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진혜미,조금준 ( Geum Joon Cho ) 대한주산의학회 2015 Perinatology Vol.26 No.3
Vitamin D deficiency is a global health problem that increases risk for metabolic bone diseases in children and adults as well as many chronic illnesses including autoimmune diseases, type 2 diabetes, cardiovascular disease, infectious disease, and cancer. This has raised important questions concerning the physiological and clinical impact of low vitamin D levels during pregnancy, with implications for functions of vitamin D. The review describes the pathways that are required for metabolism and function of vitamin D, the various clinical complications that have been linked to impaired vitamin D status during pregnancy, and effects of vitamin D supplementation on maternal and neonatal outcomes.
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김정철,진혜미,조영난,권용수,기승정,박용욱 대한의학회 2015 Journal of Korean medical science Vol.30 No.5
Mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells are known to play crucial roles in a variety of diseases, including autoimmunity, infectious diseases, and cancers. However, little is known about the roles of these invariant T cells in acute cholecystitis. The purposes of this study were to examine the levels of MAIT cells and NKT cells in patients with acute cholecystitis and to investigate potential relationships between clinical parameters and these cell levels. Thirty patients with pathologically proven acute cholecystitis and 47 age- and sex-matched healthy controls were enrolled. Disease grades were classified according to the revised Tokyo guidelines (TG13) for the severity assessment for acute cholecystitis. Levels of MAIT and NKT cells in peripheral blood were measured by flow cytometry. Circulating MAIT and NKT cell numbers were significantly lower in acute cholecystitis patients than in healthy controls, and these deficiencies in MAIT cells and NKT cell numbers were associated with aging in acute cholecystitis patients. Notably, a reduction in NKT cell numbers was found to be associated with severe TG13 grade, death, and high blood urea nitrogen levels. The study shows numerical deficiencies of circulating MAIT and NKT cells and age-related decline of these invariant T cells. In addition, NKT cell deficiency was associated with acute cholecystitis severity and outcome. These findings provide an information regarding the monitoring of these changes in circulating MAIT and NKT cell numbers during the course of acute cholecystitis and predicting prognosis.
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권용수,조영난,김문주,진혜미,기승정,박용욱 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-
Background: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the detailed information of MAIT cells in patients with mycobacterial infection. Methods: Patients with pulmonary tuberculosis (TB; n=35), nontuberculous mycobacterial lung disease (NTM; n=29), and healthy controls (n=75) were enrolled in the study. MAIT cell levels and functions were measured by flow cytometry. Results: Circluating MAIT cell levels were found to be reduced in TB and NTM patients. Serum C-reactive protein was an independent predictor of MAIT cell deficiency. MAIT cells in TB patients failed to produce interferon-γ irrespective of the mode of stimulation, whereas NTM patients displayed a defect in MR1-dependent signaling pathway. TB patients showed the positive correlation between MAIT cell levels and natural killer T (NKT) cell levels. In vitro experiments revealed that MAIT cell dysfunction was related to NKT cell dysfunction. Notably, an elevated expression of programmed death-1 was associated with MAIT cell deficiency in TB. Conclusions: This study shows that MAIT cells are numerically and functionally deficient in TB and NTM patients and these deficiencies could contribute to immune system dysreguation in mycobacterial infection.Background: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the detailed information of MAIT cells in patients with mycobacterial infection. Methods: Patients with pulmonary tuberculosis (TB; n=35), nontuberculous mycobacterial lung disease (NTM; n=29), and healthy controls (n=75) were enrolled in the study. MAIT cell levels and functions were measured by flow cytometry. Results: Circluating MAIT cell levels were found to be reduced in TB and NTM patients. Serum C-reactive protein was an independent predictor of MAIT cell deficiency. MAIT cells in TB patients failed to produce interferon-γ irrespective of the mode of stimulation, whereas NTM patients displayed a defect in MR1-dependent signaling pathway. TB patients showed the positive correlation between MAIT cell levels and natural killer T (NKT) cell levels. In vitro experiments revealed that MAIT cell dysfunction was related to NKT cell dysfunction. Notably, an elevated expression of programmed death-1 was associated with MAIT cell deficiency in TB. Conclusions: This study shows that MAIT cells are numerically and functionally deficient in TB and NTM patients and these deficiencies could contribute to immune system dysreguation in mycobacterial infection.
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조영권,최현정,김정철,조영난,강정화,진혜미,기승정,박용욱 대한의학회 2017 Journal of Korean medical science Vol.32 No.5
Mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells are known to play important roles in autoimmunity, infectious diseases and cancers. However, little is known about the roles of these invariant T cells in multiple trauma. The purposes of this study were to examine MAIT and NKT cell levels in patients with multiple trauma and to investigate potential relationships between these cell levels and clinical parameters. The study cohort was composed of 14 patients with multiple trauma and 22 non-injured healthy controls (HCs). Circulating MAIT and NKT cell levels in the peripheral blood were measured by flow cytometry. The severity of injury was categorised according to the scoring systems, such as Acute Physiology and Chronic Health Evaluation (APACHE) II score, Simplified Acute Physiology Score (SAPS) II, and Injury Severity Score (ISS). Circulating MAIT and NKT cell numbers were significantly lower in multiple trauma patients than in HCs. Linear regression analysis showed that circulating MAIT cell numbers were significantly correlated with age, APACHE II, SAPS II, ISS category, hemoglobin, and platelet count. NKT cell numbers in the peripheral blood were found to be significantly correlated with APACHE II, SAPS II, and ISS category. This study shows numerical deficiencies of circulating MAIT cells and NKT cells in multiple trauma. In addition, these invariant T cell deficiencies were found to be associated with disease severity. These findings provide important information for predicting the prognosis of multiple trauma.
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