국내 종합병원 병동부 휴게공간의 이용행태에 관한 조사 연구

지혜진,양내원 한국의료복지시설학회 2007 의료·복지 건축 Vol.13 No.2

The most recent study of the hospital design indicates that the researchers focus more on creating the healing environment within the hospital facility. Furthermore, it demonstrates the environment of individual living space for patients such as hospital wards becomes much more significant. This study seeks to analyze how various configurations and compositions of the resting space in the general hospital in Korea affect on patients in the aspect of healing environment and its treatment provided within the facility. The behavior of patients and their family members are analyzed thru the observation and the surveying process in order to find out the level of satisfaction and their demand for the healing environment in the resting space such as day-rooms, corridors and external garden. Finally, the purpose of this study is to create the principles of architectural composition for the healing environment in the hospital design.

기도상피세포에서 Mentha piperita 발효물에 의한 MUC5AC 억제 효능

지혜진(Hye Jin Jee),Katrina Joy Bormate,임옥(Ok Lim),정이숙(Yi-Sook Jung) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.4

본 연구에서는 다양한 치료적 효능이 보고된 페퍼민트의 효능을 증진하기 위하여 유산균으로 발효하여 페퍼민트 추출발효물(FEP)을 수득하였으며, FEP의 점액 과다분비에 대한 조절 효능을 확인하고 그 기전을 규명하여 호흡기 개선에 활용될 수 있도록 정확한 용량과 효능 관계를 증명하고자 한다. 먼저 FEP는 PMA에 의해 증가한 MUC5AC의 유전자 발현 및 단백질 분비를 농도 의존적으로 억제하였으며 100 μg/mL의 농도에서 가장 효과적이었다. 이러한 억제기전은 MUC5AC 발현에 주로 관여하는 것으로 알려진 ERK/MAPK 신호전달 체계를 통해 이루어지는 것으로 추정할 수 있다. 또한 FEP의 항산화 효능을 관찰한 결과 농도 의존적인 DPPH 라디칼 소거능에 대한 효능과 ROS 억제 능력을 통해 FEP의 항산화능이 우수함을 확인하였다. 이러한 결과는 FEP가 PMA에 의해 증가한 MUC5AC의 유전자 발현을 억제하고 ERK의 활성을 억제하여 활성산소 생성조절에 관여한다. 이를 통해 FEP가 점액 과분비를 억제할 수 있는 새로운 조절제로서의 활용 가능성이 있음을 시사한다. 또한 페퍼민트의 호흡기 개선 기능을 확인하여 기능성 허브 소재로 개발한다면 현대인의 건강증진 및 기능성식품 산업발전 모두에 기여할 수 있을 것으로 사료된다. Airway mucus hypersecretion is an important clinical manifestation of asthma and can be elicited by a wide variety of endogenous and exogenous stimuli leading to airway constriction and worsening of the disease. Gene expression for MUC5AC, a principal component of mucin, is known to significantly increase in the epithelial cells of patients with asthma. Therefore, many studies have proposed that regulating the MUC5AC expression in airway epithelial cells could be a target candidate as therapy for asthma treatment. Mentha piperita, also known as peppermint, is a popular medicinal herb due to its various pharmacological uses, and polyphenolic components with strong antioxidant activity. Based on these studies, we investigated whether peppermint could improve airway function through its inhibitory effect on phorbol myristate acetate (PMA)-induced expression of MUC5AC in NCI-H292 cells, a human airway epithelial cell line. Peppermint leaves were sourced from Herb Island and fermented with Bacillus subtillis. The fermented extract of peppermint (FEP) significantly reduced PMA-induced MUC5AC mRNA expression and protein release. FEP also inhibited the phosphorylation of extracellular signal regulated kinases (ERK) and U0126 (ERK inhibitor) inhibited PMA-induced MUC5AC expression and secretion. FEP also inhibited reactive oxygen species (ROS) production, and Trolox, a ROS scavenging agent, inhibited PMA-induced MUC5AC mRNA expression and protein secretion through the inhibition of ERK activation. These results suggest that FEP can protect the respiratory tract from inflammatory damage by reducing mucus hypersecretion through the ERK signaling pathway and antioxidant activity.

공자 『논어』 에 나타난 음악교육의 당위성 연구

지혜진 ( Ji Hyejin ) 미래음악교육학회 2017 미래음악교육연구 Vol.2 No.1

본 연구는 『논어』 에 나타난 공자의 음악사상에 대해 고찰하고, 그 것을 바탕으로 음악교육의 당위성에 대한 논리적 근거를 탐구하는데 목적을 두었다. 『논어』 에 나타난 음악과 관련구절은 전체 521장 중 23장이며, 공자의 음악사상을 바탕으로 해석하여 얻은 음악교육의 당위성은 다음과 같다. 첫째, 공자는 음악과 더불어 생활하며, 음악을 통하여 자신의 생각과 감정을 표현하고, 타인의 음악적 표현을 이해하고 공감하며 소통하였다. 이러한 태도는 음악적 감성과 소통하는 능력을 향상시켜 음악으로 인해 풍요로운 삶을 유지할 수 있도록 하였다. 둘째, 공자는 도덕적 가치로서의 음악을 중요시 하였으며, 음악 안에 인과 덕이 담겨 있다고 여겼다. 즉, 음악은 내면적 인격의 표현으로서 음악을 통해 훌륭한 인격의 경지에 도달할 수 있다 하였다. 셋째, 공자는 음악과 사람의 감정은 밀접한 관계가 있으며, 음악을 통하여 사회를 조화롭게 하고 통합시킬 수 있다고 하였다. 그는 인간과 사회에 기여하는 사회적 가치로서의 음악을 중요시 여겼다. 공자의 음악교육의 목적은 단순히 즐거움을 위한 것이 아닌, 올바른 인격을 완성하게 되는 것으로 비로소 이상적인 사회를 이룩하는 것이다. The aim of this study was to examine the musical thoughts of Confucius expressed in “The Analects,” and to explore the logical basis of the justification of musical education based on such consideration. The justification of musical education found in the idea of Confucius was as follows. First, Confucius` life was with music. He expressed his thoughts and feelings through music, and understood and sympathized with the musical expression of others. Such an attitude of expressing, appreciating, and living with music helps improve the ability to communicate through musical sensibility, which leads to a rich life through music. Second, Confucius considered music as a moral value as an important aspect, and regarded music containing benevolence and virtue. In other words, music is an expression of internal personality, and people can reach the stage of excellent personality through music. Last, Confucius asserted music was closely related to human emotion, and our emotion could be either purified or exacerbated through music. Thus, music seeks for the harmonization and unity of the society. His purpose of musical education was not only to seek pleasure, but to accomplish an ideal society, through the completion of proper personalities.

차량 리어 스포일러를 위한 딥러닝 기반 제너레이티브 디자인

이정훈(Junghun Lee),장승헌(Suenghun Jang),진아현(Ah-hyeon Jin),강남우(Namwoo Kang) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.5

대화형 인공지능을 활용한 수리 가능한 무기체계 필드 데이터 기반 고장율 분석 방안

성형민,지혜진,이학재,김현서,우민규 한국신뢰성학회 2023 한국신뢰성학회 학술대회논문집 Vol.2023 No.6

수학적 모델을 이용한 신종인플루엔자 환자 예측 및 대응 전략 평가

서민아,이지현,지혜진,김영근,강대용,허남욱,하경화,이동한,김창수,Suh, Min-A,Lee, Jee-Hyun,Chi, Hye-Jin,Kim, Young-Keun,Kang, Dae-Yong,Hur, Nam-Wook,Ha, Kyung-Hwa,Lee, Dong-Han,Kim, Chang-Soo 대한예방의학회 2010 예방의학회지 Vol.43 No.2

Objectives: The pandemic of novel influenza A (H1N1) virus has required decision-makers to act in the face of the substantial uncertainties. In this study, we evaluated the potential impact of the pandemic response strategies in the Republic of Korea using a mathematical model. Methods: We developed a deterministic model of a pandemic (H1N1) 2009 in a structured population using the demographic data from the Korean population and the epidemiological feature of the pandemic (H1N1) 2009. To estimate the parameter values for the deterministic model, we used the available data from the previous studies on pandemic influenza. The pandemic response strategies of the Republic of Korea for novel influenza A (H1N1) virus such as school closure, mass vaccination (70% of population in 30 days), and a policy for anti-viral drug (treatment or prophylaxis) were applied to the deterministic model. Results: The effect of two-week school closure on the attack rate was low regardless of the timing of the intervention. The earlier vaccination showed the effect of greater delays in reaching the peak of outbreaks. When it was no vaccination, vaccination at initiation of outbreak, vaccination 90 days after the initiation of outbreak and vaccination at the epidemic peak point, the total number of clinical cases for 400 days were 20.8 million, 4.4 million, 4.7 million and 12.6 million, respectively. The pandemic response strategies of the Republic of Korea delayed the peak of outbreaks (about 40 days) and decreased the number of cumulative clinical cases (8 million). Conclusions: Rapid vaccination was the most important factor to control the spread of pandemic influenza, and the response strategies of the Republic of Korea were shown to delay the spread of pandemic influenza in this deterministic model.

Disturbing Effects of Chronic Low-dose 4-nonylphenol Exposing on Gonadal Weight and Reproductive Outcome over One-generation

차선영,백정원,지혜진,최준희,김채림,이민영,황연정,양은혁,이성호,정효일,전용필 한국발생생물학회 2017 발생과 생식 Vol.21 No.2

4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guide-line 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both F0 and F1. In females, NP decreased the weight of ovary and uterus in F0 but not in pre-pubertal F1 pubs. Fertility of male and female in F0 or F1 was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both F0 and F1. Besides, the difference of the sperm number between generations was not de-tected. The number of ovulated oocytes was similar between groups in F0, but significantly decreased in NP 50 group of F1. The litter size and sex ratios of offspring in F1 and F2 were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of F0 and F1 but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.

청소년소비자의 유명패션 브랜드 복제품에 대한 태도와 구매경험에 영향을 미치는 요인

박은숙(Eun Sook Park),지혜진(Hye Jin Ji),진지환(Ji Hwan Jin),이희숙(Hee Sook Lee) 충북대학교 생활과학연구소 2011 생활과학연구논총 Vol.15 No.1

The purpose of this study was to find the factors influencing the attitudes toward and purchasing experiences of copy of luxury goods among adolescents. Questionnaire survey method was conducted during 7~17 July, 2009. And 340 secondary students were selected living in Cheongju-si. Major findings were 1) 53.0% of respondents answered they bought copy of luxury goods in last 2 years. And high school students had more buying experiences copy of luxury goods than middle school students. 2) Respondents bought copy of shoes most implying that relatively cheaper than other copy of luxury goods. 3) The attitude toward copy of luxury goods found to be rather negative, and showed significant relationship with purchasing experience of copy of luxury goods. 4) It was found that the psychological factors had significant effects on purchasing experience of and attitudes toward copy of luxury goods.

열공경색과 파킨슨병 환자의 인지기능저하

최선아,신수정,이준홍,조정희,김규식,지혜진,김종헌 대한신경과학회 2012 대한신경과학회지 Vol.30 No.2

Background: The cause of dementia in Parkinson’s disease (PD) remains incompletely understood. Cerebrovascular lesions (CVLs) are frequently found in the aging brain and may coexist with PD pathology. We hypothesized that lacunar infarction, which is one type of CVL, impacts on cognitive decline in patients with PD. Methods: The Mini Mental Status Examination (MMSE) and Clinical Dementia Rating (CDR) tools were applied to PD patients with lacunar infarction (<1.5 cm on brain MRI; PD-S) and PD patients with normal brain MRI (PD-NS). Results: Totals of 19 PD-S patients (9 males and 10 females) and 59 PD-NS patients (16 males and 43 females) took part in this study. Univariate analysis revealed that the gender distribution did not differ between the PD-S and PD-NS groups (p=0.1731), whereas age did differ significantly [79.1±5.0 years vs 73.0±7.8 years (mean±SD), respectively; p=0.0002]. There was no difference between the PD-S and PD-NS patients in either PD disease duration (6.9±3.2 vs 5.6±3.8 years,respectively; p=0.1790) or education duration (5.3±5.4 vs 6.4±5.3 years, respectively; p=0.4168). After adjustment for age in ANCOVA analysis, the MMSE score was significantly lower (p=0.0128) and the CDR score was significantly higher (p=0.0426) in the PD-S group than in the PD-NS group. Ten of the PD-S patients had a single lesion. The lacunar infarctions appeared in various locations in these patients, but they were most common in the basal ganglia, thalamus,and periventricular white matter. Conclusions: Lacunar infarction appears to be associated with cognitive decline in patients with PD even after adjustment for age. Analysis of larger age-matched cases for PD-S and PD-NS is required in order to validate these results. Background: The cause of dementia in Parkinson’s disease (PD) remains incompletely understood. Cerebrovascular lesions (CVLs) are frequently found in the aging brain and may coexist with PD pathology. We hypothesized that lacunar infarction, which is one type of CVL, impacts on cognitive decline in patients with PD. Methods: The Mini Mental Status Examination (MMSE) and Clinical Dementia Rating (CDR) tools were applied to PD patients with lacunar infarction (<1.5 cm on brain MRI; PD-S) and PD patients with normal brain MRI (PD-NS). Results: Totals of 19 PD-S patients (9 males and 10 females) and 59 PD-NS patients (16 males and 43 females) took part in this study. Univariate analysis revealed that the gender distribution did not differ between the PD-S and PD-NS groups (p=0.1731), whereas age did differ significantly [79.1±5.0 years vs 73.0±7.8 years (mean±SD), respectively; p=0.0002]. There was no difference between the PD-S and PD-NS patients in either PD disease duration (6.9±3.2 vs 5.6±3.8 years,respectively; p=0.1790) or education duration (5.3±5.4 vs 6.4±5.3 years, respectively; p=0.4168). After adjustment for age in ANCOVA analysis, the MMSE score was significantly lower (p=0.0128) and the CDR score was significantly higher (p=0.0426) in the PD-S group than in the PD-NS group. Ten of the PD-S patients had a single lesion. The lacunar infarctions appeared in various locations in these patients, but they were most common in the basal ganglia, thalamus,and periventricular white matter. Conclusions: Lacunar infarction appears to be associated with cognitive decline in patients with PD even after adjustment for age. Analysis of larger age-matched cases for PD-S and PD-NS is required in order to validate these results.

獨居노인의 체험연구

김태연,박진화,권정미,김건희,신호정,이진희,지혜진 이화여자대학교 간호과학대학 1999 이화간호학회지 Vol.- No.32