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- 저자 : Da-Eun Im(Da-Eun Im) (검색결과 62 건)
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( Eun Hye Cho ),( Do Hwa Im ),( Da Hyun Kim ),( Young Nam Kim ),( Jung Mi Byun ),( Moon Su Sung ),( Kyung Bok Lee ),( Dae Hoon Jeong ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: This study aimed to investigate the correlation of sarcopenia with chemotherapy-ralated complications and oncological outcomes in endometrial cancer patient Methods: We collect the data from January, 2015 to August, 2021 by electronic medical records(EMR) and reviewed the pateints who underwent chemotherapy during those periods retrospectively. We assessed patients who had abdominopelvic computerized tomography(APCT) as part of follow up. We measured L3 vertebra skeletal muscle index(L3SMI) using Slice-O-Matic program(Tomovision) and sarcopenia was defined as L3SMI < 41cm2/m2. Results: Total 117 patients were underwent chemotherapy in our hospital and 97 patients were included our study finally. There are 28 patients in sarcopenia group, 69 patients in non-sarcopenia group. In the sarcopenia group, body mass index(BMI) before chemotherapy is lower than non-sarcopenia group (26.85±4.52 vs. 22.55±2.38; P < 0.0001). The prevalence of neutropenic fever in sarcopenia group was higher than non-sarcopenia group (42.9% vs. 18.8%, P = 0.0148). Whereas recurrence rate and prevalence of anemia after 1st chemotherapy were not associated with sarcopenia. Conclusion: In endometrial cancer, the patients with sarcopenia who underwent chemotherapy have increased chemotherapy- related complication as neutropenic fever. Neutropenic fever is mortal in patients who should be treated for malignancy by chemotherapy. Based on this result, it is necessary to use the Granulocyte-Colony Stimulating Factor(G-CSF) and pegfilgrastim prophylactically after chemotherapy for endometrial cancer patients with sarcopenia to prevent neutropenic fever. Additionally we should counsel about diet and exercise to prevent sarcopenia.
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Maternal risk factors for recurrent small-for-gestational age at term neonates in South Korea
( Eun Hye Cho ),( Young Nam Kim ),( Dae Hoo Jeong ),( Kyung Bok Lee ),( Moon Su Sung ),( Da Hyun Kim ),( Do Hwa Im ),( Geum Joon Cho ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: The objective of this study is to analyze the associated maternal pre-pregnancy and pregnancy factors that affect SGA at term neonates in South Korea. Methods: This study enrolled pregnant women who had two full-term singleton deliveries from 2006 to 2016, and who had undergone a national health screening examination through the National Health Insurance during the 1 year before their delivery. We compared the pregnancy and pre-pregnancy characteristics between the SGA group and non-SGA group, and between the recurrent SGA group (second SGA delivery) and non-recurrent SGA group (second non-SGA delivery) among the women who delivered their first SGA neonate. Results: We enrolled 887,902 term singleton deliveries during the study periods. SGA neonates were delivered in 2.84% of term singleton pregnancies. Mean birth weight were 2.18 ± 0.64 kg in the SGA group and 3.28 ± 0.38 kg in the non-SGA group (p<0.001). The prevalence of pre-gestational hypertension and gestational hypertension were higher in SGA group than non-SGA group (3.99% vs. 2.85%; <0.001, and 5.88% vs. 1.22%; p<0.001, respectively). Maternal pre-gestational mean BMI and fasting glucose were lower in SGA group than non-SGA group (20.46 ± 2.58 vs. 21.08 ± 2.74, p<0.001, and 86.62 ± 10.52 mg/dl vs. 87.33 ± 11.23 mg/dl; <0.001, respectively) For the women who recurrently delivered SGA neonates, the prevalence of gestational hypertension during the second pregnancy were higher than non-recurrent SGA group (5.88% vs. 1.65%; p<0.0001), and pre-gestational fasting glucose were lower (86.31 ± 10.29 mg/dl vs. 87.76 ±11.36 mg/dl; p=.0388) than non-recurrent group. Conclusion: Pregnant women who delivered SGA neonates had more gestational and pre-gestational hypertension and lower pre-gestational BMI and fasting glucose level. Moreover, women who recurrently delivered SGA neonates had more gestational hypertension during second pregnancy. Based on this results, the management and counseling for pregnant women is necessary to prevent SGA neonates.
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Im, Chang-Nim,Kim, Byeong Mo,Moon, Eun-Yi,Hong, Da-Won,Park, Joung Whan,Hong, Sung Hee Korea Genome Organization 2013 Genomics & informatics Vol.11 No.4
A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.
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노후소득보장수단으로서의 기초연금제도의 적정성에 대한 검토
정다은 ( Da-eun Chong ),임현 ( Hyun Im ) 한국법정책학회 2016 법과 정책연구 Vol.16 No.4
Considering rapid population aging in Korea, various policy efforts in the field of social security are required to prepare for the aging society, one of which is basic pension system. After much controversy about the introduction of basic pension system suggested as a presidential election pledge in 2012, `Basic Pension Act` was eventually enacted in 2014, but it still faces a lot of problems and criticisms. Above all, questions are being raised as to whether the scope of qualified recipient and the amount of basic pension benefits are adequate. Recognizing these problems, this paper aims to suggest improvements for basic pension system so that it can fulfill its function as old-age income security system. It suggests specific improvements based on the analysis of the existing basic pension system according to the theoretical and normative standard and the standard of system structure. For the theoretical and normative analysis it reviews the fundamental purpose of basic pension system and the social security rights of the aged. For the analysis about system structure it examines the role of basic pension in the aspects of multi-pillar system for old-age income security and its institutional congruence with the other old-age income security systems. On the basis of this analysis, this paper proposes following improvements for the adequacy of basic pension system for old-age income security. Firstly, the policy goal and direction of basic pension system has to be clearly defined. That is, it needs to be reviewed and determined whether basic pension should function as social allowance or have institutional characteristics of public assistance, and accordingly the scope of the recipient needs to be redefined as well. Second, basic pension system has to be in the institutional congruence with national pension and national basic living security system in the multi-pillar system for old-age income security. In specific, `universal` basic pension system needs to be separated from national pension system for income replacement. In addition, the extreme poor must be also guaranteed their right to enjoy basic pension benefits by differentiating between the roles of basic pension system and national basic living security system for selective public assistance. This paper supports demogrant-typed basic pension system without graded payment in principle and argues that it should be ensured that the number of qualified recipient of basic pension accounts for 80 percent by extending the existing scope of 70 percent. Furthermore, it is required to raise the amount of basic pension benefits to 15 percent of average income in order that basic pension system can accomplish its purpose of old-age income security. Most important of all is, however, social consensus should be reached in the formation of basic pension system. It is enough discussion and social consensus that are essential to define the contents of basic pension system by determining the purpose of basic pension, the scope of recipient and the amount of benefits.
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ICR 마우스를 이용한 오미자, 상엽 에탄올 단독추출물 및 복합추출물의 단회경구투여 독성시험
최은옥(Eun Ok Choi),권다혜(Da Hye Kwon),김민영(Min Young Kim),황보현(Hyun Hwang-Bo),김홍재(Hong Jae Kim),안규임(Kyu Im Ahn),정진우(Jin-Woo Jeong),이기원(Ki Won Lee),김기영(Ki Young Kim),김성구(Sung Goo Kim),최영환(Young Whan Choi),홍수 한국생명과학회 2016 생명과학회지 Vol.26 No.10
오미자(Schisandrae Fructus)와 상엽(Mori folium)은 한국, 중국, 일본을 포함한 아시아 지역에서 오랫동안 식품자원 및 전통 의약제로 광범위하게 사용되어 왔다. 최근 연구에 따르면 오미자와 상엽은 항균, 항염증, 항산화, 면역기능 조절 및 혈관신생억제 등과 같은 많은 효능을 가지는 것으로 알려져 있다. 그러나 오미자(SF), 상엽(MF) 에탄올 단독추출물 및 복합추출물(medicinal herber mixture, MHMIX)에 대한 독성 및 안전성에 대해서는 거의 알려져 있지 않은 실정이다. 따라서 본 연구에서는 SF, MF 및 MHMIX가 유발하는 급성독성 및 안전성을 확인하였다. 이를 위하여 ICR mice를 대상으로 SF, MF 및 MHMIX 5,000 ㎎/㎏을 최고농도로 설정하여 단회 경구 투여하였으며, 투여 후 14일 동안의 치사율, 체중 변화, 임상증상, 음수율 및 사료섭취량과 함께 부검 소견, 장기무게 변화, 혈액학 및 혈액생화학적 검사를 실시하였다. 결과에서 나타난 바와 같이 SF, MF 및 MHMIX의 투여 후 치사율, 임상증상, 체중 및 부검 소견 상의 유의적인 변화는 관찰되지 않았다. 또한 SF, MF 및 MHMIX 투여에 따른 각 장기의 무게, 혈액학적 및 혈청학적 임상 화학적 지표에도 유의적인 변화는 관찰할 수 없었다. 따라서 SF, MF 및 MHMIX는 단회 경구 투여에 따른 치사량이 5,000 ㎎/㎏ 이상일 것으로 추정되어 ICR 마우스에 대하여 급성 독성이 없는 비교적 안전한 물질이라는 것을 알 수 있었으며, 향후 천연물 소재로서의 효능 규명을 통한 활용이 기대된다. Schisandrae fructus (SF) and Mori folium (MF) have been used as traditional medicines for thousands of years in parts of Asia, including Korea, China, and Japan. Recent researches on SF and MF have documented a wide spectrum of therapeutic properties, including anti-microbial, anti-inflammatory, anti-oxidative, immunomodulatory and anti-angiogenesis effects. However, the toxicity and safety of SF and MF, and their mixture (medicinal herber mixture, MHMIX) were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of SF, MF and MHMIX. SF, MF and MHMIX were orally administered at a dose of 5,000 ㎎/㎏ in ICR mice. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. We also measured parameters of organ weight, clinical chemistry, and hematology. No dead and no clinical signs were found during the experiment period after administration of a single oral dose of SF, MF and MHMIX. There were no adverse effects on clinical signs, body weight, or organ weight and no gross pathological findings in any treatment group. Therefore, LD50 value of SF, MF and MHMIX may be over 5,000 ㎎/㎏ and it may have no side toxic effect to ICR mice. The results on the single-dose toxicity of SF, MF and MHMIX indicate that it is not possible to reach oral dose levels related to death or dose levels with any harmful side effects.
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