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이영신,조용균,박철휘 한서대학교 산학협력연구원 부설 환경연구소 2000 환경연구소 논문집 Vol.3 No.-
Seosan city is facing fast industrialization, urbanization, and populization growth. It speedy changes into engineering oriented area around Dae-San engineering district causefuuture increase of general sewages and industrial waste water. the environmentally hazardous materials will also aggravate water quality of neighboring rivers and ocean. Thus, this study has been performed to investigate current lever of industrial waste water, and then project future level of those environmental damages.
盧澈均,金佑鉉,李武永 慶一大學校 1997 論文集 Vol.14 No.2
The dynamic characteristics of nine-switch matrix converter(NSMC), under the control strategy proposed by Venturini, is evaluated by simulations and experiments. Experiment sets are composed of the CPU part including TMS320C30, gate driver part, power supply part, A/D converter part and switch part. In this experiments, switching signal is generated in the real time by using TMS320C30. Switching frequency is increased by using 8253 counters which handle the some part of TMS320C30's calculation. In the experiment results, we can verify that the amplitude, frequency and power factor are controlled, AC-AC converter can be made up single module, and the volume of motor driving part can be reduced by excluding DC link. This experiment sets have error, which is calculation error of TMS320C30, and delay error of the counter. Furthermore researches should be focused on the minimization of these error.
Ciprofloxacin 제제의 생물학적 동등성에 관한 연구
최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1
국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.
Lee Keon-Joo,Shin Dong Woo,Park Hong-Kyun,Kim Beom Joon,박종무,Kang Kyusik,Park Tai Hwan,Lee Kyung Bok,Hong Keun-Sik,Cho Yong-Jin,Kim Dong-Eog,Ryu Wi-Sun,Lee Byung-Chul,Yu Kyung-Ho,오미선,Lee Soo Joo,Kim Ja 대한의학회 2022 Journal of Korean medical science Vol.37 No.33
This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.
만성 Cadmium 중독 백서의 간장에서 킬레이트 제제의 Cadmium 잔류량에 미치는 영향
이석호,이규택,김재준,백승운,이종균,이준혁,고광철,이풍렬,이종철,최규완 대한간학회 1998 Clinical and Molecular Hepatology(대한간학회지) Vol.4 No.1
Background/Aims : The heavy metals like cadmium (Cd) are neither destroyed nor produced in human body and may infiltrated into air, water, soil, food, human body and redistributed by biological and geographical circulation. With advent of recent industrialization detrimental heavy metal poisoning in human body is increased by industrial pollution. We aimed to establish the relative abilities of chelators to mobilized liver cadmium contents in chronic cadmium intoxication rats. Methods - Sprague-Dawley albino male rats weighing 200 to 250 mg were used. All animals were loaded with 3 intraperitoneal injections of cadmium chloride (1.5 mg/kg) given at % hourly interval. Intraperitoneal injection of chelators commenced 1 week after the last loading injection and continued every 72 hour for a total of 10 injections. Chelators were given at a level of 1 mmole/kg (except 0.01 mmol/kg of BAL). The chelators used in present experiment are 1,2-diaminocyclohexane tetra acetate (CDTA), disodium calcium ethylene diamine tetra acetate (EDTA), sodium 2.3-dimer capto propane sulfonate (DMPS), sodium di ethyl dithio carbamate (DDTC), dimercapto succinate (DMSA), 2,3-dimer capto propanol (BAL), diethylene triamine penta acetate (DTPA), triethylene tetr amine hexa acetate (TTHA), D-penicillamine(DPA), Nacetyl penicillamine (NAPA). Results : 1) The residual liver cadmium content was reduced in rats administered DPA, EDTA, NAPA, CDTA,DDTC and DMSA (32%, 23%, 19%, 17%, 16% and 15% respectively) compared with control group. 2) The residual kidney cadmium content was reduced in rats administered DPA, DDTC, CDTA and EDTA (33%, 21%, 18% and 17% respectively) 3) The summation of residual cadmium content in liver and kidney was reduced in rats administered DPA, EDTA, DDTC and CDTA (33%, 20%, 18% and 17% respectively) compared with control group. Conculusions - We suggested that DPA, EDTA, CDTA and DDTC might have protective role against the toxic effects of cadmium (Korean J Hepatol 1998;8:59 - 68)
이석호,손희정,이규택,김재준,강인구,백승운,이종균,이준혁,고광철,이풍렬,오성윤,이종철,최규완,오영륜 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.4
Amyloidosis is characterized by deposition of amyloid, which is resistant to proteolysis & phagocytosis, in intercellular spaces & vascular walls. The amyloid deposition provokes dysfunction of an accumulated organ & displays variable clinical symptoms depending upon the involved organ. A diagnosis is rendered through a biopsy of the affected organ, followed by staining using congo red which reveals an apple greenish refractile birefringence via polarizing microscopy. Using an electro-microscopy specific filaments can be found. Amyloidosis is classified into primary amyloidosis, composed of light chain filaments (AL) and secondary amyloidosis, comprised of A protain (AA). The AL type of amyloidosis shows deposition of amyloid in muscularis mucosa & muscularis externa. Priunary amyloidosis on the other hand, is relatively rare. We experienced primary stornach amyloidosis (AL), which was mistaken for stomch cancer.
간암의 술전 검사로서 CT AP , CT HA 및 Lipiodol CT 의 유용성
이석호,이규택,김재준,김승훈,백승운,이종균,이준혁,고광철,이풍렬,이종철,최규완,도영수 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6
Background/Aims: Computed tomography during arterial portography (CTAP), computed tomo-graphy during hepatic arteriography (CTHA) and Lipiodol CT are highly sensitive methods to detec intrahepatic tumor. Their sensitivity and accuracy are over 90% and 85%, respectively. We evaluated the usefulness of CTAP, CTHA and Lipiodol CT as a preoperative examination. Methods: For eighty two patients with hepatocellular carcinoma which were considered as the resectable on spiral CT and angiogram, CTAP and CTHA were performed. The additional nodules on CTAP and CTHA were confirmed by Lipiodol CT. Results: CTAP and CTHA could find additional nodules in 28% of the patients. The treatment plan was changed from surgical to nonsurgical method in 12% of the patients The larger tumor nodules were on the spiral CT, the more additional tumor nodules were found on CTAP and CTHA (p=0.03). The probability of finding additional nodules on CTAP and CTHA is no related with the counts of tumor nodules on the spiral CT (p=0.84). CTAP and CTHA could find additional nodules in 6 cases of 27 cases who underwent Lipiodol CT. The treatment plan was changed to nonsurgical treatment in 3 cases by the results of CTAP and CTHA. Conculusions: We concluded that CTAP, CTHA and Lipiodol CT are useful in avoiding unnecessory operation.