척추체의 골파괴를 일으키는 병소 : 염증성질환 및 악성종양의 전산화단층촬영 소견 과 감별진단

최석진 대한영상의학회 1993 대한영상의학회지 Vol.29 No.5

The CT findings and their differential points were evaluated by reviewing the CT scans of 47 patients with destructive lesions of vertebral bodies which included tuberculous spondylitis (23), pyogenic infection(9), syphilitic spondylitis (1) and malignant lesions(14). Twenty-one (91.3%) of 23 patients with tuberculous spondylitis showed mixed osteolytic and osteosclerotic patterns of bony destruction. Six(66.7%) of 9 patients with pyogenic infection and 10(71.4%) of 14 malignant lesions showed osteolytic pattern of bony destruction. Thirty (90.9%) of 33 infectious lesions including pyogenic infection and tuberculous spondylitis involved intervertebral disc, while the involvement of intervertebral disc was not found in malignant lesions. The Swiss-cheese appearance of bony destruction was commonly seen in tuberculous spondylitis, but pyogenic infections and malignant lesions more commonly revealed geographic or moth-eaten appearance. The sequestral pattern and sclerotic rims in and around bony destruction were mainly seen in tuberculous spondylitis, and they were thought to be specific findings in tuberculous spondylitis. CT of the spine appears to offer the detailed the detailed findings of vertebral body destruction and may be a useful adjunct in differentiation between tuberculous spondylitis, pyogenic infections and malignant lesions of the spine.

대학 환경동아리 실태 분석 연구

최석진,김윤태,류진수 한국환경교육학회 2018 한국환경교육학회 학술대회 자료집 Vol.2018 No.6

자궁경부의 전암 병변 및 침윤성암종에서 Mikdine의 발현 양상

최석진,송은섭,김루시아,박인서,한지영,김준미,주영채 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.2

Background : Midkine (MK) is a member of the heparin-binding growth factor family. Overexpression of MK is observed not only in cancerous tissue but also in precancerous lesions of the colon and the prostate. Using immunohistochemical methods, we investigated MK expression in preinvasive and invasive neoplasia of the uterine cervix. Methods : We performed immunohistochemical analysis of archived cone biopsy and hysterectomy specimens from 161 squamous cell lesions of the uterine cervix (29 cervical intraepithelial neoplasia 1 (CIN1), 35 CIN2, 49 CIN3, 30 microinvasive squamous cell carcinomas (MIC), and 18 invasive squamous cell carcinoma). In addition, we examined if there is a correlation between MK expression and status of human papilloma virus infection determined by a commercially available DNA chip. Results : None of the normal cervical mucosa showed MK immunostaining. The level of MK expression gradually increased according to the histologic grade. Moderate and strong expressions were most frequently observed in cervical tissue with CIN3 and MIC. MK immunostaining was more accentuated in the invasive border of MIC. Conclusion : MK may play a functional role in the disease progression of cervical squamous cell neoplasia.

환경 교육 교수-학습 및 평가 방법 연구·개발

최석진 한국교육과정평가원 2001 교육광장 Vol.8 No.-

Extrapulmonary Small Cell Carcinoma of the Liver: Clinicopathological and Immunohistochemical Findings

최석진,김준미,한지영,안승익,김진수,김루시아,박인서,주영채 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.6

Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature.

Thermal and Morphological Properties of Rigid Polyurethane Foam Using Various Blowing Agents

최석진,김우년,김지문,한미선 한국고분자학회 2007 한국고분자학회 학술대회 연구논문 초록집 Vol.2007 No.4

Preparation of Compact Agarose Cell Blocks from the Residues of Liquid-Based Cytology Samples

최석진,최연일,김루시아,박인서,한지영,김준미,주영채 대한병리학회 2014 Journal of Pathology and Translational Medicine Vol.48 No.5

Background: Inevitable loss of diagnostic material should be minimized during cell block preparation. We introduce a modified agarose cell block technique that enables the synthesis of compact cell blocks by using the entirety of a cell pellet without the loss of diagnostic material during cell block preparations. The feasibility of this technique is illustrated by high-throughput immunocytochemistry using high-density cell block microarray (CMA). Methods: The cell pellets of Sure-Path residues were pre-embedded in ultra-low gelling temperature agarose gel and re-embedded in standard agarose gel. They were fixed, processed, and embedded in paraffin using the same method as tissue sample processing. The resulting agarose cell blocks were trimmed and represented on a CMA for high-throughput analysis using immunocytochemical staining. Results: The SurePath residues were effectively and entirely incorporated into compact agarose cell buttons and embedded in paraffin. Sections of the agarose cell blocks revealed cellularities that correlated well with corresponding SurePath smears and had immunocytochemical features that were sufficient for diagnosis of difficult cases. Conclusions: This agarose-based compact cell block technique enables preparation of high-quality cell blocks by using up the residual SurePath samples without loss of diagnostic material during cell block preparation.

교육으로 환경보전과 지속가능발전

최석진,Choe, Seok-Jin 환경보전협회 2006 환경정보 Vol.28 No.365

액와상완신경총차단술 이후에 발생한 근위정중신경병

최석진,김동건,박경석 대한신경과학회 2016 대한신경과학회지 Vol.34 No.3

An axillary brachial plexus block (BPB) is commonly used in local anesthesia, especially for hand surgery. Infraclavicular brachial plexopathy is a potential complication of axillary BPB. A 44-year-old man with an injury to his left third fingertip presented with weakness of the left thumb and index finger flexion after orthopedic surgery under axillary BPB. This was a rare case of proximal median neuropathy caused by axillary BPB. The diagnosis was confirmed by a detailed neurological examination and electrodiagnostic studies.

객혈 환자의 동맥 색전술 후 재발성 출혈: 재발 기간에 따른 혈관조영술 소견

최석진,전제량,차성숙,Choe, Seok-Jin,Jeon, Je-Ryang,Cha, Seong-Suk 대한영상의학회 2001 대한영상의학회지 Vol.45 No.6

목적: 재발성객혈을 주소로 내원한 환자에서 동맥색전술 후 객혈의 재발기간에 따른 혈관조영술 소견의 차이점을 알아보고자 하였다. 대상과 방법: 1996년 10월부터 2000년 6월까지 객혈을 주소로 내원하여 동맥색전술을 시행 후 객혈이 재발하여 동맥색전술을 재시행한 18명의 환자(동맥색전술을 재시행한 횟수 : 23회)를 대상으로 하였다. 재발기간을 2주 이내(Group I)와 2주 이후(Group II)로 분류하고 처음 동맥색전술과 추가 동맥색전술의 소견, 공급혈관의 구성, 공급혈관의 성격 등을 후향적으로 비교분석하고 Chi-square test를 이용하여 두 군의 통계학적 유의성을 알아보았다. 결과: I군은 9명(Group I, 색전술 시행 n=10)이며 II군은 9명(Group II, 색전술 시행 n=13)이었다. I군(혈관조영술 이상소견 n=29)에서 직접소견을 보인 경우가 2예, 간접소견을 보인 경우가 27예였으며 II군(혈관조영술 이상소견 n=31)에서 직접소견을 보인 경우가 2예, 간접소견을 보인 경우가 29예로 객혈을 시사하는 여러 혈관조영술 소견이 두군간에서는 통계학적 유의성을 보이지 않았다(x$^2$=0.005, p=0.945). 객혈을 유발하는 공급혈관의 구성에서, I군(총 공급혈관수 n=30)에서 기관지동맥이 원인이 되어 객혈을 한 경우는 20개, 체측부동맥이 원인이 되어 객혈을 한 경우는 10개였으며 II군(총 공급혈관 n=35)에서 기관지동맥이 원인이 되어 객혈을 한 경우는 21개, 체측부동맥이 원인이 되어 객혈을 한 경우는 14개로 역시 공급혈관의 구성에서도 두군간에서는 통계학적 유의성을 보이지 않았다(x$^2$=0.308,p=0.579). 공급혈관의 성격에서, I군(추가 동맥색전술시행 수 n=10)에서 재발성 객혈을 유발한 새로운 공급혈관이 1예(10.0%),예전 공급혈관이 5예(50.0%), 놓친 혈관이 4예(40.0%)였으며, II군(추가 동맥색 전술시행 수 n=13)에는 재발성 객혈을 유발한 새로운 공급혈관은 없었으며 예전 공급혈관이 12예(92.3%),놓친 혈관이 1예(7.7%)로 통계학적 유의성은 없었으나 빈도면에서 2주 이후 객혈이 재발한 환자의 경우 재발성 객혈의 유발인자로 예전 공급혈관이 많았다(x$^2$=5.383, p=0.068). 결론: 재발성 객혈환자에서 재발기간에 따라 혈관조영술 소견과 공급혈관의 구성은 차이가 없었으나 출혈혈관 성격에서는 차이를 보였다. 2주 이후 재발된 객혈에서 예전에 색전술을 시행하였던 공급혈관이 재개통되어 다시 공급혈관으로 관찰되는 경우가 2주 이내 재발성 객혈보다 많았다. Purpose: To describe the angiographic findings of patients with recurrent hemoptysis after bronchial artery embolization (BAE) according to the point at which relapse occurred. Materials and Methods: From 125 patients who underwent BAE due to hemoptysis between 1996 and 2000, we selected 18 of 23 who underwent additional BAE due to recurrent bleeding after initial BAE . Depending on the point at which relapse occurred, they were divided into two groups (I and II, according to whether additional BAE was performed within two weeks of initial BAE or more than two weeks after this). We retrospectively compared the two groups in terms of angiographic findings, number of embolized arteries, and character of feeding arteries at initial and additional BAE. Results: Nine patients in group I (additional BAE: n=10) and nine in group II (additional BAE: n=13) were admitted for recurrent hemoptysis within two weeks of initial BAE and more than two weeks after this, respectively. In group I(n=29) and II(n=31), angiography demonstrated two direct and 27 indirect, and two direct and 29 indirect signs of hemorrhage, respectively. No statistically significant differences were observed (x$^2$=0.005, p=0.945). Among the embolized feeder ressels in group I (n=30) there were 20 bronchial artery and 10 non bronchial systemic collaterals, while for group II(n=35), the corresponding totals were 21 and 14. Again, no statistically significant differences were encountered(x$^2$=0.308; p=0.579). In group I, feeders were newly developed in one case(10%), previously embolized in five(50%), and missed in four(40%), while in group two the corresponding figures were none, twelve(92.3%), and one(7.7%). No significant differences were noted, though the incidence of previously embolized feeders in Group II was very high (x$^2$=5.383,p=0.068). Conclusion: Among patients in whom hemoptysis after BAE recurred at different times, the angiographic findings and number of embolized arteries were not significantly different, but differences in the nature of the feeder were noted. Patients in whom hemoptysis recurred more than two weeks after BAE showed more recanalization of previously embolized feeders than those in whom there was recurrence within two weeks.