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이달의 X-선 : 악성 임파종의 항암 치료 후 빠르게 진행되는 범발성 폐침윤
손장원 ( Jang Won Sohn ),신동호 ( Dong Ho Shin ),양석철 ( Seok Chul Yang ),윤호주 ( Ho Joo Yoon ),박성수 ( Sung Soo Park ),이정희 ( Jung Hee Lee ),이영열 ( Young Yul Lee ),최요원 ( Yo Won Choi ),박문향 ( Moom Hyang Park ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.2
중증 감염증에서 정주용 면역글로불린의 치료효과에 대한 연구
정태준,이영열,최일영 대한감염학회 1989 감염 Vol.21 No.3
In case of servere infection, depressed host immunity and nutritional deficit may make antibiotic therapy alone insufficient for getting satisfactory outcome. Theoretically, combined use of intravenous immunoglobulin(IVIG) with antibiotics is a good alternative not only for temporary relief of symptoms through its anti-endotoxic effect but also for atibody substitution purpose. However, IVIG therapy can block the monocyte function by the interaction of the IgG with Fc receptors, which causes decreased phagocytosis and ADCC of infected organisms. We have compared the antibiotic therapy alone with combined use of IVIG and antibiotics to investigate the role of IVIG for the treatment of severe infection. 100㎎/㎏ of IVIG for 5 days was our protocol to study and was enough to increase and maintain the serum concentration of IgG above normal range for at least 14 days. Overall response rate of IVIG treated group was 95.2% compared to 83.3% of antibiotic therapy alone group. Febrile period was also shortened by IVIG combination (9.1 vs 12.0 days). But ADCC activity of the peripheral blood monocytes was not affected by our therapy protocol with IVIG (33.4±16.7% in IVIG group vs 32.8±10.1% in control). Our results suggest that IVIG therapy in combination with antibiotics is superior to antibiotic therapy alone for the effective management of severe infection.
Ahn, Myung-Ju,Noh, Yun-Hee,Kim, Wo-Chul,Kim, Hyun-Soo,Lee, Young-Yul,Jung, Tae-June,Choi, Il-Young,Kim, In-Soon,Lee, Young-Sung 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.1
고용량 항암 치료와 자가조혈모세포 이식을 받은 고위험군 및 전이성 유방암 환자에서 채취한 말초조혈모세포의 암세포오염을 검출하기 위해 암세포 표지자의 하나인 CEA mRNA를 역전사중합연쇄반응을 이용하여 연구하였다. 말초혈액조혈모세포는 G-CSF 단독 또는 항암제와 G-CSF을 이용하여 가동화 하였다. 음성 대조군인 9예의 정상인의 말초혈액에서는 CEA mRNA가 검출되지 않은 반면, 7예의 고위험군 중 3예(42.8%)과 21예의 전이성 유방암 환자중 6예(28.5%)에서 각각 CEA mRNA가 검출되었다. 항암제 및 G-CSF로 가동한 18예 중 5예(27.8%)에서 CEA mRNA가 검출되었고, G-CSF만으로 가동화한 경우 10예 중 4예(40%)에서 검출되었다. 고위험군에서 CEA mRNA 양성군의 평균 림프절전이수는 32.3으로 음성군의 14보다 많았다. 전이성 유방암 환자에서 무재발생존기간 또는 생존기간에서 두군간에 차이는 없었다. 본 저자들은 많은 수의 고위험군 및 전이성 유방암 환자의 말초혈액조혈모세포에 암세포의 오염이 있음을 확인하였고, CEA mRNA를 표지자로 역전사중합연쇄반응을 이용한 암세포 검출은 향후 자가조혈모세포 이식후의 재발 등을 추적하는데 유용한 지표로 사용될 것으로 사료된다. 본 연구에서 암세포의 오염이 이식후 재발이나 생존에 어떠한 영향을 미치는가에 대하서 적은 환자수와 짧은 추적기간으로 결론 내리기는 어려우나 향후 좀 더 많은 수의 환자를 대상으로 장기적인 추적관찰을 통해 말초조혈모세포에서의 암세포 오염 임상적 의의를 밝힐수 있으리라 기대된다. We analyzed the peripheral blood stem cells obtained from patients with high risk or metastatic breast cancer undergoing high dose chemotherapy with autologous peripheral blood stem cell transplantation to assess the presence of CEA mRNA by RT-PCR(reverse transcription-polymerase chain reaction) as an indicator of malignant cell contamination and to evaluate its clinical significance. The peripheral blood stem cells were obtained from chemotherapy and/or G-CSF mobilization. A total of 7 high risk and 21 metastatic breast cancer patients and nine normal healthy subject were studied. No CEA mRNA was detected in all the nine normal subjects. Three out of 7 (42.8%) high risk and 6 out of 21 (28.5%) metastatic breast cancer were found to be positive for CEA mRNA. CEA mRNA was found in the apheresis products of 27.8%(5/18) of patients mobilized with chemotherapy plus G-CSF and 40%(4/10) of patients with G-CSF alone. In high risk patients, the number of lymph node metastasis in positive group was higher than that of negative group (mean 32.3 vs 14). In metastasis breast cancer, there was no significant difference between CEA mRNA positive and negative group in progression free or overall survival. Our study suggests that a significant number of high risk of metastatic breast cancer patients undergoing autologous transplantation are contaminated with circulating malignant cells in apheresis product. This assay may be useful in monitoring tumor cell contamination and in developing prognostic models for the risk of relapse after transplantation. Although it is unclear what role the contaminating malignant cells have in relapse in our study, further studies with large number of patients and the comparison with other prognostic factors and characteristics of the tumor may determine the significance of tumor contamination in apheresis products.