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Bulk properties of the van der Waals hard ferromagnet <tex> $ \mathrm{VI}_{3}$</tex>
Son, Suhan,Coak, Matthew J.,Lee, Nahyun,Kim, Jonghyeon,Kim, Tae Yun,Hamidov, Hayrullo,Cho, Hwanbeom,Liu, Cheng,Jarvis, David M.,Brown, Philip A. C.,Kim, Jae Hoon,Park, Cheol-Hwan,Khomskii, Daniel I.,S American Physical Society 2019 Physical Review B Vol.99 No.4
( Ju Hyun Oh ),( Grace Hyun J. Kim ),( David W Dai ),( S Sam Weigt ),( Jonathan G Goldin ),( Lila Pourzand ),( Jooae Choe ),( Fereidoun Abtin ),( Matthew S. Brown ),( Pangyu Teng ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Interstitial lung disease (ILD) includes a heterogeneous group of disease entities. Idiopathic pulmonary fibrosis (IPF) is ultimately fatal, and accurate diagnosis of IPF is critical to clinical decision making. Visual interpretation of chest high resolution CT (HRCT) is subjective and has limited reproducibility, especially with early disease. So we have previously developed attention-gated deep learning algorithm to diagnosis IPF and machine learning to predict IPF progression. The overall aim of IS-IPF is to collect the data from two centers of excellence and evaluate the robustness of the algorithm. We present the preliminary data of the patients studied following disease classification by the multidisciplinary review committees (MDCs) at UCLA and Asan Medical Center (AMC). Methods The IS-IPF study plans to include 234 IPF and 266 non-IPF cases from two large ILD centers (UCLA and AMC). Eligible patients were evaluated in ILD MDC, were >18 years old, had a HRCT, pulmonary function testing, and a committee diagnosis of IPF or non-IPF. Relevant demographic information was collected from the medical record. Results Total 185 IPF and 266 non-IPF patients’ HRCT images have been collected in the IS-IPF study. By center, 51 IPF and 133 non- IPF patients’ HRCT were collected from UCLA, and 134 IPF and 133 non-IPF patients’ HRCT were collected from AMC. On MDC diagnosis, non-IPF cohorts consisted of 33% hypersensitivity pneumonitis, and 67% other connective tissue disease-ILD. Mean age was 61 years (63 IPF and 58 non-IPF), and 63% were male (82% IPF and 57 % non-IPF). Up to date, the predicted FVC was 74.7% and the predicted DLco was 61.6 % in the IPF cohort. Data collection is on-going. Conclusions These well-characterized cohorts will be used to evaluate HRCT image signatures for distinguishing IPF from other ILD, and predicting patient-specific IPF progression within 2 years of diagnosis.
( Su Jong Yu ),( Chi Ma ),( Bernd Heinrich ),( Zachary J. Brown ),( Milan Sandhu ),( Qianfei Zhang ),( Qiong Fu ),( David Agdashian ),( Firouzeh Korangy ),( Tim F. Greten ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Cytokine-induced killer (CIK) cell-based immunotherapy is effective as adjuvant therapy in early stage hepatocellular carcinoma (HCC), but lacks efficacy in advanced HCC. We investigated immune suppressor mechanisms and focused on CIKs and myeloid-derived suppressor cells (MDSCs). Methods: MDSCs were quantified by flow cytometry, PCR, and immunohistochemistry. Cytokines were detected by cytokine array. LDH cytotoxicity assay was performed in the presence or absence of MDSCs to study CIK function against HCC cells in vitro. An FDA approved PDE5 inhibitor, tadalafil, was used to target MDSCs in vitro and in vivo. Two different murine HCC cell lines were tested as subcutaneous and orthotopic tumor models in C57BL/6 and BALB/c mice. Anti-tumor effects of human CIK and MDSC were tested in vitro. Results: Adoptive cell transfer of CIK cells into tumor bearing mice induced inflammatory mediators (e.g., CX3CL1, IL-13) in the tumor microenvironment and an increase of tumor infiltrating MDSCs leading to impaired anti-tumor activity in two different HCC tumor models. MDSCs efficiently suppressed the cytotoxic activity of CIK cells in vitro. In contrast, treatment with a PDE5 inhibitor reversed MDSC suppressor function via ARG1 and iNOS blockade and systemic treatment with a PDE5 inhibitor prevented MDSC accumulation in the tumor microenvironment upon CIK cell therapy and increased its anti-tumor efficacy. Similar results were seen when human CIK cells were tested in vitro in the presence of CD14+HLA-DR<sup>-/low</sup> MDSCs. Treatment of MDSCs with a PDE5 inhibitor suppressed MDSCs suppressor function and enhanced CIK activity against human HCC cell lines in vitro. Conclusions: Our results suggest that targeting MDSCs is an efficient strategy to enhance the antitumor efficacy of CIK cells for the treatment of patients with HCC.
Wafer-scale synthesis of monolayer two-dimensional porphyrin polymers for hybrid superlattices
Zhong, Yu,Cheng, Baorui,Park, Chibeom,Ray, Ariana,Brown, Sarah,Mujid, Fauzia,Lee, Jae-Ung,Zhou, Hua,Suh, Joonki,Lee, Kan-Heng,Mannix, Andrew J.,Kang, Kibum,Sibener, S. J.,Muller, David A.,Park, Jiwoon American Association for the Advancement of Scienc 2019 Science Vol.366 No.6471
<P><B>Single-layer porphyrin polymerization</B></P><P>Two-dimensional polymers can be made as monolayer sheets through controlled synthesis at an interface. However, it is often difficult to create intact sheets over large areas that can be transferred onto substrates. Zhong <I>et al.</I> polymerized derivatized porphyrin molecules during laminar flow at a sharp pentane-water interface to form sheets that are 5 centimeters in diameter (see the Perspective by MacLean and Rosei). The authors used electron microscopy and spectroscopy to confirm that they had produced intact monolayers. These films were then transferred onto monolayer sheets of molybdenum disulfide to form superlattices for use as capacitors.</P><P><I>Science</I>, this issue p. 1379; see also p. 1308</P><P>The large-scale synthesis of high-quality thin films with extensive tunability derived from molecular building blocks will advance the development of artificial solids with designed functionalities. We report the synthesis of two-dimensional (2D) porphyrin polymer films with wafer-scale homogeneity in the ultimate limit of monolayer thickness by growing films at a sharp pentane/water interface, which allows the fabrication of their hybrid superlattices. Laminar assembly polymerization of porphyrin monomers could form monolayers of metal-organic frameworks with Cu<SUP>2+</SUP> linkers or covalent organic frameworks with terephthalaldehyde linkers. Both the lattice structures and optical properties of these 2D films were directly controlled by the molecular monomers and polymerization chemistries. The 2D polymers were used to fabricate arrays of hybrid superlattices with molybdenum disulfide that could be used in electrical capacitors.</P>