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      • KCI등재

        대학생의 굼뜬 인지적 속도(SCT) 성향과 대학생활적응의 관계: 경험회피와 스마트폰 과의존의 순차적 매개효과

        임수정,오지현 한국지역사회생활과학회 2024 한국지역사회생활과학회지 Vol.35 No.1

        This study attempted to examine the sequential mediating effect of experiential avoidance and smartphone overdependence on the sluggish cognitive tempo (SCT) of college students and adaptation to college life. The survey was conducted on 1st, 2nd, and 3rd grade college students attending universities located in South Korea. Data from 350 participants were analyzed using Model 4 and Model 6 of the PROCESS Macro version 4.1 to verify the simple mediating and sequential mediating effects of experiential avoidance and smartphone overdependence in the relationship between the sluggish cognitive tempo among college students and college life adaptation. The results are summarized as follows: First, experiential avoidance partially mediated the relationship between the SCT in college students and college life adaptation. Second, smartphone overdependence partially mediated the relationship between the SCT among college students and college life adaptation. Third, the sequential mediating effects of experiential avoidance and smartphone overdependence on the relationship between the SCT of college students and college life adaptation were found to be significant. Based on the findings, the implications for counseling and the limitations of this study were discussed.

      • SCOPUSKCI등재

        [123I]Idoxifene 합성과 유방암의 세포섭취에 관한 연구

        임수정,임상무,양승대,서용섭,전권수,안순혁,유국현,조영섭 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.5

        Purpose: Idoxifene is currently entering phase Ⅱ clinical trials for the treatment of advanced breast cancer. The radiolabeled idoxifene using 123I provides an opportunity for clinical pharmacology with single photon emission computed tomography (SPECT). The purpose of this study was to prepare radiolabeled idoxifene using 123I and to determine its cell uptake of breast cancer cell line. Materials and Methods: With a view to evaluating new anticancer drugs, we are investigating the novel antiestrogen pyrrolidino- 4-iodotamoxifen (idoxifene). [123I]Idoxifene has been prepared in no-carrier-added form using a tributyl stannylated precursor which has been synthesized by means of (2-chloroethoxy)benzene with (±)-2- phenylbutanoic acid on the basis of previously reported standard methods. The biodistribution and dynamic behavior of the compound were investigated using the comparative breast cancer cell line, MCF-7 (estrogen receptor-positive) and MDA-MB-468 (non-estrogen receptor). Results and Conclusion: Acylatn of (2-chloroethoxy)benzene with (±)-2-phenylbutanoic acid gave the versatile ketone (81%) which reacted with 1,4-diiodobenzene to give triphenylethylene as a mixture of E and Z geometric isomers, which were separated by the recrystallization in ethanol. The E-isomer was treated with pyrrolidine to give idoxifene (67%). In order to incorporate radioactive iodine into the 4-position, the 4-stannylated precursor was prepared (30%). The yield of radioiodination was 90-92% with a high radiochemical purity greater than 98%. The ratio of tumor uptake of the breast cancer cell line between MCF-7 and MDA-MB-468 was about 1.7.

      • SCOPUSKCI등재

        농양이식백서에서 99mTc , 188Re 직접표지항체의 비교

        임수정,최창운,최태현,임상무,우광선,정위섭 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.1

        Purpose: We investigated the direct labeling method of antibody with 99mTc and 188Re and examined the stability and function of these labeled compounds in in vitro and in vivo. Materials and Methods: Disulfide bond of nonspecific human IgG was reduced to -SH group by 2-mercaptoethanol. Stannous ion was used to reduce 99mTc and 188Re. The stability of 99mTc-IgG and 188Re-IgG was estimated upto 24 hrs. Biodistribution was evaluated in abscess bearing rats at 4 and 24 hr post-injection of 99mTc or 188Re labeled IgG. Results: The number of -SH group per reduced IgG molecule was 2.34. The labeling yield of 99mTc-IgG and 188Re-IgG were 90% and 95%, respectively. The stability of 99mTc-IgG at 1, 4, 6 and 24 hr was 91%, 83%, 78%, 7% and that of 188Re-IgG, high uptake was found on kidney, blood, stomach and abscess (9.42±0.68, 1.43±0.24, 0.86±0.18, 0.72±0.10 %ID/g, respectively). The uptakes at 24 hr were kidney, abscess, stomach, and blood in descending order. In case of 188Re-IgG, high uptake at 4 hr post injectappeared on kidney, blood, abscess and stomach (3.92±0.62, 1.32±0.08, 0.88±0.01, 0.26±0.06, respectively). The upatkes at 24 hr were kidney, abscess, blood abd stomach in descending order. The abscess to blood uptake ratio of 99mTc-IgG was 0.5 at 4 hr and 2.02 at 24 hr and that of 188Re-IgG was 0.67 and 1.29. Conclusion: 99mTc-IgG and 188Re-IgG and 188Re-IgG canbe labeled efficiently with direct labeling method. However, 99mTc-IgG and 188Re-IgG, labeled with direct method, was unstable. Further study in needed to enhance the stability of the antibody labeling.

      • SCOPUSKCI등재
      • 온라인 커뮤니티에서 공동체의식과 몰입의 충성도 예측

        임수정 이화여자대학교 교육대학원 2007 이화교육논총 Vol.17 No.-

        The human is a 'social animal'; for this reason, they have been constantly trying to make relationships with others and have attempted to form large and small forms of communities participate in them based on the connections such as blood ties, the same regional and academic relations (Kim Ju-jeong and Jo Su-seon, 2001). Such communities have showed up in the name of 'Community' on the online thanks to the development of information and telecommunication in the 20th century; meanwhile, new technologies have affected the formation of human relationship so that new forms of human relationship have been formulated. As a part of such changes, some communities using the Internet (an electronic medium) have showed up and they have been developed from the previous traditional communities based on geographical proximity to a new concept of communities that have existed beyond time and space. As people have formed some sorts of communities beyond spatial limits, the so-called online communities have been generated. In this regard, this study investigated what the essence of 'a sense of Community' felt by online community members would be and what factors made them to have cognitive absorption m the communities. In addition, it attempted to analyze why certain community users showed loyalty to specific communities and formed them through such a sense of Community and cognitive absorption. This study attempted to help people deduce success elements of online learning websites, by closely examining the relationship between a sense of Community, cognitive absorption and their resultant loyalty to certain online communities. That is, it groped for the elements to increase the members of learning websites and demonstrated that they could lead to the re-visit to the corresponding websites; in doing so, the study attempted to provide basic data that would be helpful to the development of future online learning websites.

      • KCI등재

        장애인근로자의 삶의 만족 요인에 관한 인과관계분석

        임수정,이준우 한국장애인고용공단 고용개발원 2011 장애와 고용 Vol.21 No.1

        본 연구의 목적은 장애인근로자의 근로환경과 삶의 만족도의 인과관계를 설명하고 예 측할 수 있는 연구모형을 제시하여 요인들 간 직접ㆍ간접적 관계를 검증하는 데 있다. 이 를 위해 장애인고용패널 1차년도(2008년) 원자료를 사용하였으며, 임금근로자 1,211명을 대상으로 분석을 실시하였다. 본 연구에서 사용한 근로환경 요인은 직위, 고용형태, 채용 방법, 복리후생이며 직업유지기간, 임금 그리고 삶의 만족도와의 인과관계 검증을 위한 가 설을 설정하였다. 가설검증을 위해 SPSS 18.0과 AMOS 18.0을 사용하여 t-검정(t-test)과 일원변량분석(One-way ANOVA), 상관관계분석, 그리고 경로분석(Path Analysis)을 실 시하였다. 본 연구의 결과는 주요변인 간 차이검증에서 근로환경 요인 중 관리자급의 경우, 정규 직인 경우, 공개채용인 경우, 복리후생이 있는 경우에 직업유지기간, 임금, 삶의 만족도 평 균이 높게 나타났다. 또한 주요변인 간 인과관계 검증결과 관리자급이, 정규직인 경우에 직업유지 기간에 직접적인 영향을 미치고 있으며, 관리자급인 경우, 정규직인 경우, 공개 채용인 경우, 복리후생이 있는 경우 임금에 직접적인 영향을 미치는 것으로 나타났다. 또 한 복리후생이 있는 경우, 정규직인 경우, 그리고 임금이 높을수록 삶의 만족도에 직접적 인 영향력을 미치는 것으로 나타났으며, 임금이 근로환경요인과 삶의 만족도 사이에서 매 개효과를 내는 것으로 나타났다. 본 연구는 장애인근로자의 근로환경과 삶의 만족도 사이에 밀접한 인과관계가 성립되 고 있음을 밝힘으로써 직업정책의 관점이 개인적 관점에서 사회적 관점으로 변화되어야 할 필요성을 제기한다는 점에서 의의가 있다. The purpose of this study is to explain the causal relationship between the working environment of disabled workers and life satisfaction and verify the direct and indirect relationships between the factors through providing a research model. ‘Disabled Employment Panel’(2008) was used as a raw data and analysis was done with 1,211 employed workers as the subjects. Work environmental factors used in this study were job positions, types of employment, recruitment methods, welfare benefits and a hypothesis was set to verify the causal relationship between job maintenance period, wage and life satisfaction. To verify the hypothesis t-test (t-test), ANOVA (One-way ANOVA), correlation analysis and path analysis (Path Analysis) was carried out by using SPSS 18.0 and AMOS 18.0. The result of verifying the difference between main factors of this study showed that in the case of administrator level among work environment factors, as the work was a permanent position, an open recruitment, and had welfare benefits the average of job maintenance period, wage, and life satisfaction is higher. Moreover, the result of verifying the causal relationship between main factors of this study showed that as the administrator level is a permanent position it has a direct influence on job maintenance period and as the position is an administrator level, permanent, open recruited and have welfare benefits it has a direct influence on wage as well. Also, if you have welfare benefits in a permanent position with a high wage it has a direct influence on life satisfaction and found that wage has a mediating effect between work environment factor and life satisfaction. This study is meaningful because it raises the need for transformation of employment policy perspective from an individual one to a social one through identifying the close causal relationship between work environment and life satisfaction of disabled workers.

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