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Intravenous Nefopam Reduces Postherpetic Neuralgia during the Titration of Oral Medications
( Young Chan Joo ),( Eun Sung Ko ),( Jae Geun Cho ),( Young Min Ok ),( Gyu Yong Jung ),( Kyung Hoon Kim ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.1
Background: The recently known analgesic action mechanisms of nefopam (NFP) are similar to those of anticonvulsants and antidepressants in neuropathic pain treatment. It is difficult to prescribe high doses of oral neuropathic drugs without titration due to adverse effects. Unfortunately, there are few available intravenous analgesics for the immediate management of acute flare-ups of the chronic neuropathic pain. The aim of this study was to determine the additional analgesic effects for neuropathic pain of NFP and its adverse effects during the titration of oral medications for neuropathic pain among inpatients with postherpetic neuralgia (PHN). Methods: Eighty inpatients with PHN were randomly divided into either the NFP or normal saline (NS) groups. Each patient received a 3-day intravenous continuous infusion of either NFP with a consecutive dose reduction of 60, 40, and 20 mg/d, or NS simultaneously while dose titrations of oral medications for neuropathic pain gradually increased every 3 days. The efficacy of additional NFP was evaluated by using the neuropathic pain symptom inventory (NPSI) score for 12 days. Adverse effects were also recorded. Results: The median NPSI score was significantly lower in the NFP group from days 1 to 6 of hospitalization. The representative alleviating symptoms of pain after using NFP were both spontaneous and evoked neuropathic pain. Reported common adverse effects were nausea, dizziness, and somnolence, in order of frequency. Conclusions: An intravenous continuous infusion of NFP reduces spontaneous and evoked neuropathic pain with tolerable adverse effects during the titration of oral medications in inpatients with PHN. (Korean J Pain 2014; 27: 54-62)
High-Performance of 70 nm T-Gate InGaAs/InAlAs Metamorphic HEMTs on GaAs Substrate
Sung Chan Kim,Dong Hoon Shin,Baek Seok Ko,Byoung Ok Lim,Jin Koo Rhee,Tae Jong Baek 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1
We present a technology to fabricate 70-nm-gate-length InGaAs/InAlAs/GaAs metamorphic high electron mobility transistors (MHEMTs). This technology uses a ZEP520/P(MMA-MAA)/PMMA tri-layer and double exposure with 50-kV electron-beam lithography. The fabricated 70-nm MHEMTs with a 70-m unit gate width and two ngers were characterized through DC, RF, and noise measurements. The maximum drain current density and extrinsic transconductance (gm) are 400 mA/mm and 1.02 S/mm, respectively. From the RF measurements, we obtained a current gain cutoff frequency (ft) of 320 GHz and a maximum oscillation frequency (fmax) of 430 GHz. The noise gure was less than 1.5 dB across the measured frequency range of 56 to 60 GHz.
고병찬 ( Ko Byeong-chan ),허광희 ( Heo Gwang-hee ),김용석 ( Kim Yong-suk ),이진옥 ( Lee Chin-ok ),김충길 ( Kim Chung-gil ) 한국구조물진단유지관리공학회 2019 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.23 No.2
본 논문에서는 사장교를 지탱하는 주요 부재인 케이블의 손상 위치를 빠르게 검출할 수 있는 손상평가 기술을 개발하고, 모형 교량 손상 실험을 통하여 개발한 기술의 손상평가 성능을 검증하고자 하였다. 손상평가 기술의 개발을 위하여 통계적 패턴 인식 기술인 마할라노비스 거리 이론을 활용하였으며, 복잡한 구조체의 손상위치 판별을 위하여 계측 위치별 획득 데이터의 변동성을 손상평가 기술에 반영하였다. 개발한 기술의 손상평가 성능을 확인하기 위하여 모형 사장교를 대상으로 손상 실험을 진행하였다. 그 결과, 개발한 손상평가 기술은 무손상 상태의 응답과 손상 상태의 응답을 활용하여 사장교 케이블의 손상 위치를 검출할 수 있는 통계적 패턴을 제공하는 성능을 보이는 것을 확인하였다.
Intravenous Nefopam Reduces Postherpetic Neuralgia during the Titration of Oral Medications
Joo, Young Chan,Ko, Eun Sung,Cho, Jae Geun,Ok, Young Min,Jung, Gyu Yong,Kim, Kyung Hoon The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.1
Background: The recently known analgesic action mechanisms of nefopam (NFP) are similar to those of anticonvulsants and antidepressants in neuropathic pain treatment. It is difficult to prescribe high doses of oral neuropathic drugs without titration due to adverse effects. Unfortunately, there are few available intravenous analgesics for the immediate management of acute flare-ups of the chronic neuropathic pain. The aim of this study was to determine the additional analgesic effects for neuropathic pain of NFP and its adverse effects during the titration of oral medications for neuropathic pain among inpatients with postherpetic neuralgia (PHN). Methods: Eighty inpatients with PHN were randomly divided into either the NFP or normal saline (NS) groups. Each patient received a 3-day intravenous continuous infusion of either NFP with a consecutive dose reduction of 60, 40, and 20 mg/d, or NS simultaneously while dose titrations of oral medications for neuropathic pain gradually increased every 3 days. The efficacy of additional NFP was evaluated by using the neuropathic pain symptom inventory (NPSI) score for 12 days. Adverse effects were also recorded. Results: The median NPSI score was significantly lower in the NFP group from days 1 to 6 of hospitalization. The representative alleviating symptoms of pain after using NFP were both spontaneous and evoked neuropathic pain. Reported common adverse effects were nausea, dizziness, and somnolence, in order of frequency. Conclusions: An intravenous continuous infusion of NFP reduces spontaneous and evoked neuropathic pain with tolerable adverse effects during the titration of oral medications in inpatients with PHN.
Establishment of a Resource Population of SLA Haplotype-Defined Korean Native Pigs
Cho, Han-Ok,Ho, Chak-Sum,Lee, Yu-Joo,Cho, In-Cheol,Lee, Sung-Soo,Ko, Moon-Suck,Park, Chan-Kyu,Smith, Douglas M.,Jeon, Jin-Tae,Lee, Jun-Heon Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.5
The highly polymorphic porcine major histocompatibility complex (MHC), or the swine leukocyte antigens (SLA), has been repeatedly associated with variations in swine immune response to pathogens and vaccines as well as with production traits. The SLA antigens are also important targets for immunological recognition of foreign tissue grafts. We recently established a resource population of Korean native pigs as models for human transplantation and xenotransplantation research. In this study, 115 animals derived from three generations of the Korean native pigs were genotyped for three SLA class I (SLA-2, SLA-3 and SLA-1) and three SLA class II loci (DRB1, DQB1, DQA) using PCR with sequence-specific primers (PCR-SSP) at the allele group resolution. A total of seven SLA haplotypes (Lr-5.34, Lr-7.23, Lr-31.13, Lr-56.23, Lr-56.30, Lr-59.1, Lr-65.34), comprising six unique class I and five unique class II haplotypes, were characterized in the founding animals. Class I haplotype Lr-65.0 and class II haplotype Lr-0.34 were novel; and together with Lr-56.0 these haplotypes appeared to be breed-specific. In the progeny population, Lr-7.23 and Lr-56.30 appeared to be the most prevalent haplotypes with frequencies of 34.7% and 31.6%, respectively; the overall homozygosity was 27.4%. This resource population of SLA-defined Korean native pigs will be useful as large animal models for various transplantation and xenotransplantation experiments, as well as for dissecting the roles of SLA proteins in swine disease resistance and production traits.
Woo, Jinhee,Shin, Ki-Ok,Park, Chan-Ho,Yoon, Byung-Kon,Kim, Do-Yeon,Bae, Ju-Yong,Lee, Yul-Hyo,Ko, Kangeun,Roh, Hee-Tae The Korean Society of Applied Science and Technolo 2019 한국응용과학기술학회지 Vol.36 No.3
The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). HOMA-IR was significantly higher in IGT group than CO group (p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group (p < 0.05), while beta-amyloid ($A{\beta}$) was significantly higher in IGT group than in CO group (p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups (p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.