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직접 검화법을 이용한 조제분유의 콜레스테롤 분석법 개발
김진만,박정민,윤태형,임동길,윤창용,정자영,정인식,곽병만,안장혁,Kim, Jin-Man,Park, Jung-Min,Yoon, Tae-Hyung,Leem, Dong-Gil,Yoon, Chang-Yong,Jeong, Ja-Young,Jeong, In-Seek,Kwak, Byung-Man,Ahn, Jang-Hyuk 한국축산식품학회 2011 한국축산식품학회지 Vol.31 No.6
본 연구에서는 조제분유 중의 콜레스테롤을 신속하고 정확하게 분석하기 위해 지방 추출 과정을 거치지 않는 직접 검화 방법을 선택하여 분석법 개발을 시도하였다. 조제분유 분말시료를 직접 검화 수기에 취하여 검화 온도, 검화 시간, KOH 농도의 3가지 인자에 대해 콜레스테롤 회수율이 가장 양호하게 나타나는 최적 검화조건을 확립하고, 검화 후 수세과정에서 액액 분배가 용이한 용매 조건도 확립하였다. 또한 콜레스테롤 피크의 완전한 분리를 위한 적정 기기 조건을 확립하였다. 그 결과, 시료 약 2 g에 16 M-KOH 10 mL를 넣고 $90^{\circ}C$에서 60분 가열하여 검화한 후 diethyl ether로 3회 추출하고 hexane을 최종시험용액으로 하여 기기분석을 했을 때의 회수율이 98.80%로서 가장 양호하게 나타났다. 본 연구를 통해 개발된 조제분유의 효율적인 액액분배 및 직접가열 검화법은 일원배치 분산법에 의해 유화가공식품의 콜레스테롤 분석법으로 유효성이 검증되었으며, 아울러 개발된 전처리 방법 및 기기 분석 조건을 활용해 다양한 분석 기관에서 신속 정확하고 효율적인 콜레스테롤 분석을 수행할 수 있을 것으로 기대된다. 또한 산업체의 품질관리 및 검증기관에서 필요시 모니터링에 적극 활용 가능할 것으로 사료되며, 이를 통해 유화가공식품 류의 함량표시 및 규격관리의 정확성과 효율성 증대에 기여하여 제조업체의 정확하고도 효과적인 품질 및 안전성 확보에 기여할 수 있을 것으로 판단된다. 특히 위해 물질에 대한 정확한 함량 판단이 중요한 조제분유 등의 영 유아용 식품의 안전성 확보에 지대한 공헌을 할 수 있을 것으로 기대된다. An improved cholesterol analysis method was developed for powdered infant formula by gas chromatographic separation after liquid-liquid extraction and partition. In the official Korea Food Standard method for cholesterol analysis, the water phase and solvent phase were not well separated in the case of emulsified foods such as powdered infant formulas and baby foods. For the rapid and simple sample preparation method, an optimized direct saponification condition was established for heating temperature, heating time, and KOH concentration. From the results, the optimum conditions were as follows: heating temperature $90^{\circ}C$, heating time 60 min, and 16 M KOH 10 mL for a 2 g infant formula sample; improved separation condition for gas chromatography was as follows: the initial oven condition was $250^{\circ}C$ for 25 min, the oven temperature was increased to $290^{\circ}C$ by $10^{\circ}C$/min ratio, and finally the oven temperature remained at $290^{\circ}C$for 9 min. The developed method could be implemented for the study of cholesterol, providing the advantages of reduced inspection time and cost in emulsified foods such as infant formula.
추교영(Kyo Young Choo),박수헌(Soo Heon Park),백기현(Ki Hyun Baik),민도준(Do Jun Min),한준열(Jun Yul Han),최명규(Myung Kyu Choi),정인식(In Sik Chung),정규원(Kyu Won Chung),선희식(Hee Sik Sun) 대한내과학회 1996 대한내과학회지 Vol.51 No.3
Collagenous colitis is a newly recognized disease that causes chronic watery diarrhea and occurs predominantly in middle aged woman. Radiologic and endoscopic examination of the colon are usually normal, therefore diagnosis must be associated with some autoimmune diseases and medication history of certain drugs, The involvement of collagenous colitis is mainly in large intestine but rarely occurs in both large and small intestine. A 36 years old female presented with a 5-month history of watery diarrhea and weight loss. She had a past medical history of rheumatoid arthritis. Multiple biopsies of colonic mucosa revealed a nonspecific findings. Jejunal biopsy showed subepithelial band of collagen deposition that was compatible to collagenous colitis. Some improvement of symptoms occurred with prednisolone therapy. Hence, we present the first case of collagenous enteritis with histologic evidence of intestinal involvement.
Dong-Hyun Kim,Young-Jun oh,Kyung-Min Han,정인식,김대근,김성훈,권병목,Mi-Hyun Park,백남인 한국응용생명화학회 2005 Journal of Applied Biological Chemistry (J. Appl. Vol.48 No.1
Campsis grandiflora K. Schum. flower was extracted with 80% aqueous MeOH, and concentrated extract was successively partitioned with EtOAc, n-BuOH, and H2O. From n-BuOH fraction, two cyclohexylethanoids were isolated through repeated silica gel and Sephadex LH-20 column chromatographies. Based on physico-chemical data obtained from NMR, MS, and IR, chemical structures of compounds were determined as 1,4-dihydroxy-3,4-(epoxyethano)-5-cyclohexene (1) and cornoside (2). These compounds were isolated for the first time from C. grandiflora K. Schum flower.
소화성궤양 1,179 예에 대한 역학적 및 내시경적 고찰
김재광 ( Jae Kwang Kim ),정인식 ( In Sik Chug ),안병민 ( Byung Min Ahn ),한남익 ( Nam Ik Han ),서정민 ( Jeong Min Suh ),조현미 ( Hyun Mi Cho ),최상욱 ( Sang Wook Choi ),박영민 ( Young Min Park ),한석원 ( Suk Won Han ),심규식 ( Kyu 대한내과학회 1990 대한내과학회지 Vol.39 No.2
Several environmental factors are known to contribute to the development of peptic ulcer. The incidence and prevalence of peptic ulcer are changing along with changes in the environment. Therefore, we analyzed 1,179 prospective patients, who were diagnosed as peptic ulcer with gastrofiberscopy, in eight hospitals of Catholic University Medical College from August, 1988 to April, 1989. The results were as follows: 1) Of the 1,179 cases, the number of patients with duodenal ulcer was 606 (51.4%), with gastric ulcer 489 (41.5%), and with gastric ulcer and duodenal ulcer (combined ulcer) 84(7.1%). 2) The mean age of each group of patients with gastric ulcer, duodenal ulcer, and combined ulcer was 50.3±14.4 years, 39.6±12.7 years, and 47.9±13.0 years (p<0.005), respectively. The ratio of males to females was 3.4:1 in patients with gastric ulcer, 3.1:1 in patients with duodenal ulcer, and 4.3:1 in patients with combined ulcer. 3) The percentage of smokers was higher in patients with peptic ulcer (68.1% in patients with gastric ulcer, 58.9% in patients with duodenal ulcer and 69.0% in patients with combined ulcer) than the percentage of smokers in the general population(32%). 4) Blood type was not associated with incidence of peptic ulcer, but non-steroidal anti-inflammatory drugs and stressful stimuli may play a part in the genesis of peptic ulcer. 5) The incidence of peptic ulcer was characterized by regional variation and occupation. 6) The most common symptom was epigastric pain, but 3-4.5% in patients with pepetic ulcer had no complaints. 7) The most common shape of the ulcer was round or oval, and the most common aite was angle in gastric ulcer and anterior wall of bulb in duodenal ulcer. 8) The mean size was 1.4±1.0cm in gastric ulcer, 0.9±0.6 cm in duodenal ulcer, and 1.2±0.7 cm in combined ulcer (p<0.005). 9) The multiplicity of ulcers was 22.9% of gastric and 10.6% of duodenal ulcer.
위장관 : Helicobacter pylori 제균 치료 1년 후 위 점막의 Cyclooxygenase-2 및 Inducible Nitric Oxide Synthase 발현 변화
김성수 ( Sung Soo Kim ),성용직 ( Young Jick Sung ),박민경 ( Min Kyoung Park ),임창훈 ( Chang Hoon Lim ),양홍준 ( Hong Jun Yang ),김태호 ( Tae Ho Kim ),김창환 ( Chang Whan Kim ),김진일 ( Jin Il Kim ),한석원 ( Sok Won Han ),정인식 ( 대한소화기학회 2008 대한소화기학회지 Vol.52 No.5
목적: H. pylori는 직접 혹은 간접적으로 위 점막의 COX-2와 iNOS 발현을 유도하며, H. pylori를 제균하면 이들 단백의 발현은 감소한다. 그러나 H. pylori 제균 치료 후에 COX-2와 iNOS 발현 변화에 대한 장기간의 관찰 보고는 없었다. 이에 저자는 만성위염 환자를 대상으로 H. pylori 제균치료 1년 후에 위 점막에서 COX-2와 iNOS 발현의 변화를 관찰하고자 하였다. 대상 및 방법: H. pylori 감염이 확인된 만성위염 환자 58명을 대상으로 하였으며, 45명에 제균 치료를 했다. H. pylori 제균 치료 전과 1년 후에 위전정부 점막 조직에서 면역화학 염색을 이용하여 COX-2와 iNOS 단백의 발현 강도 및 발현율 변화를 관찰하였다. 결과: COX-2와 iNOS 단백은 상피세포와 염증세포 및 점막근판의 평활근세포에서 발현되었다. 제균 치료에 성공한 38명에서 제균 치료 1년 후에 COX-2 및 iNOS의 발현율은 모두 유의하게 감소되는 것을 관찰할 수 있었다. 그러나 제균 치료에 실패하였거나 제균 치료를 받지 않아 H. pylori 감염이 있는 환자에서 COX-2 및 iNOS 발현은 변화가 없었다. COX-2의 발현율은 위 점막의 H. pylori 밀도, 중성백혈구 및 단핵구 침윤 정도와 유의한 상관관계를 보였으며, iNOS 발현율은 위 점막의 H. pylori 밀도와 중성백혈구의 침윤 정도와 유의한 상관관계를 보였다. 결론: H. pylori의 제균 치료는 COX-2와 iNOS의 발현을 장기간 억제할 수 있으며 이는 H. pylori 제균 및 이로 인한 위 염증 감소와 관련 있을 것으로 생각한다. Background/Aims: The cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), the proteins that have the role in the gastric carcinogenesis, are stimulated by H. pylori infection in the gastric mucosa. The aim of this study was to evaluate the expression of COX-2 and iNOS proteins one year after the eradication of H. pylori. Methods: Gastric antral mucosa from fifty eight patients with chronic gastritis who were all infected with H. pylori was examined for the expression of COX-2 and iNOS proteins before and one year after the eradication of H. pylori by immunohistochemical stain. Results: COX-2 and iNOS proteins were expressed in the epithelial cells and interstitial inflammatory cells of gastric mucosa. Percent expressions of COX-2 and iNOS were significantly decreased one year after the eradication in the patients with cured infection, but not in those having persistent H. pylori. COX-2 and iNOS expressions were well correlated with H. pylori density, acute and chronic inflammation of gastric mucosa. Conclusions: The eradication of H. pylori can decrease the expression of COX-2 and iNOS in the gastric mucosa in long-term period. This seems to be due to the removal of H. pylori itself and related regression of gastric inflammation. (Korean J Gastroenterol 2008;52:286-292)
초음파내시경검사로 조기위암의 심달도 판정시 오진의 원인이 된 호산구성 농양 1예
정인식,김부성,박두호,변병훈,최종영,박영민,김상우,양영상,최상욱 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.3
Eosinophilic abscess is a rare disease of stomach that consists of many eosinophils in submucosa and muscle layers of stomach. Eosinophilic abscess is usually observed in liver after parasite infestation such as hepatic fascioliasis or in intradermal lesion of pemphigus. A 67-year-old female was admitted due to epigastric pain and indigestion. Endoscopic finding suggested early gastric cancer type IIc with the depth of invasion to mucosal layer at the lesser curvature of lower body. Histologic examination of endoscopic biopsy proved to be signet ring cell type adenocarcinoma. On endoscopic ultrasonography, the tumor was imaged as a slightly elevated mass with 15 mm in diameter. The lesion was localized from the first layer to the fourth layer which correspond to the mucosa and the proper muscle layer, The lesion consisted of low echoic and isoechoic densities. The lower echoic lesion ranging from the third layer to the fourth layer was thought to be necrotic or hemorrhagic portion within the tumor. Subtotal gasterectomy was performed. We compared the endoscopic and endosonographic features with the histologic findings of the resected stomach. Histologic examination showed signet ring cell carcinoma in mucosal layer and eosinophilic abscess in submucosal and proper muscle layer. We concluded that the endosonographic depth of invasion was overestimated because of the eosinophilic abscess.
정인식,이강문,안병민,박두호,이동수,김상우,송호진,양영상,채현석 대한소화기학회 2001 대한소화기학회지 Vol.37 No.2
The use of histamine (H₂)-receptor blockers has been associated with central nervous system (CNS) toxicities manifesting as delirium, mental confusion, dizziness, and hallucination. Elderly patients with renal or hepatic dysfunction are more susceptible to these adverse reactions. Most of these reactions have been reported with both cimetidine and ranitidine. Famotidine, one of H₂ blockers, has been shown to be effective in improving symptoms and healing gastrointestinal lesions. Since 1986, an estimated 18.8 million worldwide patients have been treated with famotidine, but CNS adverse reactions associated with famotidine have been reported very rarely. The authors report a case of famotidine-associated delirium in an elderly patient with mild renal insufficiency, which was cleared completely after stopping the administration of famotidine.