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쌍생아에서 발생한 선천성 Hyperekplexia 1례
최봉석,김영미,이윤진,박수은,남상욱,Choi, Bong Seok,Kim, Young Mi,Lee, Yun Jin,Park, Su Eun,Nam, Sang Ook 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.10
저자들은 수유 중 우연히 발견된 전신 과긴장성과 자극에 대한 과도한 반응을 나타내는 일란성 쌍생아를 hyperekplexia로 진단하고 치료한 경험을 문헌 고찰과 함께 보고하는 바이다. Hyperekplexia or startle disease is a hereditary neurological disorder characterized by an abnormally exaggerated startle response to tactile, auditory and visual stimuli, together with a global muscular hypertonia and hyperactive tendon reflexes. This disease is a rare, genetically determined disorder, with an autosomal dominant inheritance with variable expression, first described by Suhren, et al. We report two cases of familial hyperekplexia, who developed hypertonia and pathologic startle response to tactile stimulation in the immediate neonatal period. The infant showed a marked improvement of the startle response and muscular hypertonia with low-dose clobazam.
신세뇨관 확장증, Caroli 증후군 및 총 담관낭을 동반한 선천성 간 섬유증 1례
최봉석,배상남,임영탁,박재홍,이창훈,이준우,Choi, Bong Seok,Bae, Sang Nam,Im, Yong Tak,Park, Jae Hong,Lee, Chang Hoon,Lee, Jun Woo 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.7
우연히 발견된 간비장 종대를 주소로 내원한 3세 여아에서 신낭종을 동반한 선천성 간섬유화증을 진단한 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Congenital hepatic fibrosis is a relatively rare disease, characterized by bile ductular proliferation and prominent fibrosis in the portal area of liver resulting in portal hypertension. It is frequently associated with other abnormalities such as polycystic kidney, Caroli syndrome, cystic dysplasia of pancreas, intestinal lymphangiectasia, pulmonary emphysema, hemangioma, and cleft palate. We report here a case of congenital hepatic fibrosis associated with renal tubular ectasia in a 3-year-old girl, whose chief complaint was abdominal distension. Her liver function test did not reveal any abnormal findings. Hepatosplenomegaly and multiple dilated bile ducts were seen in the abdominal CT scaning. Esophageal varix was not detected by an endoscopic examination. Microscopically, diffuse portal fibrosis and widening with proliferation of blie ductules in the liver specimen and tubular ectasia in renal cortex were seen.
수열합성법에 의해 합성된 수산화아파타이트 결정의 입자 형상에 관한 EDTA의 영향
최봉석,김동현,김태완,박홍채,윤석영,Choi, Bong-Seok,Kim, Dong-Hyun,Kim, Tae-Wan,Park, Hong-Chae,Yoon, Seog-Young 한국결정성장학회 2011 한국결정성장학회지 Vol.21 No.2
Hydroxyapatite (HAP) crystals with hexagonal structure have been successfully synthesized by using EDTA(ethylene diamine tetraacetic acid) as chelate under hydrothermal condition. The as-prepared HAp powders were characterized by XRD and SEM. The XRD result indicated that the products were preferentially oriented along c-axis. The SEM photographs showed that the morphology of the HAp crystals was well controlled by the reaction parameters such as temperature, pH value, and the molar ratio of EDTA/Ca. 육방정계 구조를 가지는 수산화아파타이트 결정은 킬레이트 착화합물을 형성 할 수 있는 EDTA(ethylene diamine tetraacetic acid)를 이용하여 수열조건에서 합성 하였다. 제조된 분말은 X-선 회절 패턴 및 주사전자현미경에 의해 특성 평가 하였다. 제조된 수산화아파타이트 분말은 육방정계 구조의 c축에 따라 결정이 성장하였고, 결정의 형상은 수열온도, pH, EDTA/Ca 및 출발물질의 Ca/P 몰 비와 같은 반응 파라메타에 의해 제어 되었다.
약물 방출 시스템으로서 이부프로펜/클레이 유-무기 나노복합체의 층간삽입 거동 연구
최봉석,김동현,김태완,진형호,박홍채,윤석영,Choi, Bong-Seok,Kim, Dong-Hyun,Kim, Tae-Wan,Jin, Heoyng-Ho,Park, Hong-Chae,Yoon, Seog-Young 한국결정성장학회 2011 韓國結晶成長學會誌 Vol.21 No.6
본 연구는 지속적 약물방출 전달체로서의 클레이 내의 재결정화 된 이부프로펜 층간삽입 거동에 대해 주안점을 두었다. 이부프로펜의 층간삽입 거동은 X-선 회절 및 열 중량 분석을 통해 확인하였다. 클레이의 기저 공간은 이부프로펜 분자에 의해 1.2 nm에서 1.5 nm까지 증가하였다. 또한 클레이 내부 공간 층에 존재하는 이부프로펜의 부분 운동은 이부프로펜/클레이 나노복합체의 열적 안정성을 증가시켰다. 나노복합체의 in vitro 약물방출 결과는 이부프로펜이 클레이로부터 일정하게 방출됨을 보였다. This research focused on the intercalation behavior of recrystallized ibuprofen into clay as a sustained release drug carrier. The intercalation behaviors of ibuprofen were determined by X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The basal spacing ($d_{001}$) of clay increased from 1.2 nm to 1.5 nm by ibuprofen molecules. The segmental motion effect of ibuprofen into the clay interlayer spacing also increased the thermal stability of the ibuprofen/clay nanocomposites. The in vitro drug release results of nanocomposites showed that ibuprofen was released from clay steadily.
최봉석(Bong-Seok Choi) 한국토지공법학회 2003 土地公法硏究 Vol.19 No.-
As the advert of capital society divided the production function, and consumption in the family, family's living expenses and supporting the elder members of the family became to be dependent on the male's labor income. Thus, it created a contradiction between the family law of civil society and the distributive system of capitalism, leading to a requirement of a new law, arising from the sociologicaldimension for survival as well as family supportiveness. In addition, as the capital society became systemized by the mechanism, mass production, and urbanization, it created many social risks that threatened the existence of the laborers. The systemic social change such as industrialization and capitalization caused incongruity between social structure and individual, but furthermore, as poverty became a subject of a social problem, social assistance was introduced. In addition, due to a newly formation of classes within urban industrial sector, problems such as unemployment, labor accident, poor working condition became social problem. Therefore the principle of social insurance was introduced within the pivot of laborers. As social relations became complicated,due to difficulties arising in the absence of knowledge in prevention as well as unavailability of methods, individuals'everyday social risk could not be relieved via compensation system. Society required a new system that was able to link the individuals and organizations, hence various social security programsand human services(social insurance system) came to existence. This new management of the risk and efforts to solve the social · economic alienation, became systemized, and gave birth to social welfare law in order to secure it. After all, social welfare law can be understood as a sphere that copes with new social phenomenon that can not be translated or solved by existing law which has been sustained capital society. Social welfare law could be produced as the social welfare's origin such as relief and mutual aid became institutionalized. It can be saidthat social welfare law has been formed, changed, developed, created, replaced and disappeared with industrialization, capitalistic development, and political, economical, social and cultural system. Social welfare law has been developed from the narrow social welfare law to a broad social welfare law that serves not only to the people who are in poor condition but also to meet every citizen's basic need. Furthermore, social welfare law is developing to broadest meaning that secures every citizen's life in the optimum level and secures minimum level of life of foreigner in the country based on interdependence at the same time. This article tried to find how developed countries developed social welfare law under the political, economical, social and cultural environment in relation of social welfare forming process. And it tried to analyze socio-political movement, causes of development and condition of social welfare's law by analyzing Korea's laws administration.