Numerical solution for multiple confocal elliptic dissimilar cylinders

Y. Z. Chen 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.2

This paper provides a numerical solution for multiple confocal elliptic dissimilar cylinders. In the problem, the inner elliptic notch is under the traction free condition. The medium is composed of many confocal elliptic dissimilar cylinders. The transfer matrix method is used to study the continuity condition for the stress and displacement along the interfaces. Two cases, or the infinite matrix case and the finite matrix case, are studied in this paper. In the former case, the remote tension is applied in y- direction. In the latter case, the normal loading is applied along the exterior elliptic contour. For two cases, several numerical results are provided.

Evaluation of Elastic In-plane Flexural Rigidity of Unstiffened Multiplanar CHS X-joints

L. J. Jia,Y. Y. Chen 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.1

Tubular structures have been widely applied in offshore structures and civil buildings in past decades. Some research has beencarried out on rigidity of unstiffened circular hollow section (CHS) joints with various types, e.g. T-, Y-, K- and X-joints byformer researchers. However, limited investigations on the in-plane flexural rigidity of multiplanar CHS X-joints which arecommonly used in single-layered latticed structures are found in available literatures. In this paper, first a finite element modelwas calibrated through comparison with test results, and then a numerical parametric study on elastic axial rigidity ofmultiplanar unstiffened CHS X-joints was carried out using the calibrated models with package ABAQUS. Based on theparametric results, an in-plane flexural rigidity formula for the joints was fitted. Finally, a comparison among the differentformulae in predicting joint rigidity of unstiffened CHS X-joints was carried out, which indicated a good reliability of theproposed formula.

간호대생과 비보건계열 여대생의 미세먼지 위험에 대한 인식과 지식, 건강 관리행위 비교 연구

김선미,김슬기,김진선,박주형,배다희,유수빈,유영주,임지향,최유진,Chen Mengyao,양숙자,손지희 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53

Purpose: This study aimed to know whether there is a comparison of perception, knowledge and health promoting behaviors about particular matter between nursing students and non-health departments college students. Methods: A quantitative research is used. Data were collected from August 1 to 19. The study sample was nursing students and non-health departments students. For the similar condition of samples, this study excluded whose first language is not Korean. Independent T-test and pearson’s correlation was used for this study. Results: A significant positive correlation did not existed between difference of major and perception(t=0.017, p=0.986), knwledge(t=0.652, p=.516) and health promoting behaviors(t=-0.114, p=.910) about particular matters. Conclusion: Based on the study results, there is no significant correlation of perception and actions about particular matters between nursing students and non-health department college students.

1997~2000년에 관측된 황사의 농도와 부하량 및 시정 : 위성과 기상 분석 Satellite and Meteorological Analysis

정용승,김학성,박기현,전종갑,첸수젠 한국교원대학교 환경과학연구소 2001 환경연구논문집 Vol.- No.6

This Korea-China study was to monitor the phenomena of yellow sand(YS) occurred during the period of 1997~2000. The analysis on observed data included ground measurements of dust concentration, visibility, satellite imagery, aircraft and lidar observations. In addition, an estimation of atmospheric loadings and study on the relationship between dust concentrations and visibility were carried out. The movement and invasion of YS clouds to Korea were clearly identified with meterological and satellite data. The increasing concentrations of TSP and PM10 agreed well with the satellite information. We define the YS episode with the following values: TSP ≥250, PM10 ≥190 ㎍m-3, and visibility 6.5 km or less. From case studies, we estimated that atmospheric loadings of a dust cloud were over 1 million ton and that the deposition over the Korean Peninsula was in the range of 46,000 and 86,000 ton. For the YS with visibility 3 km, we predict TSP 659 ㎍m-3, PM10 493 ㎍m-3. We recommend the issuance of the YS Watch (advisory) and the YS Warning for the general public. There is a need for the general use of dust collectors in the indoor environment to reduce YS concentrations in spring.

A Phase 3 Evaluation of Daclatasvir plus Asunaprevir in Treatment-Naive Patients with Chronic HCV Genotype 1b Infection

( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.

Genetic polymorphism in pvmdr1 and pvcrt-o genes in relation to in vitro drug susceptibility of Plasmodium vivax isolates from malaria-endemic countries

Lu, F.,Lim, C.S.,Nam, D.H.,Kim, K.,Lin, K.,Kim, T.S.,Lee, H.W.,Chen, J.H.,Wang, Y.,Sattabongkot, J.,Han, E.T. Verlag für Recht und Gesellschaft ; Elsevier 2011 Acta Tropica Vol.117 No.2

Treatment failure of chloroquine for Plasmodium vivax infection has increased in endemic countries. However, the molecular mechanisms for resistance and in vitro susceptibility of P. vivax to chloroquine remain elusive. We investigated the prevalence of mutations in the pvmdr1 and pvcrt-o genes, and the copy number of the pvmdr1 gene in isolates from the Republic of Korea (ROK), Thailand, the Union of Myanmar (Myanmar), and Papua New Guinea (PNG). We also measured in vitro susceptibility of Korean isolates to antimalarial drugs. The pvmdr1 analysis showed that mutations at amino acid position Y976F of pvmdr1 were found in isolates from Thailand (17.9%), Myanmar (13.3%), and PNG (100%), but none from the ROK, and mutation at position F1076L was present in isolates from the ROK (100%), Thailand (60.7%), and Myanmar (46.7%). One copy of the pvmdr1 gene was observed in most isolates and double copy numbers of the gene were observed in two Thai isolates. In the exons of the pvcrt-o gene that were sequenced, a K10 insertion was present in isolates from Thailand (56.0%) and Myanmar (46.2%), and the wild type was found in all Korean isolates. The results suggest that gene polymorphisms and copy number variation was observed in isolates of P. vivax from Southeast Asian countries. In Korean isolates polymorphism as limited to the F1076L variant, and no isolates with high level of resistance were found by in vitro susceptibility determinations. Moreover, our results provide a baseline for future prospective drug studies in malaria-endemic areas.

Radiative decay of theψ(2S)into two pseudoscalar mesons

Bai, J. Z.,Ban, Y.,Bian, J. G.,Blum, I.,Chen, A. D.,Chen, G. P.,Chen, H. F.,Chen, H. S.,Chen, J.,Chen, J. C.,Chen, X. D.,Chen, Y.,Chen, Y. B.,Cheng, B. S.,Choi, J. B.,Cui, X. Z.,Ding, H. L.,Dong, L. Y American Physical Society 2003 Physical review. D, Particles and fields Vol.67 No.3

Schoolchildren's antioxidation genotypes are susceptible factors for reduced lung function and airway inflammation caused by air pollution

Chen, B.Y.,Chen, C.H.,Chuang, Y.C.,Kim, H.,Honda, Y.,Chiang, H.C.,Guo, Y.L. Academic Press 2016 Environmental research Vol.149 No.-

Background: We recently reported the relationship between exposure to ambient air pollutants and changes in lung function and nasal inflammation among schoolchildren. A study was conducted to investigate whether antioxidation genotypes influence these associations. Methods: A follow-up study of 97 schoolchildren was conducted in New Taipei City, Taiwan. A structured respiratory health questionnaire was administered in September 2007, followed by monthly spirometry and measurement of nasal inflammation from October 2007 to November 2009. During the study period, complete daily monitoring data for air pollutants were obtained from the Environmental Protection Administration monitoring station and Aerosol Supersite. The genotypes of glutathione S-transferase (GST) subunits M1, T1, P1 and superoxide dismutases subunit 2 (SOD2) were characterized. Mixed-effects models were used, adjusting for known confounders. Result: GSTM1 null children had significant PM<SUB>2.5</SUB>-related increment in leukocyte (8.52%; 95% confidence interval (CI): 3.13-13.92%) and neutrophil (9.68%; 95% CI: 4.51-14.85%) in nasal lavage. Ozone levels were significantly and inversely associated with forced expiratory flow at 25% of forced vital capacity (FEF<SUB>25%</SUB>) (-0.43L/s; 95% CI: -0.58,-0.28L/s) in SOD2 Ala16 variant children. Conclusion: In this longitudinal study of schoolchildren. Our data provide evidence that antioxidation genotype modifies the airway inflammation caused by PM<SUB>2.5</SUB>. Antioxidation genotype also acts as an effect modifier, but not strong, in ozone-related small airway function response.

EXPERIMENTAL STUDY ON REGENERATING FOULED EGR COOLER BY NTPI TECHNOLOGY

Y. Y. CHEN,Y. X. CAI,X. H. LI,Y. X. SHI,Y. ZHENG 한국자동차공학회 2015 International journal of automotive technology Vol.16 No.2

In order to investigate the regeneration effect of non-thermal plasma injection (NTPI) technology on fouled exhaust gas recirculation (EGR) cooler, NTPI regeneration apparatus and EGR cooler performance test system were built up. Results showed that non-thermal plasma (NTP) could peel off the deposit layer and improve the heat exchange performance effectively. The carbon removal energy efficiency of this NTPI regeneration setup was 22.46 g/kWh and the O3 utilization ratio was 96.50%. To get a deeper understanding of the regeneration effect, thermo-gravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) were introduced to investigate the variation of deposit layer’s physical and chemical characteristics before and after regeneration. Results showed that the content of soluble organic fraction (SOF) in deposit specimen decreased obviously, mainly because the carbonyls were effectively removed by NTP. Moreover, soot in deposit specimen was successfully activated by NTP.

Fragile X-like behaviors and abnormal cortical dendritic spines in <i>Cytoplasmic FMR1-interacting protein 2</i>-mutant mice

Han, Kihoon,Chen, Hogmei,Gennarino, Vincenzo A.,Richman, Ronald,Lu, Hui-Chen,Zoghbi, Huda Y. IRL Press 2015 Human molecular genetics Vol.24 No.7

<P>Silencing of fragile X mental retardation 1 (<I>FMR1</I>) gene and loss of fragile X mental retardation protein (FMRP) cause fragile X syndrome (FXS), a genetic disorder characterized by intellectual disability and autistic behaviors. FMRP is an mRNA-binding protein regulating neuronal translation of target mRNAs. Abnormalities in actin-rich dendritic spines are major neuronal features in FXS, but the molecular mechanism and identity of FMRP targets mediating this phenotype remain largely unknown. Cytoplasmic FMR1-interacting protein 2 (Cyfip2) was identified as an interactor of FMRP, and its mRNA is a highly ranked FMRP target in mouse brain. Importantly, Cyfip2 is a component of WAVE regulatory complex, a key regulator of actin cytoskeleton, suggesting that Cyfip2 could be implicated in the dendritic spine phenotype of FXS. Here, we generated and characterized <I>Cyfip2</I>-mutant (<I>Cyfip2<SUP>+/−</SUP></I>) mice. We found that <I>Cyfip2<SUP>+/−</SUP></I> mice exhibited behavioral phenotypes similar to <I>Fmr1</I>-null (<I>Fmr1<SUP>−/y</SUP></I>) mice, an animal model of FXS. Synaptic plasticity and dendritic spines were normal in <I>Cyfip2<SUP>+/−</SUP></I> hippocampus. However, dendritic spines were altered in <I>Cyfip2<SUP>+/−</SUP></I> cortex, and the dendritic spine phenotype of <I>Fmr1<SUP>−/y</SUP></I> cortex was aggravated in <I>Fmr1<SUP>−/y</SUP></I>; <I>Cyfip2<SUP>+/−</SUP></I> double-mutant mice. In addition to the spine changes at basal state, metabotropic glutamate receptor (mGluR)-induced dendritic spine regulation was impaired in both <I>Fmr1<SUP>−/y</SUP></I> and <I>Cyfip2<SUP>+/−</SUP></I> cortical neurons. Mechanistically, mGluR activation induced mRNA translation-dependent increase of Cyfip2 in wild-type cortical neurons, but not in <I>Fmr1<SUP>−/y</SUP></I> or <I>Cyfip2<SUP>+/−</SUP></I> neurons. These results suggest that misregulation of Cyfip2 function and its mGluR-induced expression contribute to the neurobehavioral phenotypes of FXS.</P>