정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

職場人의 健康維持ㆍ增進을 위한 運動處方 模型開發에 關한 硏究

金正幸,金秉洙,陸調永 龍仁大學校 1993 용인대학교 논문집 Vol.9 No.-

We measured rest HR blood pressure, boots lactate, blood fat in male 132, female 98, total 230 on purpose of developement of exercise prescription model to improve and maintain the health, physical strength and our altimate goal is to increase work efficiency and occupational persons condition. To evaluate exorcise function and work capacity we did exercise test using exercise program and measured maximun oxygen up take and simultaneously individual physical constitution and physical strength was meassural. "There for in the course of scientific systematic efficiert program and efficient exercise prescription model studying" "We tried analysis of working jogging terdmil test cycle ergometar physical condition, physical strength of sexs and ages for adapt to individual health and exercise capacity. The HR was dicreased in proportion to inclosing blood pressure and blood pressure was higher in male but incresing rate was higher in female." All so cholesterol and triglycerine were higher in male and incresing rate was higher in female. Body fat was relatively higher in female but incresing corpare to other physical strength but paralleisem and flexibility showed large, dicreasement, physical strength was showed in sexual differences in proportion to ageing. This study's significance is basic guide for further study by conpare to occupational person's health state and phsycial strength in sexes, ages. Particulary we sertain that this model minized chronic hypokinetic phenomenon and various pathologic phenomenon for the maintenance of all occupational persons.

자발성 뇌지주막하출혈 환자에서 Cardiac Troponin Ⅰ를 이용한 심근손상의 발생율

김용권,류진호,소정일,문원식,전병조,허탁,민용일 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Background : More than 90% of acute stroke patients have measurable cardiovascular sequelae, but we have been often overlooked in formal discussions of treatment. If we estimate the incidence of myocardial injury in patients with spontaneous SAH, we may figure the possibility of cardiac dysfunction in such patients. This study was designed to investigate the incidence of myocardial injury in patients with spontaneous SAH using cardiac troponin I(cTnI). Methods : A prospective single emergency center study was performed to determined preoperative incidence of unrecognized cardiac injury in patients suffering spontaneous SAH. We include the spontaneous SAH patients who underwent serum measurements of the cardic troponin I immediately upon admission last six month period. ECG, CK, CK-MB and myoglobin were also performed at admission. We excluded the spontaneous SAH patients who had past history of myocardial ischemia and ECG abnormality. Results : Fifty-two patients(34 females, 18 males) with spontaneous SAH were studied prospectively. 18 patients(34.6% of the total study population) had cTnI level above 0.5ng/ml. ECG was performed in 52 patients and was abnormal in 15 of the 52 patients(28.8%). Conclusion : The measurement of cTnI has provided physicians with a myocardial marker that has a cardiac sensitivity for cardiac injury equal to that of CK-MB yet with greater specificity. So, cardiac troponin I is useful to estimate the incidence of myocardial injury in patients with spontaneous SAH. And we may estimate the possibility of cardiac dysfunction in such patients. This knowledge will hopefully aid in the care and improve the outcome.

산후의 우울 증상과 연관된 심리사회적 및 산과적 변인

김재원,김정화,김병조 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : The purpose of this study is to examine the psychosocial and obstetric factors associated with postpartum de-pressive symptoms in Korea. Methods : At the 1-week and 4-week postpartum visit, 61 postpartum women completed Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory (BDI), Stait-Trait Anxiety Inventory (STAI), and Symptom Check List-90-Revised (SCL-90-R). Data related to psychiatric and obstetric characteristics, pregnancy and delivery related events were collected from standard medical records. 42 women without a history of pregnancy or delivery within 6 months were recmited as a control group. The postpartum group were divided into depressive and non-depressive groups according to the EPDS and BDI results of 4-week postpartum. Results : Compared to the normal control group, the mean scores of EPDS and BDI at 1-week postpartum were significantly higher (p<.05 and p<.01, respectively) in the postpartum group. The postpartum group also scored significantly higher in the somatization, Psychoticism, and global severity index profiles according to the SCL-90-R results (p<.05). The mean score of BDI at 4-week postpartum was significantly higher (p<.01) in the postpartum group. There were significant correlations (p<.01) between the EPDS and BDI reports at 1- and 4-week postpartum. The rates of having experienced severe emotionalstress during pregnancy and of smokers and drinkers before pregnancy were significantly higher (p<.05) in the postpartum depressive group (EPDS ≥10 and BDI ≥ 10) compared to the postpartum non-depressive group. The rate of having experi-enced depressive symptoms at 1-week postpartum was also significantly higher in the postpartum group. The depressive sym-ptomatology at 1-week postpartum was identified as a significant risk factor for the depressive symptoms of 4-week postpartum when multiple logistic regression analysis was performed after controlling for age and education level. Conclusion : These findings suggest that postpartum women in Korea have many psychiatric problems such as depressive mood and somatization which necessitate proper care and assessment during the early postpartum period. Stress management during pregnancy may be helpful as a measure of preventing postpartum depression.

전기화상 환자에 대한 임상적 고찰

유병대,김성진,이명갑,서영조,강재구,이동필 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: Good documentation of electrical injuries at the time of presentation is very important to emergency management, so this study was designed to investigate the clinical characteristics and the outcomes of patients with electrical injury. Methods: A review of 75 cases of electrical injuries admitted to our hospital via the emergency department over a 4 year period from 1996 to 1999 was conducted. Results: There were 49 patients with high-voltage injuries and 19 patients with low-voltage injuries. All but 4 patients were males, with a mean age of 29.5 years. The most common type of injury was electrothermal burn. The most common point of entry was hand. The average size of burn wounds was 14.5% TBSA in the high-voltage group and 2.5% in the low-voltage group. Forty-nine(72.1%) of the injuries were work related. The number of patients with compartment syndrome was 19, and fasciotomies were performed in all but one patient. Myoglobinuria was noted in 22 patients, but no patient developed acute renal failure due to myoglobinuria. In the high-voltage group, 10 limb amputations were performed. Complication were observed in 12 patients. The most common complication was neurological injury. The average length of hospital stay was 50.7 days in the high-voltage group and 13.8 days in the low-voltage group. The overall mortality rate was 4.3%. Couclusion: Prevention of electrical injuries is very important. Education and compliance with safety measures, as well as basic knowledge and precaution in dealing with electricity, are essential to avoid these injuries.

Supra Pubic Catheter를 施行한 腦卒中 患者 1例에 對한 證例報告

유병찬,오병렬,김민상,안정조,임승민,최영,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

According to the literary study on catheterization of bladder in one case of patient with C.V.A. who was treated by supra pubic catheterization, the results were as follows. 1. If not immediately treat ischuria, emergency disease, very great danger to life can happen by loss of kidney function. So we must treat ischuria instantly by consideration of treatment from the factor. 2. Catheterization of bladder generally acted in emergency room, is emergency treatment only in the lower part of urethral obstruction. 3. Catheterization of bladder was put on record in Son Saimiao's Qianjinyaofang, which is the first book on it. It had been developed by Luo Qianyi, Zhang Jiepin, and Wang Dao. 4. Ancient times, an urethral catheter was made of green onion leaf, pig bladder, goose feather and so on. 5. Nelaton is catheterization of bladder in functional or momentary ischuria. Indwelling catheterization is treatment keeping in urethral canal for a long time. 6. Supra pubic catheterization is a surgical operating catheterization when urethral catheterization is impossible, is very easy and can decrease risk of infection. 7. After catheterization, for decreasing risk of the infection, a complication of catheterization, it is must be taken precedence, ascetic treatment, constantly management and sterilization, anti-biotic medication. 8. At times, increasing patient of emergency disease, as C.V.A etc., the needing of catheterization of bladder is increasing also for preventing infection and bed sore by ischuria and incontinence of urine. Therefore a specialty knowledge and skill about it is necessary.

신장기법 프로그램이 슬건근의 유연성에 미치는 영향

정병옥 ; 김근조 김천대학교 2009 김천대학교 논문집 Vol.29 No.-

Purpose: This study was designed to examine increase in hamstring muscle extensibility with ballistic stretching, static stretching, hold- relax, and hold-relax-agonist techniques. Materials and methods: Subjects were designed randomly to passive stretching, static stretching, hold- relax, and hold-relax-agonist techniques. A total of 40 subjects, with limited hamstring flexibility (defined as 30° loss of knee extension measured with the tight held at 90° of hip flexion) were recruited for this study. Hamstring muscle extensibility was measured using the passive 90/90 test before and after the 3-weeks program. the range of knee extension was measured by Goniometer(made in USA). Data analysis were compared the flexibility within treatment period on each group after program by repeated measure 2- way ANOVA using SPSS for window Results: Difference were signification for test and for the test by-group interaction. 1. All stretch technique programs produced a greater decrease in knee extension range within treatment period on each group (p<0.05). 2. The hold-relax-agonist technique produced a greater decrease in knee extension range than did passive stretch, static stretch, and hald-relax (p<0.05). 3. passive stretching technique produced a lesser decrease in knee extension range than did other stretch technique programs (p<0.05)

후막 전계발광소자(Electroluminescence)의 제조와 발광특성

정영호,김병권,박조용,명광식,Khatkar, S.P.,Liang, Yujun,한상도 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

Calcium Aluminoborosilicate-Based Dielectrics Containing CaCu3Ti4O12 as a Filler : Calcium Aluminoborosilicate-Based Dielectrics

Kim, Byeong Kon,Lee, Dong Wook,Key, Sung Hun,Jo, Tae Jin,Jeong, Seong Min,Kim, Kwang Jin,Jeon, Min Seok,Song, Jun Kwang,Cho, Yong Soo Wiley (Blackwell Publishing) 2010 Journal of the American Ceramic Society Vol. No.

Effects of Temperature, Salinity, and Diet on the Growth and Survival of the Freshwater Rotifer Brachionus angularis

Kim, Byeong-Ho,Kim, Hyung-Seop,Jo, Soo-Gun The Korean Society of Fisheries and Aquatic Scienc 2006 Fisheries and Aquatic Sciences Vol.9 No.4

We explored the possibilities of using the freshwater rotifer Brachionus angularis as a live food for small fishes cultured in fresh- or brackish waters. Brachionus angularis were collected from a reservoir for isolation and laboratory culture. Length and width of the lorica were $102.3{\mu}m$ and $76.6{\mu}m$, respectively, and those of amictic eggs were $64.4{\mu}m\;and\;47.9{\mu}m$, respectively. When their growth rates were examined at six different temperatures, i.e., 15, 20, 25, 30, 35, and $40^{\circ}C$, the highest daily growth rate of 0.801 was observed at $35^{\circ}C$, and growth was lower with decreasing temperature. Adaptation to salinity change was evaluated with two different modes of salinity increase: step-wise elevation lasting for short durations of 5 to 30 min or a long duration of 24 h. With the short duration modes, no individuals survived salinity higher than 10 psu, and the number of live individuals did not increase throughout the experiment. However, in the 24-h elevation, the number of individuals increased when salinity was elevated by 1 to 2 psu per day for the first 2 or 3 days, while no increase in number occurred at salinity increments higher than 3 psu per day. In addition, to assess the effect of different diets, four single-component diets (Chlorella vulgaris, Nannochloris sp., baker's yeast, or dry yeast) and three combination diets (C. vulgaris + Nannochloris sp. + baker's yeast + dry yeast; C. vulgaris 70% + baker's yeast 30%; C. vulgaris 30% + baker's yeast 70%) were used. The specific growth rates of B. angularis fed combination diets were higher than those of rotifers fed any single-component diet, with the highest rate of 0.648 in B. angularis fed a mixture of C. vulgaris, Nannochloris sp., baker's yeast, and dry yeast, and the lowest rate of 0.200 in those fed dry yeast only. Our results indicate that the freshwater rotifer B. angularis can be used for seedling production of both freshwater and brackish-water fishes that require small (less than about $120{\mu}m$) live food during their early stages.