Halothane 마취후 발생한 간염 2례보고

이준원,김은경,손영은,원임수 한림대학교의료원 1989 人間科學 Vol.13 No.1

한국 농촌지역 코호트에서 중년 성인의 혈압 변화와 연관 요인

이준원,유병수,이지현,윤영진,안성균,안민수,김장영,이승환,윤정한,최은희 대한고혈압학회 2014 Clinical Hypertension Vol.20 No.2

Background: Elevation of blood pressure (BP) and the increasing incidence of hypertension have been known to be associatedwith time course, especially age. But there is still lack of evidence of BP change and the association with biochemical markersor markers for subclinical organ damage in Korean general population. Thus, the purpose of this study is to investigate BPchange and the related factors in established Korean mid-aged rural cohort. Methods: This study was performed by usingdata from ARIRANG cohort (Atherosclerosis Risk of a Rural Area Korean General Population) in Gangwon rural area. Data werecollected from baseline survey (Nov 2005-Jan 2008) and follow-up survey (Apr 2008-Jan 2011). Among 5,515 participants,1,863 were analyzed after excluding individuals with hypertension, diabetes mellitus, cerebral infarction, myocardialinfarction, missing data for BP, and newly-developed hypertension. Results: Mean age was 53.4 ± 8.2 years and men were718 (38.5%). Mean follow-up period was 2.4 ± 0.9 years. Baseline systolic and diastolic BP were 123.6 ± 15.7 mm Hg and79.2 ± 10.8 mm Hg. Systolic BP changes were -10.9 ± 15.3 mm Hg and diastolic BP changes were -7.7 ± 11.8 mm Hg. Inlogistic regression analysis, predictors for elevation of systolic BP on follow-up were start regular exercise (odds ratio [OR],0.765; 95% confidence interval [CI], 0.604 to 0.968; p=0.0257) and fasting glucose (OR, 0.984; 95% CI, 0.972 to 0.996;p=0.0102) and homeostasis assessment-insulin resistance (OR, 0.82; 95% CI, 0.707 to 0.952; p = 0.0086). Conclusions:Follow-up systolic and diastolic BP were significantly decreased when compared to baseline BP in mid-aged Korean ruralcohort population. Long-term follow-up is needed to discriminate the periodic change of BP and the associated factors. 연구배경: 시간의 흐름, 특히 연령의 증가에 따라 혈압이 상승하고 고혈압이 발생하는 것으로 알려져 있다. 하지만 한국인을 대상으로 한 일반 인구집단에서, 시간에따른 혈압의 변화 및 이와 연관된 혈액학적 지표, 무증상장기손상 지표들과의 연관성에 대한 자료는 부족한 실정이다. 따라서 본 연구에서는 코호트 집단에서 혈압의 변화를 분석하고 이와 연관된 요인들을 알아보고자 하였다. 방법: 이 연구는 원주, 평창 농촌지역의 인구집단을 대상으로 한 ARIRANG 코호트(Atherosclerosis Risk of a Rural Area Korean General Population) 자료를 이용하여분석하였다. 2005년 11월부터 2008년 1월까지 기초조사를실시하였고, 2008년 4월부터 2011년 1월까지 재조사를시행받은 대상자들 중 고혈압, 당뇨, 고지혈증, 뇌경색, 심근경색의 과거력이 있거나, 혈압을 측정하지 않은 자, 항고혈압 약물치료에 대한 정보가 부족한 새로 진단된 고혈압환자를 제외한 1,863명을 대상으로 분석을 시행하였다. 결과: 평균 나이는 53.4 ± 8.2세, 남자가 718명(38.5%) 를 차지했다. 평균 추적관찰기간은 2.4 ± 0.9년이었다. 전체집단의 기초조사 수축기혈압은 123.6 ± 15.7 mm Hg이었고, 이완기혈압은 79.2 ± 10.8 mm Hg였다. 재조사 수축기혈압은 전체집단에서 -10.9 ± 15.3 mm Hg, 남자-12.0 ± 15.6 mm Hg, 여자 -10.2 ± 15.1 mm Hg(남자 대여자 p = 0.0141)로 감소했다. 이완기혈압도 -7.7 ± 11.8 mm Hg(전체집단), -8.9 ± 11.8 mm Hg(남자), -6.9 ± 11.6 mm Hg(여자) (남자 대 여자 p = 0.0003)으로 감소했다. 다중 로지스틱회귀분석에서 혈압의 변화(상승)과 연관된의미 있는 예측인자는 운동 시작(odds ratio [OR], 0.765; 95% confidence interval [CI], 0.604 to 0.968; p = 0.0257), 공복혈당(OR, 0.984; 95% CI, 0.972 to 0.996; p = 0.0102), HOMA-IR (OR, 0.820; 95% CI, 0.707 to 0.952; p = 0.0086)이었다. 결론: 중년의 원주 평창 농촌 코호트 집단에서 혈압의변화를 관찰했을 때, 재조사 혈압이 처음보다 유의한 감소를 보였다. 장기적인 추적관찰을 통한 혈압의 변화 및이와 연관된 요인들에 대한 분석이 필요하다.

급성 허혈성 뇌졸중의 관류 자기공명영상 소견

이준원 관동대학교 의과학연구소 2001 關東醫大學術誌 Vol.5 No.1

Background & Objective: Perfusion imaging (PI) of magnetic resonance imaging (MRI) uses the signal loss that occurs during dynamic tracking of the first pass of intravenous paramagnetic contrast agent. Then different hemodynamic measurements can be calculated and displayed as perfusion maps. We evaluated clinical usefulness of PI in acute ischemic stroke. Methods: Fifteen patients with clinical diagnosis of acute cerebral infarction were imaged with PI, DWI, and magnetic resonance angiogram (MRA) including FLAIR within 24 hours after onset. Comparisons were made between infarct volumes measured by PI using the parameters including relative mean transit time (rMTT) map, relative cerebral blood volume (rCBV) map, and relative cerebral blood flow (rCBF) map. Results: Two patterns were found: 1) rMTT map in PI lesion larger than the rCBV map lesion(n=7/15), and 2) rMTT map in PI lesion of the same size or smaller than rCBV map lesion(n=8/15). The former pattern was shown in cases with severe stenosis or occlusion of the major cerebral artery(MCA, PCA, or ICA) on MRA. The majority of latter pattern was lacunes(n=6/8). Also, we found presence of infarction cores surrounded by hypoperfused areas in rMTT map in acute large-arterial territorial infarction. Conclusions: Perfusion MRIs may be useful in differentiating large-arterial territorial infarction from lacunes.

고성장기업 선정을 위한 적응적 판단 기법에 대한 연구

이준원,성시호,오동찬 한국시뮬레이션학회 2017 한국시뮬레이션학회 학술대회집 Vol.2017 No.-

기술금융․기술평가 등이 정책적으로 이슈화 되면서, 높은 경제적 부가가치 및 고용을 창출할수 있는 기업선정 방법에 대한 중요성이 부각되고 있다. 본 논문에서는 평가대상기업이 속한 산업의 특징 및 기업의 업력을 고려한 적응적 고성장기업 선정기법에 대해 제안한다. 기존 연구 결과들이 고성장기업을 선정하는데 있어 고정된 임계값을 사용하는데 반해, 제안기법은 기업이 속한 산업및 기업의 업력에 따라 가변하는(adaptive) 임계값을 사용하여 기업 특성에 따른 공정한 평가가 가능하도록 한다. 제안기법을 활용하여 기업 평가자는 산업 특징 및 기업의 업력에 따른 유불리 없이 고성장기업을 선정할 수 있다. 더나아가 제안기법은 평가의 신뢰성을 제고함으로써 기술금융의 활성화에 기여할 것으로 기대된다.

R.Wagner의 Reingold에서 Theme의 사용에 관하여

李俊源 서원대학교 예술문화연구소 1996 예술문화논총 Vol.5 No.-

To attain his ideal of composite art, Wagner thought that poetic, musical, and dramatic ingredients should be closely correlated with one another, and accordingly used Leitmotiv and Melody Infinite. In this paper, we study the phraselogy of Wagner's operas by examining how the motives of the Ring and of Walhall are correlated in the prelude Das Reingiold of his opera The Ring of Nibelungen. The motive of Walhall is derived from that of the Ring. The two motives share the characteristic of being a means in governing the whole world: the Ring is pictured as the symbol of money and power, and Walhall, as the symbol of immortality. Wagner attempts a musical contrast in characterizing the two different, but correlated, motives by means of the melodies and of the rhythms of the music, on the one hand, and by means of the wood wind and of the brass on the other. Closely correlated since their birth, the two Leitmotivs function to unite the acts of the drama together and attempt to harmonize the drama itself and the music by explicating and implicating the present, past, and future dramatic situations. This musical phraselogy of Wagner has strong influences on the late works by G.Verdi(18j13-1901) and opera composers of the late period of romanticism.

L.da. Palestrina의 Mottetto의 分析 硏究

李俊源 서원대학교 예술문화연구소 2000 예술문화논총 Vol.9 No.-

C.Gesualdo da Venosa의 Madrigal의 分析硏究

李俊源 서원대학교 예술문화연구소 1999 예술문화논총 Vol.8 No.-

Although he was born in a distinguished family and was in the position of a leader of the high class society, Gesualdo had to lead a life full of mental distress and pain due to his tragic marriage life. His miserable life exerted more influences on his works than with any other composers; he couldn't express his musical desires with traditional techniques only. This necessarily demanded new modes of expression; he expressed the inner world of human beings through protruding notes in the high key, grand and unpredictably piquant cacophonies, chromatic development of harmony, and so on. His experimental attempts not precluding traditional techniques raised the music of his own age onto a new level and placed him in the seat of the musician who perfected the Renaissance music. Although not large in number of works, his restrained and refined music influenced many composers in the 20th century including Stravinsky (Pietroburt 1882-New York 1971).

지방의회의 예산심의과정분석

이준원 公州大學校 地域開發硏究所 1998 地域開發硏究論叢 Vol.6 No.1

The purpose of this thesis is to describe for understanding about the Budget Review Process in Local Government. I selected a case city, and analyzed the budget review process as the framework; actors' role, budgetary function, and budgeting strategies. The Results of this study are as follows; (1) They act cutter's role in the budget review process. (2) The functions of legislature are to coordinate cinflicts among interest groups, and to set the political climates. (3) The primary strategies are control-oriented and management-oriented.

L.MARENZIO의 MADRIGAL의 分析 硏究

李俊源 서원대학교 예술문화연구소 1997 예술문화논총 Vol.6 No.-

Marenzio was a representative composer of 16th Century, and new chapter by integrating the previous techniques of expression into his various ones and making poetry and music have a closer relationship with a set of new techniques. He depicted with music everything in poems(that is the objects, motions psychological changes, and so), as if he drew a painting: particularly by means of contrast between homophony and polyphony, altermative male and chorus, contrast in tone colors, declamation, avoidance of cadence, intervals of tones, consecutive advances, syncopation, radical harmonies, and an emphasis of the melody on the high vocal parts. His such techniques exerted a great influence on the technical advances of the 16th Century and further the development of Italian vocal music literature.

혁신인증 중소기업과 일반 중소기업의 재무성과 비교․분석

이준원 한국생산관리학회 2022 한국생산관리학회지 Vol.33 No.1

The financial performance of innovation-certified SMEs and general SMEs was compared and analyzed for the period 2016-2020. General SMEs, which are the target companies for comparison between technology innovation-type SMEs (venture certification, inno-biz certification) and management innovation-type SMEs (main-biz certification), were selected through propensity score matching. The results of the analysis indicated that innovation-certified SMEs that have been innovative for at least five years achieve higher levels of growth than general SMEs and excellent profitability within a limited range. In addition, there is a fundamental difference in the composition of technology innovation-type SMEs and management innovation-type SMEs by industry. Hence, rather than integrating and closing the innovation certification system, supplementing the existing system by strengthening the re-certification process is a way to maximize the purpose of the innovation certification system. 혁신인증 중소기업과 일반 중소기업의 2016년~2020년 재무성과를 성장성(매출액 증가율), 수익성(영업이익률), 안정성(부채비율)의 관점에서 비교․분석하였다. 한국표준산업분류, 업력, 고용인원, 자산 및 자본 규모, 매출액 및 영업이익을기반으로 성향점수매칭을 통해 기술혁신형 중소기업(벤처인증, 이노비즈인증)과 경영혁신형 중소기업(메인비즈인증)의 비교 대상기업인 일반 중소기업을 각각 선별한 후 분석을 수행하였다. 분석 결과 최소 5년 간 혁신성을 유지한 혁신인증 중소기업은 일반 중소기업 대비 높은 수준의 성장성과 제한된 범위 내에서 우수한 수익성을 달성하고 있다는 결론을 도출하였다. 또한 기술혁신형 중소기업과 경영혁신형 중소기업은 산업별 구성에 근본적인 차이가 있어 혁신인증 제도의 통⋅폐합보다는 재인증 프로세스의 강화 등을 통한 기존 제도의 보완이 혁신인증 제도의 취지를 극대화할 수 있는 방안이라고판단된다.