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한지민,김혜인,이유지,김광민,배지철 한국지질동맥경화학회 2019 지질·동맥경화학회지 Vol.8 No.2
Objective: Fatty liver is associated with insulin resistance-related diseases, such as dyslipidemia, obesity, and type 2 diabetes. The aim of this study was to evaluate the association of dyslipidemia with fatty liver and assess the differences in these associations according to the degree of hepatic steatosis. Methods: A total of 2,462 subjects (1,679 men and 783 women) who underwent a comprehensive health check-up (including abdominal computed tomography) from January 2010 to December 2013 were enrolled at Samsung Changwon Hospital Healthcare Center. The liver attenuation index (LAI), defined as the difference between mean hepatic and splenic attenuation, was used to assess the degree of hepatic steatosis. An LAI below 5 Hounsfield units was defined as fatty liver. Results: We found that 32.2% of the study subjects had fatty liver. Serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG), and fasting blood glucose concentrations and glycated hemoglobin (HbA1c percentage) were significant greater in the fatty liver group compared with the non-fatty liver group, while serum high-density lipoprotein cholesterol (HDL-C) was significantly lower in the fatty liver group. Subjects with fatty liver had 1.7-fold greater risk of dyslipidemia than those without fatty liver after adjusting for age, sex, body mass index (BMI), and HbA1c. When individuals with fatty liver were analyzed by tertiles of LAI values, LDL-C, TG, fasting glucose, BMI, and HbA1c concentrations increased while HDL-C decreased with decreasing LAI tertiles. Compared with LAI tertile 3, the risk for dyslipidemia significantly increased with adjusted odds ratios of 1.42, and 1.81 in tertiles 2 and 1, respectively. Conclusion: Fatty liver was significantly associated with dyslipidemia and this association varied according to the degree of hepatic steatosis.
한지민,조정환,김혜인,서성환,이유지,이정원,김광민,배지철 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.4
Background: Fatty liver is associated with increased risk of developing type 2 diabetes. We aimed to evaluate whether the severity of hepatic steatosis is associated with incident diabetes. Methods: We conducted a longitudinal analysis using data from 1,798 participants who underwent a comprehensive health checkup and abdominal computed tomography (CT). We assessed the association between baseline liver attenuation value on non-contrast CT images and risk of incident diabetes. All the participants were categorized into three groups based on the baseline liver attenuation value on non-contrast CT images: without hepatic steatosis (>57 Hounsfield unit [HU]), mild hepatic steatosis (41–57 HU), and moderate to severe hepatic steatosis (≤40 HU). Results: During a median follow-up period of 5 years, 6.0% of the study participants progressed to diabetes. The incidence of diabetes was 17.3% in the moderate to severe hepatic steatosis group, 9.0% in the mild steatosis group, and 2.9% in those without hepatic steatosis. In a multivariate adjustment model, as compared with participants without hepatic steatosis, those with moderate to severesteatosis had a hazard ratio (HR) of 3.24 (95% confidence interval [CI], 1.64 to 4.2) for the development of diabetes, and those in the mild steatosis group had a HR of 2.33 (95% CI, 1.42 to 3.80). One standard deviation decrease in mean CT attenuation values of the liver was associated with a 40% increase in the development of diabetes (multivariate adjusted HR, 1.40; 95% CI, 1.2 to 1.63). Conclusion: We found a positive association between severity of hepatic steatosis and risk of incident diabetes. Greater severity of steatosis was associated with a higher risk of incident diabetes.
Pancreatic Tail Mass: A Diagnostic Challenge
한지민 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.5
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한지민,권지언,이위형,김봉기 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Gas sensor based on organic field-effect transistors (OFETs) was performed analyte detect by inducing current change which be caused by charge transfer between electron donating polymer and electron accepting NO<sub>2</sub> gas analyte. In this study, three designed conjugated polymers (CPs) containing ICZs derivative with different functional groups were utilized as active layer materials. Each CPs was exhibited different film crystallinity and reaction sites with analyte, influencing the diffusion pathway and polymer-analyte interaction, which in affect gas responsivity. Introduction of polar side chain was achieved high responsivity by enhanced analyte diffusion into conducting channel and charge transfer. OFET devices were fabricated by adjusting thickness of the active layer of CPs, respectively. Several studies have reported that reducing the active layer thickness have been made to improve the sensitivity, but our work showed the highest responsivity at optimized thickness for all three CPs.
한지민,김종원,배기광,박주식,정성욱,김영호,강경수 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Renewable energy provides an intermittent operation environment, so the electrodes of water electrolysis need high durability and long life time for hydrogen production. In this study, 3-electrode system prepared using NiZnFe electrodes plated under two different conditions and the degradation characteristics of the electrode were confirmed by the cathodic potential on/off test in the hydrogen generation evolution reaction. The on/off test was operated about 150 cycles in the range of about -1.3 V to 0 V and reverse current occurred in the off step. As a result of LSV(Linear sweep voltammetry) for electrochemical analysis, the HER activity of 80 mA/㎠, 2000 s electrode and 320 mA/㎠, 2000 s electrode decreased about 10% and 15%, respectively. This results show that Zn dissolution and reverse current are related to deactivation. 320 mA/㎠, 600 s electrode is relatively less deactivation and less peeling off coating layer than 80 mA/㎠, 2000 s electrode.