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최근 8 년간 방문한 벌독 알레르기 환자들의 임상적 특성
허규영 ( Gyu Young Hur ),김정은 ( Jeong Eun Kim ),예영민 ( Young Min Ye ),서창희 ( Chang Hee Suh ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.2
Background: There were a few reports about the clinical features of bee venom allergy in Korea, which had a limitation of small study subjects. Objective: The aim of the present study was to observe the clinical features of bee venom allergy and to evaluate the risk factors associated with severe systemic reactions. Method: Fifty-two patients presenting local and systemic bee venom allergies were enrolled, and skin prick test was performed to determine atopy status. Serum specific IgE antibodies to causative bee venom (honeybee, yellow jacket, yellow hornet, white faced hornet, and paper wasp) were detected by immunoCAP or RIA. Result: Thirty-three patients (63.5%) were male and nineteen patients (36.5%) were female. Local reaction was developed in nine (17.3%) patients and systemic reaction in fourty-three (82.7%) patients. Bee venom allergy was developed mainly in adults during summer, and the major causative allergen was honeybee. The presence of serum specific IgE to honeybee was significantly related with the development of severe systemic reaction (P=0.02). Severe systemic reaction was more common in males than in females (P<0.05). Conclusion: Honeybee sting and male gender are noted as significant risk factors for severe systemic reaction after bee sting in this country. (Korean J Asthma Allergy Clin Immunol 2006;26:145-150)
노인 천식에서 인지 기능 장애가 천식 조절에 미치는 영향
허규영 ( Gyu-young Hur ),예영민 ( Young-min Ye ),문소영 ( So Young Moon ),김주희 ( Joo-hee Kim ),정기석 ( Ki-suck Jung ),박해심 ( Hae-sim Park ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.1
Purpose: Assessment of the severity and clinical course of asthma is important for effective disease control. Cognitive and physical impairments occur due to the aging process, which may impact on asthma control. We aimed to evaluate the impact of cognitive function on the assessment of asthma control in older asthmatics as a prospective interventional trial. Methods: A total of 50 mild to moderate asthmatics over 60 years of age were enrolled. Three questionnaires were used: the asthma control test (ACT), the asthma-specific quality of life, and the Korean version of the Short Form of the Geriatric Depression Scale. The Seoul neuropsychological screening battery-dementia version (SNSB-D), Korean version of the Mini-Mental Status Examination, and the Seoul instrumental activities of daily living scale were applied for neuropsychological assessment. Results: The mean patient age was 67.0±4.9 years, and 30 patients (60.0%) were female. The sensitivity and specificity of the ACT for determining well-controlled asthma were 91.7% and 39.5%, respectively. Regarding neuropsychological assessment, 22 patients (44%) had mild cognitive impairment, 4 (8.7%) had dementia, and 17 (34%) had depression. Total SNSB-D score was significantly higher in patients with an ACT score of ≥20 (P=0.015). The ACT scores were significantly associated with SNSB-D results in analyses adjusted for age, sex, education duration, lung function, and depression (P=0.004). Conclusion: We found significant positive correlations between cognitive functions, as measured by SNSB-D, and asthma control status, as measured by ACT scores, in older patients with asthma. Therefore, cognitive impairment may be associated with poor asthma control in older asthmatics. (Allergy Asthma Respir Dis 2017:5:34-40)
만성 폐쇄성 폐질환 환자에서 기관지확장제의 사용에 따른 단독 폐용적 반응 (isolated volume response)과 GOLD 분류와의 관계
허규영 ( Gyu Young Hur ),이승현 ( Seung Hyeun Lee ),정진용 ( Jin Yong Jung ),김세중 ( Se Joong Kim ),이경주 ( Kyoung Ju Lee ),이은주 ( Eun Joo Lee ),정혜철 ( Hye Cheol Jung ),이승룡 ( Sung Yong Lee ),이상엽 ( Sang Yeub Lee ),김제 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.1
집먼지진드기 면역요법 후 천식이 소실된 성인 천식 환자들의 임상적 특성
허규영 ( Gyu Young Hur ),이현영 ( Hyung Youn Lee ),최길순 ( Gil Soon Choi ),박한정 ( Han Jung Park ),최성진 ( Sung Jin Choi ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.4
Background: Although allergen specific immunotherapy has been used as the only curative treatment for allergic diseases, there have been few studies that observed the efficacy of immunotherapy in asthmatics. Objective: We attempted to determine clinical parameters for predicting the remission of asthma after immunotherapy with house dust mite extracts. Method: Fifty-six adult asthmatic patients undergoing immunotherapy with house dust mite extracts for more than 3 years were enrolled. They were classified into the remitted and unremitted group according to the results of following methacholine challenge test. Skin reactivity, immunologic findings, spirometry, and airway hyperreactivity were compared between the 2 groups. Result: Twenty-six subjects (46.4%) were in the remitted group and 30 subjects (53.6%) were in the unremitted group. Both onset age of asthma symptoms and starting age of immunotherapy were significantly lower in the remitted group (P<0.05, for each). Baseline FEV1 levels and degree of airway hyperreactivity were significantly better in the remitted group (P<0.01 and 0.05, respectively). Conclusion: Younger age, earlier immunotherapy as well as better lung function and airway hyperreactivity at baseline can be used to predict the remission of asthma in adults. Therefore, earlier allergen immunotherapy in younger age group might help achieve remission in adult allergic asthma. (Korean J Asthma Allergy Clin Immunol 2007;27:257-262)
허규영 ( Gyu Young Hur ) 대한내과학회 2013 대한내과학회지 Vol.85 No.5
Allergic rhinitis (AR) is defined as chronic inflammatory reactions to common allergens in the nasal mucosa with at least two AR symptoms including rhinorrhea, nasal congestion, sneezing, nasal/ocular pruritus, and postnasal drainage. AR is a common health problem, and it affects around 10-25% of general population. Its prevalence is increasing according to the environmental changes. AR and asthma frequently coexist in the same patient, therefore we should consider it and check for asthma to diagnose AR. Antihistamines and nasal corticosteroids are recommended as the 1st line treatment of AR. Decongestants may be effective for nasal congestion, and leukotrienes are helpful to improve both nasal and bronchial inflammations in patients with AR and asthma. Allergen specific immunotherapy is useful in IgE mediated AR and can prevent the progression to asthma and new sensitizations. Appropriate AR treatment including medications and immunotherapy can improve symptoms and reduce medications. Finally improvement of quality of life can be achieved. (Korean J Med 2013;85:463-468)
스티렌(Styrene)과 Toluene Diisocyanate (TDI)에 의한 직업성 천식
예영민 ( Young Min Ye ),최길순 ( Gil Soon Choi ),박한정 ( Han Jung Park ),김현아 ( Hyoun Ah Kim ),허규영 ( Gyu Young Hur ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.1
Styrene, a common solvent and volatile organic compound (VOC), is widely used in the factories of plastics, resins, insulators, coatings, and paints. While toluene diisocyanate (TDI) is a well-known causative agent of asthma, styrene has been rarely reported to cause occupational asthma (OA). We report a 50-year-old repairman with OA due to both styrene and TDI in whose job was filling cracks and flattening the surface of vehicles with styrene-containing plaster`s putty, followed by spray painting. He suffered from cough, dyspnea durings the work with putty. He presented with a 2-year history of asthma and allergic rhinitis. The level of serum total IgE and sputum eosinophils were 2,878 IU/L and 63%, respectively. The methacholine challenge test was positive (PC20 0.59 mg/mL). The bronchoprovacation tests with TDI and styrene showed early and dual responses, respectively. Currently, he is in well-controlled state with the use of a combination of inhaled corticosteroid and long acting β2-agonist after the avoidance of the causative agents. (Korean J Asthma Allergy Clin Immunol 2007;27:70-73)
아목시실린에 의한 약물 과민반응 16예의 임상적 특성과 혈청학적 검사의 의의
박한정 ( Han Jung Park ),허규영 ( Gyu Young Hur ),김현아 ( Hyoun Ah Kim ),최길순 ( Gil Soon Choi ),최성진 ( Sung Jin Choi ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.3
Background: Amoxicillin is one of the broad spectrum antibiotics and is widely used in the treatment of various infective diseases. There are various forms of amoxicillin-induced hypersensitivity reactions including urticaria/angioedema, erythema multiforme and anaphylaxis. Objective: To observe the clinical features and evaluate the significance of in vitro testing of amoxicilin-induced hypersensitivity reactions. Method: We retrospectively reviewed medical records of patients diagnosed as having amoxicillin-induced hypersensitivity reactions from January 2002 to February 2007. Serum-specifc IgE antiboides to ampicilloyl (AMP) and amoxicilloyl (AXO) were determined using the immunoCAP Result: Sixteen subjects were enrolled in this study. Clinical features of amoxicillin-induced hypersensitivity reactions included erythema multiforme (n=6, 37.5%), urticaria/angioedema (n=4, 25.0%), anaphylaxis (n=3, 18.8%), maculopapular skin eruption (n=2, 12.5%) and fixed-drug eruptions (n=1, 6.3%). Six subjects had a high serum specific IgE to AMP and all anaphylaxis patients had a high serum specific IgE to AXO and/or AMP. Conclusion: These findings suggest that amoxicillin could induce various cutaneous manifestations in which the most common ones are erythema multiforme and urticaria/ angioedema. The serious reactions of anaphylaxis were noted in 18.8% of subjects in which IgE mediated responses to 2 antigenic determinants were involved. (Korean J Asthma Allergy Clin Immunol 2007;27:162-167)