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Silva, Claudia Gomes,De Miguel, Maykel,Ferrer, Belen,Alvaro, Mercedes,Garcia, Hermenegildo Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.12
Cucurbiturils are cyclic oligomers of glycoluril units whose molecular shape defines an internal hollow space accessible through carbonyl portals. It is known that methyl viologen forms strong host-guest complexes with CB[7] and CB[8]. In the latter case even a dimer can be hosted inside CB[8]. Classical solution systems for visible light $H_2$ generation use methyl viologen as an electron relay. In this work we have found that the efficiency for $H_2$ generation of the photocatalytic system comprising EDTA.ruthenium tris(2,2'-bipyridyl)-methyl viologen-Pt increases when cucurbiturils are present in the solution. The enhancement follows the order CB[6] < CB[7] < CB[8]. By means of laser flash photolysis we have established that this efficiency increase arises from the combination of an increase in the relative quantum yield of charge separation (higher efficiency in the formation of $MV^{{\cdot}+}$) and a decrease of $MV^{{\cdot}+}$ lifetime.
Fernandez, Juan C. Gutierrez,Garcia, Claudia I. The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.2
In a paper of S. H. Choi [2], the author studied the derivations of a restricted Weyl Type non-associative algebra, and determined a 1-dimensional vector space of derivations. We describe all the derivations of this algebra and prove that they form a 3-dimensional Lie algebra.
Nadia Soledad Alegre,Cecilia Claudia Garcia,Luis Ariel Billordo,Beatriz Ameigeiras,Daniel Poncino,Javier Benavides,Luis Colombato,Alejandra Claudia Cherñavsky 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.2
Background/Aims: Toll-like receptors (TLRs) modulate T cell responses in diverse diseases. Co-stimulation of T cell activation via TLR9 induces production of interferon gamma (IFN-γ), priming of which is critical for differentiation of proinflammatory macrophages. These macrophages have a crucial role in nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the expression of TLR9 protein on T cells and the consequences of TLR9-mediated triggering of these cells in patients with NAFLD. Methods: Our study included 34 patients with simple steatosis, 34 patients with nonalcoholic steatohepatitis, eight patients with NAFLD who met general diagnostic criteria but lacked histological diagnosis, and 51 control subjects. We used a synthetic TLR9 ligand to co-stimulate T cells. We measured TLR9 expression in liver and peripheral T cells and CD69 and IFN-γ as phenotypic markers of T cell activation and differentiation by flow cytometry. Results: TLR9 expression on liver and peripheral T cells was lowest in patients with simple steatosis and was positively associated with anthropometric, biochemical, and histopathological features of NAFLD. In vitro co-stimulation of T cells from patients with simple steatosis induced a limited number of IFN-γ-producing CD8+ T cells. At baseline, these patients showed a low frequency of circulating type 1 CD8+ cells. Conclusions: The positive associations between TLR9 and anthropometric, clinical, and histological features and the crucial role of IFN-γ-in NAFLD suggest that limited TLR9 expression and production of IFN-γ play a protective role in patients with simple steatosi
( Juan C. Gutierrez Fernandez ),( Claudia I. Garcia ) 호남수학회 2016 호남수학학술지 Vol.38 No.2
In a paper of S. H. Choi [2], the author studied the derivations of a restricted Weyl Type non-associative algebra, and determined a 1-dimensional vector space of derivations. We de- scribe all the derivations of this algebra and prove that they form a 3-dimensional Lie algebra.
Farzad Deyhim,Cheri Gonzales,Claudia Garcia,Arnulfo Villarreal,Kristi Garcia,Ryan Rios,Kranthi Mandadi,Bhimanagouda S. Patil 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.3
Vitamin E is known to improve antioxidant status and to prevent lipoprotein oxidation. However, the effectof vitamin E on other cardiovascular risk factors, including C-reactive protein (CRP) and lipid profile status, in orchiectomizedrats is unknown. In the present study, 32 1-year-old male rats were randomized into two groups: a sham-control group (n .8) and an orchiectomized group (n . 24). The orchiectomized group was divided into three groups of eight and assigned toone of the following treatments: orchiectomy (ORX), ORX . vitamin E mixture (65.6 mg/kg) diet, or ORX . vitamin Emixture (656 mg/kg) diet. For 120 days all four groups consumed a basal AIN-93M diet, while the vitamin E groups ate di-ets containing an additional vitamin E mixture. Four months after the study began, all the rats were killed, the blood was col-lected, and the plasma was assayed for antioxidant status, CRP, lipid profile, and indices of peroxidation. ORX decreased(P. .05) the plasma antioxidant status, superoxide dismutase (SOD) activity, and CRP level and increased (P. .05) theplasma malondialdeyde, nitrite, and lipid profile compared with that of the sham-control group. In contrast to the ORX group,supplementation with vitamin E mixture increased (P. .05) plasma antioxidant status and dose-dependently increased (P..05) SOD activity, while the vitamin E decreased (P. .05) plasma malondialdeyde and nitrite. The vitamin E mixture hadno effect on CRP or on lipid profiles when compared to the orchiectomized rats. In conclusion, vitamin E appears to reduceoxidative stress without modulating lipid profile or inflammatory response.
Marjorie Reyes-Farias,Karla Vasquez,Angelica Ovalle-Marin,Francisco Fuentes,Claudia Parra,Vilma Quitral,Paula Jimenez,Diego F. Garcia-Diaz 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.5
Obesity is characterized by an increase in the infiltration of monocytes into the adipose tissue, causing an inflammatory condition associated with, for example, the development of insulin resistance. Thus, anti-inflammatory-based treatments could emerge as a novel and interesting approach. It has been reported that Chilean native fruits maqui (Aristotelia chilensis) and calafate (Berberis microphylla) present high contents of polyphenols, which are known for their antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the ability of extracts of these fruits to block the pathogenic interaction between adipocytes and macrophages in vitro and to compare its effect with blueberry (Vaccinium corymbosum) extract treatment, which has been already described to possess several biomedical benefits. RAW264.7 macrophages were treated with 5 μg/mL lipopolysaccharides (LPS), with conditioned media (CM) from fully differentiated 3T3-L1 adipocytes, or in a coculture (CC) with 3T3-L1 adipocytes, in the presence or absence of 100 μM [total polyphenolic content] of each extract for 24 h. The gene expression and secretion profile of several inflammatory markers were evaluated. Nitric oxide secretion induced by LPS, CM, and CC was reduced by the presence of maqui (- 12.2%, - 45.6%, and - 14.7%, respectively) and calafate (- 27.6%, - 43.9%, and - 11.8%, respectively) extracts. Gene expression of inducible nitric oxide synthase and TNF-α was inhibited and of IL-10 was induced by maqui and calafate extract incubation. In conclusion, the extracts of these fruits present important inhibitory-like features over the inflammatory response of the interaction between adipocytes and macrophages, comprising a potential therapeutic tool against comorbidities associated with obesity development.
Farzad Deyhim,Bhimanagouda S. Patil,Arnulfo Villarreal,Erica Lopez,Kristi Garcia,Ryan Rios,Claudia Garcia,Cheri Gonzales,Kranthi Mandadi 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Oxidative stress and hypogonadism are linked to the increased incidence of cardiovascular disease in males.The objective of this research was to delineate whether drinking cranberry juice for 4 months affects antioxidant capacity andlipid profile in orchidectomized rats. Thirty-two 1-year-old male rats were randomized to two groups: a sham-control group(n . 8) and an orchidectomized group (n . 24). The orchidectomized group was divided into three groups of eight and as-cranberry juice. At 120 days after initiation of the study, all rats were killed, blood was collected, and plasma was harvestedfor total antioxidant status, malondialdehyde, nitrate. nitrite, and superoxide dismutase (SOD) activity in liver, and concen-trations of cholesterol and triglyceride in liver and in plasma. Orchidectomy depressed (P. .05) plasma antioxidant capac-ity and SOD activity, elevated (P. .05) nitrate. nitrite and malondialdehyde in plasma, and increased (P. .05) triglycerideand cholesterol values in liver and in plasma. Cranberry juice increased (P. .05) plasma antioxidant capacity and SOD ac-P. .05) nitrate. nitrite and malondialdehyde concentrations. Drinking cranberry juice did not affect cho-lesterol concentrations in liver and in plasma. Triglyceride concentration in plasma of orchidectomized rats that were drink-ing cranberry juice increased (P. .05), but its concentration in liver decreased (P. .05) to the level of shams. The protectiveeffect of cranberry juice from oxidative damage may be mediated by a decrease in nitrate. nitrite and dose-dependent de-crease in peroxidation.
Lopera Alex A.,Bezzon Vinicius D. N.,Ospina Victoria,Higuita-Castro Jorge L.,Ramirez Francisco J.,Ferraz Humberto G.,Orlando Marcos T. A.,Paucar Carlos G.,Robledo Sara M.,Garcia Claudia P. 한국세라믹학회 2023 한국세라믹학회지 Vol.60 No.1
Many efforts in the tissue engineering field have been devoted to producing biomedical devices with several physico-chemical properties that could promote an increase in the quality of therapeutic treatments. Thus, 3D printing is an efficient method which facilitates manufacturing high quality products to be used as medical devices. However, high-performance materials are required for obtaining products that are able to be 3D printed to attend the biomedical concerns. In this work, fused PLA-calcium phosphate-tobramycin-based filaments with antimicrobial properties were produced. X-ray powder diffraction, Fourier transform infrared spectroscopy and thermal analysis were performed to characterize the pure compounds as well as the composite filaments, revealing that the drug is preserved into the filaments by the implemented methodology, even after the hot extrusion procedure. The filaments and the printed pieces presented great antimicrobial effect and a controlled-release profile was also observed by the drug-release assays for the filaments produced, thereby indicating this material as a promising candidate to be used for implantable medical devices in the future.