A survey on the awareness and knowledge about elective oocyte cryopreservation among unmarried women of reproductive age visiting a private fertility center

홍연희,박정우,김혜인,김슬기,주창우,지병철,서창석,김석현 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.6

ObjectiveThe aim of this study was to investigate the level of awareness and knowledge regarding elective oocytecryopreservation (OC) among unmarried women of reproductive age in Korea. MethodsA survey was conducted among 86 women who visited a fertility preservation clinic for counseling about elective OCbetween December 2016 and May 2018. Participants were asked to fill out a questionnaire regarding their awarenessand knowledge of fertility and OC. ResultsThe questionnaire was completed by 71 women. Among them, 73% decided to undergo OC after counseling. Themain reason for making this decision was that they wished to maintain their fertility in the future (70.6%). Conversely,the high cost for the procedure was the main reason given by those who chose to forego this procedure. Regardingfertility and OC, the participants’ knowledge was poor. Most women expected greater financial support from thegovernment or from their place of employment. ConclusionThis study demonstrated that the awareness andknowledge about elective OC were relatively pooramong the female Korean population. These findingsmay help clinicians in better counselling of their patients.

가임력 보존을 위한 난소조직 동결 보존과 이식

홍연희,이정렬 대한의사협회 2022 대한의사협회지 Vol.65 No.6

Background: As the number of cancer survivors has increased with advancements in cancer treatment, fertility preservation has become a treatment goal. Ovarian tissue cryopreservation (OTC) and transplantation (OTT) has made great progress over the past few decades. It has become the treatment of choice for fertility preservation in adolescents or patients in urgent need of chemotherapy. However, it is considered to be experimental compared with oocyte or embryo cryopreservation in some countries. Nevertheless, OTC and OTT is regarded as the more ideal method for fertility preservation in that it can also restore hormonal functions. Current Concepts: Currently, over 200 live births have been reported worldwide after OTC and OTT, proving the excellence of the technology. However, before its application in clinical settings, some challenges, including cryoinjury, ischemic injury, and cancer cell reimplantation, should be overcome. For cryoinjury, studies are underway on protocol improvement with the addition of agents such as antifreeze protein during cryopreservation. For ischemic injury, various agents have been studied to promote angiogenesis or revascularization. Furthermore, studies are underway on artificial ovary or xenotransplantation for fertility preservation in an effort to avoid cancer cell metastasis. Discussion and Conclusion: OTC and OTT is a clinically applicable option for fertility preservation. To set OTC and OTT as an established method for fertility preservation, further research is necessary to overcome the current challenges.

무월경의 진단 및 치료

홍연희 대한산부인과학회 2023 대한산부인과학회 학술대회 Vol.109 No.-

Fertility Preservation in Young Women With Breast Cancer: A Review

홍연희,박창희,백혜린,이경훈,이정렬,한원식,박세호,정석훈,김희정 한국유방암학회 2023 Journal of breast cancer Vol.26 No.3

Fertility preservation is a major concern in young patients diagnosed with breast cancer and planning to receive multimodality treatment, including gonadotoxic chemotherapy with or without age-related decline through long-term endocrine therapy. Most breast cancer patients undergo multimodality treatments; many short-term and long-term side effects arise during these therapies. One of the most detrimental side effects is reduced fertility due to gonadotoxic treatments with resultant psychosocial stress. Cryopreservation of oocytes, embryos, and ovarian tissue are currently available fertility preservation methods for these patients. As an adjunct to these methods, in vitro maturation or gonadotropin-releasing hormone agonist could also be considered. It is also essential to communicate well with patients in the decision-making process on fertility preservation. It is essential to refer patients diagnosed with breast cancer on time to fertility specialists for individualized treatment, which may lead to desirable outcomes. To do so, a multimodal team-based approach and in-depth discussion on the treatment of breast cancer and fertility preservation is crucial. This review aims to summarize infertility risk related to currently available breast cancer treatment, options for fertility preservation and its details, barriers to oncofertility counseling, and psychosocial issues.

암환자의 가임력 보존

홍연희 대한내과학회 2022 대한내과학회 추계학술대회 Vol.2022 No.1

생식내분비학

홍연희 ( Yeon Hee Hong ),( Jeong Woo Park ),( Hyein Kim ),( Seul Ki Kim ),( Chang Woo Choo ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: The aim of this study was to investigate the level of awareness and knowledge regarding elective oocyte cryopreservation (OC) among unmarried women of reproductive age in Korea. Methods: A survey was conducted among 86 women who visited a fertility preservation clinic for counseling about elective OC between December 2016 and May 2018. Participants were asked to fill out a questionnaire regarding their awareness and knowledge of fertility and OC. Results: The questionnaire was completed by 71 women. Among them, 73% decided to undergo OC after counseling. The main reason for making this decision was that they wished to maintain their fertility in the future (70.6%). Conversely, the high cost for the procedure was the main reason given by those who chose to forego this procedure. Regarding fertility and OC, the participants’ knowledge was poor. Most women expected greater financial support from the government or from their place of employment. Conclusion: This study demonstrated that the awareness and knowledge about elective OC were relatively poor among the female Korean population. These findings may help clinicians in better counselling of their patients.

7世紀 阿彌陀佛像의 圖像 硏究

洪連禧(Hong, Ryun-Hee) 한국고대사탐구학회 2012 한국고대사탐구 Vol.10 No.-

무량수불에서 아미타불로의 불명의 변화는 중국에서 6세기 후반에 시작하여 수ㆍ당대에 크게 유행하였다. 이는 아미타신앙이 서방정토신앙을 중심으로 한 신앙으로 확실히 자리 잡고, 아미타불의 위치가 장수기원에서 구제자로 변화하는 신앙형태의 변화에 따른 것이다. 우리나라에서도 7세기 무렵 서방정토 중심의 아미타신앙이 유행하기 시작하며, 무량수불에서 아미타불로의 명칭변화가 확인된다. 이는 나당연합군에 의한 고구려ㆍ백제의 함락, 신라와 당의 전쟁 등 혼란스러웠던 당시의 상황에 따른 신앙형태의 변화에 의한 것으로 추정된다. 7세기 후반에는 연기지역 발견 아미타불상에서 현재까지 알려진 최초의 아미타불명이 확인된다. 또한 협시보살의 도상을 통해 아미타불로 추정되는 상이 확인된다. 이 상들에서는 이전에 확인되지 않던 새로운 도상이 보인다. 본존에서는 다양한 수인이 나타나며, 「선도산 마애삼존불」이나 「군위석굴 삼존석불」의 양 협시 보살에서는 관음과 대세지보살의 도상으로 언급되는 보관 화불과 보병이 확인된다. 이외에도 연기지역 발견 아미타불상에서는 다존의 구성, 줄기가 있는 연화대좌 등이 확인된다. 다양한 수인, 협시보살 보관 화불과 보병 등은 중국에서 수ㆍ당대부터 확인되는 것으로 새로운 아미타신앙과 함께 새로운 도상의 영향을 받아 조성된 것으로 생각된다. 다존의 구성은 중국 남조의 영향이 확인되나 당대의 영향이 함께 확인되며, 이전에 확인되지 않던 줄기가 있는 연화대좌가 연기지역 아미타불상에 무량수불에서 아미타불로의 불명의 변화는 중국에서 6세기 후반에 시작하여 수ㆍ당대에 크게 유행하였다. 이는 아미타신앙이 서방정토신앙을 중심으로 한 신앙으로 확실히 자리 잡고, 아미타불의 위치가 장수기원에서 구제자로 변화하는 신앙 형태의 변화에 따른 것이다. 우리나라에서도 7세기 무렵 서방정토 중심의 아미타 신앙이 유행하기 시작하며, 무량수불에서 아미타불로의 명칭변화가 확인된다. 이는 나당연합군에 의한 고구려ㆍ백제의 함락, 신라와 당의 전쟁 등 혼란스러웠던 당시의 상황에 따른 신앙형태의 변화에 의한 것으로 추정된다. 7세기 후반에는 연기지역 발견 아미타불상에서 현재까지 알려진 최초의 아미타불명이 확인된다. 또한 협시보살의 도상을 통해 아미타불로 추정되는 상이 확인된다. 이 상들에서는 이전에 확인되지 않던 새로운 도상이 보인다. 본존에서는 다양한 수인이 나타나며, 「선도산 마애삼존불」이나 「군위석굴 삼존석불」의 양 협시 보살에서는 관음과 대세지보살의 도상으로 언급되는 보관 화불과 보병이 확인된다. 이외에도 연기지역 발견 아미타불상에서는 다존의 구성, 줄기가 있는 연화대좌 등이 확인된다. 다양한 수인, 협시보살 보관 화불과 보병 등은 중국에서 수ㆍ당대부터 확인되는 것으로 새로운 아미타신앙과 함께 새로운 도상의 영향을 받아 조성된 것으로 생각된다. 다존의 구성은 중국 남조의 영향이 확인되나 당대의 영향이 함께 확인되며, 이전에 확인되지 않던 줄기가 있는 연화대좌가 연기지역 아미타불상에서 확인되는 것은 수ㆍ당대의 아미타도상에서 줄기가 있는 연화대좌가 적극적으로 표현되는 영향을 받은 것으로 추정해볼 수 있다. 7세기에는 아미타도상이 명확하게는 확립되지 않았던 것으로 추정된다. 그러나 새로운 아미타신앙과 함께 아미타도상이 유입되어 조성되기 시작한 시기로 이후의 아미타도상에 영향을 미쳤음을 알 수 있다. 그러므로 7세기에 아미타불상을 살펴봄으로서 이전과는 다른 도상의 유입과 분명한 아미타도상이 성립되기 이전, 아미타도상의 유입 초기 도상들을 알 수 있다는 것에 의의가 있을 것이다. “Amit?” (阿彌陀), a new alternative name for the “Wuliangshou” Buddha (無量壽, Buddha of Immeasurable Life) appeared in the late sixth century China and grew prevalent by Sui and Tang dynasties. The change of its name took place as the cult settled into a belief centered by the Western Pure Land and the status of Amit? Buddha changed from the one who grants long life to an icon of salvation. The cult of Amit? began to prevail in Korea around the seventh century, and the same transition of designation from “Muryangsu” (無量壽) to “Amit?” took place. It presumably took place in line with changing forms of belief due to the turmoil caused by the frequent battles around the fall of Kogury? and Paekje kingdoms. At present, the earliest culptural piece inscribed with the name “Amit?” and another inferred as an Amit? Buddha are found among the late seventh century Korean Buddhist sculpture, and both possess some unprecedented stylistic features. Other variety of mudras than the one assuring protection and granting wishes are found in the main Buddha. Features of Avalokite?vara and Mahasthamaprapta such as crowned transformed image of a Buddha and jeweled bottles appear, as exemplified by the pair of flanking bodhisattvas in the stone-relief triad of Mt. S?ndo and the stone triad of Kunwi Grotto. In case of the Amit? steles found in Y?n’gi area a stemmed lotus flower seat and composition featuring multiple Buddhas are found. New features such as additional variety of mudras, crowned bodhisattvas and jeweled bottles are found in Sui and Tang dynasty examples, and their emergence in Korea at this time are thought to be influenced by an introduction of the new form of belief and image from the Chinese empires. The multiple Buddha images have traces of Southern Chinese dynasties style together with Tang dynasty, while the unprecedented stemmed louts seats found in the Y?n’gi steles can be seen as effected Sui and Tang dynasty examples of Amit? sculpture, where stemmed lotus seats frequently appear. Although the image of the Amit? Buddha appears not to have been fully established by the seventh century, introduction of the new image with the cult of Amit? Buddha nonetheless was reproduced to influence later Korean images of Amit? Buddha. The seventh century examples of Amit? Buddha images are thus significant in understanding the early forms of Amit? Buddha images before settling down to consistency, as well as aspects of how a new icon was introduced from one culture to another.

형태학 연산자를 이용한 하이브리드 FCNN의 영상 에지 고양 검출에 관한 연구

홍연희(Yun-Hui Hong),변오성(Oh-Sung Byun),조수형(Soo-Hyung Cho),문성룡(Sung-Ryong Moon) 대한전자공학회 1999 대한전자공학회 학술대회 Vol.1999 No.6

DAQ based Impedance Measurement System for Low Cost and Portable Electrical Cell-Substrate Impedance Sensing

박일환,홍연희,전희숙,조의식,조성보 한국바이오칩학회 2018 BioChip Journal Vol.12 No.1

Electric cell-substrate impedance sensing (ECIS), a technique for label-free and real-time detection of cells, is emerging as an alternative or assistive method to traditional biochemical assays for diagnostic and pharmaceutical applications. In this work, we developed a DAQ based impedance measurement system for low cost and portable ECIS applications. The alternating input signal for ECIS was generated from the digital-to-analog converter (DAC) channel of the DAQ board and applied through the current limited resistor to the cells on the electrode. The responding signal was recorded by the analog-to-digital converter (ADC) channel of the DAQ board, and its amplitude and phase were analyzed by software lock-in amplifier. The feasibility of the developed ECIS system was evaluated by impedance measurement and DAPI analysis of C2C12 cell growth on the indium tin oxide microelectrode, and by impedimetric and MTT cell viability assay of HEK293 cells exposed to H2O2.

Thomson spectrometer를 이용한 액체금속 이온원의 특성조사

이우범,홍연희,최은하,조광섭,강승언 한국진공학회 1994 한국진공학회 학술발표회초록집 Vol.- No.-