I-131 치료시 환자의 신장기능과 다양한 요인으로 의한 퇴원선량 및 치료병실 오염도의 유의성에 관한 연구

임광석,최학기,이기현,Im, Kwang Seok,Choi, Hak Gi,Lee, Gi Hyun 대한핵의학기술학회 2013 핵의학 기술 Vol.17 No.1

우리나라의 갑상선 암이 증가함에 따라서 갑상선 전 절제술 후 고용량 방사성동위원소 치료를 받는 환자 또한 증가하였다. 하지만 치료를 위해서 사용되는 I-131의 경우 반감기가 8.01일 이며 감마선과 베타선을 내는 특징이 있어 타인에게 줄 수 있는 외부 피폭의 영향을 막기 위해 일정기간 동안 환자가 격리병실에 입원하여 치료를 받게 된다. 이틀 내지 사흘 동안의 격리치료를 한 후 퇴원 전 환자의 몸에서 나오는 방사선량이 법적 기준(70 uSv/h)에 만족하는지 확인한 후 퇴원을 하게 된다. 그리고 다음 환자가 입원 시까지 병실 곳곳의 오염도를 확인 한 후 필요 시에는 제염작업을 수행하게 된다. 우리는 이러한 일련의 과정들 상에서 의료진들이 피폭의 영향을 받게 되는 주 요인으로는 환자의 퇴원선량 확인 및 치료병실의 오염도확인과 제염작업시의 피폭으로 예상된다. 본 연구는 환자의 여러 가지 요소들을(환자의 신기능, 연령, 성별, 초기 투여용량, Tg, Tg-ab)정하고 그 인자들을 통해 환자의 퇴원선량 및 치료병실 오염도에 어떠한 영향을 미치는지 알아보고자 한다. 본원에서 2011년 8월 1일부터 2012년 5월 29일까지 입원하여 고용량방사성 요오드 치료를 받은 환자 151명을 대상으로 실시하였다. 환자의 glomerular filtration rate (GFR) 값이 높을수록 퇴원선량이 낮은 상관관계를 보였다(P<0.001).초기 투여용량의 경우 5.5 GBq (150 mCi) 미만과 5.5 GBq (150 mCi) 이상을 투여 받은 환자군 두 그룹 사이에 평균 퇴원선량을 비교 분석한 결과 5.5 GBq (150 mCi) 미만을 투여 받은 환자 군에서 퇴원선량이 유의하게 낮음을 알 수 있었다($23.95{\pm}10.44uSv/h$, $28.65{\pm}11.79uSv/h$). 연령,성별, Tg, Tg-ab는 환자의 퇴원 선량과 유의한 관계를 보이지 않았다(p>0.05). 그리고 치료병실 오염도는 환자의 퇴원선량과 환자의 신기능과는 유의한 관계를 보이지 않았다 (p>0.05). 병실 오염도의 경우는 입원기간 동안 환자의 생활습관이나 기타 다른 다양한 요인에 의해 영향을 받을 것으로 사료된다. 비록 성별의 집단 간에 따라서 오차가 있다고 여겨지지만 추후 더 많은 환자들을 비교 분석 한다면 도움이 될 것이라고 판단된다. 또한 퇴원선량과 병실의 오염도에 영향을 줄 수 있는 기타 다른 요인들에 대해서도 지속적으로 연구한다면 환자 본인의 피폭뿐만 아니라 가족과 그주변인 의료진들에게도 조금이나마 피폭의 영향을 감소 시킬 수 있을 것이라고 사료된다. Purpose: I-131 is a radioisotope widely used for thyroid gland treatments. The physical half life is 8.01 and characterized by emitting beta and gamma rays which is used in clinical practice for the purpose of acquiring treatment and images. In order to reduce the recurrence rate after surgery in high-risk thyroid cancer patients, the remaining thyroid tissue is either removed or the I-131 is used for treatment during relapse. In cases of using a high dosage of radioactive iodine requiring hospitalization, the patient is administered dosage in the hospital isolation ward over a certain period of time preventing I-131 exposure to others. By checking the radiation amount emitted from patients before discharge, the patients are discharged after checking whether they meet the legal standards (50 uSv/h). After patients are discharged from the hospital, the contamination level is checked in many parts of the ward before the next patients are hospitalized and when necessary, decontamination operations are performed. It is expected that there is exposure to radiation when measuring the ward contamination level and dose check emitted from patients at the time of discharge whereby the radiation exposure by health workers that come from the patients in this process is the main factor. This study analyzed the correlation between discharge dose of patients and ward contamination level through a variety of factors such as renal functions, gender, age, dosage, etc.). Materials and Method: The study was conducted on 151 patients who received high-dosage radioactive iodine treatment at Soon Chun Hyang University Hospital during the period between 8/1/2011~5/31/2012 (Male: Female: 31:120, $47.5{\pm}11.9$, average dosage of $138{\pm}22.4$ mCi). As various factors expected to influence the patient discharge dose & ward contamination such as the beds, floors, bathroom floors, and washbasins, the patient renal function (GFR), age, gender, dosage, and the correlation between the expected Tg & Tg-Tb expected to reflect the remaining tissue in patients were analyzed. Results: In terms of the discharge dose and GFR, a low correlation was shown in the patient discharge dose as the GFR was higher (p < 0.0001). When comparing the group with a dosage of over 150mCi and the group with a lower dosage, the lower dosage group showed a significantly lower discharge dose ($24{\pm}10.4uSv/h$ vs $28.7{\pm}11.8uSv/h$, p<0.05). Age, gender, Tg, Tg-Tb did not show a significant relationship with discharge dose (p> 0.05). The contamination level in each spot of the treatment ward showed no significant relationship with GFR, Tg, Tg-Tb, age, gender, and dosage (p>0.05 ). Conclusion: This study says that discharge of the dose in the patient's body is low in GFR higher and Dosage 150mCi under lower. There was no case of contamination of the treatment ward, depending on the dose and renal association. This suggests that patients' lifestyles or be affected by a variety of other factors.

선택과 인연이 만들어주는 현재...

임광석 한국생물공학회 2019 BT NEWS Vol.26 No.1

SSD 성능 향상을 위한 DRAM 버퍼 데이터 처리 기법

임광석(Kwang Seok Im),한태희(Tae Hee Han) 大韓電子工學會 2011 電子工學會論文誌-SD (Semiconductor and devices) Vol.48 No.7

SSD(Solid State Disk)는 호스트 인터페이스와 낸드 플래시 메모리의 대역폭 차이를 완충하기 위한 버퍼로 DRAM을 적용하고 있다. 본 논문에서는 대역폭이 높은 고가의 DRAM을 사용하는 대신 저비용으로 SSD의 성능을 향상시킬 수 있는 효과적인 방법을 제안하였다. SSD 데이터는 사용자 데이터, 사용자 데이터 관리를 위한 메타데이터, 데이터의 오류 제어를 위한 FEC(Forward Error Correction) 패리티/CRC(Cyclic Redundancy Check) 등 크게 세 가지로 구분할 수 있다. 본 논문에서는 데이터 유형 별 특성을 고려하여 성능을 향상시키기 위해 모니터링 시스템을 통한 가변적인 버스트 데이터 처리 방법과 페이지 단위를 이용한 FEC 패리티/CRC 방식을 적용하였다. 실험을 통하여 0.07%의 무시할만한 칩 면적의 증가만으로 평균 25.9%의 SSD 성능 개선을 확인할 수 있었다. To adjust the difference of bandwidth between host interface and NAND flash memory, DRAM is adopted as the buffer management in SSD (Solid-state Disk). In this paper, we propose cost-effective techniques to enhance SSD performance instead of using expensive high bandwidth DRAM. The SSD data can be classified into three groups such as user data, meta data for handling user data, and FEC(Forward Error Correction) parity/ CRC(Cyclic Redundancy Check) for error control. In order to improve the performance by considering the features of each data, we devise a flexible burst control method through monitoring system and a page based FEC parity/CRC application. Experimental results show that proposed methods enhance the SSD performance up to 25.9% with a negligible 0.07% increase in chip size.

Gene delivery systems based on Nano-self assembly

Kwangsuk Lim(임광석) 한국고분자학회 2019 한국고분자학회 학술대회 연구논문 초록집 Vol.44 No.1

In vitro and in vivo Characterization of a Coronary Stent Coated with an Elastic Biodegradable Polymer for the Sustained Release of Paclitaxel

신영민,임광석,진지용,정성인,이영무,김경수,신흥수 한국고분자학회 2009 Macromolecular Research Vol.17 No.12

Udenafil이 혈관 평활근 세포의 증식과 백서 경동맥 손상 모델에서 신생내막 증식에 미치는 영향

조준호,임광석,Ji Yong Jin,김경수 대한심장학회 2008 Korean Circulation Journal Vol.38 No.6

Background and Objectives: Neointimal hyperplasia, which was caused by smooth muscle cell proliferation, was noted to occur after performing percutaneous coronary intervention. Phosphodiesterase type 5 (PDE5) inhibitor has been shown to inhibit smooth muscle cell proliferation. Udenafil is one of the PDE5 inhibitors, and it is also expected to inhibit smooth muscle cell proliferation and reduce neointimal hyperplasia. We investigated the effect of udenafil on the smooth muscle cell proliferation and neointimal hyperplasia that occurs after balloon injury in the carotid arteries of rats. Materials and Methods: Smooth muscle cells were treated with 1 mM, 100 μM, 10 μM, 1 μM and 100 nM concentrations of udenafil. The viability of the smooth muscle cells was evaluated by MTT assay. The carotid arteries of rats were injured with a balloon catheter. Udenafil (100 μM, 10 μM and 1 μM) was applied on the carotid artery adventitia after balloon injury. At 21 days after treatment, the carotid arteries were harvested and stained with H & E. The neointima and media area were measured with a computerized image analysis program. Results: In the in vitro experiment, treatment with 1 mM udenafil reduced smooth muscle cell viability by 68.8±4.42% compared to the control group. In the balloon injured rat carotid artery, treatment with 100 μM udenafil reduced the neointima area by 71.8% compared to the control group. Conclusion: Udenafil administration effectively inhibited smooth muscle cell proliferation and it reduced neointimal hyperplasia in the balloon-injured rat carotid artery. Background and Objectives: Neointimal hyperplasia, which was caused by smooth muscle cell proliferation, was noted to occur after performing percutaneous coronary intervention. Phosphodiesterase type 5 (PDE5) inhibitor has been shown to inhibit smooth muscle cell proliferation. Udenafil is one of the PDE5 inhibitors, and it is also expected to inhibit smooth muscle cell proliferation and reduce neointimal hyperplasia. We investigated the effect of udenafil on the smooth muscle cell proliferation and neointimal hyperplasia that occurs after balloon injury in the carotid arteries of rats. Materials and Methods: Smooth muscle cells were treated with 1 mM, 100 μM, 10 μM, 1 μM and 100 nM concentrations of udenafil. The viability of the smooth muscle cells was evaluated by MTT assay. The carotid arteries of rats were injured with a balloon catheter. Udenafil (100 μM, 10 μM and 1 μM) was applied on the carotid artery adventitia after balloon injury. At 21 days after treatment, the carotid arteries were harvested and stained with H & E. The neointima and media area were measured with a computerized image analysis program. Results: In the in vitro experiment, treatment with 1 mM udenafil reduced smooth muscle cell viability by 68.8±4.42% compared to the control group. In the balloon injured rat carotid artery, treatment with 100 μM udenafil reduced the neointima area by 71.8% compared to the control group. Conclusion: Udenafil administration effectively inhibited smooth muscle cell proliferation and it reduced neointimal hyperplasia in the balloon-injured rat carotid artery.

Sequential protein delivery using a microsphere/hydrogel combination system for therapeutic angiogenesis

신승화,이장욱,임광석,이상경,김용희,이근용 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.1

생물공학전공 교과 연계형 비교과프로그램 운영 사례연구 - K대학 CUBE 프로그램을 중심으로

이지수,박희호,임광석,이희제,하석진 한국생물공학회 2019 KSBB Journal Vol.34 No.4

The purpose of this study is to understand the effects of extracurricular program, and to draw implications for the subject curriculum environment through the case study by the biotechnology major among the interdisciplinary comparative course programs conducted by K University. The research data used for the study are student grade data gathered from three subjects in the biotechnology major from the second semester of 2018 and the first semester of 2019, and the survey results of participating students in the extracurricular program. As a result, professor's intended instructional goal, learner's extracurricular learning objectives, and core competencies were consistent, and participants' academic achievement was higher than non-participants. In addition, it was shown that the experience of extracurricular program in connection with the major subject helped the participants to increase their interest in the major subjects and explore their career. Therefore, extracurricular program is composed of competency development education suitable for learner's characteristics. However, it is necessary to study the effect of extracurricular program experiences related to major subjects on the learning continuity of participating students.

메탈로티오네인 단백질의 약학적 효능과 이의 응용

유한진,이지현,임광석 한국생물공학회 2019 KSBB Journal Vol.34 No.4

Metallothionein (MT) protein consists of about 60 amino acids including 20 cysteine residues. MT as a lowmolecular weight intra-cellular protein is over-expressed in the cell exposed stressful conditions such as in the presence of heavy metals, starvation, heat, or inflammation. Recently, MT has been reported as an antioxidant proteins having an antioxidant effect to protect cells from oxidative stress by reactive oxygen species (ROS). Oxidative stress has been known as a cause of various diseases such as diabetes, diabetic complications and myocardial disease and has been also found to be associated with cancer. MT has potential as a therapeutic agent due to its excellent antioxidant effect and control of cell growth. Recombinant fusion metallothionein, which is fused a protein transduction domain or mitochondrial targeted domain into metallothionein, showed enhanced therapeutic effect. In addition, the expression of metallothionein was related anticancer drug sensitivity in the cancer cells and resistance. Because MT could control cell growth and survival, it is necessary to develop a therapeutic agent targeting MT. Therefore, we discussed the characteristics and therapeutic efficacy of metallothionein.

진핵생물 개시인자 유래 펩타이드의 세포 성장 억제 효능

유한진(HanJin Yu),임광석(Kwang Suk Lim) 강원대학교 산업기술연구소 2020 産業技術硏究 Vol.40 No.1

In the process of protein transcription and translation, various protein complexes bind to DNA, and all processes are precisely controlled. Among the proteins constituting this complex, a peptide derived from eukaryotic initiation factor (eIF) 2 was synthesized. In addition, in order to increase the efficiency of transduction of this peptide into cells, peptides with polyarginine, one of the protein transduction domains (PTD), were synthesized. Cell growth inhibition was confirmed in HER2 positive breast cancer (SK-Br-3) and HER2 negative breast cancer (MDA-MB-231), and cardiomyocytes (H9c2). The peptide with polyarginine had high transduction efficiency in all cells, and had excellent cancer cell growth inhibitory effects. The peptide used in this study might be useful peptide therapeutics for the treatment of cancer through future research.