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Gitelman 증후군 환자에서 면역조직화학법으로 확인한 원위세관 sodium-chloride cotransporter (NCCT)의 결손
장혜련 ( Hye Ryoun Jang ),허남주 ( Nam Ju Heo ),손민정 ( Min Jung Son ),이재욱 ( Jay Wook Lee ),이정환 ( Jeong Hwan Lee ),전은실 ( Un Sil Jeon ),신성준 ( Sung Jun Shin ),나기영 ( Ki Young Na ),주권욱 ( Kwon Wook Joo ),이정상 ( Jun 대한내과학회 2005 대한내과학회지 Vol.69 No.6
Background : Gitelman`s syndrome is an autosomal recessive renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. It is known to be caused by a mutation of SLC12A3 gene coding the sodium-chloride cotransporter (NCCT) in the distal tubule. The defect of NCCT in human renal tissues has not been investigated, and we tested whether the defect of NCCT can be detected in renal tissue of a patient with Gitelman`s syndrome by using immunohistochemistry. Methods : In an adult patient with Gitelman`s syndrome, blood and urine samples were collected for measurement of biochemical parameters. Renal clearance study and gene analysis were performed. Immunohistochemistry was performed on the renal tissue of the patient using a rabbit polyclonal antibody directed against a synthetic peptide corresponding to a portion in the amino terminal tail for human NCCT. Normal human renal tissues from surgical nephrectomy due to renal cell carcinoma and renal biopsy tissues from patients with glomerulonephritis but without any electrolyte disturbance were used as controls. Results : The patient had hypokalemic metabolic alkalosis, hypocalciuria and hypomagnesemia. Renal clearance study revealed a decrease in distal fractional chloride reabsorption after the administration of furosemide. SLC12A3 gene mutation (S967F) was found by direct sequencing method. Immunohistochemistry showed the absence of NCCT staining in the renal tissue of the patient. On the other hand, the immunostaining of other transporters was all positive in renal tissues from both Gitelman`s syndrome patients and controls. Conclusions : We report the absence of intact NCCT in the renal tissue of a Gitelman`s syndrome patient.(Korean J Med 69:642-650, 2005)
광방기에 의해 발생한 Chinese Herb Nephropathy
이재욱 ( Jay Wook Lee ),손민정 ( Min Jung Sohn ),허남주 ( Nam Joo Heo ),주권욱 ( Kwon Wook Joo ),정윤철 ( Yoon Chul Jung ),이정상 ( Jung Sang Lee ),한진석 ( Jin Suk Han ) 대한내과학회 2006 대한내과학회지 Vol.71 No.2
Chinese herb nephropathy (CHN) is characterized by progressive tubulointerstitial nephritis and development of renal failure in a couple of years after diagnosis. Aristolochic acid (AA) is believed to be associated with the development of CHN. The authors report a case of CHN in which AA in the herb regimen was identified by high-performance liquid chromatography (HPLC). A 32-year-old female presented with nausea, vomiting and generalized weakness. She had been taking Chinese herbs for symptomatic care. Clinical and laboratory examinations revealed Fanconi syndrome, renal failure, and severe anemia. Renal biopsy showed severe tubulointerstitial nephritis with moderate tubular atrophy and interstitial fibrosis. She developed end-stage renal failure 4 months after diagnosis. The herb she had been taking was Aristolochia fangchi. HPLC technique was used to identify AA and to measure its concentration in the herb. From the clinical and laboratory data, the patient was diagnosed with CHN caused by aristolochic acid.(Korean J Med 71:224-228, 2006)
기능성식품의 구매 및 섭취 실태와 아로니아 첨가식품 개발에 대한 소비자의 인식
박민규, 주신윤, 허남주, 이홍미 충북대학교 생활과학연구소 2008 생활과학연구논총 Vol.24 No.2
This study was conducted to provide the basic information in order to develop the aronia added functional foods by determining the consumers’s needs and status of consuming functional foods and those with aronia. The subjects were 43 men and 142 women over 20 years of age who had regular income residing Seoul and Gyeonggi area. The information were obtained by using self-administered questionnaire and data were analysed by SPSS 25.0. The proportion of the subjects who had experienced eating aronia and aronia added foods were only 64.9% and 35.1%, suggesting insufficient supply to market yet as of 2019. The subjects evaluated the importance of 8 factors when they purchase the functional foods; physiological active function and easiness to consume the highest (4.19, respectively); patent or certification (4.03), price (3.79), recommendation (3.65), brand (3.61), advertisement or broadcasting (2.75), and design (2.64). More over, ‘physiological function’ was evaluated higher by women, by those graduated with food and nutrition major, by those with more concern of their own health and by those who buy functional foods for their own or family members’ health; ‘the easiness to consume’ by the subjects who had experience of purchasing functional foods; ‘price’ by younger subjects under 30 years of age; ‘brand’ by those with experience of buying the functional foods than by their counterparts, respectively (p<0.05). The most answered reason for dissatisfaction with the foods with aronia was ‘unsatisfactory taste’ (52.4%) and followed by ‘unsatisfactory effectiveness’ (33.3%) and the most wanted type of foods with aronia was beverage (41.8%) followed by jam (26.9%), jelly (11.5%), bakery (10.4%), and sauce such as gochujang (7.1%), which should be reflected in developing new functional foods with aronia.