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간경변 환자의 근경련에 대한 전침 치료의 효과 무작위 대조군 연구
이창형,김병석,김경순,곽민아,김승모,Lee, Chang-hyeong,Kim, Byung-seok,Kim, Kyung-soon,Kwak, Min-a,Kim, Seung-mo 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objectives: The purpose of this clinical trial was to examine the efficacy and safety of electroacupuncture on liver cirrhosis patients suffering from muscle cramps. Methods: Fourteen patients with liver cirrhosis who experienced muscle cramps at least once a week, regardless of cramp location, were enrolled and randomly allocated to an experimental group (n=12) or a control group (n=12). The experimental patients were treated with electroacupuncture at an electrical stimulation frequency of 100 Hz three times a week for four weeks (12 times in total). Muscle cramps were evaluated by a questionnaire that probed subjective symptoms. We analyzed the frequency of muscle cramps 3 times (at screening, 14 th visit, 15 th visit) during 8 weeks. Results: The number of patients with cramps occurring 'more than once a week' was reduced and the proportion of patients decreased in response to electroacupuncture. The number of patients with cramps occurring 'less than once every two weeks' increased and the proportion of patients also increased in response to eletroacupunture. Conclusions: The results of this study suggest that electroacupuncture treatment will be beneficial for improving muscle cramps in patients with liver cirrhosis. Electroacupuncture is considered a safe and efficacious treatment for patients with liver cirrhosis who complain of muscle cramps.
Systemic Sclerosis Sine Scleroderma
김채기 ( Chae Gi Kim ),류헌모 ( Hun Mo Rhoo ),권중구 ( Joong Goo Kwon ),이창형 ( Chang Hyeong Lee ),송용호 ( Yong Ho Song ),최정윤 ( Jung Yoon Choe ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3
Systemic sclerosis (SSc) is a generalized connective tissue disorder of unknown etiology. Clinically, there is a broad spectrum of disease ranging from widespread severe skin thickening to skin thickening limited to the distal extremities. In rare cases of systemic sclerosis, no cutaneous change only with internal organ involvement has been reported, which is called `systemic sclerosis sine scleroderma (ssSSc)`. We describe a patient with Raynaud`s phenomenon, who showed intestinal pseudoobstruction as a presenting symptom but did not show any skin change. She had also an esophageal motility disorder, but other organ involvement was not evident. Antinuclear antibody was positive. Her obstruction symptoms were improved by decompression by nasogastric tube and pharmaceutical treatment with erythromycin and octreotide.
이창형 ( Chang Hyeong Lee ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.2(S)
Liver cirrhosis and portal hypertension may present with distinct clinitcal entities such as portopulmonary hypertension (POPH) and hepatopulmonary syndrome (HPS). The pathophysiology of these two conditions is not fully understood. HPS leads to progressive hypoxiema secondary to intrapulmonary vasodilatation. Imbalance in the pulmonary circulation between vasodilators and vasoconstrictors, intestinal endotoxemia, and activation of alveolar macrophage system may play a roles in pathogenesis of HPS. In POPH, there is excessive pulmonary vasoconstriction and vascular remodeling that cause an increase in pulmonary vascular resistance. Both diseases have a substantial negative impact on survival. There is no evidence for any pharmacologic modalities to successfully treat HPS. Liver transplantation, although associated with increased mortality, is a clear and definitive treatment for HPS. Liver transplantation may be beneficial in only highly carefully selected patients with POPH and is definite contraindication for severe POPH due to high perioperative and postoperative mortality rate. New and evolving medical therapies might change the natural course of POPH, but randomized, controlled multicenter trials are urgently needed.