http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
전원선,박세은,이은정,박철영,오기원,박성우,이원영 대한내분비학회 2013 Endocrinology and metabolism Vol.28 No.4
Background: Adipocyte-specific fatty acid-binding protein (A-FABP) is a cytoplasmic protein expressed in macrophages and adipocytes and it plays a role in insulin resistance and metabolic syndrome. Recently, the fatty liver index (FLI) was introduced as an indicator of nonalcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the relationship between baseline serum A-FABP levels and FLI after 4 years in apparently healthy subjects. Methods: A total of 238 subjects without a past history of alcoholism or hepatitis were recruited from a medical check-up program. The NAFLD state was evaluated 4 years later in the same subjects using FLI. Fatty liver disease was diagnosed as diffusely increased echogenicity of the hepatic parenchyma compared to the kidneys, vascular blurring, and deep-echo attenuation. NAFLD was defined as subjects with fatty liver and no history of alcohol consumption (>20 g/day). Results: Baseline serum A-FABP levels were significantly associated with FLI after adjustment for age and sex (P<0.001). The subjects with higher A-FABP levels had a higher mean FLI (P for trend=0.006). After adjusting for age and sex, serum A-FABP levels at baseline were shown to be significantly associated with FLI as a marker of development of NAFLD after 4 years (odds ratio, 2.68; 95% confidence interval, 1.24 to 5.80 for highest tertile vs. lowest tertile; P=0.012). Conclusion: This study demonstrated that higher baseline serum A-FABP levels were associated with FLI as a predictive indicator of NAFLD after 4 years of follow-up in healthy Korean adults.
전원선,이은정,김태형,유쾌한,왕동현,오태연,위지완,윤서영,서미선,조아라,박진성,전민혁,추은주,추은주 순천향대학교 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1
The synergistic infection of syphilis and HIV (Human immunodeficiency virus) infection is a re-emerging problem of global health after AIDS (Acquired immunodeficiency syndrome) era. Neglected treatment of syphilis in HIV-positive patients may lead to increased chance of HIV transmission in community and neglected screening of HIV in syphilis patients may delay diagnosis of HIV which now become a controllable chronic diseases. HIV-positive persons with syphilis co-infection are more likely to have neurologic complications and a higher rate of treatment failure with currently recommended regimens. And the neurologic manifestations of syphilis in HIV patients tend to occur earlier periods of HIV infection. But neuropsyphilis in HIV patients is still poorly understood, despite > 2 decades of clinical experiences.
전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2
Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.
Antiobesity Pharmacotherapy for Patients with Type 2 Diabetes: Focus on Long-Term Management
전원선,박철영 대한내분비학회 2014 Endocrinology and metabolism Vol.29 No.4
Type 2 diabetes and obesity have a complex relationship; obesity is linked to insulin resistance, the precursor to type 2 diabetes. The management of obesity is an important method to delay onset of diabetes and improve the glycemic durability of antidiabetic agents. However, insulin and some of the oral hypoglycemic agents used to treat diabetes cause significant weight gain, and it is difficult for patients with diabetes to reduce and maintain their weight by life-style changes alone. Thus, antiobesity medications or bariatric surgery may be a necessary adjunct for certain obese patients with diabetes. In 2012, the U.S. Food and Drug Administration (FDA) approved lorcaserin and phentermine/topiramate extended-release for the management of chronic weight, and approval for naltrexone/bupropion sustained-release as an adjunct to exercise and reduced caloric intake followed in 2014. Liraglutide is pending FDA approval for antiobesity drug. Here we review the efficacy of approved and new promising drugs for the management of obesity.
유정문,전원선,Yoo, Jung-Moon,Jeon, Won-Sun 한국지구과학회 2000 한국지구과학회지 Vol.21 No.6
전지구(全地球)에 대한 오존전량과 반사율의 경년(經年) 변화를 조사하기 위하여 1979-92년 기간의 Nimbus-7/TOMS 자료의 월평균과 그 아노말리 값을 사용하였다. 여기서 대기 열적 변화에 따른 오존의 경년 변화를 분석하기 위하여 TOMS 자료 외에 위성관측 MSU채널4(하부성층권) 자기온도와 두 개의 대기대순환 모델(NCEP, GEOS) 재분석 온도를 이용하였다. 또한 대기의 열적 및 강수(구름) 변화에 따른 반사율의 경년 변화를 분석하기 위하여는 MSU 채널1(하부 대류권)밝기온도를 이용하였다. 오존전량의 시계열은 뚜렷한 계절 변화와 함께 전구적으로 감소 경향(-6.3${\pm}$0.6 DU/decade)을, 그리고 엘니뇨보다는 화산폭발이 있었던 기간에 더 뚜렷한 변동을 보였다. 오존전량과 위성관측 및 모델 재분석의 하부 성층권 온도는 1980-92년 기간의 경년 변화에 있어서 서로 양의 상관(0.2-0.7)을 보였다. 반사율은 같은 기간에 전구적으로 다소 증가 경향(0.20${\pm}$0.06 %/decade)을 보였으며 1982-83년, 1991-92년의 엘니뇨 특징을 잘 반영하였다. 열대 지역에서의 반사율의 연주기 변동은 양반구의 고위도에 비하여 작게 나타났으며, 이는 아열대 고압대 및 열대 용승 지역에서 대기 침강으로 인하여 구름이 소산되거나 하층운의 발달로 인하여 낮은 반사율과 함께 그 변동도 작기 때문인 것으로 추정되었다. 전구에 대한 반사율과 MSU 하부 대류권 온도는 경년 변화에 있어서 서로 음의 상관(-0.9)을 보였으나, 대류활동이 활발한 열대 해양에서는 낮은 양의 상관(0.2)을 보였다. 이러한 양의 상관은 해양에서 구름 및 강수의 증가에 따라 채널1 밝기온도를 증가하게 하는 마이크로파 방출율의 효과를 반영하였다. 오존과 하부 성층권 온도 사이에, 그리고 반사율과 하부 대류권 온도 사이에 존재하는 유의적인 상관은 오존 및 반사율의 위성관측 자료가 기후변동에서의 피이드백 작용을 이해하는데에 유용하게 사용될수 있음을 본 연구는 제시한다. In order to investigate interannual variation of total ozone and reflectivity over the globe, Nimbus-7/TOMS data were used on the monthly mean and its anomaly for the period of 1979-92. This study also examined MSU channel 4(Ch4; lower-stratosphere) brightness temperature data and two model reanalyses of NCEP and GEOS to compare the ozone variation with atmospheric thermal condition. In addition, the MSU channel 1(Ch1 ; lower-troposphere) brightness temperature was used to compare with the reflectivity. The ozone showed strong annual cycle with downward trend(-6.3${\pm}$0.6 DU/decade) over the globe, and more distinct response to volcanic eruption than El Ni${\tilde{n}$o. The relationship between total ozone and MSU Ch4 observation, and between the ozone and model reanalyses of lower stratosphere temperature showed positive correlation(0.2-0.7) during the period of 1980-92. Reflectivity increased interannually by 0.2${\pm}$0.06%/decade over the globe during the above period and reflected El Ni${\tilde{n}$o(1982-83, 1991-92) well. Its variability in annual cycle was remarkably smaller in tropics than in higher latitudes. This is inferred due to cloud suppression and tropical upwelling regions. Reflectivity correlated negatively(-0.9) to the Ch1 temperature over the globe, but positively(0.2) over tropical ocean. The positive value over the ocean results from the effect of microwave emissivity which increases the Ch1 temperature with enhanced hydrometeor activity. Significant correlations between total ozone and the Ch4 temperature, and between reflectivity and the Ch1 Suggest that the TOMS data may use valuably to better understand the feedback mechanism of climate change.