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Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.
Du, Ze-Peng,Wu, Bing-Li,Wang, Shao-Hong,Shen, Jin-Hui,Lin, Xuan-Hao,Zheng, Chun-Peng,Wu, Zhi-Yong,Qiu, Xiao-Yang,Zhan, Xiao-Fen,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
NGAL (neutrophil gelatinase-associated lipocalin) is a novel cancer-related protein involves multiple functions in many cancers and other diseases. We previously overexpressed NGAL to analyze its role in esophageal squamous cell carcinoma (ESCC). In this study, a protein-protein interaction (PPI) was constructed and the shortest paths from NGAL to transcription factors in the network were analyzed. We found 28 shortest paths from NGAL to RELA, most of them obeying the principle of extracellular to cytoplasm, then nucleus. These shortest paths were also prioritized according to their normalized intensity from the microarray by the order of interaction cascades. A systems approach was developed in this study by linking differentially expressed genes with publicly available PPI data, Gene Ontology and subcellular localizaton for the integrated analyses. These shortest paths from NGAL to DEG transcription factors or other transcription factors in the PPI network provide important clues for future experimental identification of new pathways.
Lgr4 Promotes Glioma Cell Proliferation through Activation of Wnt Signaling
Yu, Chun-Yong,Liang, Guo-Biao,Du, Peng,Liu, Yun-Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
The key signaling networks regulating glioma cell proliferation remain poorly defined. The leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) has been implicated in intestinal, gastric, and epidermal cell functions. We investigated whether Lgr4 functions in glioma cells and found that Lgr4 expression was significantly increased in glioma tissues. In addition, Lgr4 overexpression promoted while its knockdown using small interfering RNA oligos inhibited glioma cell proliferation. In addition, Wnt/${\beta}$-catenin signaling was activated in cells overexpressing Lgr4. Therefore, our results revealed that Lgr4 activates Wnt/${\beta}$-catenin signaling to regulate glioma cell proliferation.
부산지역 한 3차 병원으로 내원한 폐결핵 환자에서 약제 내성률과 예측인자간의 연관성
손춘희 ( Son Chun Hui ),양두경 ( Yang Du Gyeong ),노미숙 ( No Mi Sug ),정진숙 ( Jeong Jin Sug ),이혁 ( Lee Hyeog ),이기남 ( Lee Gi Nam ),최필조 ( Choe Pil Jo ),이수걸 ( Lee Su Geol ),장광열 ( Jang Gwang Yeol ),최익수 ( Choe Ig Su 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.51 No.5
American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice
Chunhao Yu,Xiao-Dong Wen,Zhiyu Zhang,Chun-Feng Zhang,Xiao-Hui Wu,Adiba Martin,Wei Du,Tong-Chuan He,Chong-Zhi Wang,Chun-Su Yuan 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.3
Background: Colorectal cancer is a leading cause of cancer-related death, and inflammatory bowel disease is a risk factor for this malignancy. We previously reported colon cancer chemoprevention potential using American ginseng (AG) in a xenograft mice model. However, the nude mouse model is not a gutspecific colon carcinogenesis animal model. Methods: In this study, an experimental colitis and colitis-associated colorectal carcinogenesis mouse model, chemically induced by azoxymethane/dextran sodium sulfate (DSS) was established and the effects of oral AG were evaluated. The contents of representative ginseng saponins in the extract were determined. Results: AG significantly reduced experimental colitis measured by the disease activity index scores. This suppression of the experimental colitis was not only evident during DSS treatment, but also very obvious after the cessation of DSS, suggesting that the ginseng significantly promoted recovery from the colitis. Consistent with the anti-inflammation data, we showed that ginseng very significantly attenuated azoxymethane/DSS-induced colon carcinogenesis by reducing the colon tumor number and tumor load. The ginseng also effectively suppressed DSS-induced proinflammatory cytokines activation using an enzyme-linked immunosorbent assay array, in which 12 proinflammatory cytokine levels were assessed, and this effect was supported subsequently by real-time polymerase chain reaction data. Conclusion: AG, as a candidate of botanical-based colon cancer chemoprevention, should be further investigated for its potential clinical utility.
American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice
Chunhao Yu,Xiao-Dong Wen,Zhiyu Zhang,Chun-Feng Zhang,Xiao-Hui Wu,Adiba Martin,Wei Du,Tong-Chuan He,Chong-Zhi Wang,Chun-Su Yuan 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.1
Background: Colorectal cancer is a leading cause of cancer-related death, and inflammatory bowel diseaseis a risk factor for this malignancy. We previously reported colon cancer chemoprevention potentialusing American ginseng (AG) in a xenograft mice model. However, the nude mouse model is not a gutspecificcolon carcinogenesis animal model. Methods: In this study, an experimental colitis and colitis-associated colorectal carcinogenesis mousemodel, chemically induced by azoxymethane/dextran sodium sulfate (DSS) was established and theeffects of oral AG were evaluated. The contents of representative ginseng saponins in the extract weredetermined. Results: AG significantly reduced experimental colitis measured by the disease activity index scores. Thissuppression of the experimental colitis was not only evident during DSS treatment, but also very obviousafter the cessation of DSS, suggesting that the ginseng significantly promoted recovery from the colitis. Consistent with the anti-inflammation data, we showed that ginseng very significantly attenuatedazoxymethane/DSS-induced colon carcinogenesis by reducing the colon tumor number and tumor load. The ginseng also effectively suppressed DSS-induced proinflammatory cytokines activation using anenzyme-linked immunosorbent assay array, in which 12 proinflammatory cytokine levels were assessed,and this effect was supported subsequently by real-time polymerase chain reaction data. Conclusion: AG, as a candidate of botanical-based colon cancer chemoprevention, should be furtherinvestigated for its potential clinical utility.
Jing-Tian Xie,Guang-Jian Du,Eryn McEntee,Han H. Aung,Hui He,Sangeeta R. Mehendale,Chong-Zhi Wang,Chun-Su Yuan 대한암학회 2011 Cancer Research and Treatment Vol.43 No.1
Purpose The pharmacological activities, notably the anticancer properties, of bioactive constituents from fresh American ginseng berry have not yet been well studied. In this study, we investigated the antiproliferative effects of fresh American ginseng berry extract (AGBE) and its representative triterpenoid glycosides using the human colorectal cancer cell line SW480. Materials and Methods Using high performance liquid chromatography (HPLC), the contents of 8 ginsenosides in AGBE were determined. The cell growth inhibitory effects of AGBE and three triterpenoid glycosides (ginsenosides Rb3, Re, and Rg3) were evaluated by proliferation assay and 3H-thymidine incorporation assay. Cell cycle and apoptotic effects were analyzed by using flow cytometry after staining with propidium iodide and annexin V. Results HPLC analysis data showed that AGBE has a distinct ginsenoside profile. AGBE inhibited SW480 cell growth significantly in a time-dependent (24-96 hours) and concentration-dependent (0.1-1.0 mg/mL) manner. Ginsenosides Rb3, Re, and Rg3 also possess significant antiproliferative activities on SW480 cells. 3H-thymidine incorporation assay indicated that AGBE and ginsenosides Rb3, Re, and Rg3 might inhibit the transferring and duplication of DNA in SW480 cells. Flow cytometric assay data suggested that AGBE arrested SW480 cells in S and G2/M phases, and significantly induced cell apoptosis. Conclusion AGBE and ginsenosides Rb3, Re, and Rg3 possessed significant antiproliferative effects and induced changes of morphological appearance on SW480 cells. The mechanisms of the antiproliferation of AGBE and tested ginsenosides involved could be cell cycle arrest and induction of apoptosis.
Study on the Seismic Optimization Scheme of Steel Bundled-Tube Structure with Vertical Setback
Yong Hao,Feng Chen,Yun-hui Han,Xue-qian Hao,Chun-hui Du,Qiu-yu Ding 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.2
In order to improve the seismic performance of vertical setback steel bundled-tube structure and meet the dynamic multi-objective requirements of seismic performance-based design, the optimization effects under rare earthquakes on the zone of fortification intensity 7 and 8 in China are researched by improving members stiffness and adding dampers in the weak parts of structure, based on dynamic elastic-plastic analysis. The results show that: 1) Under rare earthquakes on the zone of fortification intensity 7, increasing the stiffness of weak skirt beam can improve the seismic performance of spiral and symmetrical setback structure; 2) For the spiral setback structure, under rare earthquakes on the zone of fortification intensity 7, the damper can only be arranged at the junction of the first layer of the setback frame unit and the frame unit without setback. However, under rare earthquakes on the zone of fortification intensity 8, it is not advisable to install dampers at the weak areas; 3) After incorporating dampers at the weak areas of symmetrical setback structure, the optimized members experienced a reduction in stress levels, significantly decreased the inter-layer displacement angles with a maximum reduction of 43%, and the optimization effect is significant.