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Radiotherapy Versus Cordectomy in the Management of Early Glottic Cancer
정승연,김경환,금기창,고윤우,김세헌,최은창,이창걸 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1
Purpose The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. Materials and Methods A total of 165 patients who were diagnosed with T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), diseasefree survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. Results The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9% and 89.9%, respectively, for the RT group, and 82.8% and 73.2%, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5% and 83.7%, respectively, for the RT group and 79.2% and 68.0%, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8% vs. 90.6%, p=0.713) or larynx preservation rates (98.2% vs. 97.2%, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. Conclusion RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.
정승연,이대규,이유나,한신우 한국감성과학회 2020 춘계학술대회 Vol.2020 No.-
일상생활에서 사고가 빈번하게 일어나는 자전거, 전동 킥보드 등에 대한 안전을 확보하기 위한 장치이다. 자전거나 킥보드에 경우 반사판 및 깜빡이가 작게 부착만 되어 있어, 안전에 대한 시인성이 떨어지고 있는 실정이다. 따라서 어깨고정용 밴드에 화살표형 LED를 부착하고 컨트롤러를 손목 쪽에 똑딱이 버튼 형식으로 부착한다. 또한 자전거나, 전동 킥보드 앞에 LCD 모니터를 부착하여 방향 지시등의 상태(on/off)를 알 수 있도록 한다. 자전거와 킥보드는 블루투스로 신호가 가도록 구성하며, 뒤에 오는 자동차 또는 보행자 등이 자전거나 킥보드가 어디로 가려고 하는지에 대해 알 수 있도록 한다. 웨어러블 형태의 깜빡이를 장착한다면 안전 확보가 극대화될 것이다.
이동수단의 안전확보를 위한 웨어러블 사고방지 방향지시등에 관한 연구
정승연,이대규,이유나,한신우,민승남 한국감성과학회 2020 춘계학술대회 Vol.2020 No.-
본 연구는 일상생활에서의 사고가 빈번하게 일어나는 자전거, 전동 킥보드 등에 대한 안전을 위해 자동차 방향지시등을 활용하여 제 3 자에게 신호를 알려주고 안전을 확보하기 위한 목적이다. 이를 위해 30 명의 피실험자를 모집하였으며, 만족도, 시인성, 제품작동을 분석하였다. 그 결과 시인성과 제품작동에서 긍정적으로 나왔으며 만족도는 높게 나타났다. 추후 이 기술이 보급화 된다면 자전거, 전동 킥보드 사고의 감소가 될 거라 판단된다.
A Case of Diffuse Neonatal Hemangiomatosis Successfully Treated with Propranolol
정승연,이미정,유지숙 대한소아혈액종양학회 2016 Clinical Pediatric Hematology-Oncology Vol.23 No.1
We present a case of a 41-day-old girl with diffuse hemangiomatosis on her chin, right thigh, occipital area, and liver. She also had hepatomegaly, heart failure, and hypothyroidism. Hemangiomatosis did not respond to 2 weeks of oral administration of prednisolone, but was successfully treated with propranolol. After 2 years of propranolol treatment, the lesions of hemangiomatosis nearly disappeared. Hypothyroidism was controlled by levothyroxine replacement. As hemangiomatosis regressed, thyroid function was normalized. Propranolol may have adverse effects including hypotension, hypoglycemia, bronchoconstriction, and restlessness, but she did not experience such adverse effects. Propranolol could be the first choice for diffuse neonatal hemangiomatosis (DNH). Our case also suggests that thyroid function test is needed in patient with DNH.
정승연,장종희,김혜련,조병철,이창걸,서창옥 대한방사선종양학회 2017 Radiation Oncology Journal Vol.35 No.2
Purpose: To evaluate intracranial control after surgical resection according to the adjuvant treatment received in order to assess the optimal radiotherapy (RT) dose and volume. Materials and Methods: Between 2003 and 2015, a total of 53 patients with brain oligometastases from non-small cell lung cancer (NSCLC) underwent metastasectomy. The patients were divided into three groups according to the adjuvant treatment received: whole brain radiotherapy (WBRT) ± boost (WBRT ± boost group, n = 26), local RT/Gamma Knife surgery (local RT group, n = 14), and the observation group (n = 13). The most commonly used dose schedule was WBRT (25 Gy in 10 fractions, equivalent dose in 2 Gy fractions [EQD2] 26.04 Gy) with tumor bed boost (15 Gy in 5 fractions, EQD2 16.25 Gy). Results: The WBRT ± boost group showed the lowest 1-year intracranial recurrence rate of 30.4%, followed by the local RT and observation groups, at 66.7%, and 76.9%, respectively (p = 0.006). In the WBRT ± boost group, there was no significant increase in the 1-year new site recurrence rate of patients receiving a lower dose of WBRT (EQD2) <27 Gy compared to that in patients receiving a higher WBRT dose (p = 0.553). The 1-year initial tumor site recurrence rate was lower in patients receiving tumor bed dose (EQD2) of ≥42.3 Gy compared to those receiving <42.3 Gy, although the difference was not significant (p = 0.347). Conclusions: Adding WBRT after resection of brain oligometastases from NSCLC seems to enhance intracranial control. Furthermore, combining lower-dose WBRT with a tumor bed boost may be an attractive option.
정승연 한일경상학회 2007 韓日經商論集 Vol.38 No.-
A Study on Exploitation of Intellectual Property Rights in Japan: On Relating to Japanese Economic System