성인에서 천미부 기형종의 선암으로 전환

조장호 ( Jang Ho Cho ),김소희 ( So Hee Kim ),김용훈 ( Yong Hoon Kim ),박혜성 ( Heae Surng Park ),조은석 ( Eun Suk Cho ),임재윤 ( Jae Yun Lim ),조재용 ( Jae Yong Cho ) 대한내과학회 2013 대한내과학회지 Vol.85 No.1

Sacrococcygeal teratoma (SCT) is an unusual tumor in adults. The incidence of malignant transformation of this tumor increases when its excision is delayed beyond 1 month of age. We report an uncommon case of adenocarcinoma arising within the colonic mucosa of a mature teratoma of the sacrococcyx in a 44-year-old male. The patient received surgical resection for a sacrococcygeal mass in a local hospital and was diagnosed with adenocarcinoma arising from SCT. He was referred to our hospital for further treatment and received chemotherapy as adjuvant treatment. After 4.5 years, the coccygeal mass recurred on follow-up imaging workup, and surgical resection was performed. On pathologic work-up, residual disease at the resection margin was identified microscopically. Pathologic diagnosis was a primary adenocarcinoma arising from the colonic mucosa within a mature teratoma. The patient received adjuvant-chemotherapy and radiotherapy and has been followed up. (Korean J Med 2013;85:101-105)

임상연구 : 외경정맥: 이면성 초음파를 이용한 우측 내경정맥 천자지표로서의 유용성

조장은 ( Jang Eun Cho ),김원옥 ( Won Oak Kim ),이민정 ( Min Jeong Lee ),길혜금 ( Hae Keum Kil ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.6

Background: Measuring the distance between internal jugular vein (IJV) and external jugular vein (EJV) on ultrasound image can give the information of the whereabouts of the IJV. We compared the success rate between carotid artery (CA)-guided and EJV-guided cannulation based on the information gathered from ultrasound. Methods: We studied 152 patients requiring central venous cannulation during anesthesia. Ultrasound images were obtained with 7.5 MHz probe on the right neck at 0°, 30°, and maximum rotation of the head in flat and 15° Trendelenberg (T) position. The horizontal diameter of the RIJV and % overlap of the CA with the RIJV at each position, and the horizontal distance of RIJV-REJV at 30° were measured on ultrasound images. In EJV group, the distance of RIJV-REJV was drawn along the cricoid level and the point of IJV was marked as the needle insertion site. Cannulation was performed with palpation of the CA in CA group and performed at the marked point in EJV group without palpation of CA. Results: Overall RIJV diameter was increased in T-position compared to flat position. Following head rotation, RIJV diameter was decreased and % overlap of CA was increased (P < 0.05). In 26.8% of patients at 30° in T position, CA overlapped 26-50% of RIJV. The success rate of cannulation at the first trial was 97.4% in CA group and 96.1% in REJV group. Conclusions: With the IJV identified on ultrasound image, the distance between the IJV and the EJV can be used as another landmark for RIJV cannulation provided the EJV is visualized with the naked eye. (Korean J Anesthesiol 2006; 50: 605~10)

임상연구 : 갑상선절제술과 유방절제술에서 Propofol과 Remifentanil을 이용한 전정맥마취 시 마취 유지 및 각성의 비교

조장은 ( Jang Eun Cho ),김원옥 ( Won Oak Kim ),전나형 ( Na Hyung Jun ),양소영 ( So Young Yang ),길혜금 ( Hae Keum Kil ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.2

Background: This study investigated the effect of type of surgery on consumption of propofol and remifentanil and recovery index. Methods: Fifty female patients (ASA physical status 1, 2) scheduled for thyroidectomy (Group I) or mastectomy (Group II) received total intravenous anesthesia (TIVA) with propofol and remifentanil. The anesthesia was maintained with target-controlled infusion (TCI) of propofol and remifentanil under bispectral index (BIS) monitoring. The effect site concentration of propofol was controlled for maintaining BIS values within the range of 45-50. The effect site concentration of remifentanil was controlled for maintaining blood pressure and heart rate within 20% of baseline values. Blood pressure, heart rate, BIS, effect site concentration of propofol and remifentanil were measured before induction, during induction, at the beginning of operation, at the end of operation, and during recovery. The time from discontinuation of propofol to eye opening and regaining of orientation, total amount of propofol and remifentanil used, and the amount of drug per body weight kilogram per hour were investigated. Results: There were no significant differences between Group I and II on the amount of remifentanil used. Although the amount of propofol consumed per body weight kilogram per hour was larger in Group II, there were no significant differences of recovery index between Group I and II. Conclusions: There were no significant differences in the amount of propofol and remifentanil consumed and recovery index in thyroidectomy and mastectomy under TIVA. The larger amount of propofol consumed per body weight per hour in Group II was thought as a result of shorter operation time than Group I. (Korean J Anesthesiol 2007; 53: 169~73)

BCG 예방접종을 받은 개체에서 유도되어 있는 결핵균 균체항원에 특정한 CD8+T 세포의 보호 면역반응

조장은 ( Jang Eun Cho ),조상래 ( Sang Nae Cho ),이경화 ( Kyung Wha Lee ),박승규 ( Seung Kyu Park ),조성애 ( Sung Ae Cho ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.3

아파트 동남향․서남향 배치에 따른 물리적 주거환경에 대한 비교연구

조장현(Cho, Jang-Hyun),현은미(Hyun, Eun-Mi),김용식(Kim, Yong-Sik) 한국실내디자인학회 2012 한국실내디자인학회논문집 Vol.21 No.5

Apartments with a southern exposure are often thought to have advantages in receiving winter sunlights and summer natural ventilation. However, as due-south-apartments increase recently, the consideration for residential environment for households with no southern exposure is necessary. In case of due-south-apartments, residents prefer east-sided apartments than west facing apartments which might receive more hot sunlight in the afternoon; however in case of west-oriented apartments with active ventilation, the interior area is bright until late afternoon without unpleasant heat and has advantage in light environment aspects. This study aims to compare and analyze merits and demerits of air flow and sunlighted environment of buildings through sunshine duration simulation using CFD simulation ad sunlights about southeast-sided and southwest-sided apartments based on general opinions for apartment directions. As results of the interior natural ventilation analysis, as the average air flow speed in southwest-sided apartments was 1m/s faster than that of southeast-sided, it has effects of lowering sensory temperature of residents in summer, and for sunlighted environment, southwest-sided apartments are advantageous for sunlighted area for duration time inside. As a result of the research, the calculation of physical residential environment of apartment residential space should be reached through integrated evaluation of natural ventilation and sunlighted time from placement and facing direction of the buildings considering characteristics and environment of each apartment, not based on general opinions.

MHC class I 분자들에 의해 제시되는 Epitope을 인지하는 CD8+ T 림프구의 결핵균 감염에 대한 면역반응의 연구: 결핵 환자와 PPD+ 건강개체에 존재하는 결핵균 항원에 특정한 CD8+ T세포

조장은,이경화,박승규,천선희,조상래,조성애,Cho, Jang-Eun,Lee, Kyung Wha,Park, Seung Kyu,Cheon, Seon-Hee,Cho, Sang-Nae,Cho, Sungae 대한면역학회 2003 Immune Network Vol.3 No.3

Background: The protective immunity against tuberculosis (TB) involves both CD4+ T cells and CD8+ T cells. In our previous study, we defined four Mycobacterium tuberculosis derived peptide epitopes specific for HLA-$A^*0201$ restricted CD8+ T cells ($ThyA_{30-38}$, $RpoB_{127-135}$, $85B_{15-23}$, $PstA1_{75-83}$). In this study, we investigated the immune responses induced by these peptide specific CD8+ T cells in latently and chronically infected people with TB. Methods: We characterized these peptide specific CD8+ T cell population present in PBMC of both TB patients and PPD+healthy people using IFN-${\gamma}$elispot assay, intracellular staining and HLA-A2 dimer staining. Results: The frequency of peptide specific CD8+ T cell was in the range of 1 to 25 in $1.7{\times}10^5$ PBMC based on ex vivo IFN-${\gamma}$ elispot assay, demonstrating that these peptide specific CD8+ T cell responses are induced in both TB patients and PPD+ people. Short term cell lines (STCL) specific for these peptides proliferated in vitro and secreted IFN-${\gamma}$ upon antigenic stimulation in PPD+ donors. Lastly, HLA-$A^*0201$ dimer assays indicated that $PstA1_{75-83}$ specific CD8+ T cell population in PPD+ healthy donors is heterogeneous since approximately 25~33% of $PstA1_{75-83}$ specific CD8+ T cell population in PPD+ healthy donors produced IFN-${\gamma}$ upon peptide stimulation. Conclusion: Our results suggest that MHC class I restricted CD8+ T cell mediated immune responses to M. tuberculosis infection are induced in both TB patients and PPD + people; however, the CD8+ T cell population is functionally heterogeneous.

관상동맥질환자의 건강 임파워먼트, 배우자지지, 외상 후 성장이 건강증진행위에 미치는 영향

정은(Jeong, Eun),이경심(Lee, Kyung Sim),양승경(Yang, Seung Kyoung),조장현(Cho, Jang Hyun) 한국기초간호학회 2022 Journal of korean biological nursing science Vol.24 No.2

Purpose: The purpose of this study was to identify influence of health behavior in patients with coronary artery disease. Methods: A cross-sectional descriptive design included 150 patients treated with percutaneous coronary intervention in S hospital in S city. Data were collected by using self-questionnaires July 5-August 26, 2021 and were analyzed by descriptive statistics, t-test, ANOVA, Scheffé test, Pearson’s correlation coefficients, and multiple regression with SPSS 23.0. Results: Factors significantly influencing health behavior in patients with coronary artery disease were health empowerment (β=.48, p<.001), and post-traumatic growth (β=.20, p=.013). The explanatory power of related variables was 39%. Conclusion: Based on the this study, it was found that health empowerment and post-traumatic growth had a significant effect on the health behavior of patients with coronary artery disease. Thus, it is necessary to promote the health behavior of patients with coronary artery disease through the development of intervention programs to improve health empowerment and post-traumatic growth.

증례보고 : Noonan 증후군 환자의 마취 경험 -증례보고-

김민수 ( Min Soo Kim ),조장은 ( Jang Eun Cho ),길혜금 ( Hae Keum Kil ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.1

Noonan syndrome is featured by short stature, mental retardation, facial dysmorphia, webbed neck, and heart defects. The phenotype has some similarities with Turner syndrome, but the karyotype is normal and males can be affected. We used Bonfils fiberscope for intubation because we suspected the difficult airway. We report the experience of anesthetic management for osteotomy of calcaneonavicular coalition in a patient with Noonan syndrome. (Korean J Anesthesiol 2006; 51: 120~3)

KOSDAQ 시장에서 히든챔피언 종목은 과연 히든챔피언인가?

박진우(Jin Woo Park),조장은(Jang Eun Cho) 한국증권학회 2015 한국증권학회지 Vol.44 No.4

본 논문에서는 코스닥시장에서 히든챔피언 선정제도가 시작된 2009년 이후부터 2013년까지 히든챔피언 기업을 대상으로 선정 및 탈락의 정보효과를 확인하고, 중장기 주가 움직임을 분석하며, 투자자유형별 매매 패턴을 살펴보고 있다. 또한, 로짓회귀분석을 통해 히든챔피언에 선정된 기업의 선정유지 또는 탈락에 영향을 미치는 요인들을 분석하고 있다. 분석결과, 히든챔피언 선정은 이미 기업가치가 상당 부분 시장에 반영된 기업들이 선정되면서 선정 발표의 정보효과가 예상 만큼 크지 않고, 히든챔피언 선정 이후 뚜렷한 투자성과가 나타나고 있지 않아 히든챔피언 종목이 유용한 투자 정보가 되지 못하고 있다. 한편, 개인투자자는 선정이전에 높은 투자성과를 나타내는 신규선정 종목을 순매도하고 탈락 이전부터 부진한 주가흐름을 보이는 선정탈락 종목은 순매수함으로써 반대의 매매 패턴을 보이는 기관투자자에 비해 불리한 거래행태를 보여주고 있다. 그리고 로짓회귀분석 모형에서는 총자산순이익률(ROA), 매출액 성장률, 과거 투자성과 등이 유의한 음(-)의 값을 보이며 기업의 수익성과 주가 흐름이 히든챔피언 재선정 또는 탈락의 중요한 예측 변수임을 확인해 주고 있다. 결론적으로, 히든챔피언 선정은 이미 기업가치가 상당 부분 시장에 반영된 기업들이 선정되면서 ‘숨은(hidden)’ 우량 기업을 발굴해 낸다는 취지가 퇴색되고 있고, 히든챔피언 선정 이후 뚜렷한 투자성과가 나타나고 있지 않아 ‘미래의 챔피언(champion)’을 선정한 것으로 보기 어렵다. This paper examines the information effect of ‘hidden champion’ selection announcement and investors’ trading behavior in the KOSDAQ market for the period from 2009 to 2013. The empirical results are summarized as follow. First, we find that the information effect of ‘hidden champion’ selection announcement is smaller than expected since the firm value has been reflected in the market prior to the announcement. Second, individual investors exhibit different trading patterns from those of institutional investors by showing that individual investors earn relatively lower returns surrounding the announcement. Finally, using the logit regression, we find that the firm’s profitability and the stock returns prior to the announcement are predictive variables for the selection of ‘hidden champion’ stocks.

공동주택 인접 도로교통소음에 대한 방음벽에 관한 연구

이재은(Lee, Jae-Eun),조장현(Cho, Jang-Hyun),김용식(Kim, Yong-Sik) 대한건축학회 2010 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.30 No.1(계획계)