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( Daeun You ),( Seung Pil Jung ),( Yisun Jeong ),( Soo Youn Bae ),( Jeong Eon Lee ),( Sangmin Kim ) 생화학분자생물학회 2017 BMB Reports Vol.50 No.12
Fibronectin (FN) plays important roles in the EMT in a variety of cancer cell types. However, the mechanism by which FN expression is regulated in tamoxifen-resistant (TamR) breast cancer cells has not yet been fully elucidated. Aberrant FN expression was associated with poor prognosis in patients with luminal type A breast cancer. In addition, FN was upregulated in TamR cells. To investigate the mechanism by which FN expression is regulated, we assessed the levels of phosphorylated Akt, JNK, and STAT3 and found that they were all increased in TamR cells. Induction of FN expression was dampened by LY294002 or AKT IV in TamR cells. Furthermore, FN expression was increased by constitutively active (CA)-Akt overexpression in tamoxifen-sensitive MCF7 (TamS) cells and colony formation of TamR cells was blocked by AKT IV treatment. Taken together, these results demonstrate that FN expression is upregulated through the PI-3K/Akt pathway in tamoxifen-resistant breast cancer cells. [BMB Reports 2017; 50(12): 615-620]
( Daeun Jeong ),( Min Kyoung Kim ),( Sung Ae Koh ),( Kyoung Hee Lee ),( Eun Ju Goo ),( Myung Soo Hyun ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Sarcoidosis is a systemic disease of unknown cause that involves multiple organs and is characterized by non-caseating granuloma. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to the presence of an antibody to the platelet and abnormal platelet production. There is no known pathogenesis that occur concurrently ITP and sarcoidosis. But considering together of two known pathogenesis, abnormal immune response trigger either ITP or sarcoidosis. And the disease which is developed earlier stimulates secondary disease. After secondary disease developed, they are stimulates each other. A few cases of ITP associated with sarcoidosis are documented, but the disease has rarely been reported in Korea. Here, we report a case of ITP with sarcoidosis in 29-year-old man. He suffered from easy bruising. The chest X-ray and the contrast-enhanced computed tomography revealed bihilar lymphadenopathy and reticulonodular infiltrates. Bone marrow study and fiuoroscopy-guided percutaneous needle biopsy was done and diagnosed with ITP and sarcoidosis. The patient was put on 400mg/kg of intravenous immunoglobulin for five days and after 4th day of the administration, uveitis is confirmed and then put on 20mg of prednisolone. Since platelets was restored to 200,000/uL, he was discharged with 20mg of prednisolone. During 7 months after discharge, prednisolone was slowly reduced to 7.5mg/2days but platelet count was decreased to 19,000/uL. It is difficult to reduce steroid, immunosuppressive agents which are azathioprine and methotrexate are administrated for additional 4 months. Follow-up 14 months, platelet count was 62,000/uL and lung infiltrates and lymphadenopathy was improved in chest X-ray. It has been good response without significant bleeding event. But it needed more administration of oral steroid, additional immunosuppressive agents and more duration of follow-up than single disease whether sarcoidosis or ITP.
정다은(DaEun Jeong),권소희(SoHee Kwon),이승미(SeungMi Lee),양보은(BoEun Yang),장현진(HyunJin Jang),정진경(JinKyung Jung) 학습자중심교과교육학회 2023 학습자중심교과교육연구 Vol.23 No.20
목적 본 연구는 결혼이주여성 대상 문화예술교육과 관련된 연구 동향을 살펴봄으로써 향후 결혼이주여성 대상 문화예술교육에 대한 방향성 및 시사점을 제시하고자 한다. 방법 본 연구의 분석 대상은 결혼이주여성 대상 문화예술교육 관련 학술지 및 학위논문 총 59편이다. 결혼이주여성 대상 문화예술교육과 관련된 연구 동향을 발표연도, 연구 방법, 연구 분야, 연구 주제, 주제어로 범주화하여 분석하였다. 결과 첫째, 결혼이주여성 대상 문화예술교육과 관련된 연구는 2010년부터 2011년 사이 가장 많이 이루어졌다. 둘째, 연구 방법별 동향은 문헌 연구로 가장 많이 이루어졌고, 질적 연구, 혼합 연구, 양적 연구 순으로 나타났다. 셋째, 연구 분야별 동향은 문학과 관련된 내용이 가장 많았고, 이어서 일반, 미술, 무용, 음악, 연극 순으로 나타났다. 넷째, 연구 주제별 동향은 대영역 중 방향과 관련된 주제에서 교육방안이 가장 높은 비중을 차지하고 있는 것으로 나타났다. 다섯째, 주제어로 알아본 동향은 워드 클라우드의 주제어 크기로 살펴본 결과 다문화가정, 한국문화교육, 한국어 교육, 다문화사회, 문학교육, 문화적응 순으로 나타났고, 정체성 복원, 융합적 문화 정체성, 자아정체성, 서사적 정체성 등 결혼이주여성의 정체성과 관련된 주제어가 포함되어 있음을 알 수 있었다. 결론 본 연구는 다문화 시대에 도래한 한국 사회에 결혼이주여성이 큰 비중을 차지하고 있는 상황 속에서 결혼이주여성 대상 문화예술교육에 관한 연구의 동향을 분석하였으며, 이와 관련된 시사점 및 향후 관련 연구의 방향을 제시한다는 점에서 의의가 있다. Objectives The purposes of this study were to examine the research trends related to culture and arts education for marriage migrant women. Through this study, it intends to provide insights and directions for future culture and arts education targeting marriage migrant women. Methods The subject of this study consists of a total of 59 academic journals and dissertations related to culture and arts education for marriage migrant women. The research trends in cultural arts education targeting marriage migrant women were analyzed and categorized based on publication year, research methodology, research field, research topics, and keywords. Results First, the research related to culture and arts education for marriage migrant women was most prevalent between 2010 and 2011. Second, in terms of research methodology, literature review was the most commonly used method, followed by qualitative research, mixed-methods research, and quantitative research. Third, the re-search fields were predominantly related to literature, followed by general arts, visual arts, dance, music, and theater. Fourth, regarding research topics, the majority focused on educational approaches in the context of broader themes. Lastly, the analysis of keywords through word cloud visualization revealed that topics related to multicultural families, Korean culture education, Korean language education, multicultural society, literary educa-tion, and cultural adaptation were prominent. Additionally, themes associated with the identity of marriage mi-grant women, such as identity restoration, hybrid cultural identity, self-identity, and narrative identity, were also identified. Conclusions This study analyzed the trends in research on culture and arts education targeting marriage migrant women in Korean society, where marriage migrant women hold a significant presence in the multicultural era. The significance lies in providing insights and future directions for related research in the context of marriage migrant women's culture and arts education within the multicultural society of Korea.
Jeong, Ji Seong,Nam, Ki Taek,Lee, Buhyun,Pamungkas, Aryo Dimas,Song, Daeun,Kim, Minjeong,Yu, Wook-Joon,Lee, Jinsoo,Jee, Sunha,Park, Youngja H.,Lim, Kyung-Min The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett's test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in $C_{max}$, and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in $C_{max}$ and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups.