대장암의 항암화학요법

홍용상 ( Yong Sang Hong ),김태원 ( Tae Won Kim ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.6

Recent advances in chemotherapy lead to improved survival outcomes in patients with colorectal cancer. The 5-fluorouracil (5-FU) is still one of the important chemotherapeutic agents since 1950s, but the introduction of newer cytotoxic agents, irinotecan and oxaliplatin, or targeted agents, bevacizumab and cetuximab, have changed treatment strategies for these patients. A deliberate choice should be made for adjuvant chemotherapy, because it has became complicated more than ever before. Oxaliplatin plus 5-FU seemed to be superior in terms of disease-free and overall survival than 5-FU alone after curative surgery for colon cancers. However not all of these patients seemed to receive benefit from this intensive adjuvant treatment, and some limitations are present according to the postoperative stage, tumor biology and clinical characteristics. For metastatic disease, there is no doubt that more complicated strategies are present because we have more abundant chemotherapeutic agents available for metastatic setting compared to adjuvant setting. Recently, targeted agents, such as bevacizumab or cetuximab, also took an important place in the treatment of metastatic colorectal cancer, and many efforts are also made to find the biomarkers for predicting treatment responses to these targeted agents. In this review, we intended to sort up the standard strategies of chemotherapy for patients with colorectal cancer according to the latest pivotal publications. (Korean J Gastroenterol 2009;54:355-363)

볼트결합에 의한 복합소재 데크 조립식 아치가교의 거동분석

조용상(Cho Yong-Sang),이성우(Lee Sung Woo),홍기증(Hong Kee Jeung) 대한토목학회 2008 대한토목학회 학술대회 Vol.2008 No.10

조립식 복합소재 데크를 이용한 아치가교 개발

조용상,이성우,홍기증,Cho, Yong-Sang,Lee, Sung-Woo,Hong, Kee-Jeung 한국전산구조공학회 2008 한국전산구조공학회논문집 Vol.21 No.3

유리섬유강화 폴리에스터(GFRP) 복합소재는 가볍고 내구성이 뛰어나 강재, 콘크리트, 나무 등과 같은 기존의 구조 재료들을 대체할 수 있는 재료로 최근 각광 받고 있다. GFRP 복합소재 데크를 조립하여 아치가교를 만들면 짧은 시간에 시공이 가능하고 복합소재 데크의 재사용이 가능할 수 있다. 이 논문에서는 쉽게 조립할 수 있는 수직결구식 복합소재 데크를 활용한 아치가교 시스템을 개발하고자 한다. 이를 위해 몇 가지 가능한 아치가교의 유형을 제안하고 이를 유한요소해석을 통해 검증한다. Glass-fiber reinforced polyester (GFRP) composite material is a promising alternative to existing construction materials such as steel, concrete and wood due to light weight and high durability of GFRP composite material. If a temporary arch bridge is built by GFRP composite deck, rapid construction of the bridge and reuse of the GFRP composite deck are possible. In this paper, we develop a type of temporary arch bridges that can be built by easy assembling of GFRP composite decks. For this purpose, several possible types of temporary arch bridges are suggested and verified by finite element analysis.

경부 림프절 종대로 발현한 원발 부위 불명의 전이암

김태용(Tae Yong Kim),조요한(Yo Han Joh),김진수(Jin Su Kim),홍용상(Yong Sang Hong),이근욱(Keun Wook Lee),윤탁(Tak Yun),송은기(Eun Ki Song),나임일(Im Il Na),신현춘(Hyun Chun Shin),김동완(Dong Wan Kim),이재서(Chae Seo RLee),성명훈(Myung W 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.2

Background: About 3% of all cancer patients suffer from cancer of unknown primary origin. Generally, carcinoma of unknown primary (CUP) carries a grave prognosis, but primary tumor presented to the neck is exception to this. The aims of study are to determine the role of chemotherapy and to find the prognostic factors in unknown primary tumor presented to the neck. Method and Material: Eighty-four patients were diagnosed with unknown primary tumor presented to the neck between January 1996 and June 2002. Among 84 patients, 43 patients (52%) received chemotherapy, radiation or surgery were performed in 20 patients (23%), 21 patients (25%) had no treatment. Results: The response rates to chemotherapy were 87.5% in CUP only localized to the neck and 44.0% in CUP systemically involved (p=0.012). A median follow-up duration was 6.4 years and overall median survival time was 9 months. The median overall survival time of patients treated with chemotherapy were 17 months and that of patients who received surgery or radiation were 20 months (p=0.3548). The important prognostic factors were performance status and the number of involved organ. Conclusion: The prognosis of patients with CUP presented to the neck is more favorable than that of patients with CUP of other localization. The effectiveness of chemotherapy for CUP only localized to the neck was similar to that of surgery or radiation. The important prognostic factors were performance status and the number of involved organ.

혈액종양 : Anthracycline 기반 항암화학요법에 반응을 한 염증성 근섬유모세포종

김달용 ( Dal Yong Kim ),박한승 ( Han Seung Park ),김선목 ( Sun Mok Kim ),박지현 ( Ji Hyun Park ),홍용상 ( Yong Sang Hong ),이재련 ( Jae Lyun Lee ),서철원 ( Cheok Won Suh ) 대한내과학회 2012 대한내과학회지 Vol.82 No.6

염증성 근섬유모세포종에 대한 정립된 치료 방침은 없다. 수술이 완치를 위한 치료로 알려져 있으나 조직 검사상 염증세포의 침윤이 있고 기존에 보고된 증례들을 바탕으로 하여 스테로이드 또는 비스테로이드성 염증약물도 하나의 치료 방침이 될 수 있겠다. 본 증례와 같이 급속히 진행하는 종양의 경우 연부 조직 육종에 준한 anthracycline 기반 항암 화학요법을 시행하는 것이 질병을 조절하고 생존기간의 연장하는 데에 적절한 선택이 될 수 있을 것으로 보이며 이것을 뒷받침하기 위한 추가 연구가 필요하겠다. An inflammatory myofibroblastic tumor (IMT) is a rare disease entity, and the clinical characteristics range from indolent to aggressive forms. No established management for patients with unresectable or aggressive IMT is available. We report on a 62-year-old patient with aggressive IMT who achieved a durable partial response lasting 12 months after anthracycline-containing cytotoxic chemotherapy without corticosteroids. The patient was admitted for an evaluation of progressive weight loss and lower abdominal pain lasting for 2 weeks. Abdominopelvic computed tomography revealed a 10 cm sized heterogeneous mass in the mesentery that encased the superior mesenteric artery and a liver metastasis. The diagnosis of IMT was confirmed by percutaneous core needle biopsy of the mesenteric mass. Systemic chemotherapy was performed after confirming disease progression during a 1 month observation period. A partial response was obtained after two cycles of chemotherapy. Anthracycline-containing cytotoxic chemotherapy could be a treatment option for patients with aggressive IMT.

증례 : Thalidomide 치료 후 호전된 심장 침범을 동반한 원발성 아밀로이드증 1예

오일영 ( Il Young Oh ),손대원 ( Dae Won Sohn ),서정주 ( Jung Ju Sir ),홍용상 ( Yong Sang Hong ),윤성수 ( Sung Soo Yoon ),박영배 ( Young Bae Park ),최윤식 ( Yun Shik Choi ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-

저자들은 심장침범을 동반한 원발성 아밀로이드증이 생긴 52세 남자 환자에서 thalidomide 치료 후 임상적 증상, 심초음파 소견, 검사실 소견이 큰 부작용 없이 현저히 좋아진 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Patients with primary amyloidosis (AL) have poor prognosis with a median survival of one to two years. In patients with symptomatic cardiac involvement, prognosis is even worse with the reported median survival of 6 months. One patient, diagnosed as AL amyloidosis with cardiac involvement, was treated with thalidomide and showed remarkable improvement in functional capacity, cardiac function, and various laboratory parameters without any significant adverse effect and, therefore, we report the case with the review of literatures.(Korean J Med 69:S910-S914, 2005)

항암화학요법으로 인한 말초신경병증을 경험하는 대장암 환자의 삶의 질

김정혜(Kim Jeong Hye),최경숙(Choi Kyung Sook),김태원(Kim Tae Won),홍용상(Hong Yong Sang) 대한종양간호학회 2011 Asian Oncology Nursing Vol.11 No.3

Purpose: The purpose of this study was to identify the quality of life in colorectal cancer patients with chemotherapy-induced peripheral neuropathy. Methods: A total of 93 patients were recruited in the cross-sectional survey design. Quality of life in colorectal cancer patients were measured by European Organization for Research and Treatment of Cancer (EORTC) QLQ C30 and CIPN20. Results: In the QLQ C30 the mean score of the global health status was 59.41 the functional scale was 73.29 and symptom scale was 26.72. In CIPN20 the mean score of sensory scale was 32.70 autonomic scale was 22.88 and motor scale was 16.12. In the QLQ C30 the global health status showed significant differences according to surgery (p=.027) and the functional scale and the symptom scale showed significant differences according to gender (p=.046 p=.020) and nonpharmacologic intervention (p=.001 p=.009). The CIPN20 the sensory scale showed significant differences according to age (p=.006) DM (p=.005) grade of CIPN (p=<.001) the status of chemotherapy (p=.001) and nonpharmacologic intervention (p=.010). Conclusion: The level of quality of life in colorectal cancer patients with peripheral neuropathy was relatively low. There is a need for developing a nursing intervention for colorectal cancer patients to improve their quality of life and to decrease chemotherapy-induced peripheral neuropathy.

버팀보로 지지된 흙막이벽의 거동에 관한 연구

홍원표,여규권,윤중만,조용상 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

버팀보 축력으로부터 산정된 측방토압은 지표면에서 굴착깊이의 17%에 해당되는 깊이까지 선형적으로 증가하다가 그 깊이 아래로부터는 일정토압분포를 보이는 사다리꼴모양의 분포를 보였다. 이 일정토압 분포부분의 토압 크기는 평균적으로 최종굴착깊이에서의 Rankine 주동토압의 58%에 해당하거나 연직상재압의 17%에 해당하였다. 또한 흙막이벽의 수평변위와 굴착깊이와의 관계로부터 흙막이구조물의 안정성을 판단할 수 있는 시공관리기준을 설정하였다. 흙막이벽의 수평변위량이 굴착깊이의 0.20%보다 작으면 흙막이벽과 굴착배면지반은 안정된 상태에 있다. 그러나 벽체의 수평변위가 굴착깊이의 0.20%보다 크게 발생하면 굴착공사의 안정성을 주의깊게 관찰해야만 하며, 필요하다면 흙막이 구조물을 보강해야만 한다. The lateral earth pressures on braced earth retaining walls, which are estimated form the measured strut force, shows a trapezoidal distribution that the earth pressure increases linearly with depth from the ground surface to 17% of the final excavation depth, and then keeps constant value. The maximum lateral earth pressure was same to 58% of Rankine's active earth pressure or 17% of the vertical overburden pressure at the final excavation depth. Also, empirical criterion is established for construction management to monitor and ensure the stability of deep excavation from the relationship between horizontal displacement of wall and excavated depth. If the horizontal displacement of wall measured from inclinometer shows less than 0.20 percent of the excavated depth, the retention wall and surrounding ground exist under stable state. When the horizontal displacement is developed more than 0.20 percent of the excavated depth, excavation works should be carefully observed and reinforced the earth retention wall, if necessary.