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Phenolic Constituents from the Flowers of Hamamelis japonica Sieb. et Zucc.
임순호,이영주,박기덕,이익수,신부안,정다운,Darren R. Williams,김현정 한국생약학회 2015 Natural Product Sciences Vol.21 No.3
Hamamelis japonica (Hamamelidaceae), widely known as Japanese witch hazel, is a deciduous flowering shrub that produces compact clumps of yellow or orange-red flowers with long and thin petals. As a part of our ongoing search for phenolic constituents from this plant, eleven phenolic constituents including six flavonol glycosides, a chalcone glycoside, two coumaroyl flavonol glycosides and two galloylated compounds were isolated from the flowers. Their structures were elucidated as methyl gallate (1), myricitrin (2), hyperoside (3), isoquercitrin (4), quercitrin (5), spiraeoside (6), kaempferol 4'-O-b-glucopyranoside (7), chalcononaringenin 2'-O-b-glucopyranoside (8), trans-tiliroside (9), cis-tiliroside (10), and pentagalloyl-O-b-D-glucose (11), respectively. These structures of the compounds were identified on the basis of spectroscopic studies including the on-line LC-NMR-MS and conventional NMR techniques. Particularly, directly coupled LC-NMR-MS afforded sufficient structural information rapidly to identify three flavonol glycosides (2 - 4) with the same molecular weight in an extract of Hamamelis japonica flowers without laborious fractionation and purification step. Cytotoxic effects of all the isolated phenolic compounds were evaluated on HCT116 human colon cancer cells, and pentagalloyl-O-b-D-glucose (11) was found to be significantly potent in inhibiting cancer cell growth.
임순호,김현정,정나리,박기덕,이영주,조성동,이익수 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.4
Two phenolic allopyranosides and two phenolic amide allopyranosides, along with eight known phenolic compounds, including cimicifugic acids, shomaside B, fukiic acid, isoferulic acid, and piscidic acid, were isolated from the n-butanolic extract of rhizomes of Cimicifuga heracleifolia. On-line spectroscopic data for UV, NMR, and MS from a combination of LC-NMR and LC-MS techniques directly and rapidly provided sufficient structural information to identify and confirm all the structures of major phenolic compounds in the extract, in addition to their HPLC profiles. This combined analytic information was then used as a dereplication tool for structure-guided screening in order to isolate unknown phenolic compounds in the extract. Successive fractionation and purification using semi-preparative HPLC acquired four unknown allopyranosides, and their structures were identified as cis-ferulic acid 4-O-β-D-allopyranoside, trans-ferulic acid 4-O-β-D-allopyranoside, trans-feruloyltyramine 4-O-β-D-allopyranoside, and trans-feruloyl-(3-O-methyl)dopamine 4-O-β-D-allopyranoside, based on a subsequent spectroscopic interpretation.
고로쇠 Coumarinolignans의 b-Cyclodextrin 포접화합물 제조 및 암세포증식 억제활성
임순호,정다운,윌리엄스다렌,게클러커트,김경근,신부안,이익수,김현정 한국생약학회 2015 생약학회지 Vol.46 No.2
Two coumarinolignans, cleomiscosins C (1) and D (2) were isolated from the heartwood of Acer mono, together with four compounds, 5-O-methyl-(E)-resveratrol-3-O-b-D-glucopyranoside (3), 5-O-methyl-(E)-resveratrol-3-O-b-D-apiofuranosyl-(1?6)-b-D-glucopyranoside (4), scopoletin (5), and (E)-resveratrol-3-O-b-D-glucopyranoside (6). Of them, cleomiscosins C (1) and D (2) were applied to preparing inclusion complex molecules with b-cyclodextrin (b-CD) to improve the very poor solubility in cell media. The CD complexes of 1 and 2 exhibited an enhancement of water solubility which is feasible to measure their cytotoxicity using a spectrophotometer in a cell-based assay. Anti-proliferative activity of these complex molecules was successfully estimated on HCT116 human colon cancer cells, and cleomiscosin D (2) showed anti-proliferative effects at the concentration of 1.95~31.2 mg/mL in a dose-dependent manner.
유리단 국소의치에서 Suprabulge Clasp와 Infrabulge Clasp가 지대치 동요에 미치는 영향에 관한 연구
임순호,Yim, Soon-Ho 대한치과보철학회 1981 대한치과보철학회지 Vol.19 No.1
Distal-extension removable partial dentures have long been implicated in the increase in mobility and the destruction of the supporting structures of the primary abutment teeth. Various clasping systems have traditionally been used to retain distal extension removable partial dentures, and other designs have been proposed to minimize torquing forces on the abutment teeth. Most recent studies investigating the effects of removable partial dentures on abutment teeth have been performed in it laboratory setting. Results obtained from in vitro research have given dentists insight into removable partial denture design, but laboratory test model cannot be constructed that simulates actual functional or parafunctiona1 movements and forces. The purpose of this study was to clinically evaluate the degree of tooth mobility produced by two clasping systems (suprabulge type and infrabulge type) used for distal extension removable partial dentures. Akers clasp and R.P.I. system were selected for the evaluation, and four patients required a distal extension removable partial denture on the mandibular arch were selected for participation in the study. Two partial dentures were constructed in the same condition expect the design of clasp. All abutments in the study were mandibular first or second premolars. Measurements of mobility were made with a research tool designed by $M\"{u}hlemann$. This instrument, periodontometer, measures tooth mobility in the mouth by means of a dial gauge accurated to 0.01mm when the tooth is stressed with a force meter. Lingual and buccal deflection of abutment tooth was measured using buccal and lingual pressure. The amount of force applied was 500gm. Tooth mobility tests were made at four key stages; 1. Before insertion of the first removable partial denture, baseline mobility was establsihed. 2. After wearing of the first prosthesis, measurement was made at weekly intervals for 4 weeks. 3. The removable partial denture was then taken from the patient, and tooth mobility was measured again at weekly intervals until the patient's established baseline mobility had returned. 4. The second prosthesis of different clasp design was worn for a month and evaluated in the same manner as the first. The sequence of placement of clasping system was alternated between patients. The following results were obtained from this study; 1. The mobility of abutment tooth increased during the initial stage of wear and returned to baseline mobility after removal of removable partial dentures. 2. The mobility of abutment tooth showed no difference between Akers clasp and I-bar clasp during the 4-week test period. 3. All teeth tested showed greater mobility toward the buccal than the lingual direction.