요소제를 혼입한 콘크리트의 수화열 특성에 관한 연구

최원일(Choi, Won-Il),김학영(Kim, Hak-Young),백민수(Baek, Min-Su),이상철(Lee, Sang-Chul),여상길(Yu, Sang-Gil),정상진(Jung, Sang-Jin) 한국콘크리트학회 2012 한국콘크리트학회 학술대회 논문집 Vol.2012 No.11

터널 정보화 시공을 위한 계측 최적방안 분석

최원일 ( Won Il Choi ),조국환 ( Kook Hwan Cho ),박성욱 ( Sung Wook Park ) 대한지질공학회 2008 대한지질공학회 학술발표회논문집 Vol.2008 No.-

폐색전증에서 혈전용해

최원일 ( Won Il Choi ) 대한내과학회 2013 대한내과학회지 Vol.84 No.1

The standard therapy for acute pulmonary embolism is initiated with heparin. Massive pulmonary embolism (PE) is defined by the presence of cardiogenic shock, persistent arterial hypotension, or both. It is associated with a high risk of in-hospital death, particularly during the first hours after admission. Thrombolysis is recommended in massive PE. Results from a randomized trial suggested that selected patients with evidence of right ventricular dysfunction and a low risk of bleeding may benefit from thrombolysis. In this issue of the Journal, Kim Yang-Ki and colleagues conducted retrospective review of thrombolytic therapy in PE last 6.5 years in a single center. The mortality rate of massive PE (44%) was higher than submassive PE (8%) in patients with thrombolysis. Major bleeding occurred in 3/21 (14%) patients. This signal reminds us real-world hazards of thrombolysis is higher than randomized controlled trial. Although massive PE patients need more intensifying therapy to reduce mortality, we should careful assessment of bleeding risk factors before starting thrombolysis. With regard to submassive PE, this study has limitation to assessing the efficacy of thrombolysis. (Korean J Med 2013;84:46-48)

LSMAP을 활용한 기반암별 토사재해 위험도 비교

최원일(Won-il Choi),최은화(Eun-hwa Choi),전성곤(Seong-kon Jeon) 한국지반신소재학회 2017 한국지반신소재학회 논문집 Vol.16 No.3

본 연구에서는 도심지 토사재해 예비중점관리대상지역 76개중 9개 지역을 연구 지역으로 선정하였다. 연구 지역 은 기반암 특성별로 퇴적암류 3개 지역(경산시, 고흥군, 대구광역시), 화성암류 3개 지역(대전광역시, 세종특별자치시, 원주시), 변성암류 3개 지역(남양주시, 의왕시, 인제군)으로 분류하였으며, 9개 지역을 대상으로 지반정수 산정에 필요한 시험과 수목에 대한 뿌리 점착력, 수목하중을 예측 모형과 현장 조사를 통해 분석하였다. 강우시나리오(강우강도)는 부산 APEC 기후센터(APCC) 에서 제공한 확률강우량을 적용하였으며, 9개 지역의 토사재해 위험도 예측은 TRIGRS와 LSMAP을 이용하였다. TRIGRS 예측 결과, 평균적으로 퇴적암류 지역의 위험지역은 30.45%, 화성암류 지역의 위험지역은 41.03%, 변성암류 지역의 위험지역은 45.04%로 검토되었다. 수관 밀도에 따른 뿌리 점착력과 수목하중을 고려한 LSMAP 예측 결과, 퇴적암류 지역의 위험지역은 1.34%, 화성암류 지역의 위험지역은 2.76%, 변성암류 지역의 위험지역은 1.64%로 검토되었다. TRIGRS를 이용한 분석보다 LSMAP을 통한 분석이 비교적 국소적으로 예측 가능한 것으로 검토되었다. For the purpose of the study, of the 76 areas subject to preliminary concentrated management on sediment disaster in the downtown area, 9 areas were selected as research areas. They were classified into three stratified rock areas (Gyeongsan City, Goheung-gun and Daegu Metropolitan City), three igneous rock areas (Daejeon City, Sejong Special Self-Governing City and Wonju City) and three metamorphic rock areas (Namyangju City, Uiwang City and Inje District) according to the characteristics of the bedrock in the research areas. As for the 9 areas, analyses were conducted based on tests required to calculate soil characteristics, a predictive model for root adhesive power, loading of trees and on-the-spot research. As for a rainfall scenario (rainfall intensity), the probability of rainfall was applied as offered by APEC Climate Center (APCC) in Busan. As for the prediction of landslide risks in the 9 areas, TRIGRS and LSMAP were applied. As a result of TRIGRIS prediction, the risk rate was recorded 30.45% in stratified rock areas, 41.03% in igneous rock areas and 45.04% in metamorphic rock areas on average. As a result of LSMAP prediction based on root cohesion and the weight of trees according to crown density, it turned out to a 1.34% risk rate in the stratified rock areas, 2.76% in the igneous rock areas and 1.64% in the metamorphic rock areas. Analysis through LSMAP was considered to be relatively local predictive rather than analysis using TRIGRS.

소아 천식 환자의 혈청 총 IgE에서 IL-13 (+2044G/A)과 FCER1B (E237G)의 유전자 상호작용

최원아 ( Won Ah Choi ),송영화 ( Young Hwa Song ),김병주 ( Byoung Ju Kim ),유진호 ( Jin Ho Yu ),김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),김자형 ( Ja Hyung Kim ),김봉성 ( Bong Seong Kim ),강미진 ( Mi Jin Kang ),장성옥 ( Seong O 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.4

Background: Interleukin-13 (IL-13) is essential for the synthesis of Immunoglobulin E (IgE) which is a critical risk factor for the development of asthma. The high-affinity IgE receptor β (FCER1B), which is expressed on mast cells and basophils, plays an important role in the IgE-mediated allergic response. Objective: To analyze the association between IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms, and IgE production in asthmatic children. Method: Seven hundred sixty asthmatic children and 235 healthy controls were enrolled, and the levels of serum total IgE and blood eosinophil counts were evaluated. Pulmonary function test and methacholine challenge test were also performed. The genotypes of IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms were analyzed by using the restriction fragment length polymorphism method. Result: IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms were not associated with the development and phenotypes of asthma. However, in homozygote of variant genotypes, gene-gene interaction of IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms was associated with an increase of serum total IgE, whereas in homozygote of wild genotypes, this interaction was not associated with an increase of serum total IgE (P=0.030). Conclusion: Gene-gene interaction between IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms may be associated with increased levels of serum total IgE in children with asthma. (Korean J Asthma Allergy Clin Immunol 2008;28:284-291)

고속철도 터널의 정량적 위험도 분석(QRA)을 위한 세부기준에 관한 고찰

최원일(Choi Won-il),최정환(Choi Jeong-Hwan),문연오(Moon Yeon-Oh),김선홍(Kim Seon-Hong),유호식(Yoo Ho-Sik) 한국암반공학회 2008 터널과지하공간 Vol.18 No.6

철도터널에서의 화재 등과 같은 불의의 사고를 예방하고 사고 발생시에는 피해를 최소화하기 위하여 철도시설에 대한 안전기준이 필요하게 되었으며, 건설교통부(현 국토해양부)에서는 철도시설 안전기준에 관한 규칙(2005년 10월 27일)과 철도시설 안전세부기준(2006년 9월 22일)을 고시하여 일반철도와 고속철도 터널에 적용하도록 하였다. 이러한 방재관련 법규는 터널 방재설비의 과다 및 과소 설계를 방지하기 위하여 5가지 주요시설물(방연문, 배연설비, 대피통로 접속부, 대피통로 간격, 연결송수관 설비)에 대하여 안전성 분석결과에 따라 설치하도록 하여 많은 비용과 시간이 소요되는 방재시설물의 합리적인 설치방안을 제시하였다. 그러나, 안전성 분석방법은 기존 사고사례 및 자료를 토대로 화재강도, 가능한 시나리오, 사건발생 가능성, 사고영향, 사고발생확률 등에 대한 세부적인 분석방법에 따라 안전성 분석 결과의 차이가 크므로 이에 대한 구체적인 기준이 필요하다. 따라서, 본 논문에서는 고속철도 터널 안전성 분석에 대하여 단계별로 세부적인 수행방법을 소개하였으며, 이를 참고하여 합리적인 범위 및 기준을 개발하는 데 어느 정도 기여할 수 있을 것으로 판단된다. To protection of fire accident and to minimize danger of spreading the disaster. in railway tunnel, MCT (the Ministry of Construction and Transportation) published “Rules about the Safety Standard of Railroad (2005.10.27)” and “The Detailed Safety Standard of Railroad (2006.9.22)”. QRA(Quantitative Risk Analysis) results are applied to establish the fire protection facilities in railway tunnel so that institute the reasonable application about the fire safety facilities However, it is difficult to perform the fire safety design due to lack of the detailed standards about event scenario, fire intensity, incidence rate of accidents etc. Therefore, This paper introduces the practical method about detailed standards of QRA.

음식 및 숙박업의 근골격계질환에 대한 실태조사 결과

Won Il Choi(최원일),Day Sung Kim,Jung Hoon Kim,Dong Shik Choi,Yil Woo Kim,Jeung-Ho Kim,Seong-Kyu Kang 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-

The work-related musculoskeletal disorders (WMSDs) have increased at the atypical work of the food & accommodation industry as well as at the regular work such as the manufacturing industry. However, most studies related to WMSDs have focused on the manufacturing industry. This paper investigates WMSDs, their prevention activities and problems in the food & accommodation industry. This study was performed for 160 restaurants/cafeterias or hotels in Gyeongsang province through interviews, document analysis, video analysis, etc., which included jobs of bellman, front-desk, room-maids and cook, etc. Based on the results, administrative or engineering measures for preventing WMSDs were suggested.

터널 정보화 시공을 위한 계측 최적방안 분석

최원일(Choi Won Il),조국환(Cho Kook Hwan),박성욱(Park Sung Wook) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-

D&B method in tunnel construction requires accurate and rapid measurement of the ground movement, which of essential for feedback analysis. Recently, survey technique adapting IT is getting more and more emphasized in the field of construction and tunnel survey also follow the same trend. Case study and adaptability of IT technique for tunnel survey will be discussed in this study. The application of laserscannig method in the field of tunnel construction was reported in several advanced country including Austria and Japan. Survey for the crown and shoulder movements by IT survey method was conducted and the results were compared to those do the conventional method. The pipe-roof, grouting, ring-cut are installed in the this site to prevent expected large ground settlement. The result show that laserscanner system is prefered rather than conventional method in that better understanding for the displacement condition and origin condition was liable by the lasersacnnig method. IT survey solution makes if possible to execute more economic and safe construction.

30대 초반 산모의 임신과 출산에 관한 연구

최원일 ( Won Il Choi ),이희 ( Hee Lee ),양기원 ( Ki Won Yang ),최성은 ( Sung Eun Choi ),강혜주 ( Hye Ju Kang ),김정욱 ( Jeong Wook Kim ),소재성 ( Jae Sung So ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.9

플루로닉(pluronic) 기반의 나노운반체(nano-carrier)에 충진된 카이모파파인(chymopapain)의 척추 추간판 조직내 작용성에 관한 연구

최원일(Choi, Won Il),태기융(Tae, Gi Yoong),홍영기(Hong, Young Ki) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.1

이 연구의 목적은 척추 추간판 융해제인 카이모파파인을 나노캐리어 시스템에 충진시켜 주입시, 추간판내 약제의 확산범위가 감소하는지 평가하기 위한 것이다. 총 3주간 시행된 실험의 재료로는 두 개의 카데바에서 채취된 열다섯 개의 척추 추간판이 쓰였고, 이들은 주입되는 카이모파파인의 종류에 따라 일반 카이모파파인 그룹과 나노캐리어 시스템 그룹으로 나뉘었다. 나노캐리어 시스템 그룹은 다시 그 기반재료가 되는 플루로닉의 종류에 따라 플루로닉 F 127(DA-PF 127) 나노 캐리어 그룹과 플루로닉 F 68(DA-PF 68) 나노캐리어 그룹으로 나뉘었다. 실험결과 나노캐리어 시스템을 사용한 그룹은 일반 카이모파파인 그룹에 비해, 척추 추간판 내부로 주입되었을 때, 주입지점에서 멀리 확산되지 않고 국소적으로 작용하는 특성을 보였다(p<0.01). 이러한 특성은 향후 추간판 내 병소만을 선택적으로 제거하는 최소침습적 척추시술의 기반약제로 응용될 가능성을 제시해준다 The objective of this study is to determine if when chymopapain is loaded onto a nano-carrier, an injection of it reduces the spreading range of the drug within the discs. The materials for the experiment, which were conducted for three weeks, included fifteen intervertebral discs taken from two cadavers, which were divided according to the types of injected chymopapain solutions as follows: ordinary chymopapain group and nano-carrier system group. The nano-carrier system group was again divided into two subgroups according to the types of pluronics, the basic material for the nano-carriers: Pluronic F 127(DA-PF 127) in the nano-carrier group and Pluronic F 68(DA-PF 68) in the nano-carrier group. The results showed that the action of chymopapain using a pluronic-based nano-carrier system was localized around the center of the injection site instead of broad spreading, compared to that of the ordinary chymopapain group (p<0.01). This characteristic suggests a possible application to effective agents for minimally invasive spinal treatment through which disc lesions were removed selectively.