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Chitooligosaccharides attenuate UVB-induced damages in human dermal fibroblasts.
Ahn, Byul-Nim,Kim, Jung-Ae,Himaya, S W A,Bak, Soon-Sun,Kong, Chang-Suk,Kim, Se-Kwon Springer-Verlag 2012 Naunyn-Schmiedeberg's archives of pharmacology Vol.385 No.1
<P>As a continuation of our research on chitooligosaccharides (COS), this study focused on the protective effect of COS of various molecular weights (1-3, 3-5, and 5-10?kDa) on cellular damage caused by ultraviolet B (UVB)-induced oxidative stress in human dermal fibroblast cells. The results show that the protective effect of COS on UVB-stressed human fibroblasts was dependent on molecular weight. COS suppressed UVB irradiation-induced reactive oxygen species generation and DNA damage, accompanied by the downregulation of matrix metalloproteinase (MMP)-1 and MMP-13. In a comparative analysis, COS (3-5?kDa) exhibited the most potent protective effect on UVB-stressed fibroblasts. The presence of COS (3-5?kDa) attenuated UVB-induced collagenolytic MMP production and collagen degradation. The photoprotective activity of COS (3-5?kDa) was confirmed by transcriptional phosphorylation of mitogen-activated protein kinase-responsive signaling pathways.</P>
복강내 NF-κB decoy oligodeoxynucleotide를 이용한 수술 후 복강내 유착 발생 감소
안별님 ( Byul Nim Ahn,),송미현 ( Mi Hyun Song,),김주현 ( Ju Hyun Kim,),김경현 ( Kyung Hyun Kim ),박관규 ( Kwan Kyu Park ),최윤석 ( Youn Seok Choi ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.4
Objective The objective of this study was to evaluate the effect of intra-peritoneal nuclear factor κB (NF-κB) decoy oligodeoxynucleotide on the prevention of postoperative intra-abdominal adhesion. Methods Forty female BALB/c mice were randomly assigned into 2 groups. The mice were anesthetized and then midline abdominal incision was made. Peritoneal injury was given using cytobrush until deperitonealization. The experimental group (n = 20) received NF-κB decoy oligodeoxynucleotide (NF-κB decoy ODN) in the peritoneal cavity before abdominal closure, while the control group (n = 20) received saline. At 2 weeks postoperation, after the mice were euthanized, the status of intra-abdominal adhesion was evaluated. The degrees of adhesion were graded into no (grade 0), mild (grade 1), moderate (grade 2), and severe adhesion (grade 3). Results Two mice in the experimental group and 3 mice in the control group were dead within 1 day postoperation. In the control group, 2, 2, and 13 mice showed mild, moderate, and severe adhesion, respectively. In the experimental group, 4 mice showed no adhesion, whereas, 6 and 8 mice showed mild and moderate adhesion, respectively. The difference of degrees of adhesion between the groups was statistically signifi cant ( P<0.001). Conclusion Intra-peritoneal NF-κB decoy ODN reduced the severity of postoperative intra-abdominal adhesion.