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Park Su Hyun,Lee Kang Nyeong,Lee Oh Young,Choi Myung Gyu,Kim Jie-Hyun,Sung In-Kyung,Jang Jae Young,Park Kyung Sik,Chun Hoon Jai,Kim Eun Young,Lee Jun Kyu,Jang Jin Seok,Kim Gwang Ha,Hong Su Jin,Lee Yon 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Efficacy of proton pump inhibitors is limited in patients with nonerosive reflux disease (NERD). The aim of this study was to comparatively evaluate the efficacy and safety of esomeprazole with sodium bicarbonate and esomeprazole alone. Methods: This was a multicenter, randomized, double-blind, active-controlled, noninferiority comparative study. A total of 379 patients with NERD were randomly allocated to receive either EsoduoⓇ (esomeprazole 20 mg with sodium bicarbonate 800 mg) or NexiumⓇ (esomeprazole 20 mg) once daily for 4 weeks from January 2019 to December 2019. The patients had a history of heartburn for at least 2 days in the week before randomization as well as in the last 3 months and no esophageal mucosal breaks on endoscopy. The primary endpoint was a complete cure of heartburn at week 4. The secondary and exploratory endpoints as well as the safety profiles were compared in the groups at weeks 2 and 4. Results: A total of 355 patients completed the study (180 in the EsoduoⓇ group and 175 in the NexiumⓇ group). The proportions of patients without heartburn in the entire 4th week of treatment were not different between the two groups (33.33% in the EsoduoⓇ group and 35% in the NexiumⓇ group, p=0.737). There were no significant differences in most of the secondary and exploratory endpoints as well as the safety profiles. Conclusions: EsoduoⓇ is as effective and safe as NexiumⓇ for managing typical symptoms in patients with NERD (ClinicalTrial.gov identifier: NCT03928470).
Inactivation of Foot-and-Mouth Disease Virus by Citric Acid and Sodium Carbonate with Deicers
Hong, Jang-Kwan,Lee, Kwang-Nyeong,You, Su-Hwa,Kim, Su-Mi,Tark, Dongseob,Lee, Hyang-Sim,Ko, Young-Joon,Seo, Min-Goo,Park, Jong-Hyeon,Kim, Byounghan American Society for Microbiology 2015 Applied and environmental microbiology Vol.81 No.21
<P>Three out of five outbreaks of foot-and-mouth disease (FMD) since 2010 in the Republic of Korea have occurred in the winter. At the freezing temperatures, it was impossible to spray disinfectant on the surfaces of vehicles, roads, and farm premises because the disinfectant would be frozen shortly after discharge and the surfaces of the roads or machines would become slippery in cold weather. In this study, we added chemical deicers (ethylene glycol, propylene glycol, sodium chloride, calcium chloride, ethyl alcohol, and commercial windshield washer fluid) to keep disinfectants (0.2% citric acid and 4% sodium carbonate) from freezing, and we tested their virucidal efficacies under simulated cold temperatures in a tube. The 0.2% citric acid could reduce the virus titer 4 logs at −20°C with all the deicers. On the other hand, 4% sodium carbonate showed little virucidal activity at −20°C within 30 min, although it resisted being frozen with the function of the deicers. In conclusion, for the winter season, we may recommend the use of citric acid (>0.2%) diluted in 30% ethyl alcohol or 25% sodium chloride solvent, depending on its purpose.</P>
장동욱 ( Jang Dong Ug ),이지영 ( Lee Ji Yeong ),손인숙 ( Son In Sug ),김수녕 ( Kim Su Nyeong ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.2
목적 : 극소복부절개술을 이용한 자궁부속기 수술과 고식적 복부절개술을 시행한 대조군의 이환율을 비교하였다. 연구 방법 : 고식적 복부절개술을 통하여 자궁부속기 수술을 시행하였던 80예를 대조군으로 하여 국소복부절개술을 시행하였던 84예의 환자군에서 연령, 수술시간, 수술 후 이환율, 입원기간 등을 비교하였다. 결과 : 평균연령은 극소복부절개술군에서 29.7±5.9세, 고식적 복부절개술군에서 26.8±6.0세로 의의 있는 차이가 없었고 수술시간은 국소복부절개술군에서 평균 29.7±9.2분, 고식적 복부절개술군에서 34.1±4.1분으로 의미있는 차이는 없었다. 진통제 근육주사 (Nubaine^(??) 10 mL)를 요하였던 겨우는 극소복부절개술군이 29예 (34.5%)로 고식적 복부절개술군의 42예 (52.5%)에 비하여 적었으며 (p<0.05), 수술 후 소화장관회복 시작 시간은 극소복부절개술군에서 평균 28.2±15.6시간으로 고식적 복부절개술군와 34.1±16.7시간보다 의의 있게 감소 되었다 (p<0.05). 수술 후 발열을 비교한 결과 극소복부절개술군에서 4예 (4.8%)로 고식적 복부절개술군의 14예(17.5%)에 비하여 감소하였다 (p<0.05). 수술 후 창상감염은 극소복부절개술군에서는 없었으나 고식적 복부절개술군에서 3예 (3.75%)에서 발생하였다. 수술 후 평균 입원기간은 극소복부절개술군이 3.4±1.0일, 고식적 복부절개술군이 8.0±1.4일로 극소복부절개술군에서 의의있게 감소되었다 (p<0.05). 결론 : 결론적으로 부인과 자궁부속기 수술시 극소복부절개술은 수술 후 환자의 이환율을 감소시키고 입원기간을 단축시킬 수 있으며 미용적인 면에서 환자 만족도가 높고 통원치료가 가능하며 고식적 복부절개술을 대체할 수 있는 시술방법이라고 사료된다. N/A
Inhibitory Potential of Bilobetin Against CYP2J2 Activities in Human Liver Microsomes
( Zhexue Wu ),( Su-nyeong Jang ),( So-young Park ),( Nguyen Minh Phuc ),( Kwang-hyeon Liu ) 한국질량분석학회 2020 Mass spectrometry letters Vol.11 No.4
Cytochrome P450 2J2 (CYP2J2) is a member of the cytochrome P450 superfamily, and is known to be arachidonic acid epoxygenase that mediates the formation of four bioactive regioisomers of epoxyeicosatrienoic acids (EETs). CYP2J2 is also involved in the metabolism of drugs such as albendazole, astemizole, danazol, ebastine, and terfenadine. CYP2J2 is highly expressed in the heart and cancer tissues. In this study, the inhibitory potential of ten natural products against CYP2J2 activity was evaluated using human liver microsomes and tandem mass spectrometry. Among them, bilobetin, which is a kind of biflavonoid, exhibits a strong inhibitory effect against the CYP2J2-mediated astemizole O-demethylation (IC<sub>50</sub> = 0.73 μM) and terfenadine hydroxylation (IC<sub>50</sub> = 0.89 μM). This result suggests that bilobetin can be used as strong CYP2J2 inhibitor in drug metabolism study.
Si Jun Kim,Jang Jae Lee,Young Seok Lee,Chul Hee Cho,In Ho Seong,Han Sol Choi,Jin Ho Lee,Won Nyeong Jeong,Ha Jeong Choi,Ye Bin You,Min Su Choi,Shin Jae You 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
This presentation presented analysis of the electron heating mechanism in capacitively coupled plasma based on particle-in-cell Monte Carlo collision (PIC-MCC) simulation. As discharge current decreases, abrupt reduction of low energy electron population in electron energy probability function(EEPF) were observed, while the gradual decrease of high energy electrons. This change of the EEPF shape was analyzed in terms of power absorption and electric filed. It is believed that this research elucidates the understanding of the electron heating mechanism at low discharge current