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정준오 ( Jeong Jun O ),곽금연 ( Gwag Geum Yeon ),임영석 ( Im Yeong Seog ),김정룡 ( Kim Jeong Lyong ),이효석 ( Lee Hyo Seog ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Background/Aims: Hepatic stellate cells (HSCs) in the hepatocellular carcinoma are responsible for tumor encapsulation as a host defense mechanism. Recently, it was suggested that HSCs might play an important role in hepatic angiogenesis. Thus, HSCs in the HCC may be involved in tumor angiogenesis and pathogenesis of hepatic carcinogenesis. The purpose of this study was to examine the involvement of activated HSCs in the angiogenesis of hepatoma. Methods: We investigated the effect of human HSC conditioned medium (CM) on the endothelial cell proliferation with or without stimulation of HepG2 CM, using [3H] thymidine incorporation assay. Additionally, we investigated the effect of HepG2 CM on HSCs proliferation and messenger RNA (mRNA) expression of various pro-angiogenic factors such as interleukin 8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HSCs. Results: HSC CM caused a significant increase in DNA synthesis in human umbilical vein endothelial cells (HUVEC). The endothelial proliferation effect of HSCs was augmented by HepG2 CM. HepG2 CM significantly increased HSCs proliferation and stimulated IL-8 and bFGF mRNA expression in HSCs. Conclusions: HSCs promote endothelial proliferation through various soluble factors. The soluble factors secreted in HepG2 stimulate HSC proliferation and up-regulate mRNA expression of proangiogenic factors. This result suggests that HSCs may play an important role in the angiogenesis of hepatoma. (Korean J Gastroenterol 2003;42:142-148)
이임기,정준오,박찬운,Lee, Im-Gi,Jeong, Jun-Oh,Park, Charn-Woon 대한치과보철학회 2002 대한치과보철학회지 Vol.40 No.2
This study is going to compare the degree of color change which occurs in the following two cases of the factors which cause the color change of extra-staining, one is during glazing by the dental technician, the other is tooth brush abrasion which makes the biggest influence on color change. To compare the degree of color change before and after glazing, a sample was made with vintage incisal porcelain No. 59 OPAL(Shofu Inc, Japan), after that it was painted with three colors of porcelain stainers, then the degree of color was measured with a spectrophometer(Model Chromaview 300, Spectoron Tech Co. Korea) after it had been treated with firing only and glazing after firing 40,000-cycle and 80,000-cycle of tooth brush abrasion test were carried out in order to simulate the brushing effect of 4 years and 8 years by using the abrasion tester. The colors were measured before the test, and after the 40,000-cycle and 80.000-cycle operations and the surfaces were examined by SEM. The results of this study were as follows ; 1. The color change before and after glazing was not great enough to have a clinical significance but the orange color was changed more significantly statistically than the blue and light brown(p<0.05). 2. In the case of the color change of stained porcelain by tooth brushing, carrying out staining and glazing with two-times firings resulted in statically less color change than one firing only(p<0.05). 3. In the case of the difference in the stainer's color, the orange color which has higher chroma was statically more sensitive than the blue color(p<0.05) 4. In the case of the color change after the 80,000-cycle abrasion, all showed color change when there was one firing and the orange stainer showed some color change with clinical significance when firings were done two times.
급성 악화를 보였던 만성 B형 간염 환자에서의 임상 경과
장은정 ( Eun Jeong Jang ),정준오 ( Jun Oh Jung ),김경아 ( Kyung A Kim ),임영석 ( Young Seok Lim ),김윤준 ( Yoon Jun Kim ),윤정환 ( Jung Hwan Yoon ),이효석 ( Hyo Suk Lee ),김정룡 ( Chung Yong Kim ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 만성 B형 간염환자의 자연경과 도중 환자들은 갑작스러운 간기능의 심한 악화를 경험하게되고 심한 경우는 비대상성 간경변증에서 보일 수 있는 합병증들이 동반된 간 부전의 상태가 되게 된다. 최근 그런 상황에서 일부 선택된 환자에서 항 바이러스제를 사용하면서 간 이식을 기다리는 동안에 간 이식이 필요 없게 된 환자들의 증례를 포함한 좋은 경과를 보여주는 논문들이 발표되고 있다. 그러나 이들 논문들은 환자군의 특성상 정확한 대조군을 두기 어려운 점으로
벤조디아제핀 복용 중 발생한 저나트륨혈증에 의한 횡문근융해증 1예
정재혁 ( Jae Hyeok Jeong ),조재현 ( Jae Hyun Cho ),유창민 ( Chang Min Yu ),서승오 ( Seong O Suh ),안석진 ( Seok Jin Ahn ),정준오 ( Jun Oh Jung ),김윤권 ( Youn Kwon Kim ) 대한내과학회 2008 대한내과학회지 Vol.75 No.6
저나트륨혈증은 횡문근융해증의 드문 원인이다. 보고된 증례들 중 대다수가 정신병으로 신경이완제를 복용 중인 경우들이었는데, 정신병과 신경이완제의 복용이 저나트륨혈증 또는 이의 교정으로 인한 횡문근융해증의 발생에 기여하는 것으로 생각된다. 현재까지의 보고들에서 원인이 되었던 신경이완제는 거의 모두가 항정신병 약물이었고, 단 1건의 증례보고에서만 벤조디아제핀이 관여하였을 것으로 설명하였다. 이에 저자들은 벤조디아제핀을 복용 중이던 급성 정신병의 병력이 의심되는 환자에서 저나트륨혈증의 교정 중 횡문근융해증이 발생한 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Hyponatremia is rarely reported to cause rhabdomyolysis and there has been only one case report on rhabdomyolysis due to hyponatremia, possibly complicated by benzodiazepines. We experienced a case of rhabdomyolysis due to hyponatremia during the use of benzodiazepines in a patient with an acute psychosis. A 60-year-old man was admitted to the emergency room due to altered mentality. He had been taking benzodiazepines for 1 month because of insomnia, uneasiness, and depression. His initial blood chemistry revealed severe hypotonic hyponatremia in the absence of polydipsia, edema, and features of dehydration. While correcting the hyponatremia, rhabdomyolysis developed with no evidence of trauma, seizures, or tremor. In patients with acute psychosis, the development of rhabdomyolysis due to hyponatremia or its correction should not be underestimated and should be assessed thoroughly. Clinicians also need to be aware of the potential risk of benzodiazepines for the development of rhabdomyolysis. (Korean J Med 75:718-722, 2008)
횡문근융해증으로 인한 급성신부전증의 핍뇨기에서 발생한 중증 고칼슘혈증
임수진 ( Im Su Jin ),이승희 ( Lee Seung Hui ),문창기 ( Mun Chang Gi ),정준오 ( Jeong Jun O ),박상준 ( Park Sang Jun ),김윤권 ( Kim Yun Gwon ),김소연 ( Kim So Yeon ),김영중 ( Kim Yeong Jung ),조민구 ( Jo Min Gu ),이권전 ( Lee Gwon 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.6
Hypercalcemia rarely develops in patients with acute renal failure associated with rhabdomyolysis. If hypercalcemia occurs, it happens mostly in diuretic phase and rarely in oliguric phase. Secondary hyperparathyroidism, abnormal metabolism of Vitamin D, immobilization of patient, and release of calcium from injured muscle are considered as possible pathogenetic mechanisms of hypercalcemia in acute renal failure associated with rhabdomyolysis. Among them, dissoultion of calcium from injured muscle into extracellular fluid is accepted as the major mechanism of pathogenesis of hypercalcemia. A twenty year old male patient, combat policeman, developed syncope in the course of regular physical training. He was diagnosed of acute renal failure associated with rhabdomyolysis at the hospital he initially visited. After being subjected to three sessions of acute hemodialysis, he was transferred to our hospital. During the treatment, laboratory test was performed upon his continuous complaints of lower extremity weakness. It showed severe hypercalcemia with plasma calcium level of 17.3 mg/dL. He was in oliguric phase at the time of this severe hypercalcemia. Patient`s lower extremity weakness was gradually improved by hemodialysis using low calcium dialysate. He was discharged after his renal function became normal. He has been followed on regular basis. (Korean J Nephrol 2003;22(6):731-735)
교통경찰과 비 교통경찰의 폐기능과 혈중 Carboxyhemoglobin 수치에 대한 비교연구
김성민 ( Kim Seong Min ),전규락 ( Jeon Gyu Lag ),김영욱 ( Kim Yeong Ug ),김준형 ( Kim Jun Hyeong ),이호학 ( Lee Ho Hag ),홍순창 ( Hong Sun Chang ),이승희 ( Lee Seung Hui ),박상준 ( Park Sang Jun ),정준오 ( Jeong Jun O ),김윤권 ( K 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.55 No.6
전투경찰에서 발생한 폐렴에 있어서 Macrolide와 2세대 Cephalosporin의 치료 효과에 대한 전향적 비교 연구
이재일 ( Jae Il Lee ),양병윤 ( Byeong Yoon Yang ),문창기 ( Chang Gi Moon ),정재혁 ( Jae Hyeok Jeong ),김종수 ( Jong Su Kim ),이정민 ( Jung Min Lee ),안석진 ( Seok Jin Ahn ),정준오 ( Jun Oh Jung ),박상준 ( Sang Joon Park ),김윤권 ( 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.3
목적 : 집단생활을 하는 젊은 성인에서 발생한 폐렴에 관한 연구는 매우 드물며, 국내 연구는 전무한 실정이다. 이에 저자들은 전경 대원에서 발생한 폐렴의 양상에 대해 알아보고 Macrolide와 2세대 Cephalosporin의 치료 효과를 비교하여 보고자 전향적 연구를 시행하였다. 방법 : 2003년 1월부터 2004년 4월까지 국립 경찰병원을 방문한 52명의 폐렴 환자들을 무작위로 구분하여 Cefuroxime 또는 Azithromycin을 경구 투여 Background : The study of pneumonia among young men living in a group is rare. prospective study was conducted to determine the etiology, and compare the effects of macrolide and second-generation cephalosporin on the treatment of pneumonia among combat p
문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6
Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.