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정인경,Da Hee Oh,Seung-Joon Park,Ja-Heon Kang,Sunshin Kim,Myung-Shik Lee,Myung-Jun Kim,Yoo-Chul Hwang,Kyu Jeong Ahn,Ho-Yeon Chung,Min-Kyung Chae,유형준 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.12
Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads to macrovascular complications are poorly understood. Vascular smooth muscle cell (VSMC) dysfunction due to high glucose is a characteristic of diabetic vascular complications. Activation of nuclear factor-κB (NF-κB) may play a key role in the regulation of inflammation and proliferation of VSMCs. We examined whether VSMC proliferation and plasminogen activator inhibitor-1 (PAI-1) expression induced by high glucose were mediated by NF-κB activation. Also, we determined whether selective inhibition of NF-κB would inhibit proliferation and PAI-1 expression in VSMCs. VSMCs of the aorta of male SD rats were treated with various concentrations of glucose (5.6,11.1, 16.7, and 22.2 mM) with or without an inhibitor of NF-κB or expression of a recombinant adenovirus vector encoding an IκB-α mutant (Ad-IκBαM). VSMC proliferation was examined using an MTT assay. PAI-1 expression was assayed by real-time PCR and PAI-1 protein in the media was measured by ELISA. NF-κB activation was determined by immunohistochemical staining, NF-κB reporter assay, and immunoblotting. We found that glucose stimulated VSMC proliferation and PAI-1 expression in a dose-dependent manner up to 22.2 mM. High glucose (22.2 mM) alone induced an increase in NF-κB activity. Treatment with inhibitors of NF-κB such as MG132, PDTC or expression of Ad-IκB-αM in VSMCs prevented VSMC proliferation and PAI-1 expression induced by high glucose. In conclusion,inhibition of NF-κB activity prevented high glucose-induced VSMC proliferation and PAI-1expression.
정인경 ( In Kyung Jeong ) 대한내과학회 2015 대한내과학회지 Vol.89 No.4
Glucagon like peptide-1 (GLP-1) is an intestinal L cell derived incretin hormone which stimulates insulin secretion of beta cell and inhibits glucagon secretion of alpha cell of pancreatic islets. GLP-1 receptors are located in pancreas as well as in a wide variety of tissue such as gastrointestinal tract, heart, blood vessel, lung, brain, kidney, and bone. Therefore GLP-1 and GLP-1 based treatment have multiple extrapancreatic effects which are inhibition of gastrointestinal motility, reduction of appetite, weight loss, increase of cardiac output, cardiovascular protection, neuroprotection, renoprotection, and increase of bone mineral density. Recently, besides GLP-1 receptor dependent pathway, GLP-1 receptor independent pathway has been identified in the extrapancreatic effect of GLP-1 in liver, adipose tissue, muscle, cardiovascular system. This review provides an overview of the pleiotropic effect of GLP-1 in the extrapancreatic organ through review of animal and clinical research. (Korean J Med 2015;89: 404-412)
지속적 외래 복막투석환자에서 투석 연결방법에 따른 복막염의 양상
정인경(In Kyung Jeong),홍성표(Seung Pyo Hong),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim),안재형(Jae Hyung Ahn) 대한내과학회 1998 대한내과학회지 Vol.54 No.1
Objectives : The purpose of the present study was to compare the general conditon of peritonitis through a study of three connector systems : The Straight transfer set with Spike-and-Pork system (SPS), The Straight transfer set with Luer-Lock system(SLS), and The Y-set with Two Bag system(YS). Methods: We reviewed our experience with 134 patients from 1988.1 to 1995.12. According to various kinds of connector system, we divided cases into 3 groups: The SPS(1988. 1-1991. 3) was used on 55 patients(mean age 47±12, M:F=30:25); The SLS (1991.4-1993.8) on 45 patients(mean age 55±11, M:F=30:15); and The YS(1993.9-1995.12) on 34 patients(mean age 49±15, M:F=15:19). Results: 1) Total CAPD duration was 1.22 patient ·year in SPS, 1.08 in SLS, and 0.96 in YS. The incidence of peritonitis is 1.71 episodes per patient ·year in SPS, 1.03 in SLS, and 0.61 in YS. 2) Among the causative organisms of peritonitis, coagulase negative Staphylococcus was most common in the three groups(SPS:10.4%, SLS:10%, YS: 20%). In SPS and SLS, S. aureus(7.7%, 8%), Pseudomonas(6.5%, 8%), E.coli(5.2%, 6%) were present in decreasing order. In YS, Pseudomonas (15%), S.aureus(15%), Ecoli(10%) were present in decreasing order. There were no growth of organisms in 55.9% of SPS, 38% of SLS, and 30% of YS. 3) The probability of experiencing the first peritonitis at 1, 3, 6, and 12 months was 21.4%, 21.4%, 21.4%, and 23.9% respectively in SPS, 3.4%, 34.5%, 34.5%, and 10.3% respectively in SLS, and 0%, 28.5%, 35.7%, and 28.5% respectively in YS. 4) In the response to the treatment of peritonitis, 59.7% of the peritonitis episodes in SPS, 72% in SLS, and 85% in YS were cured with antibiotics. In 37.7% of the peritonitis episodes in SPS, 24% in SLS, and 10% in YS, the catheter was removed due to fungal, tuberculous, recurrent, or peritonitis not responding to antibiotics. 2 patients in SPS, 2 patients in SLS, and 1 patient in YS died due to peritonitis. 5) The catheter survival rate at 3, 6, 12 months was 72%, 63.6%, and 40% respectively in SPS, 89%, 78.3%, and 46.7% respectively in SLS, and 94%, 85.3%, and 76.6% respectively in YS. Conclusion: Our study suggests that there is a relationship between the development of connector system and a decrease of peritonitis in CAPD.