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연구논문 : C형간염바이러스 유전자형 1b에 감염된 한국인 환자에서 인터페론 감수성 결정 영역의 유전자 돌연변이 양상
진영주 ( Young Joo Jin ),박윤경 ( Yoon Kyung Park ),윤귀준 ( Gui Jun Yun ),이한주 ( Han Chu Lee ),정숙향 ( Sook Hyang Jeong ),김강모 ( Gang Mo Kim ),임영석 ( Young Suk Lim ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ),서 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2
Background/Aims: The treatment response to interferon could differ with mutations in the interferon-sensitivity-determining region (ISDR) in patients infected with hepatitis C virus (HCV) genotype-1b (HCV-Ib). We examined the pattern of ISDR mutations and analyzed whether the number of amino acid substitutions influences the treatment response to peginterferon plus ribavirin in chronic hepatitis or cirrhotic patients infected with HCV-Ib. Methods: The study population comprised 52 patients who visited Seoul Asan Medical Center and Seoul National University Bundang Hospital from January 2006 to December 2008 and who received peginterferon alpha-2a (n=37) or -2b (n=15) plus ribavirin, and whose serum was stored. We analyzed the early virologic response, end-of-treatment response, and sustained virologic response (SVR), and examined the ISDR using direct sequencing. Results: The proportions of patients with ISDR mutation types of wild (0mutations), intermediate (1-3 mutations), and mutant (≥4 mutations) were 50.0%, 42.3%, and 7.7%,respectively, and the corresponding SVR rates were 63%, 50%, and 67% (p>0.05). The SVR rates were 59.4% and 50.0% in patients with <2 and ≥2 mutations, respectively (p>0.05). On univariate analysis, age was the only predictive factor for SVR (p=0.016). The pretreatment HCV RNA titer tended to be lower in those with SVR, but without statistical significance (p=0.069). Conclusions: The frequency of ISDR mutations was low in our cohort of Korean patients infected with HCV-Ib. Therefore, ISDR mutations might not contribute to the response to treatment with peginterferon plus ribavirin.
진영주 ( Young-joo Jin ) 대한내과학회 2020 대한내과학회지 Vol.95 No.5
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and is characterized by fat accumulation at levels exceeding 5% in hepatocytes due to insulin resistance. The disease spectrum ranges from simple nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH)/NASH-related fibrosis or cirrhosis defined by histological findings. Unlike simple NAFL, NASH/NASH-related fibrosis or cirrhosis increases the risk of liver-related morbidity or mortality. Therefore, accurate diagnosis of NASH/NASH-related fibrosis or cirrhosis is needed for management of patients with these diseases. Currently, liver biopsy is the only way to confirm the presence of NASH in an individual with features of NAFLD, but this has some limitations, including sample error, interpretation error, and the invasiveness of the procedure. Therefore, there have been a number of attempts to develop noninvasive methods for differential diagnosis of NASH/NASH-related fibrosis or cirrhosis easily and quickly. Here, we review the assessments for diagnosing NAFLD and the methods for differential diagnosis of NASH/NASH-related fibrosis or cirrhosis. (Korean J Med 2020;95:299-307)
진영주 ( Young Joo Chin ),임정묵 ( Joung Muk Leem ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3
Background/Aims: Galanin is distributed in enteric nerve terminals throughout the gastrointestinal tract. However, the effect of galanin on colonic motility in isolated colon is still unknown. Using isolated, vascularly perfused rat colon, we investigated the role of galanin on colonic motility, the difference in the effect of galanin between proximal and distal colon, and the innervation of the action of galanin on colonic motility (cholinergic or adrenergic input). Methods: An isolated rat colon was placed in temperature-controlled water bath and vascularly perfused with Krebs solution. After a controlled period, galanin was administered intraarterially and the intraluminal pressure was monitored via microtip catheter pressure transducers at the proximal and distal colon. After pretreatment of phentolamine, propranolol, hexamethonium or atropine, respectively, galanin was infused at a concentration of 240 pM and intraluminal pressure was monitored. The contractile response was expressed as % changes of motility indices over basal period. Results: Galanin significantly increased colonic motility (p<0.01). The contractile response was more potent at the distal colon but the difference was statistically insignificant (p>0.05). The stimulating effect was not inhibited by phentolamine, propranolol, hexamethonium but significantly inhibited by atropine. Conclusions: Galanin increases rat colonic motility and the action of galanin is influenced by cholinergic input. (Korean J Gastroenterol 2003;41:196-203)
급성 아황산가스 폭로후 흰쥐의 폐에 유발된 염증반응에 관한 연구
진영주 ( Young Joo Chin ),박남규 ( Nam Gyu Prak ),이현숙 ( Hyean Suk Lee ),김대수 ( Dae Soo Kim ),엄재호 ( Jae Ho Earm ),조명찬 ( Myeong Chan Cho ),윤세진 ( Sei Jin Yoon ),정화숙 ( Hwa Sook Jeong ),송형근 ( Hyung Geun Song ),성노 대한결핵 및 호흡기학회 1994 Tuberculosis and Respiratory Diseases Vol.41 No.4
기관과 기관지내 다발성 점막 병변을 동반한 Churg-Strauss 증후군
부선진 ( Sun Jin Boo ),이광하 ( Kwang Ha Lee ),나승원 ( Seung Won Ra ),진영주 ( Young Joo Jin ),박경민 ( Gyung Min Park ),홍상범 ( Sang Bum Hong ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.5
Churg-Strauss syndrome is a rare form of systemic necrotizing vasculitis that occurs exclusively in patients with asthma, and is associated with blood and tissue eosinophilia. The classic pathology findings in the lung include a combination of eosinophilic pneumonia, granulomatous inflammation and necrotizing vasculitis. However, there are few reports of tracheobronchial mucosal lesions in Churg-Strauss syndrome. We report a case of Churg-Strauss syndrome with multiple tracheobronchial mucosal lesions in a 33-year-old man with a history of bronchial asthma and allergic rhinitis. He had been diagnosed with community acquired pneumonia at another hospital and was treated with antibiotics. However, the chest radiographic findings were aggravated and showed multifocal consolidations in the whole lung fields. He was transferred to the Asan Medical Center. Fiberoptic bronchoscopy revealed multiple nodular mucosal lesions of the trachea and bronchi. The histopathology of the mucosal lesions revealed necrotizing bronchial inflammation with eosinophilic infiltration. Video Assisted Thoracic Surgery was performed. The wedge resected lung tissue revealed chronic eosinophilic pneumonia that was consistent with Churg-Strauss syndrome. Methylprednisolone (1 mg/kg q 8 hr) was prescribed and his symptoms resolved gradually. The chest radiographic findings improved significantly, and a follow-up fiberoptic bronchoscopy performed eight days later showed that the tracheobronchial mucosal lesions had resolved. The patient was prescribed oral prednisolone for 20 months after discharge. Currently, the patient is not taking steroids and is being followed up. (Tuberc Respir Dis 2008;65:405-409)
Inverse Effort Dependence 가 노력성호기류량의 측정에 미치는 영향
김대수(Dae Soo Kim),이현숙(Hyeon Suk Lee),진영주(Young Joo Chin),엄재호(Jae Ho Earm),조명찬(Myeong Chan Cho),윤세진(Sei Jin Yoon),이상도(Sang Do Lee) 대한내과학회 1995 대한내과학회지 Vol.48 No.6
N/A Objectives: During forced expiratory vital capacity maneuvers, if volume is measured at mouth instead of body surface, the flow during the effort independent portion becomes inversely effort dependent. This negative effect largely depends on compression of thoracic gas and has been termed inverse effort dependence. We performed this study to determine how the test results of FEV1, FEF25-75, FEF25, FEF50, and FEF75 are affected by effort. Methods: We compared the test results selected by effort based criteria(highest PEFR) with that selected by volume based criteria(ATS criteria). And we also studied the correlations between effort dependent changes of each paramaters. Randomly sampled routine pulmonary function test results obtained from 50 normal subjects and 45 subjects with obstructive pulmonary disease were analyzed. Results: 1) In both normal and abnormal group, selection based on the highest PEFR resulted in a decline of mean FEV1 compared to volume based criteria(p< 0.01), and was accompanied by an even more significant, decrease of FVC(p<0.01). 2) In both normal and abnormal group, there was no significant difference in FEF25-75 FEF25, FEF50, and FEF75 between volume based criteria and effort based criteria. 3) In both normal and abnormal group, there was no significant correlation between relative change of PEFR and effort dependent change of FEV1. 4) In normal group there was significant between effort dependent change of FEV1 and accompanying change of FVC(r=0.55, p<0.01). 5) In abnormal group there was significant, correlation between effort dependent change of FEV1 and accompanying change of FVC (r=0.69, p<0.01). Conclusion: It can be concluded that FEV is little affected by effort once the lungs are fully inflated and FEF25-75, FEF25, FEF50, and FEF75 are not affected significantly by inverse effort dependence in clinical practice.
사례보고 : 중증 간질환을 동반한 적혈구조혈성 포르피린증 환자에서의 cholestyramine 치료: 사례보고
유동준 ( Dong Jun Yoo ),이한주 ( Han Chu Lee ),유은실 ( Eunsil Yu ),진영주 ( Young Joo Jin ),심주현 ( Ju Hyun Shim ),김강모 ( Kang Mo Kim ),임영석 ( Young Suk Lim ),정영화 ( Young Hwa Chung ),이영상 ( Yung Sang Lee ),서동진 ( Dong 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.1
EPP는 ferrochelatase의 결핍이나 활성 감소로 프로토포르피린이 적혈구, 간, 혈장 등에 축적되는 유전질환이다 축적된 프로토포르피린은 EPP의 주된 임상적 특징인 광과민 증상과 간질환을 일으키게 된다. EPP로 인한 간질환에 대해 다양한 치료법이 개발되고 있으나, 효과적인 치료 방법은 아직 없다. 그 중 cholestyramine resion의 유용성에 대한 보고는 드물며, 다른 치료와 같이 대부분 사용되었다. 저자들은 cholestyramine resion의 단독치료로 성공적인 결과를 나타낸 사례를 보고하는 바이다. 향후 EPP로 인한 간질환의 증상 및 예후 개선을 위해서, 이번 사례를 포함한 더 많은 연구가 필요하다. Erythropoietic protoporphyria (EPP) is a rare disorder of heme biosynthesis caused by mutations in the gene encoding the enzyme ferrochelatase. In EPP, deficient ferrochelatase activity leads to the excessive production and biliary excretion of protoporphyrin (PP). The major clinical features of EPP are photosensitivity and hepatobiliary disease that may progress to severe liver disease, that are caused by the toxicity of PP. EPP-related liver disease has been treated medically or surgically including liver transplantation. We described a 20-year-old male with severe liver disease who was diagnosed with EPP based on clinical and laboratory findings. He was treated with cholestyramine resin. Six months after the treatment, he was doing well without any abdominal pain or photosensitivity. (Korean J Hepatol 2010;16:83-88)
이현숙(Hyeon Suk Lee),김대수(Dae Soo Kim),진영주(Young Joo Chin),윤세진(Sei Jin Youn),송형근(Hyeong Keun Song),성노현(Ro Hyun Sung),이동호(Dong Ho Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.3
Squamous cell papilloma of the esophagus that originates from esophageal mucosa is rare, benign tumor. The etiology is unknown. The endoscopic appearance of the squamous cell papilloma is seen as a benign sessile lesion projecting from the esophageal wall. Patients are free of symptoms directly attributable to the lesion and usually is an incidental finding at endoscopy. We observed endoscopically 5 cases of squamous cell papilloma of the esophagus and endoscopical therapy was performed 3 cases. So, the relevant literatures on the subject were reviewed. (Korean J Gastroenterol 1995;27:356 - 360)