P>Surface modified poly <SMALL>L</SMALL>-lactic acid (PLLA) samples with hydroxyapatite (HA), heparin and bone morphogenetic protein-2 (BMP-2) mediated by polydopamine (pDA) coating (PLLA/pDA/HA/Hep/BMP-2) were prepared, and their effects on the enhancements of bone formation and osseointegration were evaluated <I>in vitro</I> and <I>in vivo</I> as compared to PLLA, PLLA/pDA/HA, and PLLA/pDA/Hep/BMP-2. The changes in surface chemical compositions, morphologies and wettabilities were observed by X-ray photoelectron spectroscopy (XPS), field-emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM) and water contact angle measurements. Pre-coating of HA particles with pDA provided uniform and homogeneous anchoring of particles to PLLA surface. In addition, the strong ionic interaction between heparin and pDA led PLLA surface readily heparinized for loading of BMP-2. <I>In vitro</I> experiments revealed that the levels of alkaline phosphatase (ALP) activity, calcium deposition, and osteocalcin (OCN) gene expression were higher in MG-63 human osteosarcoma cell lines grown on PLLA/pDA/HA/Hep/BMP-2 than on control PLLA, PLLA/pDA/HA, and PLLA/pDA/Hep/BMP-2. <I>In vivo</I> studies using micro-computed tomography (micro-CT) also showed that PLLA/pDA/HA/Hep/BMP-2 screw exhibited greatest value of bone volume (BV) and bone volume/tissue volume (BV/TV) among samples. Histological evaluations with H&E and Von Kossa staining demonstrated that a combination of HA and BMP-2 contributed to the strong osseointegration.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Deok Yun Ju ),( Yong Kyun Cho ),( Woon Je Heo ),( Won Seok Choi ),( Jung Ho Park ),( Hong Joo Kim ),( Dong Il Park ),( Chong Il Sohn ),( Woo Kyu Jeon ),( Byung Ik Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Waist circumference (WC) is a valuable component of metabolic syndrome. Waist circumference is related to insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to examine the association between waist circumference and IR , NAFLD in apparently healthy Korean subjects. Methods: After exclusion criteria, 9159 (5052men, 4107 women) subjects who participated in comprehensive health checkup program enrolled this study. Cross-sectional study was performed. IR was evaluated by the homeostasis model assessment of insulin resistance (HOMA-IR) and IR was considered with HOMA-IR>2. NAFLD was presented by ultrasonographic finding. We considered alanine aminotransferase (ALT) elevated if above the upper normal limit (>40IU/L in men, >35IU/L in women). Logistic regression analysis was performed to evaluate the odds ratio in NAFLD, IR and ALT according to the categorized levels of the waist circumference. Results: NAFLD was found in 27.9% (82.6% men, 17.4% women) of the subjects. IR was 17.2% (68.1% men, 31.9% women), elevated ALT was 10% (83% men, 17% women) of subject. After adjusted for confounding factor, the prevalence of NAFLD, IR and elevated ALT was significant associated with increasing quartile of waist circumference. (highest quartile in NAFLD; OR 15.539 [95% CI 12.687?19.033] in men, 23.918[95% CI 23.918 ? 99.288] in women, p<0.001), (highest quartile in IR ; OR 17.576[95% CI 13.283?23.255] in men, 11.078[95% CI 7.813?15.708] in women, p<0.001) (highest quartile in elevated ALT ; OR 7.952[95% CI 6.046?10.459] in men, 8.487[95% CI 4.679-15.395] in women p<0.001) Conclusion: Waist circumference is contribute to IR and NAFLD in apparent healthy Korean subjects. So waist circumference may be a most important factor of developing IR and NAFLD.
( Yun Hee Chang ),( Taek Jong Kwak ),( Young Ah Shin ),( Jung Min Shin ),( In Kyu Chang ),( Bomi Won ),( Min Youl Chang ),( Sang Hwha Lee ),( Hyun Kyung Jung ),( Chang Deok Kim ),( Jeung Hoon Lee ),( 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Human skin phenotypes such as whitening, wrinkle and moisture are regulated by various factors such as genetic, environmental, and endocrine factors. Among these factors, genetic factor is one of the most potent determinants in skin phenotypes and has polygenic quantitative traits between races Objectives: We investigated the genetic factors influencingskin phenotypes(whitening, wrinkle and moisture) in Korean women Methods: For the genetic study for skin phenotypes in Korean women, we measured whitening, wrinkle and moisture in 300 women aged 30-50 and finally 78 women who show extreme phenotype were selected. Oragene® saliva kit was used to collect highly pure DNA from saliva of volunteers and Ion Proton™ sequencer was used for exome sequencing Results: Using the logistic regression analysis, we found top 10 genes in each skin phenotypes (whitening, wrinkle and moisture) which are statistically significant Conclusion: Our results suggest that multiple genetic variants in exon region could be determinant of an individual’s skin phenotypes such as whitening, wrinkle and moisture in Korean women
Yun Ho Kim,Han Kyul Park,Na Rae Choi,Seong Won Kim,Gyoo Cheon Kim,Dae Seok Hwang,Yong Deok Kim,Sang Hun Shin,Uk Kyu Kim 대한구강악안면외과학회 2017 대한구강악안면외과학회지 Vol.43 No.1
Objectives: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is systemic disease that affects kidney function. The aim of this study was to analyze the relevance of renal function in the severity of BRONJ. Materials and Methods: Ninety-three patients diagnosed with BRONJ in Pusan National University Dental Hospital from January 2012 to December 2014 were included in this study. All patients underwent a clinical exam, radiographs, and serologic lab test, including urine analysis. The patient’s medical history was also taken, including the type of bisphosphonate drug, the duration of administration and drug holiday, route of administration, and other systemic diseases. In accordance with the guidelines of the 2009 position paper of American Association of Oral and Maxillofacial Surgeons, the BRONJ stage was divided into 4 groups, from stage 0 to 3, according to the severity of disease. IBM SPSS Statistics version 21.0 (IBM Co., USA) was used to perform regression analysis with a 0.05% significance level. Results: BRONJ stage and renal factor (estimated glomerular filtration rate) showed a moderate statistically significant correlation. In the group with higher BRONJ stage, the creatinine level was higher, but the increase was not statistically significant. Other factors showed no significant correlation with BRONJ stage. There was a high statistically significant correlation between BRONJ stage and ‘responder group’ and ‘non-responder group,’ but there was no significant difference with the ‘worsened group.’ In addition, the age of the patients was a relative factor with BRONJ stage. Conclusion: With older age and lower renal function, BRONJ is more severe, and there may be a decrease in patient response to treatment.
( Deok Gyeong Kim ),( Hui Gyeong Suh ),( Ji Won Min ),( Sun Kyeong Kim ),( Yun Sook Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: The Objective of this study was to assess the positive culture rate and antimicrobial susceptibilities of Mycoplasma hominis (MH) and Ureaplasma urealyticum (UU) in general population and pregnant women. Methods: We reviewed a retrospective medical records of patients who have undergone culture test and antimicrobial susceptibilities at our center from April 2018 through January 2017. The study included all patients with positive culture for MH, UU or both. Results: The condition was assessed in 200 patients. All of them, 34 (17%) were pregnant women and 166 (83%) were non-pregnant women. From 105 (52.5%) out of total 200 had a positive culture as follows: MH 46 (23%), UU 95 (47.5%) and both 36 (18%). Susceptibilities of MH to doxycycline, erythromycin, ciprofloxacin, and azithromycin were 97.8%, 6.5%, 17.4%, and 8.7%, respectively. Susceptibilities of UU to doxycycline, erythromycin, ciprofloxacin, and azithromycin were 95.8%, 55.8%, 7.4%, and 56.8%, respectively. Susceptibilities of both MH and UU to doxycycline, erythromycin, ciprofloxacin, and azithromycin were 97.2%, 5.6%, 11.1%, and 11.1%, respectively. Conclusion: UU was the leading causative pathogen for genitourinary infection in our study. MH accounted for about half of the UU infection rate. Doxycycline was still best susceptible to UU, MU, and both. Ciprofloxacin had less than 20% susceptibility to MU, UU, both. The major problem is that the pregnant women is infected with MU and both are not sensitive to erythromycin and azithromycin at all. Acknowledgements: This work was supported by the Soonchunhyang University Research Fund
( Deok Yun Ju ),( Yong Kyun Cho ),( Woon Je Heo ),( Won Seok Choi ),( Jung Ho Park ),( Hong Joo Kim ),( Dong Il Park ),( Chong Sohn ),( Woo Kyu Jeon ),( Byung Ik Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Waist circumference (WC) is a valuable component of metabolic syndrome. Waist circumference is related to insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to examine the association between waist circumference and IR , NAFLD in apparently healthy Korean subjects. Methods: After exclusion criteria, 9159 (5052men, 4107 women) subjects who participated in comprehensive health checkup program enrolled this study. Cross-sectional study was performed. IR was evaluated by the homeostasis model assessment of insulin resistance (HOMA-IR) and IR was considered with HOMA-IR>2. NAFLD was presented by ultrasonographic finding. We considered alanine aminotransferase (ALT) elevated if above the upper normal limit (>40IU/L in men, >35IU/L in women). Logistic regression analysis was performed to evaluate the odds ratio in NAFLD, IR and ALT according to the categorized levels of the waist circumference. Results: NAFLD was found in 27.9% (82.6% men, 17.4% women) of the subjects. IR was 17.2% (68.1% men, 31.9% women), elevated ALT was 10% (83% men, 17% women) of subject. After adjusted for confounding factor, the prevalence of NAFLD, IR and elevated ALT was significant associated with increasing quartile of waist circumference. (highest quartile in NAFLD; OR 15.539 [95% CI 12.687-19.033] in men, 23.918[95% CI 23.918 - 99.288] in women, p<0.001), (highest quartile in IR ; OR 17.576[95% CI 13.283-23.255] in men, 11.078[95% CI 7.813-15.708] in women, p<0.001) (highest quartile in elevated ALT ; OR 7.952[95% CI 6.046-10.459] in men, 8.487[95% CI 4.679-15.395] in women p<0.001) Conclusion: Waist circumference is contribute to IR and NAFLD in apparent healthy Korean subjects. So waist circumference may be a most important factor of developing IR and NAFLD.