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황석연,이영구,황상구,임홍빈,김용익,장경훈,전병훈,이동욱,이형철 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5
Protaetia brevitarsis has been used as a traditional medicine for the treatment of patients with chronic hepatic diseases, although its toxicity in vivo was not proven pharmacologically or clinically. To investigate the subchronic toxicity of Protaetia brevitarsis extract (PBE) in Sprague-Dawley rats, male rats were given diet containing 0.04, 0.2, or 1.0% PBE for 4 and 12 weeks, respectively. Compared with age-matched control group, PBE treated groups have no abnormal signs(in external morphology) and significant changes in body weight and organs weight. Any abnormal signs including urinalysis and serum biochemistry parameters were also not observed after treatment with PBE for 12 weeks. Levels of total proteins and albumin in serum were significantly increased only in the group administered with 0.2% and 0.04% PBE for 4 weeks, but those were returned to the levels of control rats when rats were treated with same amount of PBE for 12 weeks. On the contrary, the activities of serum AST and ALT were decreased in the groups administered with 1.0% PBE for 4 weeks, and 1.0% and 0.04% PBE for 12 weeks. However, the alterations were located within the normal range in these parameters. Therefore, the results suggest that PBE does not induce any toxicity in SD rats administered with diet containing up to 1.0% of PBE for 12 weeks.