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Prognostic Impact of Statins in Patients with Chronic Total Occlusion
최철웅 대한의학회 2018 Journal of Korean medical science Vol.33 No.18
Since its introduction by Gruntzig,1 percutaneous coronary intervention (PCI) has become a common treatment strategy for coronary artery disease. However, the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial and other meta-analyses showed that PCI did not reduce the risk of death, myocardial infarction, or other major cardiovascular events, when added to optimal medical therapy.2,3 Improvements in guidewires, devices, and other imaging modalities have enabled PCI to be a useful tool in the treatment of coronary chronic total occlusion (CTO). Recent guidelines recommend that PCI for CTO is reasonable (class IIa) in patients with appropriate indications and suitable anatomy.4 However, some data revealed that in this CTO subgroup, successful PCI did not reduce major adverse cardiac events including cardiac death compared with optimal medical therapy.5 Although the success rate of revascularization for CTO has increased with advances in technology, approximately 20%–30% of CTO cases are not revascularized using PCI methods. Optimal medical treatment is very important, especially in patients who do not undergo revascularization. There are limited data on which drug optimally improves clinical outcomes for these patients. The study by Kim et al.6 is therefore meaningful and interesting. They investigated the association between statin therapy and clinical outcomes in stable coronary CTO without revascularization. They showed that statin therapy was associated with a low risk of cardiac death and was also an independent predictor of cardiac death.6 Plausible explanations for these results are as follows. First, the most important mechanism is the effect of statin therapy on the progression of coronary atherosclerosis. A meta-analysis by Tian et al.7 revealed that statin therapy can significantly reduce plaque volume in patients with coronary artery disease and suggested that statins can be used to reduce the atheroma burden for secondary prevention. Statins can inhibit the progression of plaque in non-CTO vessels that serve as donors for collateral circulation and decrease ischemic burden. These effects of statins may translate to better clinical outcomes. Second, in addition to decelerating the progression of atherosclerosis, statins have pleotropic effects.8 These include enhancement of antiarrhythmic effects, antioxidant properties, inhibition of inflammatory responses, and immunomodulatory activity. The pleotropic effect of statins on the cardiovascular system may play an important role. According to current American Heart Association/American College of Cardiology guidelines, high-dose statin therapy is very beneficial in selected high- risk patients. As mentioned by Kim et al.,6 the intensity or duration of statin therapy in CTO patients may also be very important. The study findings make important clinical implications. J Korean Med Sci. 2018 Apr 30;33(18):e147 https://doi.org/10.3346/jkms.2018.33.e147 eISSN 1598-6357·pISSN 1011-8934 Editorial Cheol Ung Choi Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea Prognostic Impact of Statins in Patients with Chronic Total Occlusion Received: Apr 14, 2018 Accepted: Apr 16, 2018 Address for Correspondence: Cheol Ung Choi, MD, PhD Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea. E-mail: wmagpie@korea.com © 2018 The Korean Academy of Medical Sciences. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:// creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ORCID iDs Cheol Ung Choi https://orcid.org/0000-0003-2815-9358 Disclosure The author has no potential conflicts of interest to disclose. ► See the article “Long-term Survival Benefit of Statin in Patients wi...
SNCM616 합금강을 이용한 표면조도 특성에 관한 연구
최철웅,김용경,김진수,신미정 한국산업융합학회 2019 한국산업융합학회 논문집 Vol.22 No.6
In this study, we investigate the effect of SNCM616 alloy steel, which is commonly used in industry, such as rotors and crank-shafts, on the surface roughness of CNC HBM with Ø25 mm, 8-blade reamer to objective is to analyze and present optimal cutting conditions. The higher the feedrate for the spindle speed, the rougher the surface roughness. The surface roughness was found to be better when the feed rate was lower. The resultant value of the most accurate surface roughness is Ra 0.756 μ m, and the optimal cutting conditions are 25 rpm at spindle speed and 20 mm/min at transfer speed
생명에 투자하기: 한국 생명공학 산업의 금융화와 희망의 정치경제
최철웅 경희대학교 사회과학연구원 2023 社會科學硏究 Vol.49 No.3
최근 지속 가능한 경제와 국가경쟁력의 핵심 동력으로 부상하고 있는 ‘바이오경제’의 비전에는 생명공학기술과 정치경제의 접합이 가져올 희망찬 미래에 대한 기대와 약속이 가득 담겨 있다. 본 연구는 생명공학 산업의 정치경제학적 논리를 ‘인클로저를 통한 지대 추출’의 동학으로 파악하면서 2000년대 이후 한국의 바이오산업이 금융화된 역사적 경로와 사회적 맥락을 분석했다. 또한 과학기술과 정치경제, 문화적 논리의 ‘공동생산’이라는 관점 에서 바이오경제가 ‘영원히 재생하는 생명’이라는 생명과학적 비전과 ‘끝없이 한계를 극복 하는 경제’라는 신자유주의적 비전을 접합하여 작동한다는 점을 강조했다. The vision of the ‘bioeconomy’, which has recently emerged as a key driver of sustainable economy and national competitiveness, is filled with expectations and promises of a hopeful future led by the biotechnology industry. This study analyzes the historical path and social context of the financialization of the bioindustry in South Korea since the 2000s by identifying the political-economic logic of the biotechnology industry as a dynamic of ‘rent extraction through enclosure’. It also emphasized that the bioeconomy operates by conjoining the biotechnological vision of ‘life that regenerates forever’ with the neoliberal vision of ‘an economy that endlessly overcomes its limits’.