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인간 태아의 뇌로부터 만들어진 cDNA library에서 내생 레트로바이러스 HERV-W LTR의 클로닝 및 분자계통분류
이주민,허재원,신경미,이지원,이영춘,백인호,장경립,김희수 한국생명과학회 2001 생명과학회지 Vol.11 No.4
Long terminal repeats(LTRs) of the human endogenous retrovirus(HERV) heve been found to be coexpresed with genes located nearby. It has been suggested that the LTR elements have contributed to the genetic variation of human genome connected to various diseases. Recently, HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using cHNA library derived from human fetal brain, we performed PCR amplification and identified seven new HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity(98∼99%) with HERV-W (AF072500). A phylogentic tree obtained by the neighbor-joining method revealed that seven new HERV-W LTR elements(FB-1, 2, 4, 8, 9, 10, 12) were closely related to the AX000960, AF072504, and AF072506 from Gen Bank database. Our data suggest that several copy numbers of the HERV-W LTR elements are expressed in human feta brain and may contribute to an understanding of biological function connected to neuropsychiatric diseases.
이주민,김주희,권은영,김의경,이주연,김성조,최점일 대한치주과학회 2011 Journal of Periodontal & Implant Science Vol.41 No.2
Purpose: The present study was performed to compare the treatment outcomes of non-surgical periodontal treatment according to the distribution of attachment loss of a given patient. Methods: Forty-five patients with moderate to severe periodontitis were divided in two subgroups; Group I patients with teeth manifesting attachment loss of ≥6 mm at one or more sites on the buccal/labial aspect while maintaining an attachment level ≤5 mm at the lingual/palatal aspect, Group II patients with teeth manifesting an attachment level ≥6 mm at more than one site on the lingual/palatal aspect while maintaining an attachment level ≤5 mm at the buccal/labial aspect. The probing pocket depth, probing attachment level, tooth mobility, and chewing discomfort were recorded at baseline and 6 months examinations following non-surgical periodontal therapy. Results: The buccal/labial surfaces of teeth with moderate to severe periodontitis in Group I patients demonstrated a greater amount of pocket reduction, gain of attachment level, and tooth mobility reduction than the lingual/palatal aspects of teeth examined in Group II patients. Conclusions: Within the limits of the present study, the patients demonstrating attachment loss ≥6 mm at buccal/labial surfaces responded better to the nonsurgical periodontal therapy than those demonstrating comparable attachment loss at lingual/palatal surfaces.
Osteoblastic Response to the Hydroxyapatite/Gelatin Nanocomposite and Bio-Calcium Phosphate Cement
이주민,최별보라,최정해,김규천,황대석,장명철,변준호,김욱규 한국조직공학과 재생의학회 2013 조직공학과 재생의학 Vol.10 No.2
The main purpose of the developingnew CPCs by modulating their components or ratios are to develop more proper biomaterials which can adapt to the body. In the present study, the properties of newly developed HAp/Gel Nanocomposites were tested using in-vitro experiments (The toxicity test, chromosomal aberration test, cytokinesis-block micronucleus assay, RT-PCR analysis). The data from the WST-1 experiments using HAp/Gel and human osteoblastic cells showed that this material does not induces cellular death. And this material did not induced any significant changes in the structures of chromosomes. The expression pattern of integrins after treatment with CPC or HAp/Gel powder represents that the cells in CPC forms focal adhesion as the cells on adhesive culture dish,but the cells in HAp/Gel do not. By performing several set of experiments, HAp/Gel is not toxic to hFOB-1.19human osteoblast cell and does not cause any genetic problems. In contrast to CPC, HAp/Gel promotes the final differentiation of osteoblast into osteocyte. These results represent the improved bio-mimetic properties of HAp/Gel.
Are Negative Online Consumer Reviews Always Bad? A Two-Sided Message Perspective
이주민,박세범,이상원 한국경영정보학회 2015 Asia Pacific Journal of Information Systems Vol.25 No.4
This study investigates the effects of a two-sided message on product attitude and purchase intention by using a message structure variable, such as attribute importance in the context of online consumer reviews (OCRs). Study 1 explains the previous inconsistent results of a two-side message by comparing a one-side message and a two-side message by using the attribute importance in negative reviews. Study 2 determines the reasons for the inconsistent results of a refutational two-sided message research by using the attribute importance in negative reviews and website trust. Two experiments are designed to test our hypotheses. The first experiment is a 2×2 factorial design with 84 participants. The second experiment uses a 2×2×2 factorial design with 196 participants. In study 1, two-sided OCRs are more credible than one-sided OCRs, and two-sided OCRs that use low important attributes are more effective in making favorable product attitude/purchase intention. In study 2, refutational two-sided OCRs that use high attribute importance render positive effects on product attitudes in trustworthy websites. However, the refutation could negatively affect product attitude/purchase intention in low trustworthy websites.