한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

일차배양된 설치류 호흡기 상피세포로부터의 점액소 분비에 대한 수종 약물의 영향

이충재,석정호,이재흔,허강민,박지선,배소현,노삼길,박상철 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

1. PKC activator인 PMA는 일차배양 HTSE세포로부터의 뮤신분비를 0.1μM 농도에서 30%, 1μM 농도에서 80% 가량 증가시켰다. 2. 식물 유래 성분으로, flavonoid의 일종인 TFR은 일치배양 HTSE 세포로부터의 뮤신분비를 10μM 농도에서 50%, 100μM 농도에서 80% 가량 증가시켰다. 3. 양이온성 폴리펩티드인 PLL 및 PLA는 일차 배양 HTSE 세포로부터의 뮤신분비를 0.01 - 10μM 농도에서 용량의존적으로 감소시켰다. 4. 결론적으로, 본 연구에서 얻어진 결과들은 새로운 거담제 및 점액용해제나 단백분해 효소제가 아닌 호흡기 류신의 생성/분비를 조절해 줄 수 있는 신개념의 약물을 개발함에 있어 극히 일부분이나마 단서를 제공하고 있다고 하루 수 있을 것이다. In the present study, we tried to investigate whether phorbol myristate acetate(PMA), trihydroxymethoxy-flavanone rutinoside(TFR) and cationic polypeptides significantly affect mucin release(secretion) from cultured hamster tracheal surface epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of each agent to assess the effect on 3H-mucin release. The results were as follows : (1) Both PMA and TFR significantly increased mucin release from cultured HTSE cells ; (2) Cationic polypeptides including po1y-L-lysine(PLL, mw 7,500) and poly-L-arginine(PLA, mw 10,800) significantly inhibited mucin release from cultured HTSE cells, in a dose-dependent manner. This finding suggests us that PMA and TFR be further studied for the possible use as mild expectorants and cationic polypeptides might function as a regulator for hyper-secretion of mucus, both by direct acting on airway mucin-secreting cells, during the treatment of chronic airway diseases.

경두개도플러초음파술을 이용한 중뇌동맥협착의 추적조사 : 예비연구

이재홍,최충곤 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

유연성을 갖는 분산 해쉬 테이블 기반의 피어 투 피어 인터넷 텔레포니 서비스의 구현

이주호,김재봉,정충교 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

Internet telephony provides voice communication services with added flexibility for multimedia extension at a lower cost compared to traditional telephone systems. We implemented an internet telephony system as an overlay network without a centralized server, using a distributed hash table (DHT). Compared to the current server-based internet telephony system, our system is fault-tolerant, scalable, and can be flexible extended to various services and advanced to integrated service. To demonstrate the high flexibility of our DHT-based internet telephony system, we made our system cooperate with web servers. Web users can check up others online states and establish voice communication sessions to online users at a mouse click. This technology can be tipplied to more complex services such as multimedia messaging or video conference service.

법랑라세포종의 면역조직화학적 및 전자현미경적 연구

이두형,조성덕,양문호,장충현,박재훈 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

Clinicopathologic analysis of ameloblastoma in 24 cases and their ultrastructural and immunohistochemical studies, especially to cytokeratin expressions according to morphologic classification were performed to clarify the tumor cell differentiation and origin. Reaction with broad spectrum and high molecular weight cytokeratin were generally positive in the stellate cell of the follicular and acanthomatous ameloblastoma, suggesting more squamous differentiation than peripheral basal cell type. Although ultrastructually common origin from oral epithelium was evidenced by presence of tonofilaments and desmosome, variations were prominent among the different histopathologic types of tumor. In granular cell ameloblastoma there were pleomorphic osmiophilic lysosome-like granules.

原乳의 저장조건에 따른 乳質改善에 관한 硏究

李載英,鄭忠一,裵仁烋 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

This study was carried out to determine the effects of different storage conditions on bacterial quality of raw milk. During the summer, the ratio of samples which showed total bacterial count below 4.0 x 10 exp(6)/ml were 51.5% in bulk cooled milk and 17.4% in, water cooled milk. The bacterial count of raw milk stored below 5℃ at farms was investigated according to different milk collecting method. 1. The ratio of samples that had total bacterial counts less than 4.0 × 10 exp(6)/ml, as the legal limit was 78.5% in tanklorry, and 43.6%, in ordinary truck transportation system. 2. The ratio of samples that had coliform bacteria below the number of 1.0 x 10 exp(5)/ml was 84.2% in tanklorry, and 58.3% in ordinary truck transportation system. 3. The ratio of samples that had thermoduric bacteria below the number of 1.0 × 10 exp(6)/ml was 80% in tanklorry, and 46.7% in ordinary truck transportation system, 31.1% of latter samples was above 1.0 × 10 exp(5)/ml. 4. The ratio of samples that had psychrotrophic bacteria above the number of 1.0 × 10 exp(6)/ml was 1.5% in case of tanklorry, and 38.3% in ordinary truck transportation system.

동북아 관계 환경문제

이충묵,진영재 연세대학교 동서문제연구원 2000 東西硏究 JOURNAL OF EAST AND WEST STUDIES Vol.12 No.2

1980년대 말과 1990년대를 거치면서 동북아지역환경협력은 UN 산하 환경관련기구들을 중심으로 진행되어 왔다. 그러나 리더십이 UN을 벗어나 일본과 같은 나라로 넘어가도 여전히 문제는 남는다. 동북아국가들 사이에는 오랜 역사를 통하여 적대감이 존재하여 왔다. 현재 추진중인 지역환경레짐은 이러한 측면에서 매우 고적인 현상임에는 틀림없으나 일본은 동북아환경문제에 있어서 나름대로의 이니셔티브를 장악할 가능성이 있다. 본 논문은 동북아지역에 형성된 다자간 환경협력이나 양자간 환경협력의 실례를 살펴보면서 동북아 환경문제에 대한 협력 가능성의 한계를 부각시켜 본다.

전신성 홍반성 루프스에서 고용량 경정맥 당질코르티이드로 치료된 단백질 소실성 장질환 1예

이규형,권창모,김현도,윤대영,이재웅,홍여훈,이충기 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Generalizes edema and hypoalbuminemia are relatively common presenting manifestations in many clinical situations. The differential diagnosis of hypoalbuminemia include; Kwashiorkor, synthetic dysfunction of the liver, and excessive protein loss as in nephrotic syndrome. In systemic lupus erythematosus (SLE), hypoalbuminemia and generalized edema are most commonly due to protein loss associated with lupus nephritis; gastrointestinal involvement is uncommon, and therefore protein loss through the gastrointestinal tract is quite rare. We report a case of a protein losing enteropathy (PLE) associated with SLE. The patient was referred to out hospital for generalized edema, arthralgia and facial rash. After clinical evaluation, the patient met the criteria for the SLE diagnosis; hypoalbuminemia with general edema was consistent with a protein losing enteropathy. After two weeks of therapy with parenteral high dose glucocorticoid, the patients was improved in laboratory findings as well as clinical symptoms.

급박 하지 허혈증에 대한 비수술적 치료의 장기 추적 결과

최재영,손민수,이길연,이상목,고석환,홍성화,윤층,오수명,박호철 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.1