심전도와 심근 효소가 정상인 급성 관동맥 증후군에서Ischemia Modified Albumin 측정의 진단적 의의

김장영,최경훈,윤정한,정일형,왕희성,최훈,정현숙,김현,유병수,이승환,어영,황성오 대한심장학회 2005 Korean Circulation Journal Vol.35 No.12

Background and Objectives:In the early phase of acute chest pain, the diagnosis of acute coronary syndrome(ACS) is often difficult to achieve in an emergency department (ED) due to the non-diagnostic ECG and cardiacmarkers. Ischemia modified albumin (IMA) has recently been shown to be a sensitive early biochemical markerof ischemia. The aim of this study was to evaluate the diagnostic value of IMA for the patients with suspectedACS and who have normal ECG/cardiac markers. Subjects and Methods:We enrolled 142 consecutive patientswho presented to the ED due to suspected ACS, and they had a normal EKG and troponin-I/CK-MB within 5hours after the onset of their chest pain. The diagnosis of ACS was based upon the clinical findings, the resultsof serial ECG/troponin and the coronary angiography. The ideal cutoff value of IMA for ACS was calculated bythe receiver operator characteristic (ROC) curve analysis. Results:The ACS was diagnosed in 80/142 (56%).The ROC curve area for the IMA test was 0.77 (CI; 0.70-0.85, p<0.01). At a cutoff value of 98.5 U/mL, thesensitivity, specificity and negative predictive values for ACS were 73%, 75% and 75%, respectively. At a cutoffvalue of 85 U/mL, the sensitivity and specificity and negative predictive values for ACS were 92%, 35% and95%, respectively. Conclusion:IMA might be a useful diagnostic marker of ACS for those patients with normalECG/cardiac markers and who present within 5 hours after the onset of chest pain. 배경 및 목적:급성 흉통으로 조기에 응급실에 내원한 환자에서 심전도 및CK-MB/troponin-I가 정상인 경우 관동맥 증후군을 진단하기 어려운 경우가 흔하다. 최근 소개된 혈청 내 ischemiamodified albumin은 민감한 심근 허혈의 검사법으로 알려지고 있다. 본 연구의 목적은 급성 흉통환자에서 심전도 및CK-MB/troponin-I가 정상이며 급성 관동맥 증후군이 의심되는 환자에서 IMA 측정의 진단적 의의를 알아보고자 하였다방 법:대상환자는 연속적인 급성 흉통 후 5시간 안에 응급실에내원한 환자 중 troponin-I와 CK-MB가 정상이면서 심전도상 허혈의 증거가 없는 142명(평균나이: 58±14세, 남성;56%)을 포함시켰다. 관동맥 증후군의 진단은 내원하여 검사한 연속적인 생화학적 표식자 및 침습적/비침습적 심혈관검사에 의해 전향적으로 분석하였다. ROC커브를 통해 진단적 의의를 조사하였다. 결 과: 대상환자에서 관동맥 증후군은 80예(56%)였다. ROC커브상 IMA의 area under the curve는 0.77(confidence interval,0.70~0.85)이며 통계적으로 유의하였다(p<0.01).IMA치가 98.5 units/mL에서 관동맥 증후군의 민감도, 특이도, 음성 예측도는 각각 73%, 75%, 75였다. IMA치가 85units/mL에서 관동맥 증후군의 민감도, 특이도, 음성 예측도는 각각 92%, 35%, 95%였다. 결 론: 급성 흉통으로 조기에 내원하여 심전도와 CK-MB와 troponin-I이 정상인 환자에서, IMA의 측정은 관동맥 증후군을 예측할 수 있는 유용한 검사임을 시사하였다.

학교시설의 녹색건축 활성화를 위한 인증현황 분석 연구 - 경기도 학교시설을 중심으로 -

김장영,김성중,이승민,Kim, Jang-Young,Kim, Sung-Joong,Lee, Seung-Min 한국교육녹색환경연구원 2015 교육·녹색환경연구 Vol.14 No.3

In this paper, there are several analysis on G-SEED, Building Energy Efficiency Rating System, Energy Performance Index, Energy Saving Plan about how they are applied by classification and planning standard. The analysis result found out that G-SEED has low select percentage by having difficulties to managing and additional cost when the each class is selected. And also, Building Energy Efficiency Rating System in school is planed in comparably simple design and similar size and also mostly uses high efficient machines, which was in high lever comparing to the system in facilities in other uses. In the case of EPI, there are differences on acquiring grades by each region. Especially, Gyung-gi region has a low grade on architecture part comparing to other parts, which seems to acquire more grades by strengthen insulation performance. By the result from the three standards, many facilities has only formal plan to pass the required standard without considering specialities of each buildings, which has a tendency to have a pattern to have a minimum criteria. However, School has a symbolic building which has a obligation to be the base of the aim for growing green energy buildings and green education for students. Therefore, planning with understanding of specialities of the facility, having various and rational evaluation standards from the planning of the building is necessary.

An Efficient Algorithm for Big Data Prediction of Pipelining, Concurrency (PCP) and Parallelism based on TSK Fuzzy Model

김장영,Kim, Jang-Young The Korea Institute of Information and Commucation 2015 한국정보통신학회논문지 Vol.19 No.10

The time to address the exabytes of data has come as the information age accelerates. Big data transfer technology is essential for processing large amounts of data. This paper posits to transfer big data in the optimal conditions by the proposed algorithm for predicting the optimal combination of Pipelining, Concurrency, and Parallelism (PCP), which are major functions of GridFTP. In addition, the author introduced a simple design process of Takagi-Sugeno-Kang (TSK) fuzzy model and designed a model for predicting transfer throughput with optimal combination of Pipelining, Concurrency and Parallelism. Hence, the author evaluated the model of the proposed algorithm and the TSK model to prove the superiority.

급성 심근경색증과 유사한 ST분절 상승을 보인 심장전이 폐암 1예

김장영,윤정한,유병수,이승환,정순희,홍인수,최경훈 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.5

Risk Factor Clustering in Korean Hypertensive Patients

김장영 대한심장학회 2016 Korean Circulation Journal Vol.46 No.5

Urinary Levels of 8-Iso-Prostaglandin F2α and 8-Hydroxydeoxyguanine as Markers of Oxidative Stress in Patients With Coronary Artery Disease

김장영,이준원,윤영진,안민수,안성균,유병수,이승환,윤정한,최경훈 대한심장학회 2012 Korean Circulation Journal Vol.42 No.9

Background and Objectives: The objective of this study was to determine if urinary levels of 8-iso-prostaglandin F2α (8-iso-PGF2α) and 8-hydroxydeoxyguanine (8-OHdG) could be used as markers of the oxidative stress in significant coronary artery disease (CAD). Subjects and Methods: We conducted a case-control study in 104 subjects assessed by coronary angiography with the following diagno-ses: 35 consecutive cases of significant CAD and 69 cases of non-CAD with stable angina. We compared the urinary levels of 8-iso-PGF 2 αand 8-OHdG, as measured by immunoassay between the 2 groups. Results: History of hypertension was significantly higher and high density lipoprotein-cholesterol level significantly lower in the CAD group compared with those in the non-CAD group. Median levels of 8-iso-PGF2α were significantly higher in the CAD group compared with the non-CAD group (9.2 vs. 6.0 ng/mg, p=0.001). There were no significant differences in 8-OHdG values between the 2 groups. The odds ratio of 8-iso-PGF2α for CAD in the highest tertile compared with that in the lowest tertile was 7.39 (95% confidence interval; 1.71-31.91). There was no significant difference in median values of 8-iso-PGF2 α between single- and multi-vessel CAD. Conclusion: Urinary 8-iso-PGF 2α was independently associated with significant CAD in this case-control study. Background and Objectives: The objective of this study was to determine if urinary levels of 8-iso-prostaglandin F2α (8-iso-PGF2α) and 8-hydroxydeoxyguanine (8-OHdG) could be used as markers of the oxidative stress in significant coronary artery disease (CAD). Subjects and Methods: We conducted a case-control study in 104 subjects assessed by coronary angiography with the following diagno-ses: 35 consecutive cases of significant CAD and 69 cases of non-CAD with stable angina. We compared the urinary levels of 8-iso-PGF 2 αand 8-OHdG, as measured by immunoassay between the 2 groups. Results: History of hypertension was significantly higher and high density lipoprotein-cholesterol level significantly lower in the CAD group compared with those in the non-CAD group. Median levels of 8-iso-PGF2α were significantly higher in the CAD group compared with the non-CAD group (9.2 vs. 6.0 ng/mg, p=0.001). There were no significant differences in 8-OHdG values between the 2 groups. The odds ratio of 8-iso-PGF2α for CAD in the highest tertile compared with that in the lowest tertile was 7.39 (95% confidence interval; 1.71-31.91). There was no significant difference in median values of 8-iso-PGF2 α between single- and multi-vessel CAD. Conclusion: Urinary 8-iso-PGF 2α was independently associated with significant CAD in this case-control study.

Aspirin and Clopidogrel Resistance in Drug Eluting Stent Era

김장영,윤정한 대한심장학회 2007 Korean Circulation Journal Vol.37 No.4

Platelets play a central role in the pathogenesis of atherothrombosis. Dual antiplatelet therapy with clopidogrel plusaspirin has been shown to reduce ischemic events in patients undergoing percutaneous coronary intervention(PCI) and stenting. Although dual antiplatelet therapy reduces the risk of cardiovascular episodes after PCIs, a substantialnumber of incidents continue to occur. Many cardiologists have focused their attention to the relationshipsbetween the interindividual variability of platelet inhibition after aspirin or clopidogrel administration and majorcardiac adverse events such as stent thrombosis. Recent evidence has suggested that “aspirin or clopidogrel resistance”is associated with poor health outcomes (recurrent atherothrombotic events and stent thrombosis) after drugeluting stent (DES) implantation. However, the current clinical guidelines do not support routine screenings for antiplateletresistance because standardized objective screening has not yet been established. Thus, this review describesthe antiplatelet therapy used in PCI and it outlines the mechanism, laboratory tests, clinical impact and treatmentoptions for aspirin and clopidogrel resistance in the DES era. (Korean Circulation J 2007;37:135-147)

하수처리장 부하 저감을 위한 음식물쓰레기 탈리액 내 액상 미생물 제제 적용 연구

김장영,신동철,양희성,정원식 한국도시환경학회 2022 한국도시환경학회지 Vol.22 No.4

In this study, in order to reduce the load of sewage treatment plants, the load reduction evaluation is conducted by reacting food waste leachate with liquid microbial agents. The standard food sample and water were mixed, crushed, sieve-filtrated at 0.3mm mesh to produce a desorption solution, and the liquid microbial agents eco-A, eco-C, eco-D, and eco-E were reacted for 6 hours, respectively, to analyze TCODcr and SCODcr. As a result, TCODcr and SCODcr of the desorbed solution reacted with eco-C were the highest, but the efficiency was not significant compared to the control group, and accordingly, additional experiments were performed by adding returned activated sludge from the sewage treatment plant. The experiment to add returned activated sludge showed that eco-C had the highest reduction efficiency, the Shinella strain had the highest classification configuration in eco-C, and high reactivity with returned activated sludge. Therefore, it is judged that the load of the sewage treatment plant due to food waste leachate can be reduced by mixing the liquid microbial agent eco-C and the returned activated sludge directly into the sewage pipe, but further research is needed to achieve commercialization level. 본 연구에서는 하수처리장의 부하 저감을 위해 음식물쓰레기 침출수와 액상 미생물 제제를 반응시켜 부하 저감 평가 를 하고자 한다 . 음식물 찌꺼기 표준시료와 물을 혼합하여 분쇄 후 0.3mm mesh에 체거름하여 탈리액을 생성하였으며 , 여기에 액상 미생물 제제인 eco-A, eco-C, eco-D, eco-E를 각각 6시간 동안 반응시켜 TCODcr과 SCODcr을 분석하였다 . 그 결과 eco-C와 반응한 탈리액의 TCODcr, SCODcr의 감소율이 가장 높았으나 대조군과 비교 시 큰 효율이 나타나지 않 았으며 , 이에 따라 하수처리장의 반송슬러지를 첨가하여 추가실험을 수행하였다 . 반송슬러지를 첨가 실험을 수행 결과 마 찬가지로 eco-C의 저감 효율이 가장 높았으며 , eco-C에는 Shinella 균주가 가장 높은 분류 구성을 나타내고 있으며 , 반송 슬러지와 높은 반응성을 나타난 것으로 판단된다 . 따라서 , 액상 미생물 제제 eco-C와 반송슬러지를 혼합시켜 하수관에 직 투입하면 음식물쓰레기 침출수로 인한 하수처리장의 부하 저감이 가능할 것으로 판단되나 , 상용화 수준으로 되기 위해서 는 추가적인 연구가 필요하다 .

Announcement: New Deputy Editors of the Journal of Cardiovascular Imaging

김장영 한국심초음파학회 2018 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.26 No.2

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하수처리장 부하 저감을 위한 음식물쓰레기 배수 전처리시스템 개발 연구

김장영,정원식 한국산학기술학회 2023 한국산학기술학회논문지 Vol.24 No.1

Currently, the segregation of food waste before discarding is prevalent in Korea, a process wherein the residents have complained of odor and discomfort. Disposers have therefore been introduced to overcome this problem. The domestic standard for disposal requires that less than 20% of solids by weight be discharged to the sewer, and more than 80% should be recovered. However, there is a problem with the direct input of solids into the sewage system, which results in sewage clogging and backflow, odor, and overloading of the sewage treatment plant. In the current study, we developed a food waste drainage pretreatment system by installing a centrifugal screw device for the solid-liquid separation of food pulverized by a disposer at home and a Nano Bubble device for reducing the sewage load. The recovery rate of solids from the centrifugal screw device was about 96.6%. The desorbed liquid was transferred to the rear and treated with a Nano Bubble device, resulting in a reduction rate of approximately 68.9% of COD and about 85.0% of SS compared to the raw material. We believe the results of this study can be used as basic data for reducing the sewage treatment plant loads through improved water quality and for operation management and sewage maintenance project guidelines. We also expect the data to be applied for establishing co-residential complex construction guidelines and management measures in the future.