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제갈준호,이홍재,이상천 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Surface engineering with bioactive drugs has been widely utilized to promote the performance of medical devices. A recent trend has focused on the development of surface-releasing systems that enable to accelerate the osseointegration of dental implants. In particular, the surface immobilization of nanocontainers that can control the release of bioactive molecules has emerged as a promising technique. In this study, we develop a nanoparticle-immobilized titanium surface that can release simvastatin in a controlled manner. The simvastatin-loaded nanoparticles were prepared by self-assembly of 5β-cholanic acid-conjugated glycol chitosan in the presence of simvastatin. The successful immobilization of nanoparticles onto titanium surfaces was confirmed by FESEM and XPS. The release of simvastatin lasted for up to 20 days. These results suggest that the nanoparticle immobilization technique can be tailored for the sustained release of various bioactive agents from the diverse medical devices.
Surface Engineering of Titanium with Osteogenic Agent-Releasing Nanoparticles
제갈준호,김다은,이홍재,이상천 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Surface modification of titanium is critical in generating bioactive osteogenic surface of medical devices. The surface-releasing systems that enable to accelerate the osseointegration of dental implants have been widely explored. Especially, the surface immobilization of nanoparticles that can control the release of bioactive molecules has emerged as a promising technique. Herein, we develop a nanoparticleimmobilized titanium surface that can release simvastatin in a controlled manner. The simvastatin-loaded nanoparticles were prepared by self-assembly of 5β-cholanic acid-conjugated glycol chitosan in the presence of simvastatin. The successful immobilization of nanoparticles onto titanium surfaces was confirmed by FE-SEM and XPS. The release of simvastatin lasted for up to 20 days. These results suggest that the nanoparticle immobilization technique can be tailored for the sustained release of various bioactive agents from the diverse medical devices.
Ti-adhesive nanoparticles as a surface-releasing system of dual osteogenic growth factors
최기현,제갈준호,이홍재,이상천 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Known as an effective carrier for the delivery of the cargo, the polymer nanoparticle has been used for years. By immobilizing the polymer nanoparticles on the surface of medical materials, one may be able to fabricate the controlled cargo-releasing system. Herein, we suggest a titanium (Ti)-adhesive nanoparticle as a surface-releasing system for dual osteogenetic growth factors. The key element that enables the nanoparticle immobilization is surface-exposed Ti-adhesive catechol groups. We confirmed the conjugation of the catechol groups to the surface of the nanoparticle by 1H NMR and UV-Vis spectra. The immobilization of the nanoparticles onto the surface of Ti substrates was confirmed by various analytical tools, such as Fe-SEM and XPS. The release of dual proteins lasted for up to 28 days, and we carried out various cell experiments to verify the effects of our surface-releasing system.
이석원,이홍재,이재원,제갈준호,김경희,강종호,이명현,이상천 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
In this work, we demonstrate that controlled dual release of bone morphogenic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) by catechol-functionalized adhesive polymer nanoparticles on microgrooved titanium (Ti) surface enhances in vitro osteoblastic differentiation of human mesenchymal stem cells (MSCs). The nanoparticles were immobilized both on the groove bottom surface and the ridge top surface. A fluorescence microscope visualized that BMP-2 and IGF-1 of positive charges were efficiently loaded onto the nanoparticle-immobilized Ti surfaces. We confirmed the enhanced osteoblastic differentiation of MSCs by presenting the expression results of major osteoblast marker genes and proteins. The proposed combined surface of microgrooves and growth factor-releasing nanoparticles can be used as a strong osteogenic promoter on various biomaterial surfaces.